Methods in Raman spectroscopy for saliva studies – a review

References

• Atkins, C. G.; Buckley, K.; Blades, M. W.; Turner, R. F. B. Raman Spectroscopy of Blood and Blood Components. Appl. Spectrosc. 2017, 71, 767–793. doi:https://doi.org/10.1177/0003702816686593
   PubMed Web of Science ®Google Scholar
• Sikirzhytski, V.; Sikirzhytskaya, A.; Lednev, I. K. Advanced Statistical Analysis of Raman Spectroscopic Data for the Identification of Body Fluid Traces: Semen and Blood Mixtures. Forensic Sci. Int. 2012, 222, 259–265. doi:https://doi.org/10.1016/j.forsciint.2012.07.002
   PubMed Web of Science ®Google Scholar
• Sikirzhytski, V.; Sikirzhytskaya, A.; Lednev, I. K. Multidimensional Raman Spectroscopic Signature of Sweat and Its Potential Application to Forensic Body Fluid Identification. Anal. Chim. Acta. 2012, 718, 78–83. doi:https://doi.org/10.1016/j.aca.2011.12.059
   PubMed Web of Science ®Google Scholar
• Cennamo, G.; Montorio, D.; Morra, V. B.; Criscuolo, C.; Lanzillo, R.; Salvatore, E.; Camerlingo, C.; Lisitskiy, M.; Delfino, I.; Portaccio, M.; et al. Surface-Enhanced Raman Spectroscopy of Tears: Toward a Diagnostic Tool for Neurodegenerative Disease Identification. J. Biomed. Opt. 2020, 25, 1–12. doi:https://doi.org/10.1117/1.JBO.25.8.087002
   PubMed Web of Science ®Google Scholar
• Kuo, M. T.; Lin, C. C.; Liu, H. Y.; Chang, H. C. Tear Analytical Model Based on Raman Microspectroscopy for Investigation of Infectious Diseases of the Ocular Surface. Invest. Ophthalmol. Vis. Sci. 2011, 52, 4942–4950. doi:https://doi.org/10.1167/iovs.10-7062
   PubMed Web of Science ®Google Scholar
• Pastare, D.; Bennour, M. R.; Polunosika, E.; Karelis, G. Biomarkers of Multiple Sclerosis. Open Immunol. J. 2019, 9, 1–13. doi:https://doi.org/10.2174/1874226201909010001
   Google Scholar
• Poste, G. Bring on the Biomarkers. Nature 2011, 469, 156–157. doi:https://doi.org/10.1038/469156a
   PubMed Web of Science ®Google Scholar
• Surowiec, I.; Skotare, T.; Sjögren, R.; Gouveia-Figueira, S.; Orikiiriza, J.; Bergström, S.; Normark, J.; Trygg, J. Joint and Unique Multiblock Analysis of Biological Data - Multiomics Malaria Study. Faraday Discuss. 2019, 218, 268–283. doi:https://doi.org/10.1039/c8fd00243f
   PubMed Web of Science ®Google Scholar
• Liu, J.; Duan, Y. Saliva: A Potential Media for Disease Diagnostics and Monitoring. Oral Oncol. 2012, 48, 569–577. doi:https://doi.org/10.1016/j.oraloncology.2012.01.021
   PubMed Web of Science ®Google Scholar
• Bonifacio, A.; Cervo, S.; Sergo, V. Label-Free Surface-Enhanced Raman Spectroscopy of Biofluids: Fundamental Aspects and Diagnostic Applications. Anal. Bioanal. Chem. 2015, 407, 8265–8277. doi:https://doi.org/10.1007/s00216-015-8697-z
   PubMed Web of Science ®Google Scholar
• D'Elia, V.; Montalvo García, G.; García Ruiz, C. Spectroscopic Trends for the Determination of Illicit Drugs in Oral Fluid. Appl. Spectrosc. Rev. 2015, 50, 775–796. doi:https://doi.org/10.1080/05704928.2015.1075206
   Web of Science ®Google Scholar
• Butler, H. J.; Ashton, L.; Bird, B.; Cinque, G.; Curtis, K.; Dorney, J.; Esmonde-White, K.; Fullwood, N. J.; Gardner, B.; Martin-Hirsch, P. L.; et al. Using Raman Spectroscopy to Characterize Biological Materials. Nat. Protoc. 2016, 11, 664–687. doi:https://doi.org/10.1038/nprot.2016.036
   PubMed Web of Science ®Google Scholar
• Long, D. A. The Raman Effect: A Unified Treatment of the Theory of Raman Scattering by Molecules; John Wiley and Sons: London, 2002.
   Google Scholar
• Le Ru, E. C.; Etchegoin, P. G. Principles of Surface-Enhanced Raman Spectroscopy: And Related Plasmonic Effects; Elsevier: Amsterdam, 2009. https://doi.org/10.1016/b978-0-444-52779-0.00008-8.
   Google Scholar
• Procházka, M. Surface-Enhanced Raman Spectroscopy: Bioanalytical, Biomolecular and Medical Applications; Springer: New York, 2015.
   Google Scholar
• Rohman, A.; Windarsih, A.; Lukitaningsih, E.; Rafi, M.; Betania, K.; Fadzillah, N. A. The Use of FTIR and Raman Spectroscopy in Combination with Chemometrics for Analysis of Biomolecules in Biomedical Fluids: A Review. BSI. 2020, 8, 55–71. doi:https://doi.org/10.3233/BSI-200189
   Google Scholar
• Baker, M. J.; Byrne, H. J.; Chalmers, J.; Gardner, P.; Goodacre, R.; Henderson, A.; Kazarian, S. G.; Martin, F. L.; Moger, J.; Stone, N.; Sulé-Suso, J. Clinical Applications of Infrared and Raman Spectroscopy: State of Play and Future Challenges. Analyst 2018, 143, 1735–1757. doi:https://doi.org/10.1039/C7AN01871A
   PubMed Web of Science ®Google Scholar
• Goodacre, R.; Baker, M. J.; Graham, D.; Schultz, Z. D.; Diem, M.; Marques, M. P.; Cinque, G.; Vernooij, R.; Sulé-Suso, J.; Byrne, H. J.; et al. Biofluids and Other Techniques: General Discussion. Faraday Discuss. 2016, 187, 575–601. doi:https://doi.org/10.1039/C6FD90014C
   PubMed Web of Science ®Google Scholar
• Baker, M. J.; Hussain, S. R.; Lovergne, L.; Untereiner, V.; Hughes, C.; Lukaszewski, R. A.; Thiéfin, G.; Sockalingum, G. D. Developing and Understanding Biofluid Vibrational Spectroscopy: A Critical Review. Chem. Soc. Rev. 2016, 45, 1803–1818. doi:https://doi.org/10.1039/c5cs00585j
   PubMed Web of Science ®Google Scholar
• Pfaffe, T.; Cooper-White, J.; Beyerlein, P.; Kostner, K.; Punyadeera, C. Diagnostic Potential of Saliva: Current State and Future Applications. Clin. Chem. 2011, 57, 675–687. doi:https://doi.org/10.1373/clinchem.2010.153767
   PubMed Web of Science ®Google Scholar
• Kefalides, P. T. Saliva Research Leads to New Diagnostic Tools and Therapeutic Options. Ann. Intern. Med. 1999, 131, 991–992. doi:https://doi.org/10.7326/0003-4819-131-12-199912210-00102
   PubMed Web of Science ®Google Scholar
• Edgar, M.; Dawes, C.; O’Mullane, D. Saliva and Oral Health, 3rd ed.; BDJ Books: London, 2004.
   Google Scholar
• Ericsson, Y. Clinical Investigations of the Salivary Buffering Action. Acta Odontol. Scand. 1959, 17, 131–165. doi:https://doi.org/10.3109/00016355908993928
   Google Scholar
• Dodds, M.; Roland, S.; Edgar, M.; Thornhill, M. Saliva: A Review of Its Role in Maintaining Oral Health and Preventing Dental Disease. BDJ Team 2015, 2, 15123. doi:https://doi.org/10.1038/bdjteam.2015.123
   Google Scholar
• de Almeida, P. D. V.; Grégio, A. M. T.; Machado, M. Â. N.; De Lima, A. A. S.; Azevedo, L. R. Saliva Composition and Functions: A Comprehensive Review. J. Contemp. Dent. Pract. 2008, 9, 72–80. doi:https://doi.org/10.5005/jcdp-9-3-72
   PubMedGoogle Scholar
• Edgar, W. Saliva: Its Secretion, Composition and Functions. Br. Dent. J. 1992, 172, 305–312. doi:https://doi.org/10.1038/sj.bdj.4807861
   PubMed Web of Science ®Google Scholar
• Schipper, R. G.; Silletti, E.; Vingerhoeds, M. H. Saliva as Research Material: Biochemical, Physicochemical and Practical Aspects. Arch. Oral Biol. 2007, 52, 1114–1135. doi:https://doi.org/10.1016/j.archoralbio.2007.06.009
   PubMed Web of Science ®Google Scholar
• Whelton, H. The Anatomy and Physiology of Salivary Glands. In Saliva and Oral Health; Edgar, M., Dawes, C., O’Mullane, D., Eds.; Stephen Hancocks: Bicester, UK, 2012.
   Google Scholar
• Dawes, C. Circadian Rhythms in Human Salivary Flow Rate and Composition. J. Physiol. 1972, 220, 529–545. doi:https://doi.org/10.1113/jphysiol.1972.sp009721
   PubMed Web of Science ®Google Scholar
• Humphrey, S. P.; Williamson, R. T. A Review of Saliva: Normal Composition, Flow, and Function. J. Prosthet. Dent. 2001, 85, 162–169. doi:https://doi.org/10.1067/mpr.2001.113778
   PubMed Web of Science ®Google Scholar
• Atkinson, J.; Fox, P. Salivary Gland Dysfunction. Clin. Geriatr. Med. 1992, 8, 499–511. doi:https://doi.org/10.14219/jada.archive.1994.0059.
   PubMedGoogle Scholar
• Navazesh, M. Methods for Collecting Saliva. Ann. N Y Acad. Sci. 1993, 694, 72–77. doi:https://doi.org/10.1111/j.1749-6632.1993.tb18343.x
   PubMed Web of Science ®Google Scholar
• Miller, C.; Foley, J.; Bailey, A.; Campell, C.; Humphries, R.; Christodoulides, N.; Floriano, P. N.; Simmons, G.; Bhagwandin, B.; Jacobson, J. W.; et al. Current Developments in Salivary Diagnostics. Biomark. Med. 2010, 4, 171–189. doi:https://doi.org/10.2217/bmm.09.68
   PubMed Web of Science ®Google Scholar
• Percival, P.; Challacombe, S.; Marsh, P. Flow Rates of Resting Whole and Stimulated Parotid Saliva in Relation to Age and Gender. J. Dent. Res. 1994, 73, 1416–1420. doi:https://doi.org/10.1177/00220345940730080401
   PubMed Web of Science ®Google Scholar
• Shern, R.; Fox, P.; Li, S. Influence of Age on the Secretory Rates of the Human Minor Salivary Glands and Whole Saliva. Arch. Oral Biol. 1993, 38, 755–761. doi:https://doi.org/10.1016/0003-9969(93)90071-S
   PubMed Web of Science ®Google Scholar
• Gonçalves de Oliveira, C.; Ferro Collares, E.; Barbieri, M. A.; Machado Fernandes, M. I. Produçäo e Concentraçäo de Saliva e Amilase Salivar Em Crianças Obesas [Production and Concentration of Saliva and Salivary Amylase in Obese Children]. Arq. Gastroenterol. 1997, 34, 105–111.
   PubMedGoogle Scholar
• Dawes, C. Physiological Factors Affecting Salivary Flow Rate, Oral Sugar Clearance, and the Sensation of Dry Mouth in Man. J. Dent. Res. 1987, 66, 648–653. doi:https://doi.org/10.1177/00220345870660S107
   PubMed Web of Science ®Google Scholar
• Paluszkiewicz, C.; Kwiatek, W. M.; Długoń, E.; Wesełucha-Birczyńska, A.; Piccinini, M. Surface Study of Selected Biomaterials Using Vibrational Spectroscopy. Acta Phys. Pol. A. 2009, 115, 533–536. doi:https://doi.org/10.12693/APhysPolA.115.533
   Web of Science ®Google Scholar
• Lawanstiend, D.; Gatemala, H.; Nootchanat, S.; Eakasit, S.; Wongravee, K.; Srisa-Art, M. Microfluidic Approach for in Situ Synthesis of Nanoporous Silver Microstructures as on-Chip SERS Substrates. Sens. Actuators B Chem. 2018, 270, 466–474. doi:https://doi.org/10.1016/j.snb.2018.05.051
   Web of Science ®Google Scholar
• Altuntas, S.; Buyukserin, F. Fabrication of Thioflavin-T-Modified Nanopillared SERS Substrates for Ultrasensitive Beta-Amyloid Peptide Detection. J. Raman Spectrosc. 2018, 49, 1247–1256. doi:https://doi.org/10.1002/jrs.5376
   Web of Science ®Google Scholar
• Zhou, H.; Pandya, J. K.; Tan, Y.; Liu, J.; Peng, S.; Muriel Mundo, J. L.; He, L.; Xiao, H.; McClements, D. J. Role of Mucin in Behavior of Food-Grade TiO2 Nanoparticles under Simulated Oral Conditions. J. Agric. Food Chem. 2019, 67, 5882–5890. doi:https://doi.org/10.1021/acs.jafc.9b01732
   PubMed Web of Science ®Google Scholar
• Ionta, F. Q.; Mendonça, F. L.; de Oliveira, G. C.; de Alencar, C. R. B.; Honório, H. M.; Magalhães, A. C.; Rios, D. In Vitro Assessment of Artificial Saliva Formulations on Initial Enamel Erosion Remineralization. J. Dent. 2014, 42, 175–179. doi:https://doi.org/10.1016/j.jdent.2013.11.009
   PubMed Web of Science ®Google Scholar
• Yoshizawa, J. M.; Schafer, C. A.; Schafer, J. J.; Farrell, J. J.; Paster, B. J.; Wong, D. T. W. Salivary Biomarkers: Toward Future Clinical and Diagnostic Utilities. Clin. Microbiol. Rev. 2013, 26, 781–791. doi:https://doi.org/10.1128/CMR.00021-13
   PubMed Web of Science ®Google Scholar
• Aps, J. K. M.; Martens, L. C. Review: The Physiology of Saliva and Transfer of Drugs into Saliva. Forensic Sci. Int. 2005, 150, 119–131. doi:https://doi.org/10.1016/j.forsciint.2004.10.026
   PubMed Web of Science ®Google Scholar
• Moore, T. J.; Moody, A. S.; Payne, T. D.; Sarabia, G. M.; Daniel, A. R.; Sharma, B. In Vitro and in Vivo SERS Biosensing for Disease Diagnosis. Biosensors 2018, 8, 46. doi:https://doi.org/10.3390/bios8020046
   Google Scholar
• Zhang, W.; Guo, S.; Pereira Carvalho, W. S.; Jiang, Y.; Serpe, M. J. Portable Point-of-Care Diagnostic Devices. Anal. Methods 2016, 8, 7847–7867. doi:https://doi.org/10.1039/C6AY02158A
   Web of Science ®Google Scholar
• Salemmilani, R.; Piorek, B. D.; Mirsafavi, R. Y.; Fountain, I. I. I.; A. W.; Moskovits, M.; Meinhart, C. D. Dielectrophoretic Nanoparticle Aggregation for on-Demand Surface Enhanced Raman Spectroscopy Analysis. Anal. Chem. 2018, 90, 7930–7936. doi:https://doi.org/10.1021/acs.analchem.8b00510
   PubMed Web of Science ®Google Scholar
• Deriu, C.; Conticello, I.; Mebel, A. M.; McCord, B. Micro Solid Phase Extraction Surface-Enhanced Raman Spectroscopy (μ-SPE/SERS) Screening Test for the Detection of the Synthetic Cannabinoid JWH-018 in Oral Fluid. Anal. Chem. 2019, 91, 4780–4789. doi:https://doi.org/10.1021/acs.analchem.9b00335
   PubMed Web of Science ®Google Scholar
• Dadas, A.; Washington, J.; Diaz-Arrastia, R.; Janigro, D. Biomarkers in Traumatic Brain Injury (TBI): A Review. Neuropsychiatr. Dis. Treat. 2018, 14, 2989–3000. doi:https://doi.org/10.2147/NDT.S125620
   PubMed Web of Science ®Google Scholar
• Inscore, F.; Shende, C.; Sengupta, A.; Huang, H.; Farquharson, S. Detection of Drugs of Abuse in Saliva by Surface-Enhanced Raman Spectroscopy (SERS). Appl. Spectrosc. 2011, 65, 1004–1008. doi:https://doi.org/10.1366/11-06310
   PubMed Web of Science ®Google Scholar
• Roi, A.; Rusu, L. C.; Roi, C. I.; Luca, R. E.; Boia, S.; Munteanu, R. I. A New Approach for the Diagnosis of Systemic and Oral Diseases Based on Salivary Biomolecules. Dis. Markers. 2019, 2019, 8761860. doi:https://doi.org/10.1155/2019/8761860
   PubMed Web of Science ®Google Scholar
• Bonassi, S.; Neri, M.; Puntoni, R. Validation of Biomarkers as Early Predictors of Disease. Mutat. Res. 2001, 480-481, 349–358. doi:https://doi.org/10.1016/S0027-5107(01)00194-4
   PubMed Web of Science ®Google Scholar
• Anderson, N. L.; Anderson, N. G. The Human Plasma Proteome: History, Character, and Diagnostic Prospects. Mol. Cell. Proteom. 2002, 1, 845–867. doi:https://doi.org/10.1074/mcp.r200007-mcp200
   PubMed Web of Science ®Google Scholar
• Khan, R. S.; Rehman, I. U. Spectroscopy as a Tool for Detection and Monitoring of Coronavirus (COVID-19). Expert Rev. Mol. Diagn. 2020, 20, 647–649. doi:https://doi.org/10.1080/14737159.2020.1766968
   PubMed Web of Science ®Google Scholar
• Khan, R. S.; Rehman, H. U.; Rehman, I. U. Saliva for the Diagnosis of COVID-19. Appl. Spectrosc. Rev. 2020, 55, 805–809. doi:https://doi.org/10.1080/05704928.2020.1809442
   Web of Science ®Google Scholar
• Czumbel, L. M.; Kiss, S.; Farkas, N.; Mandel, I.; Hegyi, A.; Nagy, Á.; Lohinai, Z.; Szakács, Z.; Hegyi, P.; Steward, M. C.; Varga, G. Saliva as a Candidate for COVID-19 Diagnostic Testing: A Meta-Analysis. Front. Med. (Lausanne) 2020, 7, 465. doi:https://doi.org/10.3389/fmed.2020.00465
   PubMed Web of Science ®Google Scholar
• Santosh, T. S.; Parmar, R.; Anand, H.; Srikanth, K.; Saritha, M. A Review of Salivary Diagnostics and Its Potential Implication in Detection of Covid-19. Cureus 2020, 12, e7708. doi:https://doi.org/10.7759/cureus.7708.
   PubMed Web of Science ®Google Scholar
• Li, Y.; Ren, B.; Peng, X.; Hu, T.; Li, J.; Gong, T.; Tang, B.; Xu, X.; Zhou, X. Saliva is a Non-Negligible Factor in the Spread of COVID-19. Mol. Oral Microbiol. 2020, 35, 141–145. doi:https://doi.org/10.1111/omi.12289
   PubMed Web of Science ®Google Scholar
• Wyllie, A. L.; Fournier, J.; Casanovas-Massana, A.; Campbell, M.; Tokuyama, M.; Vijayakumar, P.; Warren, J. L.; Geng, B.; Muenker, M. C.; Moore, A. J.; et al. Saliva or Nasopharyngeal Swab Specimens for Detection of SARS-CoV-2. N. Engl. J. Med. 2020, 383, 1283–1286. doi:https://doi.org/10.1056/NEJMc2016359
   PubMed Web of Science ®Google Scholar
• Kah, J. C. Y.; Kho, K. W.; Lee, C. G. L.; James, C.; Sheppard, R.; Shen, Z. X.; Soo, K. C.; Olivo, M. C. Early Diagnosis of Oral Cancer Based on the Surface Plasmon Resonance of Gold Nanoparticles. Int. J. Nanomedicine. 2007, 2, 785–798.
   PubMed Web of Science ®Google Scholar
• Matheson, A. The Rise of Raman Spectroscopy in Biomedicine. Spectroscopy 2018, 33, 26–28.
   Web of Science ®Google Scholar
• Wickline, S. A.; Lanza, G. M. Molecular Imaging, Targeted Therapeutics, and Nanoscience. J. Cell. Biochem. Suppl. 2002, 39, 90–97. doi:https://doi.org/10.1002/jcb.10422
   PubMedGoogle Scholar
• Li, X. Z.; Bai, J.; Lin, J.; Liu, H.; Ding, J. Serum Fluorescence and Raman Spectra for Diagnosis of Cancer. SPIE Diagnostic Opt. Spectrosc. Biomed., 2001, 4432, 447127. doi:https://doi.org/10.1117/12.447127
   Google Scholar
• Ma, L.; Zhang, Z.; Li, X. Non-Invasive Disease Diagnosis Using Surface-Enhanced Raman Spectroscopy of Urine and Saliva. Appl. Spectrosc. Rev. 2020, 55, 197–219. doi:https://doi.org/10.1080/05704928.2018.1562938
   Web of Science ®Google Scholar
• Yu, B.; Ge, M.; Li, P.; Xie, Q.; Yang, L. Development of Surface-Enhanced Raman Spectroscopy Application for Determination of Illicit Drugs: Towards a Practical Sensor. Talanta 2019, 191, 1–10. doi:https://doi.org/10.1016/j.talanta.2018.08.032
   PubMed Web of Science ®Google Scholar
• Seitz, P. Photonics – Accelerating highly sensitive disease detection. https://ktn-uk.org/events/photonics-for-medical-diagnostics/.
   Google Scholar
• Szlag, V. M.; Rodriguez, R. S.; He, J.; Hudson-Smith, N.; Kang, H.; Le, N.; Reineke, T. M.; Haynes, C. L. Molecular Affinity Agents for Intrinsic Surface-Enhanced Raman Scattering (SERS) Sensors. ACS Appl. Mater. Interfaces. 2018, 10, 31825–31844. doi:https://doi.org/10.1021/acsami.8b10303
   PubMed Web of Science ®Google Scholar
• Maier, S. A. Plasmonics: Fundamentals and Applications; Springer: New York, 2007. doi:https://doi.org/10.1007/0-387-37825-1
   Google Scholar
• Malkovskiy, A. V.; Yacob, A. A.; Dunn, C. E.; Zirbes, J. M.; Ryan, S. P.; Bollyky, P. L.; Rajadas, J.; Milla, C. E. Salivary Thiocyanate as a Biomarker of Cystic Fibrosis Transmembrane Regulator Function. Anal. Chem. 2019, 91, 7929–7934. doi:https://doi.org/10.1021/acs.analchem.9b01800
   PubMed Web of Science ®Google Scholar
• Machado, A.; Maneiras, R.; Bordalo, A. A.; Mesquita, R. B. R. Monitoring Glucose, Calcium, and Magnesium Levels in Saliva as a Non-Invasive Analysis by Sequential Injection Multi-Parametric Determination. Talanta 2018, 186, 192–199. doi:https://doi.org/10.1016/j.talanta.2018.04.055
   PubMed Web of Science ®Google Scholar
• Raman, C.; V; Krishnan, K. S. A New Type of Secondary Radiation. Nature 1928, 121, 501–502. doi:https://doi.org/10.1038/121501c0
   Google Scholar
• Golightly, R. S.; Doering, W. E.; Natan, M. J. Surface-Enhanced Raman Spectroscopy and Homeland Security: A Perfect Match? ACS Nano. 2009, 3, 2859–2869. doi:https://doi.org/10.1021/nn9013593
   PubMed Web of Science ®Google Scholar
• López-López, M.; García-Ruiz, C. Infrared and Raman Spectroscopy Techniques Applied to Identification of Explosives. Trends Anal. Chem 2014, 54, 36–44. doi:https://doi.org/10.1016/j.trac.2013.10.011
   Web of Science ®Google Scholar
• Huang, Y.; Liu, W.; Gong, Z.; Wu, W.; Fan, M.; Wang, D.; Brolo, A. G. Detection of Buried Explosives Using a Surface-Enhanced Raman Scattering (SERS) Substrate Tailored for Miniaturized Spectrometers. ACS Sens. 2020, 5, 2933–2939. doi:https://doi.org/10.1021/acssensors.0c01412
   PubMed Web of Science ®Google Scholar
• Reid, L. M.; O'Donnell, C. P.; Downey, G. Recent Technological Advances for the Determination of Food Authenticity. Trends Food Sci. Technol. 2006, 17, 344–353. doi:https://doi.org/10.1016/j.tifs.2006.01.006
   Web of Science ®Google Scholar
• Neng, J.; Zhang, Q.; Sun, P. Application of Surface-Enhanced Raman Spectroscopy in Fast Detection of Toxic and Harmful Substances in Food. Biosens. Bioelectron. 2020, 167, 112480. doi:https://doi.org/10.1016/j.bios.2020.112480
   PubMed Web of Science ®Google Scholar
• Bersani, D.; Conti, C.; Matousek, P.; Pozzi, F.; Vandenabeele, P. Methodological Evolutions of Raman Spectroscopy in Art and Archaeology. Anal. Methods 2016, 8, 8395–8409. doi:https://doi.org/10.1039/C6AY02327D
   Web of Science ®Google Scholar
• Candeias, A.; Madariaga, J. M. Applications of Raman Spectroscopy in Art and Archaeology. J. Raman Spectrosc. 2019, 50, 137–142. doi:https://doi.org/10.1002/jrs.5571.
   Web of Science ®Google Scholar
• Edwards, H. G. M.; Vandenabeele, P. Raman Spectroscopy in Art and Archaeology. Philos. Trans. R. Soc. A Math. Phys. Eng. Sci. 2016, 374, 20160052. doi:https://doi.org/10.1098/rsta.2016.0052
   PubMed Web of Science ®Google Scholar
• Berger, A.; Koo, T.-W.; Itzkan, I.; Horowitz, G.; Feld, M. S. Multicomponent Blood Analysis by near-Infrared Raman Spectroscopy. Appl. Opt. 1999, 38, 2916–2926. doi:https://doi.org/10.1364/AO.38.002916
   PubMed Web of Science ®Google Scholar
• Larmour, I.; Graham, D. Surface Enhanced Optical Spectroscopies for Bioanalysis. Analyst 2011, 136, 3831–3853. doi:https://doi.org/10.1039/c1an15452d
   PubMed Web of Science ®Google Scholar
• Sharma, B.; Frontiera, R. R.; Henry, A. I.; Ringe, E.; Van Duyne, R. P. SERS: Materials, Applications, and the Future. Mater. Today 2012, 15, 16–25. doi:https://doi.org/10.1016/S1369-7021(12)70017-2
   Web of Science ®Google Scholar
• Maitra, I.; Morais, C. L.; Lima, K. M.; Ashton, K. M.; Date, R. S.; Martin, F. L. Raman Spectral Discrimination in Human Liquid Biopsies of Oesophageal Transformation to Adenocarcinoma. J. Biophoton. 2020, 13, e201960132. doi:https://doi.org/10.1002/jbio.201960132
   PubMed Web of Science ®Google Scholar
• James, J. Raman in the Clinic. Anal. Sci. 2019, 1, 46–47.
   Google Scholar
• Rickard, J. J. S.; Di-Pietro, V.; Smith, D. J.; Davies, D. J.; Belli, A.; Goldberg Oppenheimer, P. Rapid Optofluidic Detection of Biomarkers for Traumatic Brain Injury via Surface-Enhanced Raman Spectroscopy. Nat. Biomed. Eng. 2020, 4, 610–623. doi:https://doi.org/10.1038/s41551-019-0510-4
   PubMed Web of Science ®Google Scholar
• Pence, I.; Mahadevan-Jansen, A. Clinical Instrumentation and Applications of Raman Spectroscopy. Chem. Soc. Rev. 2016, 45, 1958–1979. doi:https://doi.org/10.1039/c5cs00581g
   PubMed Web of Science ®Google Scholar
• Langer, J.; Jimenez de Aberasturi, D.; Aizpurua, J.; Alvarez-Puebla, R. A.; Auguié, B.; Baumberg, J. J.; Bazan, G. C.; Bell, S. E. J.; Boisen, A.; Brolo, A. G.; et al. Present and Future of Surface-Enhanced Raman Scattering. ACS Nano. 2020, 14, 28–117. doi:https://doi.org/10.1021/acsnano.9b04224
   PubMed Web of Science ®Google Scholar
• Cialla-May, D.; Zheng, X.-S.; Weber, K.; Popp, J. Recent Progress in Surface-Enhanced Raman Spectroscopy for Biological and Biomedical Applications: From Cells to Clinics. Chem. Soc. Rev. 2017, 46, 3945–3961. doi:https://doi.org/10.1039/c7cs00172j
   PubMed Web of Science ®Google Scholar
• Pahlow, S.; Weber, K.; Popp, J. Spectroscopic Methods Guide Precision Medicine. EuroPhotonics 2020, 25, 18–23.
   Google Scholar
• Fujita, K. A. Further Leap of Biomedical Raman Imaging. Spectroscopy 2020, 35, 10.
   Web of Science ®Google Scholar
• Mayerhöfer, T.; Krafft, C.; Neugebauer, U.; Popp, J. Moving Raman Spectroscopy into the Clinic. EuroPhotonics 2014, 19, 24–28.
   Google Scholar
• Romao, V. C.; Martins, S. A. M.; Germano, J.; Cardoso, F. A.; Cardoso, S.; Freitas, P. P. Lab-on-Chip Devices: Gaining Ground Losing Size. ACS Nano. 2017, 11, 10659–10664. doi:https://doi.org/10.1021/acsnano.7b06703
   PubMed Web of Science ®Google Scholar
• Dambinova, S.; Hayes, R. L.; Wang, K. K. W. Biomarkers for Traumatic Brain Injury, 1st ed.; Royal Society of Chemistry: Cambridge, 2012.
   Google Scholar
• Movasaghi, Z.; Rehman, S.; Rehman, I. U. Raman Spectroscopy of Biological Tissues. Appl. Spectrosc. Rev. 2007, 42, 493–541. doi:https://doi.org/10.1080/05704920701551530
   Web of Science ®Google Scholar
• Chandra, A.; Talari, S.; Movasaghi, Z.; Rehman, S. Raman Spectroscopy of Biological Tissues. Appl. Spectrosc. Rev. 2015, 50, 46–111. doi:https://doi.org/10.1080/05704928.2014.923902
   Web of Science ®Google Scholar
• Colceriu-Şimon, I. M.; Hedeşiu, M.; Toma, V.; Armencea, G.; Moldovan, A.; Ştiufiuc, G.; Culic, B.; Ţărmure, V.; Dinu, C.; Berindan-Neagoe, I. The Effects of Low-Dose Irradiation on Human Saliva: A Surface-Enhanced Raman Spectroscopy Study. Diagnostics 2019, 9, 9030101. doi:https://doi.org/10.3390/diagnostics9030101
   Web of Science ®Google Scholar
• Feng, S.; Huang, S.; Lin, D.; Chen, U.; Xu, Y.; Li, Y.; Huang, Z.; Pan, J.; Chen, R.; Zeng, H. Surface-Enhanced Raman Spectroscopy of Saliva Proteins for the Noninvasive Differentiation of Benign and Malignant Breast Tumors. Int. J. Nanomed. 2015, 10, 537–547. doi:https://doi.org/10.2147/IJN.S71811.
   PubMed Web of Science ®Google Scholar
• Li, X.; Yang, T.; Lin, J. Spectral Analysis of Human Saliva for Detection of Lung Cancer Using Surface-Enhanced Raman Spectroscopy. J. Biomed. Opt. 2012, 17, 037003. doi:https://doi.org/10.1117/1.JBO.17.3.037003
   PubMed Web of Science ®Google Scholar
• Qian, K.; Wang, Y.; Hua, L.; Chen, A.; Zhang, Y. New Method of Lung Cancer Detection by Saliva Test Using Surface-Enhanced Raman Spectroscopy. Thorac. Cancer. 2018, 9, 1556–1561. doi:https://doi.org/10.1111/1759-7714.12837
   PubMed Web of Science ®Google Scholar
• Qu, D.; Wang, Y.; Chen, A.; Zheng, W.; Liu, J.; Jiao, Y.; Liu, C. New Method for Screening Drug Addicts Based on Surface-Enhanced Raman Spectroscopy Technology. IEEE 4th International Conference on Bioinformatics and Biomedical Engineering, Chengdu, China, Jul 13, 2010, pp 1–3. doi:https://doi.org/10.1109/ICBBE.2010.5515355
   Google Scholar
• Lin, H.-Y.; Huang, C.-H.; Park, J.; Pathania, D.; Castro, C. M.; Fasano, A.; Weissleder, R.; Lee, H. Integrated Magneto-Chemical Sensor for on-Site Food Allergen Detection. ACS Nano 2017, 11, 10062–10069. doi:https://doi.org/10.1021/acsnano.7b04318
   PubMed Web of Science ®Google Scholar
• Sikirzhytski, V.; Sikirzhytskaya, A.; Lednev, I. K. Multidimensional Raman Spectroscopic Signatures as a Tool for Forensic Identification of Body Fluid Traces: A Review. Appl. Spectrosc. 2011, 65, 1223–1232. doi:https://doi.org/10.1366/11-06455
   PubMed Web of Science ®Google Scholar
• Ralbovsky, N. M.; Halámková, L.; Wall, K.; Anderson-Hanley, C.; Lednev, I. K. Screening for Alzheimer's Disease Using Saliva: A New Approach Based on Machine Learning and Raman Hyperspectroscopy. J. Alzheimers. Dis. 2019, 71, 1351–1359. doi:https://doi.org/10.3233/JAD-190675
   PubMed Web of Science ®Google Scholar
• Aitchison, H.; Aizpurua, J.; Arnolds, H.; Baumberg, J.; Bell, S.; Bonifacio, A.; Chikkaraddy, R.; Dawson, P.; de Nijs, B.; Deckert, V.; et al. Analytical SERS: General Discussion. Faraday Discuss. 2017, 205, 561–600. doi:https://doi.org/10.1039/C7FD90096A
   PubMed Web of Science ®Google Scholar
• D'Elia, V.; Montalvo, G.; Ruiz, C. G.; Ermolenkov, V. V.; Ahmed, Y.; Lednev, I. K. Ultraviolet Resonance Raman Spectroscopy for the Detection of Cocaine in Oral Fluid. Spectrochim. Acta A Mol. Biomol. Spectrosc. 2018, 188, 338–340. doi:https://doi.org/10.1016/j.saa.2017.07.010
   PubMed Web of Science ®Google Scholar
• Schultz, Z. D. Demystifying SERS: A Newcomer’s Guide to Using Surface Enhanced Raman Scattering. Spectroscopy 2020, 35, 15–16.
   Google Scholar
• Gonchukov, S.; Sukhinina, A.; Bakhmutov, D.; Biryukova, T.; Tsvetkov, M.; Bagratashvily, V. Periodontitis Diagnostics Using Resonance Raman Spectroscopy on Saliva. Laser Phys. Lett. 2013, 10, 075610. doi:https://doi.org/10.1088/1612-2011/10/7/075610
   Web of Science ®Google Scholar
• Maes, E. M.; Walker, F. A.; Montfort, W. R.; Czernuszewicz, R. S. Resonance Raman Spectroscopic Study of Nitrophorin 1, a Nitric Oxide-Binding Heme Protein from Rhodnius Prolixus, and Its Nitrosyl and Cyano Adducts. J. Am. Chem. Soc. 2001, 123, 11664–11672. doi:https://doi.org/10.1021/ja0031927
   PubMed Web of Science ®Google Scholar
• Bergman, I.; Conway, B. E.; Bewick, A.; Kuwana, T.; McIntyre, J. D. E.; Gardner, C. L.; Casey, E. J.; Barrett, M. A.; Angerstein-Kozlowska, H.; Kolb, D. M.; et al. General Discussion. Faraday Discuss. Chem. Soc. 1973, 56, 152–170. doi:https://doi.org/10.1039/dc9735600152
   Google Scholar
• Fleischmann, M.; Hendra, P. J.; McQuillan, A. J. Raman Spectra of Pyridine Adsorbed at a Silver Electrode. Chem. Phys. Lett. 1974, 26, 163–166. doi:https://doi.org/10.1016/0009-2614(74)85388-1
   Web of Science ®Google Scholar
• Moskovits, M. Persistent Misconceptions Regarding SERS. Phys. Chem. Chem. Phys. 2013, 15, 5301–5311. doi:https://doi.org/10.1039/c2cp44030j
   PubMed Web of Science ®Google Scholar
• Fang, Y.; Seong, N.-H.; Dlott, D. Measurement of the Distribution of Site Enhancements in Surface-Enhanced Raman Scattering. Science 2008, 321, 388–393. doi:https://doi.org/10.1126/science.1148744.
   PubMed Web of Science ®Google Scholar
• Doherty, M. D.; Murphy, A.; McPhillips, J.; Pollard, R. J.; Dawson, P. Wavelength Dependence of Raman Enhancement from Gold Nanorod Arrays: Quantitative Experiment and Modeling of a Hot Spot Dominated System. J. Phys. Chem. C. 2010, 114, 19913–19919. doi:https://doi.org/10.1021/jp107063x
   Web of Science ®Google Scholar
• Martin, D. SERS and the rise of the Raman empire. https://www.chemistryworld.com/features/sers-and-the-rise-of-the-raman-empire/9264.article.
   Google Scholar
• Alessandri, I.; Lombardi, J. R. Enhanced Raman Scattering with Dielectrics. Chem. Rev. 2016, 116, 14921–14981. doi:https://doi.org/10.1021/acs.chemrev.6b00365
   PubMed Web of Science ®Google Scholar
• Soares Nunes, L. A.; Vaz de Macedo, D. Saliva as a Diagnostic Fluid in Sports Medicine: Potential and Limitations. J. Bras. Patol. Med. Lab. 2013, 49, 247–255. doi:https://doi.org/10.1590/S1676-24442013000400003
   Google Scholar
• Rodrigues, W. C.; Catbagan, P.; Rana, S.; Wang, G.; Moore, C. Detection of Synthetic Cannabinoids in Oral Fluid Using ELISA and LC-MS-MS. J. Anal. Toxicol. 2013, 37, 526–533. doi:https://doi.org/10.1093/jat/bkt067
   PubMed Web of Science ®Google Scholar
• Cottat, M.; Andrea, C. D.; Yasukuni, R.; Malashikhina, N.; Grinyte, R.; Lidgi-Guigui, N.; Fazio, B.; Sutton, A.; Oudar, O.; Charnaux, N.; et al. High Sensitivity, High Selectivity SERS Detection of MnSOD Using Optical Nanoantennas Functionalized with Aptamers. J. Phys. Chem. C. 2015, 119, 15532–15540. doi:https://doi.org/10.1021/acs.jpcc.5b03681
   Web of Science ®Google Scholar
• Farquharson, S.; Brouillette, C.; Smith, W.; Shende, C. A Surface-Enhanced Raman Spectral Library of Important Drugs Associated with Point-of-Care and Field Applications. Front. Chem. 2019, 7, 706. doi:https://doi.org/10.3389/fchem.2019.00706
   PubMed Web of Science ®Google Scholar
• Frosch, T.; Knebl, A.; Frosch, T. Recent Advances in Nano-Photonic Techniques for Pharmaceutical Drug Monitoring with Emphasis on Raman Spectroscopy. Nanophotonics 2019, 9, 19–37. doi:https://doi.org/10.1515/nanoph-2019-0401
   Web of Science ®Google Scholar
• Henson, B. S.; Wong, D. T. Collection, Storage, and Processing of Saliva Samples for Downstream Molecular Applications. In Oral Biology: Molecular Techniques and Applications; Seymour, G. J., Cullinan, M. P., Heng, N. C. K., Eds.; Springer Science (Humana Press): New York, 2010; pp 21–30.
   Google Scholar
• Chevalier, F.; Hirtz, C.; Chay, S.; Cuisinier, F.; Sommerer, N.; Rossignol, M.; de Périère, D. D. Proteomic Studies of Saliva: A Proposal for a Standardized Handling of Clinical Samples. Clin. Proteom. 2007, 3, 13–21. doi:https://doi.org/10.1007/s12014-007-9000-x
   Google Scholar
• Zaragoza Meneses, M. T.; de, J.; Velasco Molina, J. A. La Saliva. Auxiliar de Diagnóstico [Saliva. An Auxiliary Diagnostic], 1st ed.; UNAM, FES Zaragoza, Universidad Nacional Autónoma de México: Mexico City, 2018. doi:https://doi.org/10.22201/fesz.9786070299780e.2018
   Google Scholar
• Barnett, N.; Rathmell, C. Detecting Drugs in Saliva. Opt. Photonik 2015, 10, 31–34. doi:https://doi.org/10.1002/opph.201500040
   Google Scholar
• Zermeño-Nava, J.; de, J.; Martínez-Martínez, M. U.; Rámirez-de-Ávila, A. L.; Hernández-Arteaga, A. C.; García-Valdivieso, M. G.; Hernández-Cedillo, A.; José-Yacamán, M.; Navarro-Contreras, H. R. Determination of sialic acid in Saliva by Means of Surface-Enhanced Raman Spectroscopy as a Marker in Adnexal Mass Patients: Ovarian Cancer vs Benign Cases. J. Ovarian Res. 2018, 11, 61. doi:https://doi.org/10.1186/s13048-018-0433-9.
   PubMed Web of Science ®Google Scholar
• González, L.; Sánches, M. La Saliva: Revisión Sobre Composición, Función y Usos Diagnósticos: Primera Parte [Saliva: A Review on Composition, Function and Diagnostic Uses: Part One]. Univ. Odontol. 2003, 23, 18–24.
   Google Scholar
• Malamud, D. Salivary Diagnostics: The Future is Now. J. Am. Dent. Assoc. 2006, 137, 284, 286–286. doi:https://doi.org/10.14219/jada.archive.2006.0158
   PubMed Web of Science ®Google Scholar
• Mahesh, D. R.; Komali, G.; Jayanthi, K.; Dinesh, D.; Saikavitha, T.; V; Dinesh, P. Evaluation of Salivary Flow Rate, PH and Buffer in Pre, Post & Post Menopausal Women on HRT. J. Clin. Diagn. Res. 2014, 8, 233–236. doi:https://doi.org/10.7860/JCDR/2014/8158.4067
   Google Scholar
• Xu, F.; Laguna, L.; Sarkar, A. Aging-Related Changes in Quantity and Quality of Saliva: Where Do We Stand in Our Understanding? J. Texture Stud. 2019, 50, 27–35. doi:https://doi.org/10.1111/jtxs.12356
   PubMed Web of Science ®Google Scholar
• Hegner, M. Nanomechanical Sensors for Weighing Viruses. https://www.tcd.ie/Physics/people/Martin.Hegner/pdf/Bio-Physics_TCD_TYPE_week_2019_Dublin.pdf.
   Google Scholar
• Radzol, A. R. M.; Lee, K. Y.; Mansor, W. Nonstructural Protein 1 Characteristic Peak from NS1-Saliva Mixture with Surface-Enhanced Raman Spectroscopy. IEEE 35th Annu. Int. Conf. IEEE Eng. Med. Biol. Soc., 2013, 2013, 2396–2399. doi:https://doi.org/10.1109/EMBC.2013.6610021
   PubMedGoogle Scholar
• Othman, N. H.; Lee, K. Y.; Radzol, A. R. M. M.; Mansor, W.; Rashid, U. R. M. M. Optimal PCA-EOC-KNN Model for Detection of NS1 from Salivary SERS Spectra. IEEE 2018 Int. Conf. Intell. Informatics Biomed. Sci. 2018, 3, 204–208. doi:https://doi.org/10.1109/ICIIBMS.2018.8549984
   Google Scholar
• Bell, S. E. J.; Beattie, J. R.; McGarvey, J. J.; Peters, K. L.; Sirimuthu, N. M. S.; Speers, S. J. Development of Sampling Methods for Raman Analysis of Solid Dosage Forms of Therapeutic and Illicit Drugs. J. Raman Spectrosc. 2004, 35, 409–417. doi:https://doi.org/10.1002/jrs.1160
   Web of Science ®Google Scholar
• Jones, L. E.; Stewart, A.; Peters, K. L.; McNaul, M.; Speers, S. J.; Fletcher, N. C.; Bell, S. E. J. Infrared and Raman Screening of Seized Novel Psychoactive Substances: A Large Scale Study of >200 Samples. Analyst 2016, 141, 902–909. doi:https://doi.org/10.1039/c5an02326b
   PubMed Web of Science ®Google Scholar
• Hodges, C. M.; Hendra, P. J.; Willis, H. A.; Farley, T. Fourier Transform Raman Spectroscopy of Illicit Drugs. J. Raman Spectrosc. 1989, 20, 745–749. doi:https://doi.org/10.1002/jrs.1250201108
   Web of Science ®Google Scholar
• Ryder, A. G.; O'Connor, G. M.; Glynn, T. J. Identifications and Quantitative Measurements of Narcotics in Solid Mixtures Using Near-IR Raman Spectroscopy and Multivariate Analysis. J. Forensic Sci. 1999, 44, 12031J–121019. doi:https://doi.org/10.1520/JFS12031J
   Web of Science ®Google Scholar
• Dana, K.; Shende, C.; Huang, H.; Farquharson, S. Rapid Analysis of Cocaine in Saliva by Surface-Enhanced Raman Spectroscopy. J. Anal. Bioanal. Tech. 2015, 6, 1–5. doi:https://doi.org/10.4172/2155-9872.1000289.
   PubMedGoogle Scholar
• Farquharson, S.; Shende, C.; Sengupta, A.; Huang, H.; Inscore, F. Rapid Detection and Identification of Overdose Drugs in Saliva by Surface-Enhanced Raman Scattering Using Fused Gold Colloids. Pharmaceutics 2011, 3, 425–439. doi:https://doi.org/10.3390/pharmaceutics3030425
   PubMedGoogle Scholar
• Anyu, C.; Lin, H.; Jinghua, L.; ZiJian, C.; Yi, J.; Dian, Q.; Xun, G.; Chunwei, L.; Wen, H.; Hong, W. Detecting Narcotic Usage Using Surface-Enhanced Raman Spectroscopy on Saliva Samples. IFMBE World Congr. Med. Phys. Biomed. Eng. Diagn. Ther. Instrum. Clin. Eng. 2009, 25, /71–74. doi:https://doi.org/10.1007/978-3-642-03885-3_20.
   Google Scholar
• Andreou, C.; Hoonejani, M. R.; Barmi, M. R.; Moskovits, M.; Meinhart, C. D. Rapid Detection of Drugs of Abuse in Saliva Using Surface Enhanced Raman Spectroscopy and Microfluidics. ACS Nano. 2013, 7, 7157–7164. doi:https://doi.org/10.1021/nn402563f
   PubMed Web of Science ®Google Scholar
• Shende, C.; Farquharson, A.; Brouillette, C.; Smith, W.; Farquharson, S. Quantitative Measurements of Codeine and Fentanyl on a Surface-Enhanced Raman-Active Pad. Molecules 2019, 24, 2578. doi:https://doi.org/10.3390/molecules24142578
   PubMed Web of Science ®Google Scholar
• Gift, A.; Shende, C.; Inscore, F. E.; Maksymiuk, P.; Farquharson, S. Five-Minute Analysis of Chemotherapy Drugs and Metabolites in Saliva: Evaluating Dosage. SPIE Smart Med. Biomed. Sens. Technol. 2004, 5261, 135–141. doi:https://doi.org/10.1117/12.512228
   Google Scholar
• Farquharson, S.; Gift, A.; Shende, C.; Inscore, F.; Ordway, B.; Farquharson, C.; Murren, J. Surface-Enhanced Raman Spectral Measurements of 5-Fluorouracil in Saliva. Molecules 2008, 13, 2608–2627. doi:https://doi.org/10.3390/molecules13102608
   PubMed Web of Science ®Google Scholar
• Farquharson, S.; Shende, C.; Inscore, F. E.; Maksymiuk, P.; Gift, A. Analysis of 5-Fluorouracil in Saliva Using Surface-Enhanced Raman Spectroscopy. J. Raman Spectrosc. 2005, 36, 208–212. doi:https://doi.org/10.1002/jrs.1277
   Web of Science ®Google Scholar
• Shende, C.; Inscore, F.; Maksymiuk, P.; Farquharson, S. Five Minute Analysis of Chemotherapy Drugs in Saliva. Opt. Methods Life Sci. 2006, 6386, 638604. doi:https://doi.org/10.1117/12.683008
   Google Scholar
• Yang, T.; Guo, X.; Wang, H.; Fu, S.; Wen, Y.; Yang, H. Magnetically Optimized SERS Assay for Rapid Detection of Trace Drug-Related Biomarkers in Saliva and Fingerprints. Biosens. Bioelectron. 2015, 68, 350–357. doi:https://doi.org/10.1016/j.bios.2015.01.021
   PubMed Web of Science ®Google Scholar
• SAMHSA. Substance Abuse and Mental Health Services Administration (SAMHSA). Mandatory Guidelines for Federal Workplace Drug Testing Programs— Oral/Fluid. Fed. Regist. 2019, 84, 57554–57600.
   Google Scholar
• Sivashanmugan, K.; Zhao, Y.; Wang, A. X. Tetrahydrocannabinol Sensing in Complex Biofluid with Portable Raman Spectrometer Using Diatomaceous SERS Substrates. Biosensors 2019, 9, 125. doi:https://doi.org/10.3390/bios9040125
   PubMedGoogle Scholar
• Nilendu, D.; Kundu, A.; Chand, A.; Johnson, A. Forensic Implications of Saliva: An Overview. Ijfmt. 2020, 14, 189–194. doi:https://doi.org/10.37506/ijfmt.v14i1.39
   Google Scholar
• Virkler, K.; Lednev, I. K. Raman Spectroscopic Signature of Semen and Its Potential Application to Forensic Body Fluid Identification. Forensic Sci. Int. 2009, 193, 56–62. doi:https://doi.org/10.1016/j.forsciint.2009.09.005
   PubMed Web of Science ®Google Scholar
• Virkler, K.; Lednev, I. K. Analysis of Body Fluids for Forensic Purposes: From Laboratory Testing to Non-Destructive Rapid Confirmatory Identification at a Crime Scene. Forensic Sci. Int. 2009, 188, 1–17. doi:https://doi.org/10.1016/j.forsciint.2009.02.013
   PubMed Web of Science ®Google Scholar
• Virkler, K.; Lednev, I. K. Forensic Body Fluid Identification: The Raman Spectroscopic Signature of Saliva. Analyst 2010, 135, 512–517. doi:https://doi.org/10.1039/b919393f
   PubMed Web of Science ®Google Scholar
• Sikirzhytski, V.; Virkler, K.; Lednev, I. K. Discriminant Analysis of Raman Spectra for Body Fluid Identification for Forensic Purposes. Sensors (Basel) 2010, 10, 2869–2884. doi:https://doi.org/10.3390/s100402869
   PubMed Web of Science ®Google Scholar
• Muro, C. K.; Doty, K. C.; de Souza Fernandes, L.; Lednev, I. K. Forensic Body Fluid Identification and Differentiation by Raman Spectroscopy. Forensic Chem. 2016, 1, 31–38. doi:https://doi.org/10.1016/j.forc.2016.06.003
   Google Scholar
• Muro, C. K.; de Souza Fernandes, L.; Lednev, I. K. Sex Determination Based on Raman Spectroscopy of Saliva Traces for Forensic Purposes. Anal. Chem. 2016, 88, 12489–12593. doi:https://doi.org/10.1021/acs.analchem.6b03988
   PubMed Web of Science ®Google Scholar
• Virkler, K.; Lednev, I. K. Raman Spectroscopy Offers Great Potential for the Nondestructive Confirmatory Identification of Body Fluids. Forensic Sci. Int. 2008, 181, 1–5. doi:https://doi.org/10.1016/j.forsciint.2008.08.004.
   Web of Science ®Google Scholar
• Buchan, E.; Kelleher, L.; Clancy, M.; Goldberg Oppenheimer, P. Spectroscopic “Molecular Fingerprint” Profiling of Saliva; Elsevier: Amsterdam, 2021.
   Google Scholar
• Zapata, F.; Fernández de la Ossa, M. Á.; García-Ruiz, C. Emerging Spectrometric Techniques for the Forensic Analysis of Body Fluids. Trends Anal. Chem. 2015, 64, 53–63. doi:https://doi.org/10.1016/j.trac.2014.08.011
   Web of Science ®Google Scholar
• Cândido, M.; Silveira, J. M.; Mata, A.; Carvalho, M. L.; Pessanha, S. In Vitro Study of the Demineralization Induced in Human Enamel by an Acidic Beverage Using X-Ray Fluorescence Spectroscopy and Raman Microscopy. X-Ray Spectrom. 2019, 48, 61–69. doi:https://doi.org/10.1002/xrs.2987
   Web of Science ®Google Scholar
• Daood, U.; Swee Heng, C.; Neo Chiew Lian, J.; Fawzy, A. S. In Vitro Analysis of Riboflavin-Modified, Experimental, Two-Step Etch-and-Rinse Dentin Adhesive: Fourier Transform Infrared Spectroscopy and Micro-Raman Studies. Int. J. Oral Sci. 2015, 7, 110–124. doi:https://doi.org/10.1038/ijos.2014.49
   PubMed Web of Science ®Google Scholar
• Silva Soares, L. E.; Silva Soares, A. L.; De Oliveira, R.; Nahorny, S. The Effects of Acid Erosion and Remineralization on Enamel and Three Different Dental Materials: FT-Raman Spectroscopy and Scanning Electron Microscopy Analysis. Microsc. Res. Tech. 2016, 79, 646–656. doi:https://doi.org/10.1002/jemt.22679
   PubMed Web of Science ®Google Scholar
• Toledano, M.; Cabello, I.; Vílchez, M. A. C.; Fernández, M. A.; Osorio, R. Surface Microanalysis and Chemical Imaging of Early Dentin Remineralization. Microsc. Microanal. 2014, 20, 245–256. doi:https://doi.org/10.1017/S1431927613013639
   PubMed Web of Science ®Google Scholar
• Daood, U.; Tsoi, J. K. H.; Neelakantan, P.; Matinlinna, J. P.; Omar, H. A. K.; Al-Nabulsi, M.; Fawzy, A. S. In Vitro Assessment of Ribose Modified Two-Step Etch-and-Rinse Dentine Adhesive. Dent. Mater. 2018, 34, 1175–1187. doi:https://doi.org/10.1016/j.dental.2018.05.005
   PubMed Web of Science ®Google Scholar
• Musa Trolic, I.; Todoric, Z.; Pop Acev, D.; Makreski, P.; Pejova, B.; Spalj, S. Effects of the Presence of Probiotic Bacteria in the Aging Medium on the Surface Roughness and Chemical Composition of Two Dental Alloys. Microsc. Res. Tech. 2019, 82, 1384–1391. doi:https://doi.org/10.1002/jemt.23290
   PubMed Web of Science ®Google Scholar
• Wachesk, C. C.; Trava-Airoldi, V. J.; Da-Silva, N. S.; Lobo, A. O.; Marciano, F. R. The Influence of Titanium Dioxide on Diamond-Like Carbon Biocompatibility for Dental Applications. J. Nanomater. 2016, 2016, 1–7. doi:https://doi.org/10.1155/2016/8194516
   Web of Science ®Google Scholar
• Wang, J.; Zhou, J.; Long, H. Y.; Xie, Y. N.; Zhang, X. W.; Luo, H.; Deng, Z. J.; Wei, Q.; Yu, Z. M.; Zhang, J.; Tang, Z. G. Tribological, anti-Corrosive Properties and Biocompatibility of the Micro- and Nano-Crystalline Diamond Coated Ti6Al4V. Surf. Coatings Technol. 2014, 258, 1032–1038. doi:https://doi.org/10.1016/j.surfcoat.2014.07.034
   Web of Science ®Google Scholar
• Wang, Z.; Shen, Y.; Haapasalo, M.; Wang, J.; Jiang, T.; Wang, Y.; Watson, T. F.; Sauro, S. Polycarboxylated Microfillers Incorporated into Light-Curable Resin-Based Dental Adhesives Evoke Remineralization at the Mineral-Depleted Dentin. J. Biomater. Sci. Polym. Ed. 2014, 25, 679–697. doi:https://doi.org/10.1080/09205063.2014.891926
   PubMed Web of Science ®Google Scholar
• Wei, S.; Shao, T.; Ding, P. Study of CNx Films on 316L Stainless Steel for Orthodontic Application. Diam. Relat. Mater. 2010, 19, 648–653. doi:https://doi.org/10.1016/j.diamond.2010.02.040
   Web of Science ®Google Scholar
• Zaharia, A.; Muşat, V.; Anghel, E. M.; Atkinson, I.; Mocioiu, O. C.; Buşilă, M.; Pleşcan, V. G. Biomimetic Chitosan-Hydroxyapatite Hybrid Biocoatings for Enamel Remineralization. Ceram. Int. 2017, 43, 11390–11402. doi:https://doi.org/10.1016/j.ceramint.2017.05.346
   Web of Science ®Google Scholar
• Zaharia, A.; Plescan, V. G.; Anghel, E. M.; Musat, V. Human Dentine Remineralization under Non-Colagen Materials Action. Rev. Chim. 2017, 68, 928–932. doi:https://doi.org/10.37358/RC.17.5.5583
   Web of Science ®Google Scholar
• Hussein, M. A.; Yilbas, B.; Kumar, A. M.; Drew, R.; Al-Aqeeli, N. Influence of Laser Nitriding on the Surface and Corrosion Properties of Ti-20Nb-13Zr Alloy in Artificial Saliva for Dental Applications. J. Mater. Eng. Perform. 2018, 27, 4655–4664. doi:https://doi.org/10.1007/s11665-018-3569-2
   Web of Science ®Google Scholar
• Zhang, J.; Lynch, R. J. M.; Watson, T. F.; Banerjee, A. Remineralisation of Enamel White Spot Lesions Pre-Treated with Chitosan in the Presence of Salivary Pellicle. J. Dent. 2018, 72, 21–28. doi:https://doi.org/10.1016/j.jdent.2018.02.004
   PubMed Web of Science ®Google Scholar
• Zhang, Y.; Wang, Z.; Jiang, T.; Wang, Y. Biomimetic Regulation of Dentine Remineralization by Amino Acid in Vitro. Dent. Mater. 2019, 35, 298–309. doi:https://doi.org/10.1016/j.dental.2018.11.026
   PubMed Web of Science ®Google Scholar
• Zheng, X.; Zhang, Y.; Zhang, B. Effect of N-Ion Implantation and Diamond-like Carbon Coating on Fretting Wear Behaviors of Ti6Al7Nb in Artificial Saliva. Trans. Nonferrous Met. Soc. China 2017, 27, 1071–1080. doi:https://doi.org/10.1016/S1003-6326(17)60125-0
   Web of Science ®Google Scholar
• Daood, U.; Matinlinna, J. P.; Fawzy, A. S. Synergistic Effects of VE-TPGS and Riboflavin in Crosslinking of Dentine. Dent. Mater. 2019, 35, 356–367. doi:https://doi.org/10.1016/j.dental.2018.11.031
   PubMed Web of Science ®Google Scholar
• da Silva, E. M.; Almeida, G. S.; Poskus, L. T.; Guimarães, J. G. A. Relationship between the Degree of Conversion, Solubility and Salivary Sorption of a Hybrid and a Nanofilled Resin Composite: Influence of the Light-Activation Mode. J. Appl. Oral Sci. 2008, 16, 161–166. doi:https://doi.org/10.1590/S1678-77572008000200015
   PubMed Web of Science ®Google Scholar
• Fawzy, A. S.; Daood, U.; Matinlinna, J. P. Potential of High-Intensity Focused Ultrasound in Resin-Dentine Bonding. Dent. Mater. 2019, 35, 979–989. doi:https://doi.org/10.1016/j.dental.2019.04.001
   PubMed Web of Science ®Google Scholar
• Hua, F.; Yan, J.; Zhao, S.; Yang, H.; He, H. In Vitro Remineralization of Enamel White Spot Lesions with a Carrier-Based Amorphous Calcium Phosphate Delivery System. Clin. Oral. Investig. 2020, 24, 2079–2089. doi:https://doi.org/10.1007/s00784-019-03073-x
   PubMed Web of Science ®Google Scholar
• Veys-Renaux, D.; El Haj, Z. A.; Rocca, E. Corrosion Resistance in Artificial Saliva of Titanium Anodized by Plasma Electrolytic Oxidation in Na3PO4. Surf. Coatings Technol. 2016, 285, 214–219. doi:https://doi.org/10.1016/j.surfcoat.2015.11.028
   Web of Science ®Google Scholar
• Romonti, D. E.; Gomez Sanchez, A. V.; Milošev, I.; Demetrescu, I.; Ceré, S. Effect of Anodization on the Surface Characteristics and Electrochemical Behaviour of Zirconium in Artificial Saliva. Mater. Sci. Eng. C Mater. Biol. Appl. 2016, 62, 458–466. doi:https://doi.org/10.1016/j.msec.2016.01.079
   PubMed Web of Science ®Google Scholar
• Iafisco, M.; Degli Esposti, L.; Ramírez-Rodríguez, G. B.; Carella, F.; Gómez-Morales, J.; Ionescu, A. C.; Brambilla, E.; Tampieri, A.; Delgado-López, J. M. Fluoride-Doped Amorphous Calcium Phosphate Nanoparticles as a Promising Biomimetic Material for Dental Remineralization. Sci. Rep. 2018, 8, 17016. doi:https://doi.org/10.1038/s41598-018-35258-x.
   PubMed Web of Science ®Google Scholar
• Li, Y.; Wang, K.; He, P.; Huang, B. X.; Kovacs, P. Surface‐Enhanced Raman Spectroelectrochemical Studies of Corrosion Films on Implant Co–Cr–Mo Alloy in Biosimulating Solutions. J. Raman Spectrosc. 1999, 30, 97–103. doi:https://doi.org/10.1002/(SICI)1097-4555(199902)30:2 < 97::AID-JRS352 > 3.0.CO;2-X
   Web of Science ®Google Scholar
• Osorio, R.; Cabello, I.; Toledano, M. Bioactivity of Zinc-Doped Dental Adhesives. J. Dent. 2014, 42, 403–412. doi:https://doi.org/10.1016/j.jdent.2013.12.006
   PubMed Web of Science ®Google Scholar
• Osorio, R.; Osorio, E.; Cabello, I.; Toledano, M. Zinc Induces Apatite and Scholzite Formation during Dentin Remineralization. Caries Res. 2014, 48, 276–290. doi:https://doi.org/10.1159/000356873
   PubMed Web of Science ®Google Scholar
• Osorio, R.; Toledano-Osorio, M.; Osorio, E.; Aguilera, F. S.; Padilla-Mondéjar, S.; Toledano, M. Zinc and Silica Are Active Components to Efficiently Treat in Vitro Simulated Eroded Dentin. Clin. Oral Investig. 2018, 22, 2859–2870. doi:https://doi.org/10.1007/s00784-018-2372-7
   PubMed Web of Science ®Google Scholar
• Silveira, J.; Coutinho, S.; Marques, D.; Castro, J.; Mata, A.; Carvalho, M. L.; Pessanha, S. Raman Spectroscopy Analysis of Dental Enamel Treated with Whitening Product - Influence of saliva in the remineralization. Spectrochim. Acta. A Mol. Biomol. Spectrosc. 2018, 198, 145–149. doi:https://doi.org/10.1016/j.saa.2018.03.007
   PubMed Web of Science ®Google Scholar
• Silva Soares, L. E.; Nahorny, S.; Martin, A. A. FT-Raman Spectroscopy Study of Organic Matrix Degradation in Nanofilled Resin Composite. Microsc. Microanal. 2013, 19, 327–334. doi:https://doi.org/10.1017/S1431927612014225
   PubMed Web of Science ®Google Scholar
• Gonchukov, S.; Sukhinina, A.; Bakhmutov, D.; Minaeva, S. Raman Spectroscopy of Saliva as a Perspective Method for Periodontitis Diagnostics. Laser Phys. Lett. 2012, 9, 73–77. doi:https://doi.org/10.1002/lapl.201110095
   Web of Science ®Google Scholar
• Passos, V. F.; Sampaio de Melo, M. A.; Marques Lima, J. P.; Marçal, F. F.; Gonçalves de Araújo Costa, C. A.; Azevedo Rodrigues, L. K.; Santiago, S. L. Active Compounds and Derivatives of Camellia Sinensis Responding to Erosive Attacks on Dentin. Braz. oral Res. 2018, 32, e40. doi:https://doi.org/10.1590/1807-3107bor-2018.vol32.0040
   PubMed Web of Science ®Google Scholar
• Condò, R.; Cerroni, L.; Pasquantonio, G.; Mancini, M.; Pecora, A.; Convertino, A.; Mussi, V.; Rinaldi, A.; Maiolo, L. A Deep Morphological Characterization and Comparison of Different Dental Restorative Materials. Biomed. Res. Int. 2017, 2017, 7346317. doi:https://doi.org/10.1155/2017/7346317
   PubMed Web of Science ®Google Scholar
• Mleczko, J.; Defort, A.; Kozioł, J. J.; Nguyen, T. T.; Mirończyk, A.; Zapotoczny, B.; Nowak-Jary, J.; Gronczewska, E.; Marć, M.; Dudek, M. R. Limitation of Tuning the Antibody-Antigen Reaction by Changing the Value of PH and Its Consequence for Hyperthermia. J. Biochem. 2016, 159, 421–427. doi:https://doi.org/10.1093/jb/mvv120
   PubMed Web of Science ®Google Scholar
• Karlinsey, R. L.; Hara, A. T.; Yi, K.; Duhn, C. W. Bioactivity of Novel Self-Assembled Crystalline Nb2O5 Microstructures in Simulated and Human Salivas. Biomed. Mater. 2006, 1, 16–23. doi:https://doi.org/10.1088/1748-6041/1/1/003
   PubMed Web of Science ®Google Scholar
• Yuen, C.; Zheng, W.; Huang, Z. Improving Surface-Enhanced Raman Scattering Effect Using Gold-Coated Hierarchical Polystyrene Bead Substrates Modified with Postgrowth Microwave Treatment. J. Biomed. Opt. 2008, 13, 064040. doi:https://doi.org/10.1117/1.3050447
   PubMed Web of Science ®Google Scholar
• Yuen, C.; Zheng, W.; Huang, Z. Optimization of Extinction Efficiency of Gold-Coated Polystyrene Bead Substrates Improves Surface-Enhanced Raman Scattering Effects by Post-Growth Microwave Heating Treatment. J. Raman Spectrosc. 2009, 41, 374–380. doi:https://doi.org/10.1002/jrs.2464
   Web of Science ®Google Scholar
• Hong, Y.; Zhou, X.; Xu, B.; Huang, Y.; He, W.; Wang, S.; Wang, C.; Zhou, G.; Chen, Y.; Gong, T. Optoplasmonic Hybrid Materials for Trace Detection of Methamphetamine in Biological Fluids through SERS. ACS Appl. Mater Interfaces 2020, 12, 24192–24200. doi:https://doi.org/10.1021/acsami.0c00853
   PubMed Web of Science ®Google Scholar
• Sivashanmugan, K.; Squire, K.; Tan, A.; Zhao, Y.; Kraai, J. A.; Rorrer, G. L.; Wang, A. X. Trace Detection of Tetrahydrocannabinol in Body Fluid via Surface-Enhanced Raman Scattering and Principal Component Analysis. ACS Sens. 2019, 4, 1109–1117. doi:https://doi.org/10.1021/acssensors.9b00476
   PubMed Web of Science ®Google Scholar
• Eom, G.; Hwang, A.; Kim, H.; Yang, S.; Lee, D. K.; Song, S.; Ha, K.; Jeong, J.; Jung, J.; Lim, E.-K.; Kang, T. Diagnosis of Tamiflu-Resistant Influenza Virus in Human Nasal Fluid and Saliva Using Surface-Enhanced Raman Scattering. ACS Sens. 2019, 4, 2282–2287. doi:https://doi.org/10.1021/acssensors.9b00697
   PubMed Web of Science ®Google Scholar
• Chiappin, S.; Antonelli, G.; Gatti, R.; De Palo, E. F. Saliva Specimen: A New Laboratory Tool for Diagnostic and Basic Investigation. Clin. Chim. Acta. 2007, 383, 30–40. doi:https://doi.org/10.1016/j.cca.2007.04.011
   PubMed Web of Science ®Google Scholar
• Li, X.; Yang, T.; Ding, J. Surface Enhanced Raman Spectroscopy (SERS) of Saliva for the Diagnosis of Lung Cancer. Guang Pu Xue Yu Guang Pu Fen Xi 2012, 32, 391–393.
   PubMedGoogle Scholar
• Hernández-Arteaga, A.; Zermeño Nava, J.; de, J.; Kolosovas-Machuca, E. S.; Velázquez-Salazar, J. J.; Vinogradova, E.; José-Yacamán, M.; Navarro-Contreras, H. R. Diagnosis of Breast Cancer by Analysis of Sialic Acid Concentrations in Human Saliva by Surface-Enhanced Raman Spectroscopy of Silver Nanoparticles. Nano Res. 2017, 10, 3662–3670. doi:https://doi.org/10.1007/s12274-017-1576-5
   Web of Science ®Google Scholar
• Hernández-Arteaga, A. C.; Zermeño-Nava, J.; de, J.; Martínez-Martínez, M. U.; Hernández-Cedillo, A.; Ojeda-Galván, H. J.; José-Yacamánae, M.; Navarro-Contreras, H. R. Determination of Salivary Sialic Acid through Nanotechnology: A Useful Biomarker for the Screening of Breast Cancer. Arch. Med. Res. 2019, 50, 105–110. doi:https://doi.org/10.1016/j.arcmed.2019.05.013
   PubMed Web of Science ®Google Scholar
• Lin, X.; Lin, D.; Ge, X.; Qiu, S.; Feng, S.; Chen, R. Noninvasive Detection of Nasopharyngeal Carcinoma Based on Saliva Proteins Using Surface-Enhanced Raman Spectroscopy. J. Biomed. Opt. 2017, 22, 1–6. doi:https://doi.org/10.1117/1.JBO.22.10.105004
   Web of Science ®Google Scholar
• Stefancu, A.; Badarinza, M.; Moisoiu, V.; Iancu, S. D.; Serban, O.; Leopold, N.; Fodor, D. SERS-Based Liquid Biopsy of Saliva and Serum from Patients with Sjögren’s Syndrome. Anal. Bioanal. Chem. 2019, 411, 5877–5883. doi:https://doi.org/10.1007/s00216-019-01969-x
   PubMed Web of Science ®Google Scholar
• Yan, W.; Lin, H.; Jinghua, L.; Dian, Q.; Anyu, C.; Yi, J.; Xun, G.; Chunwei, L.; Wen, H.; Hong, W. Preliminary Study on the Quick Detection of Acquired Immune Deficiency Syndrome by saliva analysis using surface enhanced Raman spectroscopic technique. Annu. Int. Conf. IEEE Eng. Med. Biol. Soc. 2009, 2009, 885–887. doi:https://doi.org/10.1109/IEMBS.2009.5333131
   PubMedGoogle Scholar
• Gracie, K.; Pang, S.; Jones, G. M.; Faulds, K.; Braybrook, J.; Graham, D. Detection of Cortisol in Serum Using Quantitative Resonance Raman Spectroscopy. Anal. Methods 2017, 9, 1589–1594. doi:https://doi.org/10.1039/C6AY03296F
   Web of Science ®Google Scholar
• Rutherfurd-Markwick, K.; Starck, C.; Dulson, D. K.; Ali, A. Salivary Diagnostic Markers in Males and Females during Rest and Exercise. J. Int. Soc. Sports Nutr. 2017, 14, 27. doi:https://doi.org/10.1186/s12970-017-0185-8.
   PubMed Web of Science ®Google Scholar
• Taniguchi, M.; Iizuka, J.; Murata, Y.; Ito, Y.; Iwamiya, M.; Mori, H.; Hirata, Y.; Mukai, Y.; Mikuni-Takagaki, Y. Multimolecular Salivary Mucin Complex is Altered in Saliva of Cigarette Smokers: Detection of Disulfide Bridges by Raman Spectroscopy. Biomed. Res. Int. 2013, 2013, 168765. doi:https://doi.org/10.1155/2013/168765
   PubMed Web of Science ®Google Scholar
• Chicharro, J. L.; Lucía, A.; Pérez, M.; Vaquero, A. F.; Ureña, R. Saliva Composition and Exercise. Sports Med. 1998, 26, 17–27. doi:https://doi.org/10.2165/00007256-199826010-00002
   PubMed Web of Science ®Google Scholar
• Cydejko, A.; Kusiak, A.; Grzybowska, M. E.; Kochańska, B.; Ochocińska, J.; Maj, A.; Świetlik, D. Selected Physicochemical Properties of Saliva in Menopausal Women — A Pilot Study. IJERPH. 2020, 17, 2604. doi:https://doi.org/10.3390/ijerph17072604
   Google Scholar
• Affoo, R. H.; Foley, N.; Garrick, R.; Siqueira, W. L.; Martin, R. E. Meta-Analysis of Salivary Flow Rates in Young and Older Adults. J. Am. Geriatr. Soc. 2015, 63, 2142–2151. doi:https://doi.org/10.1111/jgs.13652
   PubMed Web of Science ®Google Scholar
• Lima, A. A. S.; Machado, D. F. M.; dos Santos, A. W.; Grégio, A. M. T. Avaliação Sialométrica Em Indivíduos de Terceira Idade [Sialometric Assessment in Elderly Individuals]. Rev. Odonto. Ciênc 2004, 19, 238–244.
   Google Scholar
• Walsh, N. P.; Laing, S. J.; Oliver, S. J.; Montague, J. C.; Walters, R.; Bilzon, J. L. J. Saliva Parameters as Potential Indices of Hydration Status during Acute Dehydration. Med. Sci. Sports Exerc. 2004, 36, 1535–1542. doi:https://doi.org/10.1249/01.MSS.0000139797.26760.06.
   PubMed Web of Science ®Google Scholar
• Rekha, P.; Aruna, P.; Brindha, E.; Koteeswaran, D.; Baludavid, M.; Ganesan, S. Near-Infrared Raman Spectroscopic Characterization of Salivary Metabolites in the Discrimination of Normal from Oral Premalignant and Malignant Conditions. J. Raman Spectrosc. 2016, 47, 763–772. doi:https://doi.org/10.1002/jrs.4897
   Web of Science ®Google Scholar
• Žukovskaja, O.; Jahn, I. J.; Weber, K.; Cialla-May, D.; Popp, J. Detection of Pseudomonas Aeruginosa Metabolite Pyocyanin in Water and Saliva by Employing the SERS Technique. Sensors 2017, 17, 1704. doi:https://doi.org/10.3390/s17081704
   PubMed Web of Science ®Google Scholar
• Brindha, E.; Rajasekaran, R.; Aruna, P.; Koteeswaran, D.; Ganesan, S. Raman Spectroscopy of Bio Fluids: An Exploratory Study for Oral Cancer Detection. SPIE Opt. Biopsy XIV Towar. Real-Time Spectrosc. Imaging Diagn. 2016, 9703, 97031T. doi:https://doi.org/10.1117/12.2212684
   Google Scholar
• Hou, T.; Liu, Y.; Xu, L.; Wu, Y.; Ying, Y.; Wen, Y.; Guo, X.; Yang, H. Au Dotted Magnetic Graphene Sheets for Sensitive Detection of Thiocyanate. Sens. Actuators B Chem. 2017, 241, 376–382. doi:https://doi.org/10.1016/j.snb.2016.10.094
   Web of Science ®Google Scholar
• Qiu, S.; Xu, Y.; Huang, L.; Zheng, W.; Huang, C.; Huang, S.; Lin, J.; Lin, D.; Feng, S.; Chen, R.; Pan, J. Non-Invasive Detection of Nasopharyngeal Carcinoma Using Saliva Surface-Enhanced Raman Spectroscopy. Oncol. Lett. 2016, 11, 884–890. doi:https://doi.org/10.3892/ol.2015.3969
   PubMed Web of Science ®Google Scholar
• Feng, S.; Lin, D.; Lin, J.; Huang, Z.; Chen, G.; Li, Y.; Huang, S.; Zhao, J.; Chen, R.; Zeng, H. Saliva Analysis Combining Membrane Protein Purification with Surface-Enhanced Raman Spectroscopy for Nasopharyngeal Cancer Detection. Appl. Phys. Lett. 2014, 104, 073702. doi:https://doi.org/10.1063/1.4866027
   Web of Science ®Google Scholar
• Zamora-Mendoza, B. N.; Espinosa-Tanguma, R.; Ramírez-Elías, M. G.; Cabrera-Alonso, R.; Montero-Moran, G.; Portales-Pérez, D.; Rosales-Romo, J. A.; Gonzalez, J. F.; Gonzalez, C. Surface-Enhanced Raman Spectroscopy: A Non Invasive Alternative Procedure for Early Detection in Childhood Asthma Biomarkers in Saliva. Photodiagn. Photodyn. Ther. 2019, 27, 85–91. doi:https://doi.org/10.1016/j.pdpdt.2019.05.009
   PubMed Web of Science ®Google Scholar
• Wu, W.; Gong, H.; Liu, M.; Chen, G.; Chen, R. Noninvasive Breast Tumors Detection Based on Saliva Protein Surface Enhanced Raman Spectroscopy and Regularized Multinomial Regression. IEEE 8th International Conference on Biomedical Engineering and Informatics (BMEI), Shenyang, China, Oct 14–16, 2016, pp 214–218. doi:https://doi.org/10.1109/BMEI.2015.7401503
   Google Scholar
• Chen, M.; Chen, Y.; Wu, S.; Huang, W.; Lin, J.; Weng, G.-X. G.; Chen, R. Raman Spectroscopy of Human Saliva for Acute Myocardial Infarction Detection. SPIE 12th Int. Conf. Photonics Imaging Biol. Med. 2014, 9230, 92300J. doi:https://doi.org/10.1117/12.2068876
   Google Scholar
• Chen, Y.; Cheng, S.; Zhang, A.; Song, J.; Chang, J.; Wang, K.; Zhang, Y.; Li, S.; Liu, H.; Alfranca, G.; et al. Salivary Analysis Based on Surface Enhanced Raman Scattering Sensors Distinguishes Early and Advanced Gastric Cancer Patients from Healthy Persons. J. Biomed. Nanotechnol. 2018, 14, 1773–1784. doi:https://doi.org/10.1166/jbn.2018.2621
   PubMed Web of Science ®Google Scholar
• Connolly, J. M.; Davies, K.; Kazakeviciute, A.; Wheatley, A. M.; Dockery, P.; Keogh, I.; Olivo, M. Non-Invasive and Label-Free Detection of Oral Squamous Cell Carcinoma Using Saliva Surface-Enhanced Raman Spectroscopy and Multivariate Analysis. Nanomedicine 2016, 12, 1593–1601. doi:https://doi.org/10.1016/j.nano.2016.02.021
   PubMed Web of Science ®Google Scholar
• Falamas, A.; Faur, C. I.; Baciut, M.; Rotaru, H.; Chirila, M.; Cinta Pinzaru, S.; Hedesiu, M. Raman Spectroscopic Characterization of Saliva for the Discrimination of Oral Squamous Cell Carcinoma. Anal. Lett. 2021, 54, 57–69. doi:https://doi.org/10.1080/00032719.2020.1719129
   Web of Science ®Google Scholar
• Lin, X.-L.; Lin, D.; Qiu, S.-F.; Ge, X.-S.; Pan, J.-J.; Wu, Q.; Lin, H.-J.; Huang, H. Detection of Nasopharyngeal Carcinoma Based on Human Saliva Surface-Enhanced Raman Spectroscopy. Spectrosc. Spectr. Anal. 2018, 38, 2430–2434. doi:https://doi.org/10.3964/j.issn.1000-0593(2018)08-2430-05.
   Web of Science ®Google Scholar
• Al-Ogaidi, I.; Gou, H.; Al-Kazaz, A. K. A.; Aguilar, Z. P.; Melconian, A. K.; Zheng, P.; Wu, N. A Gold@Silica Core-Shell Nanoparticle-Based Surface-Enhanced Raman Scattering Biosensor for Label-Free Glucose Detection. Anal. Chim. Acta. 2014, 811, 76–80. doi:https://doi.org/10.1016/j.aca.2013.12.009
   PubMed Web of Science ®Google Scholar
• Cao, G.; Chen, M.; Chen, Y.; Huang, Z.; Lin, J.; Lin, J.; Xu, Z.; Wu, S.; Huang, W.; Weng, G.; Chen, G. A Potential Method for Non-Invasive Acute Myocardial Infarction Detection Based on Saliva Raman Spectroscopy and Multivariate Analysis. Laser Phys. Lett. 2015, 12, 125702. doi:https://doi.org/10.1088/1612-2011/12/12/125702
   Web of Science ®Google Scholar
• Wang, Y.; Sun, S.; Qu, D.; Chen, A.; Cui, Z.; Yao, Y.; Jiao, Y.; Guo, X.; Liu, C. Preliminary Study on Early Detection Technology of Lung Cancer Based on Surface-Enhanced Raman Spectroscopy. IEEE 3rd International Conference on Biomedical Engineering and Informatics, Yantai, China, Oct 16–18, 2010, pp 2081–2084. doi:https://doi.org/10.1109/BMEI.2010.5639379
   Google Scholar
• Lotfi, Z.; Zavvar Mousavi, H.; Sajjadi, S. M. Nitrogen Doped Nano Porous Graphene as a Sorbent for Separation and Preconcentration Trace Amounts of Pb, Cd and Cr by Ultrasonic Assisted in‐Syringe Dispersive Micro Solid Phase Extraction. Appl. Organometal. Chem. 2018, 32, e4162. doi:https://doi.org/10.1002/aoc.4162
   Web of Science ®Google Scholar
• Desai, S.; Mishra, V.; S.; Joshi, A.; Sarkar, D.; Hole, A.; Mishra, R.; Dutt, S.; Chilakapati, M. K.; Gupta, S.; Dutt, A. Raman Spectroscopy-Based Detection of RNA Viruses in Saliva: A Preliminary Report. J. Biophoton. 2020, 13, e202000189. doi:https://doi.org/10.1002/jbio.202000189
   PubMed Web of Science ®Google Scholar
• Hernández‐Cedillo, A.; García-Valdivieso, M. G.; Hernández‐Arteaga, A. C.; Patiño-Marín, N.; Vértiz-Hernández, Á. A.; José‐Yacamán, M.; Navarro‐Contreras, H. R. Determination of Sialic Acid Levels by Using surface-enhanced Raman spectroscopy in Periodontitis and Gingivitis. Oral Dis. 2019, 25, 1627–1633. doi:https://doi.org/10.1111/odi.13141
   PubMed Web of Science ®Google Scholar
• Carlomagno, C.; Banfi, P. I.; Gualerzi, A.; Picciolini, S.; Volpato, E.; Meloni, M.; Lax, A.; Colombo, E.; Ticozzi, N.; Verde, F. Human Salivary Raman Fingerprint as Biomarker for the Diagnosis of Amyotrophic Lateral Sclerosis. Sci. Rep. 2020, 10, 10175. doi:https://doi.org/10.1038/s41598-020-67138-8.
   PubMed Web of Science ®Google Scholar
• Schilling, K. M.; Bowen, W. H. Glucans Synthesized in Situ in Experimental Salivary Pellicle Function as Specific Binding Sites for Streptococcus Mutans. Infect. Immun. 1992, 60, 284–295. doi:https://doi.org/10.1128/iai.60.1.284-295.1992
   PubMed Web of Science ®Google Scholar
• Andreou, C.; Kishore, S. A.; Kircher, M. F. Surface-Enhanced Raman Spectroscopy: A New Modality for Cancer Imaging. J. Nucl. Med. 2015, 56, 1295–1299. doi:https://doi.org/10.2967/jnumed.115.158196
   PubMed Web of Science ®Google Scholar
• Lin, X.; Ge, X.; Xu, Z.; Zheng, Z.; Huang, W.; Hong, Q.; Lin, D. Saliva Surface-Enhanced Raman Spectroscopy for Noninvasive Optical Detection of Nasopharyngeal Cancer. SPIE Opt. Heal. Care Biomed. Opt. VII 2016, 24, 1002440. doi:https://doi.org/10.1117/12.2246261
   Google Scholar
• Goodacre, R. The Blind Men and the Elephant: Challenges in the Analysis of Complex Natural Mixtures. Faraday Discuss. 2019, 218, 524–539. doi:https://doi.org/10.1039/C9FD00074G
   PubMed Web of Science ®Google Scholar
• Axelsson, P. Diagnosis and Risk Prediction of Dental Caries, 2nd ed.; Quintessence Books: Chicago, IL, 2000.
   Google Scholar
• Othman, N. H.; Lee, K. Y.; Radzol, A. R. M.; Mansor, W. PCA-SCG-ANN for Detection of Non-Structural Protein 1 from SERS Salivary Spectra. In ACIIDS Intelligent Information and Database Systems; Nguyen, N., Tojo, S., Nguyen, L., Trawinski, B., Eds.; Lecture Notes in Artificial Intelligence; 2017; Vol. 10192, pp 424–433. doi:https://doi.org/10.1007/978-3-319-54430-4_41
   Google Scholar
• Al-Hetlani, E.; Halámková, L.; Amin, M. O.; Lednev, I. K. Differentiating Smokers and Nonsmokers Based on Raman Spectroscopy of Oral Fluid and Advanced Statistics for Forensic Applications. J. Biophotonics. 2020, 13, e201960123. doi:https://doi.org/10.1002/jbio.201960123
   PubMed Web of Science ®Google Scholar
• Lee, K.; Yoon, T.; Yang, H. S.; Cha, S.; Cheon, Y. P.; Kashefi-Kheyrabadi, L.; Jung, H. I. All-in-One Platform for Salivary Cotinine Detection Integrated with a Microfluidic Channel and an Electrochemical Biosensor. Lab Chip. 2020, 20, 320–331. doi:https://doi.org/10.1039/c9lc01024f
   PubMed Web of Science ®Google Scholar
• Wu, L.; Wang, Z.; Zong, S.; Cui, Y. Rapid and Reproducible Analysis of Thiocyanate in Real Human Serum and Saliva Using a Droplet SERS-Microfluidic Chip. Biosens. Bioelectron. 2014, 62, 13–18. doi:https://doi.org/10.1016/j.bios.2014.06.026
   PubMed Web of Science ®Google Scholar
• Ankudze, B.; Philip, A.; Pakkanen, T. T. Ultrasensitive and Recyclable Superstructure of AuSiO2@Ag Wire for Surface-Enhanced Raman Scattering Detection of Thiocyanate in Urine and Human Serum. Anal. Chim. Acta. 2019, 1049, 179–187. doi:https://doi.org/10.1016/j.aca.2018.10.040
   PubMed Web of Science ®Google Scholar
• Yang, H.; Xiang, Y.; Guo, X.; Wu, Y.; Wen, Y.; Yang, H. Diazo-Reaction-Based SERS Substrates for Detection of Nitrite in Saliva. Sens. Actuators B Chem. 2018, 271, 118–121. doi:https://doi.org/10.1016/j.snb.2018.05.111
   Web of Science ®Google Scholar
• Dies, H.; Raveendran, J.; Escobedo, C.; Docoslis, A. Rapid Identification and Quantification of Illicit Drugs on Nanodendritic Surface-Enhanced Raman Scattering Substrates. Sens. Actuators B Chem. 2018, 257, 382–388. doi:https://doi.org/10.1016/j.snb.2017.10.181
   Web of Science ®Google Scholar
• Shah, P.; Kendall, F.; Khozin, S.; Goosen, R.; Hu, J.; Laramie, J.; Ringel, M.; Schork, N. Artificial Intelligence and Machine Learning in Clinical Development: A Translational Perspective. NPJ Digit. Med. 2019, 2, 69. doi:https://doi.org/10.1038/s41746-019-0148-3
   PubMed Web of Science ®Google Scholar
• Banbury, C.; Mason, R.; Styles, I.; Eisenstein, N.; Clancy, M.; Belli, A.; Logan, A.; Goldberg Oppenheimer, P. Development of the Self Optimising Kohonen Index Network (SKiNET) for Raman Spectroscopy Based Detection of Anatomical Eye Tissue. Sci. Rep. 2019, 9, 10812. doi:https://doi.org/10.1038/s41598-019-47205-5.
   PubMed Web of Science ®Google Scholar
• Vollmer, S.; Mateen, B. A.; Bohner, G.; Király, F. J.; Ghani, R.; Jonsson, P.; Cumbers, S.; Jonas, A.; McAllister, K. S. L.; Myles, P.; et al. Machine Learning and Artificial Intelligence Research for Patient Benefit: 20 Critical Questions on Transparency, Replicability, Ethics, and Effectiveness. BMJ 2020, 368, l6927. doi:https://doi.org/10.1136/bmj.l6927.
   PubMedGoogle Scholar
• Hans, K. M.-C.; Müller, S.; Sigrist, M. W. Infrared Attenuated Total Reflection (IR-ATR) Spectroscopy for Detecting Drugs in Human Saliva. Drug Test Anal. 2012, 4, 420–429. doi:https://doi.org/10.1002/dta.346
   PubMed Web of Science ®Google Scholar
• Shin, D. M.; Ro, J. Y.; Hong, W. K.; Hittelman, W. N. Dysregulation of Epidermal Growth Factor Receptor Expression in Premalignant Lesions during Head and Neck Tumorigenesis. Cancer Res. 1994, 54, 3153–3159.
   PubMed Web of Science ®Google Scholar
• Jones, S. R.; Carley, S.; Harrison, M. An Introduction to Power and Sample Size Estimation. Emerg. Med. J. 2003, 20, 453–458. doi:https://doi.org/10.1136/emj.20.5.453
   PubMed Web of Science ®Google Scholar
• Bel’skaya, L. V.; Sarf, E. A.; Solomatin, D. V.; Kosenok, V. K. Analysis of the Lipid Profile of Saliva in Ovarian and Endometrial Cancer by IR Fourier Spectroscopy. Vib. Spectrosc. 2019, 104, 102944–102949. doi:https://doi.org/10.1016/j.vibspec.2019.102944
   Web of Science ®Google Scholar
• Mamoun, R. Customized Extracellular Vesicles for Preventative and Therapeutic Solutions. https://www.nanoviewbio.com/exosome-blog/2020/7/17/focus-on-exosomes-with-dr-robert-mamoun.
   Google Scholar
• Hole, A.; Tyagi, G.; Deshmukh, A.; Deshpande, R.; Gota, V.; Chaturvedi, P.; Krishna, C. M. Salivary Raman Spectroscopy: Standardization of Sampling Protocols and Stratification of Healthy and Oral Cancer Subjects. Appl. Spectrosc. 2021, 75, 581–588. doi:https://doi.org/10.1177/0003702820973260
   PubMed Web of Science ®Google Scholar
• Li, W.; Li, X.; Yang, T.; Guo, X.; Song, Y. Detection of Saliva Morphine Using Surface-Enhanced Raman Spectroscopy Combined with Immunochromatographic Assay. J. Raman Spectrosc. 2020, 51, 642–648. doi:https://doi.org/10.1002/jrs.5822
   Web of Science ®Google Scholar
• Moisoiu, V.; Badarinza, M.; Stefancu, A.; Iancu, S. D.; Serban, O.; Leopold, N.; Fodor, D. Combining Surface-Enhanced Raman Scattering (SERS) of Saliva and Two-Dimensional Shear Wave Elastography (2D-SWE) of the Parotid Glands in the Diagnosis of Sjögren's syndrome. Spectrochim. Acta A Mol. Biomol. Spectrosc. 2020, 235, 118267. doi:https://doi.org/10.1016/j.saa.2020.118267
   PubMed Web of Science ®Google Scholar
• Su, M.; Jiang, Y.; Yu, F.; Yu, T.; Du, S.; Xu, Y.; Yang, L.; Liu, H. Mirrorlike Plasmonic Capsules for Online Microfluidic Raman Analysis of Drug in Human Saliva and Urine. ACS Appl. Bio Mater. 2019, 2, 3828–3835. doi:https://doi.org/10.1021/acsabm.9b00425
   PubMedGoogle Scholar
• Zhang, A.; Chang, J.; Chen, Y.; Huang, Z.; Alfranca, G.; Zhang, Q.; Cui, D. Spontaneous Implantation of Gold Nanoparticles on Graphene Oxide for Salivary SERS Sensing. Anal. Methods 2019, 11, 5089–5097. doi:https://doi.org/10.1039/C9AY01500K
   Web of Science ®Google Scholar
• Velička, M.; Zacharovas, E.; Adomavičiūtė, S.; Valdas, Š. Detection of caffeine intake by Means of EC-SERS Spectroscopy of Human Saliva. Spectrochim. Acta. A Mol. Biomol. Spectrosc. 2021, 246, 118956. doi:https://doi.org/10.1016/j.saa.2020.118956
   PubMed Web of Science ®Google Scholar
• Kim, Y.-W.; Kim, Y.-K. The Effects of Storage of Human Saliva on DNA Isolation and Stability. J. Oral Med. Pain 2006, 31, 1–16.
   Google Scholar
• Hu, S.; Loo, J. A.; Wong, D. T. Human Saliva Proteome Analysis. Ann. N Y Acad. Sci. 2007, 1098, 323–329. doi:https://doi.org/10.1196/annals.1384.015
   PubMed Web of Science ®Google Scholar
• Cui, L.; Butler, H. J.; Martin-Hirsch, P. L.; Martin, F. L. Aluminium Foil as a Potential Substrate for ATR-FTIR, Transflection FTIR or Raman Spectrochemical Analysis of Biological Specimens. Anal. Methods 2016, 8, 481–487. doi:https://doi.org/10.1039/C5AY02638E
   Web of Science ®Google Scholar
• Filik, J.; Stone, N. Drop Coating Deposition Raman Spectroscopy of Protein Mixtures. Analyst 2007, 132, 544–550. doi:https://doi.org/10.1039/b701541k
   PubMed Web of Science ®Google Scholar
• Kočišová, E.; Procházka, M.; Vaculčiaková, L. Drop-Coating Deposition Raman (DCDR) Spectroscopy as a Tool for Membrane Interaction Studies: Liposome-Porphyrin Complex. Appl. Spectrosc. 2015, 69, 939–945. doi:https://doi.org/10.1366/14-07836
   PubMed Web of Science ®Google Scholar
• Guicheteau, J. A.; Tripathi, A.; Emmons, E. D.; Christesen, S. D.; Fountain, I. I. I.; A. W. Reassessing SERS Enhancement Factors: Using Thermodynamics to Drive Substrate Design. Faraday Discuss. 2017, 205, 547–560. doi:https://doi.org/10.1039/c7fd00141j
   PubMed Web of Science ®Google Scholar
• Deegan, R. D.; Bakajin, O.; Dupont, T. F.; Huber, G.; Nagel, S. R.; Witten, T. A. Capillary Flow as the Cause of Ring Stains from Dried Liquid Drops. Nature 1997, 389, 827–829. doi:https://doi.org/10.1038/39827
   Web of Science ®Google Scholar
• Hoppmann, E. P.; Yu, W. W.; White, I. M. Highly Sensitive and Flexible Inkjet Printed SERS Sensors on Paper. Methods 2013, 63, 219–224. doi:https://doi.org/10.1016/j.ymeth.2013.07.010
   PubMed Web of Science ®Google Scholar
• Filik, J.; Stone, N. Analysis of Human Tear Fluid by Raman Spectroscopy. Anal. Chim. Acta. 2008, 616, 177–184. doi:https://doi.org/10.1016/j.aca.2008.04.036
   PubMed Web of Science ®Google Scholar
• Filik, J.; Stone, N. Investigation into the Protein Composition of Human Tear Fluid Using Centrifugal Filters and Drop Coating Deposition Raman Spectroscopy. J. Raman Spectrosc. 2009, 40, 218–224. doi:https://doi.org/10.1002/jrs.2113
   Web of Science ®Google Scholar
• Kočišová, E.; Sayedová, S.; Procházka, M. Drop Coating Deposition Raman Scattering of Selected Small Molecules of Biological Importance. J. Raman Spectrosc. 2020, 51, 871–874. doi:https://doi.org/10.1002/jrs.5840
   Web of Science ®Google Scholar
• Zhang, D.; Xie, Y.; Mrozek, M. F.; Ortiz, C.; Davisson, V. J.; Ben-Amotz, D. Raman Detection of Proteomic Analytes. Anal. Chem. 2003, 75, 5703–5709. doi:https://doi.org/10.1021/ac0345087
   PubMed Web of Science ®Google Scholar
• Kopecký, V.; Baumruk, V. Structure of the Ring in Drop Coating Deposited Proteins and Its Implication for Raman Spectroscopy of Biomolecules. Vib. Spectrosc. 2006, 42, 184–187. doi:https://doi.org/10.1016/j.vibspec.2006.04.019
   Web of Science ®Google Scholar
• Barman, I.; Dingari, N. C.; Kang, J. W.; Horowitz, G. L.; Dasari, R. R.; Feld, M. S. Raman Spectroscopy-Based Sensitive and Specific Detection of Glycated Hemoglobin. Anal. Chem. 2012, 84, 2474–2482. doi:https://doi.org/10.1021/ac203266a
   PubMed Web of Science ®Google Scholar
• Kočišová, E.; Procházka, M. Drop-Coating Deposition Raman Spectroscopy of Liposomes. J. Raman Spectrosc. 2011, 42, 1606–1610. doi:https://doi.org/10.1002/jrs.2915
   Web of Science ®Google Scholar
• Šimáková, P.; Kočišová, E.; Procházka, M. Sensitive Raman Spectroscopy of Lipids Based on Drop Deposition Using DCDR and SERS. J. Raman Spectrosc. 2013, 44, 1479–1482. doi:https://doi.org/10.1002/jrs.4364
   Web of Science ®Google Scholar
• Kočišová, E.; Procházka, M. Drop Coating Deposition Raman Spectroscopy of Dipicolinic Acid. J. Raman Spectrosc. 2018, 49, 2050–2052. doi:https://doi.org/10.1002/jrs.5493
   Web of Science ®Google Scholar
• Zhang, D.; Mrozek, M. F.; Xie, Y.; Ben-Amotz, D. O. R. Chemical Segregation and Reduction of Raman Background Interference Using Drop Coating Deposition. Appl. Spectrosc. 2004, 58, 929–933. doi:https://doi.org/10.1366/0003702041655430
   PubMed Web of Science ®Google Scholar
• Jeong, H.; Han, C.; Cho, S.; Gianchandani, Y.; Park, J. Analysis of Extracellular Vesicles Using Coffee Ring. ACS Appl Mater Interfaces 2018, 10, 22877–22882. doi:https://doi.org/10.1021/acsami.8b05793
   PubMed Web of Science ®Google Scholar
• Sefiane, K. Patterns from Drying Drops. Adv. Colloid Interface Sci. 2014, 206, 372–381. doi:https://doi.org/10.1016/j.cis.2013.05.002
   PubMed Web of Science ®Google Scholar
• Sefiane, K. On the Formation of Regular Patterns from Drying Droplets and Their Potential Use for Bio-Medical Applications. J. Bionic Eng. 2010, 7, S82–S93. doi:https://doi.org/10.1016/S1672-6529(09)60221-3
   Web of Science ®Google Scholar
• Shabalin, V. N.; Shatokhina, S. N. Method of Diagnosing Complicated Urolithiasis and Prognosticating Urolithiasis. European Patent EP0504409/A1, 1996.
   Google Scholar
• Hamadeh, L.; Imran, S.; Bencsik, M.; Sharpe, G. R.; Johnson, M. A.; Fairhurst, D. J. Machine Learning Analysis for Quantitative Discrimination of Dried Blood Droplets. Sci. Rep. 2020, 10, 3313. doi:https://doi.org/10.1038/s41598-020-59847-x.
   PubMed Web of Science ®Google Scholar
• Díaz-Liñán, M. C.; García-Valverde, M. T.; López-Lorente, A. I.; Cárdenas, S.; Lucena, R. Silver Nanoflower-Coated Paper as Dual Substrate for Surface-Enhanced Raman Spectroscopy and Ambient Pressure Mass Spectrometry Analysis. Anal. Bioanal. Chem. 2020, 412, 3547–3557. doi:https://doi.org/10.1007/s00216-020-02603-x
   PubMed Web of Science ®Google Scholar
• Pearce, E. I.; Tomlinson, A. Spatial Location Studies on the Chemical Composition of Human Tear Ferns. Oph. Phys. Opt. 2000, 20, 306–313. doi:https://doi.org/10.1046/j.1475-1313.2000.00523.x
   PubMed Web of Science ®Google Scholar
• Berg, J. C. An Introduction to Interfaces and Colloids: The Bridge to Nanoscience, 1st ed.; World Scientific Publishing Co.: Toh Tuck Link, Singapore, 2010.
   Google Scholar
• Bhardwaj, R.; Fang, X.; Somasundaran, P.; Attinger, D. Self-Assembly of Colloidal Particles from Evaporating Droplets: Role of DLVO Interactions and Proposition of a Phase Diagram. Langmuir 2010, 26, 7833–7842. doi:https://doi.org/10.1021/la9047227
   PubMed Web of Science ®Google Scholar
• Boström, M.; Williams, D. R. M.; Ninham, B. W. Specific Ion Effects: Why DLVO Theory Fails for Biology and Colloid Systems. Phys. Rev. Lett. 2001, 87, 168103. doi:https://doi.org/10.1103/PhysRevLett.87.168103
   PubMed Web of Science ®Google Scholar
• Uthayakumar, G. S.; Senthilkumar; Inbasekaran, S.; Sivasubramanian, A.; Jacob, S. J. P. Nanoparticle Analysis for Various Medicinal Drugs and Human Body Saliva at Macromolecular Level. Appl. Nanosci. 2015, 5, 563–568. doi:https://doi.org/10.1007/s13204-014-0350-1
   Web of Science ®Google Scholar
• Hardy, M.; Doherty, M. D.; Krstev, I.; Maier, K.; Möller, T.; Müller, G.; Dawson, P. Detection of Low-Concentration Contaminants in Solution by Exploiting Chemical Derivatization in Surface-Enhanced Raman Spectroscopy. Anal. Chem. 2014, 86, 9006–9012. doi:https://doi.org/10.1021/ac5014095
   PubMed Web of Science ®Google Scholar
• Zhu, R.; Avsievich, T.; Popov, A.; Meglinski, I. Optical Tweezers in Studies of Red Blood Cells. Cells 2020, 9, 545–527. doi:https://doi.org/10.3390/cells9030545
   PubMed Web of Science ®Google Scholar
• Yuan, Y.; Lin, Y.; Gu, B.; Panwar, N.; Tjin, S. C.; Song, J.; Qu, J.; Yong, K.-T. Optical Trapping-Assisted SERS Platform for Chemical and Biosensing Applications: Design Perspectives. Coord. Chem. Rev. 2017, 339, 138–152. doi:https://doi.org/10.1016/j.ccr.2017.03.013
   Web of Science ®Google Scholar
• Yang, Y.; Ren, Y.-X.; Chen, M.; Arita, Y.; Rosales-Guzmán, C. Optical Trapping with Structured Light: A Review. Adv. Photonics 2021, 3, 034001. doi:https://doi.org/10.1117/1.AP.3.3.034001.
   Google Scholar
• Raziman, T.; V; Wolke, R. J.; Martin, O. J. F. Optical Forces in Nanoplasmonic Systems: How Do They Work, What Can They Be Useful for? Faraday Discuss. 2015, 178, 421–434. doi:https://doi.org/10.1039/c4fd00224e
   PubMed Web of Science ®Google Scholar
• Huang, Z.; Cao, G.; Sun, Y.; Du, S.; Li, Y.; Feng, S.; Lin, J.; Lei, J. Evaluation and Optimization of Paper-Based SERS Substrate for Potential Label-Free Raman Analysis of Seminal Plasma. J. Nanomater. 2017, 2017, 1–8. doi:https://doi.org/10.1155/2017/4807064
   Google Scholar
• Kaneta, T.; Alahmad, W.; Varanusupakul, P. Microfluidic Paper-Based Analytical Devices with Instrument-Free Detection and Miniaturized Portable Detectors. Appl. Spectrosc. Rev. 2019, 54, 117–141. doi:https://doi.org/10.1080/05704928.2018.1457045
   Web of Science ®Google Scholar
• Zangheri, M.; Cevenini, L.; Anfossi, L.; Baggiani, C.; Simoni, P.; Di Nardo, F.; Roda, A. A Simple and Compact Smartphone Accessory for Quantitative Chemiluminescence-Based Lateral Flow Immunoassay for Salivary Cortisol Detection. Biosens. Bioelectron. 2015, 64, 63–68. doi:https://doi.org/10.1016/j.bios.2014.08.048
   PubMed Web of Science ®Google Scholar
• Álvarez-Puebla, R. A. Effects of the Excitation Wavelength on the SERS Spectrum. J. Phys. Chem. Lett. 2012, 3, 857–866. doi:https://doi.org/10.1021/jz201625j
   PubMed Web of Science ®Google Scholar
• Matousek, P.; Stone, N. Development of Deep Subsurface Raman Spectroscopy for Medical Diagnosis and Disease Monitoring. Chem. Soc. Rev. 2016, 45, 1794–1802. doi:https://doi.org/10.1039/c5cs00466g
   PubMed Web of Science ®Google Scholar
• Zhao, J.; Pinchuk, A. O.; McMahon, J. M.; Li, S.; Ausman, L. K.; Atkinson, A. L.; Schatz, G. C. Methods for Describing the Electromagnetic Properties of Silver and Gold Nanoparticles. Acc. Chem. Res. 2008, 41, 1710–1720. doi:https://doi.org/10.1021/ar800028j
   PubMed Web of Science ®Google Scholar
• Knight, M. W.; King, N. S.; Liu, L.; Everitt, H. O.; Nordlander, P.; Halas, N. J. Aluminum for Plasmonics. ACS Nano. 2014, 8, 834–840. doi:https://doi.org/10.1021/nn405495q
   PubMed Web of Science ®Google Scholar
• Sigle, D. O.; Perkins, E.; Baumberg, J. J.; Mahajan, S. Reproducible Deep-UV SERRS on Aluminum Nanovoids. J. Phys. Chem. Lett. 2013, 4, 1449–1452. doi:https://doi.org/10.1021/jz4004813
   PubMed Web of Science ®Google Scholar
• Agarwal, U. P. 1064 Nm FT-Raman Spectroscopy for Investigations of Plant Cell Walls and Other Biomass Materials. Front. Plant Sci. 2014, 5, 490. doi:https://doi.org/10.3389/fpls.2014.00490
   PubMed Web of Science ®Google Scholar
• Braga, S. R. M.; de Oliveira, E.; Sobral, M. A. P. Effect of Neodymium:Yttrium-Aluminum-Garnet Laser and Fluoride on the Acid Demineralization of Enamel. J. Invest. Clin. Dent. 2017, 8, e12185. doi:https://doi.org/10.1111/jicd.12185
   Web of Science ®Google Scholar
• Braga, S. R. M.; de Faria, D. L. A.; de Oliveira, E.; Sobral, M. A. P. Morphological and Mineral Analysis of Dental Enamel after Erosive Challenge in Gastric Juice and Orange Juice. Microsc. Res. Tech. 2011, 74, 1083–1087. doi:https://doi.org/10.1002/jemt.20998
   PubMed Web of Science ®Google Scholar
• Farquharson, S.; Gift, A. D.; Shende, C.; Maksymiuk, P.; Inscore, F. E.; Murran, J. Detection of 5-Fluorouracil in Saliva Using Surface-Enhanced Raman Spectroscopy. Vib. Spectrosc. 2005, 38, 79–84. doi:https://doi.org/10.1016/j.vibspec.2005.02.021
   Web of Science ®Google Scholar
• McLaughlin, G.; Lednev, I. K. A Modified Raman Multidimensional Spectroscopic Signature of Blood to account for the Effect of Laser Power. Forensic Sci. Int. 2014, 240, 88–94. doi:https://doi.org/10.1016/j.forsciint.2014.04.021
   PubMed Web of Science ®Google Scholar
• Moskovits, M. SERS, Surface and Interfacial Phenomena. In 11th International Conference on Raman Spectroscopy; Clark, R. J. H., Long, D. A., Eds.; Wiley–Blackwell: London, 1988.
   Google Scholar
• Dieringer, J. A.; McFarland, A. D.; Shah, N. C.; Stuart, D. A.; Whitney, A.; V; Yonzon, C. R.; Young, M. A.; Zhang, X.; Van Duyne, R. P. Surface Enhanced Raman Spectroscopy: New Materials, Concepts, Characterization Tools, and Applications. Faraday Discuss. 2006, 132, 9–26. doi:https://doi.org/10.1039/b513431p
   PubMed Web of Science ®Google Scholar
• Banholzer, M. J.; Millstone, J. E.; Qin, L.; Mirkin, C. A. Rationally Designed Nanostructures for Surface-Enhanced Raman Spectroscopy. Chem. Soc. Rev. 2008, 37, 885–897. doi:https://doi.org/10.1039/b710915f
   PubMed Web of Science ®Google Scholar
• Le Ru, E. C.; Etchegoin, P. G. Recent Developments. In Principles of Surface-Enhanced Raman Spectroscopy: And Related Plasmonic Effects; Le Ru, E. C., Etchegoin, P. G., Eds.: Elsevier: Amsterdam, 2009; pp 415–464. doi:https://doi.org/10.1016/b978-0-444-52779-0.00014-3
   Google Scholar
• Hankus, M. E.; Stratis-Cullum, D. N.; Pellegrino, P. M. Surface Enhanced Raman Scattering (SERS)-Based Next Generation Commercially Available Substrate: Physical Characterization and Biological Application. Biosens. Nanomed. IV 2011, 8099, 0990N. doi:https://doi.org/10.1117/12.893842
   Google Scholar
• Cetin, A. E.; Altug, H. Fano Resonant Ring/Disk Plasmonic Nanocavities on Conducting Substrates for Advanced Biosensing. ACS Nano. 2012, 6, 9989–9995. doi:https://doi.org/10.1021/nn303643w
   PubMed Web of Science ®Google Scholar
• Macias, G.; Alba, M.; Marsal, L. F.; Mihi, A. Surface Roughness Boosts the SERS Performance of Imprinted Plasmonic Architectures. J. Mater. Chem. C. 2016, 4, 3970–3975. doi:https://doi.org/10.1039/C5TC02779A
   Web of Science ®Google Scholar
• Wuytens, P. C.; Demol, H.; Turk, N.; Gevaert, K.; Skirtach, A. G.; Lamkanfi, M.; Baets, R. Gold Nanodome SERS Platform for Label-Free Detection of Protease Activity. Faraday Discuss. 2017, 205, 345–361. doi:https://doi.org/10.1039/c7fd00124j
   PubMed Web of Science ®Google Scholar
• Schmidt, M. S.; Hübner, J.; Boisen, A. Large Area Fabrication of Leaning Silicon Nanopillars for Surface Enhanced Raman Spectroscopy. Adv. Mater. 2012, 24, OP11–18. doi:https://doi.org/10.1002/adma.201103496
   PubMed Web of Science ®Google Scholar
• Sanger, K.; Durucan, O.; Wu, K.; Thilsted, A. H.; Heiskanen, A.; Rindzevicius, T.; Schmidt, M. S.; Zór, K.; Boisen, A. Large-Scale, Lithography-Free Production of Transparent Nanostructured Surface for Dual-Functional Electrochemical and SERS Sensing. ACS Sens. 2017, 2, 1869–1875. doi:https://doi.org/10.1021/acssensors.7b00783
   PubMed Web of Science ®Google Scholar
• Banbury, C.; Rickard, J. J. S.; Mahajan, S.; Goldberg Oppenheimer, P. Tuneable Metamaterial-Like Platforms for Surface-Enhanced Raman Scattering via Three-Dimensional Block Co-Polymer-Based Nanoarchitectures. ACS Appl. Mater. Interfaces. 2019, 11, 14437–14444. doi:https://doi.org/10.1021/acsami.9b00420
   PubMed Web of Science ®Google Scholar
• De Carvalho Gomes, P.; Rickard, J. S.; Goldberg Oppenheimer, P. Electrofluidynamic Patterning of Tailorable Nanostructured Substrates for Surface-Enhanced Raman Scattering. ACS Appl. Nano Mater. 2020, 3, 6774–6784. doi:https://doi.org/10.1021/acsanm.0c01190
   PubMed Web of Science ®Google Scholar
• Štolcová, L.; Proška, J.; Novotný, F.; Procházka, M.; Richter, I. Periodic Arrays of Metal Nanobowls as SERS-Active Substrates; NANOCON: Brno, Czech Republic, 2011.
   Google Scholar
• Dawson, P.; Duenas, J. A.; Boyle, M. G.; Doherty, M. D.; Bell, S. E. J.; Kern, A. M.; Martin, O. J. F.; Teh, A. S.; Teo, K. B. K.; Milne, W. I. Combined Antenna and Localized Plasmon Resonance in Raman Scattering from Random Arrays of Silver-Coated, Vertically Aligned Multiwalled Carbon Nanotubes. Nano Lett. 2011, 11, 365–371. doi:https://doi.org/10.1021/nl102838w
   PubMed Web of Science ®Google Scholar
• Coppé, J. P.; Xu, Z.; Chen, Y.; Logan Liu, G. Metallic Nanocone Array Photonic Substrate for High-Uniformity Surface Deposition and Optical Detection of Small Molecules. Nanotechnology 2011, 22, 245710. doi:https://doi.org/10.1088/0957-4484/22/24/245710
   PubMed Web of Science ®Google Scholar
• Doherty, M. D.; Murphy, A.; Pollard, R. J.; Dawson, P. Surface-Enhanced Raman Scattering from Metallic Nanostructures: Bridging the Gap between the near-Field and Far-Field Responses. Phys. Rev. X. 2013, 3, 011001. doi:https://doi.org/10.1103/PhysRevX.3.011001
   Web of Science ®Google Scholar
• Goldberg-Oppenheimer, P.; Mahajan, S.; Steiner, U. Hierarchical Electrohydrodynamic Structures for Surface-Enhanced Raman Scattering. Adv. Mater. 2012, 24, 175–180. doi:https://doi.org/10.1002/adma.201104159
   Web of Science ®Google Scholar
• Mahajan, S.; Baumberg, J. J.; Russell, E.; Bartlett, P. N. Reproducible SERRS from Structured Gold Surfaces. Phys. Chem. Chem. Phys. 2007, 9, 6016–6020. doi:https://doi.org/10.1039/b712144j
   PubMed Web of Science ®Google Scholar
• Šubr, M.; Petr, M.; Peksa, V.; Kylián, O.; Hanuš, J.; Procházka, M. Ag Nanorod Arrays for SERS: Aspects of Spectral Reproducibility, Surface Contamination, and Spectral Sensitivity. J. Nanomater. 2015, 2015, 1–7. doi:https://doi.org/10.1155/2015/729231
   Web of Science ®Google Scholar
• Wu, K.; Boisen, A.; Rindzevicius, T.; Thilsted, A. H.; Schmidt, M. S. Optimizing Silver‐Capped Silicon Nanopillars to Simultaneously Realize Macroscopic, Practical‐Level SERS Signal Reproducibility and High Enhancement at Low Costs. J. Raman Spectrosc. 2017, 48, 1808–1818. doi:https://doi.org/10.1002/jrs.5255
   Web of Science ®Google Scholar
• Oh, Y. J.; Kang, M.; Park, M.; Jeong, K. H. Engineering Hot Spots on Plasmonic Nanopillar Arrays for SERS: A Review. BioChip J. 2016, 10, 297–309. doi:https://doi.org/10.1007/s13206-016-0406-2
   Web of Science ®Google Scholar
• Mosier-Boss, P. Review of SERS Substrates for Chemical Sensing. Nanomater 2017, 7, 142. doi:https://doi.org/10.3390/nano7060142
   Web of Science ®Google Scholar
• Baumberg, J.; Bell, S.; Bonifacio, A.; Chikkaraddy, R.; Chisanga, M.; Corsetti, S.; Delfino, I.; Eremina, O.; Fasolato, C.; Faulds, K.; et al. SERS in Biology/Biomedical SERS: General Discussion. Faraday Discuss. 2017, 205, 429–453. doi:https://doi.org/10.1039/c7fd90089a
   PubMed Web of Science ®Google Scholar
• Perkel, J. M. Advances in Analytical Chemistry: Processes, Techniques, and Instrumentation; American Chemical Society: Washington, DC, 2017.
   Google Scholar
• Mao, B.-H.; Chen, Z.-Y.; Wang, Y.-J.; Yan, S.-J. Silver Nanoparticles Have Lethal and Sublethal Adverse Effects on Development and Longevity by Inducing ROS-Mediated Stress Responses. Sci. Rep. 2018, 8, 2445. doi:https://doi.org/10.1038/s41598-018-20728-z.
   PubMed Web of Science ®Google Scholar
• Stensberg, M. C.; Wei, Q.; McLamore, E. S.; Porterfield, D. M.; Wei, A.; Sepúlveda, M. S. Toxicological Studies on Silver Nanoparticles: Challenges and Opportunities in Assessment, Monitoring and Imaging. Nanomedicine (Lond.) 2011, 6, 879–898. doi:https://doi.org/10.2217/nnm.11.78
   PubMed Web of Science ®Google Scholar
• Goodacre, R.; Graham, D.; Faulds, K. Recent Developments in Quantitative SERS: Moving towards Absolute Quantification. Trends Anal. Chem. 2018, 102, 359–368. doi:https://doi.org/10.1016/j.trac.2018.03.005
   Web of Science ®Google Scholar
• Bell, S. E. J.; Charron, G.; Cortés, E.; Kneipp, J.; Lamy de la Chapelle, M.; Langer, J.; Procházka, M.; Tran, V.; Schlücker, S. Towards Reliable and Quantitative Surface-Enhanced Raman Scattering (SERS): from Key Parameters to Good Analytical Practice. Angew. Chem. Int. Ed. Engl. 2020, 59, 5454–5462. doi:https://doi.org/10.1002/anie.201908154
   PubMed Web of Science ®Google Scholar
• Natan, M. J. Concluding Remarks: Surface Enhanced Raman Scattering. Faraday Discuss. 2006, 132, 321. doi:https://doi.org/10.1039/b601494c
   PubMed Web of Science ®Google Scholar
• Durucan, O.; Wu, K.; Viehrig, M.; Rindzevicius, T.; Boisen, A. Nanopillar-Assisted SERS Chromatography. ACS Sens. 2018, 3, 2492–2498. doi:https://doi.org/10.1021/acssensors.8b00887
   PubMed Web of Science ®Google Scholar
• Hamon, C.; Liz-Marzán, L. M. Colloidal Design of Plasmonic Sensors Based on Surface Enhanced Raman Scattering. J. Colloid Interface Sci. 2018, 512, 834–843. doi:https://doi.org/10.1016/j.jcis.2017.10.117
   PubMed Web of Science ®Google Scholar
• Nyamekye, C. K. A.; Weibel, S. C.; Smith, E. A. Directional Raman Scattering Spectra of Metal – Sulfur Bonds at Smooth Gold and Silver Substrates. J. Raman Spectrosc. 2021, 52, 1–10. doi:https://doi.org/10.1002/jrs.6124.
   Web of Science ®Google Scholar
• Kline, N. D.; Tripathi, A.; Mirsafavi, R.; Pardoe, I.; Moskovits, M.; Meinhart, C.; Guicheteau, J. A.; Christesen, S. D.; Fountain, A. W. III, Optimization of Surface-Enhanced Raman Spectroscopy Conditions for Implementation into a Microfluidic Device for Drug Detection. Anal. Chem. 2016, 88, 10513–10522. doi:https://doi.org/10.1021/acs.analchem.6b02573
   PubMed Web of Science ®Google Scholar
• Ye, Z.; Li, C.; Xu, Y.; Bell, S. E. J. Exploiting the Chemical Differences between Ag and Au Colloids Allows Dramatically Improved SERS Detection of “Non-Adsorbing” molecules. Analyst 2019, 144, 448–453. doi:https://doi.org/10.1039/c8an01927d
   PubMed Web of Science ®Google Scholar
• Etchegoin, P. G.; Le Ru, E. C. Basic Electromagnetic Theory of SERS. In Surface Enhanced Raman Spectroscopy: Analytical, Biophysical and Life Science Applications; Schlücker, S., Ed., Wiley-VCH: Weinheim, Germany, 2010; pp 1–37.
   Google Scholar
• Gersten, J.; Nitzan, A. Electromagnetic Theory of Enhanced Raman Scattering by Molecules Adsorbed on Rough Surfaces. J. Chem. Phys. 1980, 73, 3023–3037. doi:https://doi.org/10.1063/1.440560
   Web of Science ®Google Scholar
• Farquharson, S.; Maksymiuk, P. Simultaneous Chemical Separation and Surface-Enhanced Raman Spectral Detection Using Silver-Doped Sol-Gels. Appl. Spectrosc. 2003, 57, 479–482. doi:https://doi.org/10.1366/00037020360626041
   PubMed Web of Science ®Google Scholar
• Mohammadi, A.; Nicholls, D. L.; Docoslis, A. Improving the Surface-Enhanced Raman Scattering Performance of Silver Nanodendritic Substrates with Sprayed-on Graphene-Based Coatings. Sensors 2018, 18, 3404. doi:https://doi.org/10.3390/s18103404
   Web of Science ®Google Scholar
• Lai, H.; Xu, F.; Zhang, Y.; Wang, L. Recent Progress on Graphene-Based Substrates for Surface-Enhanced Raman Scattering Applications. J. Mater. Chem. B. 2018, 6, 4008–4028. doi:https://doi.org/10.1039/c8tb00902c
   PubMed Web of Science ®Google Scholar
• Zheng, P.; Li, M.; Jurevic, R.; Cushing, S. K.; Liu, Y.; Wu, N. A Gold Nanohole Array Based Surface-Enhanced Raman Scattering Biosensor for Detection of Silver(I) and Mercury(II) in Human Saliva. Nanoscale 2015, 7, 11005–11012. doi:https://doi.org/10.1039/C5NR02142A
   PubMed Web of Science ®Google Scholar
• Han, S.; Locke, A. K.; Oaks, L. A.; Cheng, Y.-S. L.; Coté, G. L. Development of a Free-Solution SERS-Based Assay for Point-of-Care Oral Cancer Biomarker Detection Using DNA-Conjugated Gold Nanoparticles. SPIE Opt. Diagnostics Sens. XVIII Towar. Point-of-Care Diagn. 2018, 10501, 1050104. doi:https://doi.org/10.1117/12.2290516
   Google Scholar
• Kruszewski, S. Dependence of SERS Signal on Surface Roughness. Surf. Interface Anal. 1994, 21, 830–838. doi:https://doi.org/10.1002/sia.740211203
   Web of Science ®Google Scholar
• Karapetsas, G.; Matar, O. K.; Valluri, P.; Sefiane, K. Convective Rolls and Hydrothermal Waves in Evaporating Sessile Drops. Langmuir 2012, 28, 11433–11439. doi:https://doi.org/10.1021/la3019088
   PubMed Web of Science ®Google Scholar
• Mollaret, R.; Sefiane, K.; Christy, J. R. E.; Veyret, D. Experimental and Numerical Investigation of the Evaporation into Air of a Drop on a Heated Surface. Chem. Eng. Res. Des. 2004, 82, 471–480. doi:https://doi.org/10.1205/026387604323050182
   Web of Science ®Google Scholar
• Xavier, J.; Vincent, S.; Meder, F.; Vollmer, F. Advances in Optoplasmonic Sensors – Combining Optical Nano/Microcavities and Photonic Crystals with Plasmonic Nanostructures and Nanoparticles. Nanophotonics 2018, 7, 1–38. doi:https://doi.org/10.1515/nanoph-2017-0064
   Web of Science ®Google Scholar
• Chen, Y.; Yin, Y.; Ma, L.; Schmidt, O. G. Recent Progress on Optoplasmonic Whispering-Gallery-Mode Microcavities. Adv. Optical Mater. 2021, 9, 2100143. doi:https://doi.org/10.1002/adom.202100143
   Web of Science ®Google Scholar
• Blanchard-Dionne, A.-P.; Martin, O. J. F. Teaching Optics to a Machine Learning Network. Opt. Lett. 2020, 45, 2922–2925. doi:https://doi.org/10.1364/OL.390600
   PubMed Web of Science ®Google Scholar
• Gallinet, B.; Butet, J.; Martin, O. J. F. Numerical Methods for Nanophotonics: Standard Problems and Future Challenges. Laser Photon. Rev. 2015, 9, 577–603. doi:https://doi.org/10.1002/lpor.201500122
   Web of Science ®Google Scholar
• Yao, K.; Unni, R.; Zheng, Y. Intelligent Nanophotonics: Merging Photonics and Artificial Intelligence at the Nanoscale. Nanophotonics 2019, 8, 339–366. doi:https://doi.org/10.1515/nanoph-2018-0183
   PubMed Web of Science ®Google Scholar
• Muskens, O. L.; Wiecha, P. A Deep Neural Network for Generalized Prediction of the near Fields and Far Fields of Arbitrary 3D Nanostructures. SPIE Nanosci. + Eng. Emerg. Top. Artif. Intell. 2020, 11469, 1146908. doi:https://doi.org/10.1117/12.2568624
   Google Scholar
• Kochkov, D.; Smith, J. A.; Alieva, A.; Wang, Q.; Brenner, M. P.; Hoyer, S. Machine Learning – Accelerated Computational Fluid Dynamics. Proc. Natl. Acad. Sci. USA 2021, 118, e2101784118. doi:https://doi.org/10.1073/pnas.2101784118
   PubMed Web of Science ®Google Scholar
• Brunton, S. L.; Noack, B. R.; Koumoutsakos, P. Machine Learning for Fluid Mechanics. Annu. Rev. Fluid Mech. 2020, 52, 477–508. doi:https://doi.org/10.1146/annurev-fluid-010719-060214
   Web of Science ®Google Scholar
• Doty, K. C.; McLaughlin, G.; Lednev, I. K. A Raman "Spectroscopic Clock" for Bloodstain Age Determination: The First Week after Deposition. Anal. Bioanal. Chem. 2016, 408, 3993–4001. doi:https://doi.org/10.1007/s00216-016-9486-z
   PubMed Web of Science ®Google Scholar
• Acquarelli, J.; van Laarhoven, T.; Gerretzen, J.; Tran, T.; Buydens, L.; Marchiori, E. Convolutional Neural Networks for Vibrational Spectroscopic Data Analysis. Anal. Chim. Acta. 2017, 954, 22–31. doi:https://doi.org/10.1016/j.aca.2016.12.010
   PubMed Web of Science ®Google Scholar
• Othman, N. H.; Lee, K. Y.; Radzol, A. R. M.; Mansor, W. Termination Criterion for PCA with ANN for Detection of NS1 from Adulterated Saliva. J. Teknol. 2016, 78, 13–20. doi:https://doi.org/10.11113/jt.v78.9044.
   Google Scholar
• Wold, S. Chemometrics; What Do We Mean with It, and What Do We Want from It? Chemom. Intell. Lab. Syst. 1995, 30, 109–115. doi:https://doi.org/10.1016/0169-7439(95)00042-9
   Web of Science ®Google Scholar
• Liu, W.; Man, Z.; Hua, L.; Chen, A.; Wang, Y.; Qian, K.; Zhang, Y. Data Mining Methods of Lung Cancer Diagnosis by Saliva Tests Using Surface Enhanced Raman Spectroscopy. IEEE 7th International Conference on Biomedical Engineering and Informatics, Dalian, China, Oct 14–16, 2014, pp 623–627. doi:https://doi.org/10.1109/BMEI.2014.7002849
   Google Scholar
• Yang, J.; Xu, J.; Zhang, X.; Wu, C.; Lin, T.; Ying, Y. Deep Learning for Vibrational Spectral Analysis: Recent Progress and a Practical Guide. Anal. Chim. Acta. 2019, 1081, 6–17. doi:https://doi.org/10.1016/j.aca.2019.06.012
   PubMed Web of Science ®Google Scholar
• Grigorescu, I. Medical Marvels. Phys. World 2021, 34, 35–36. doi:https://doi.org/10.1088/2058-7058/34/05/36
   Web of Science ®Google Scholar
• Oresko, J. J.; Jin, Z.; Cheng, J.; Huang, S.; Sun, Y.; Duschl, H.; Cheng, A. C. A Wearable Smartphone-Based Platform for Real-Time Cardiovascular Disease Detection via Electrocardiogram Processing. IEEE Trans. Inf. Technol. Biomed. 2010, 14, 734–740. doi:https://doi.org/10.1109/TITB.2010.2047865
   PubMedGoogle Scholar
• Schwab, P.; Karlen, W. A Deep Learning Approach to Diagnosing Multiple Sclerosis from Smartphone Data. IEEE J. Biomed. Health Inform. 2021, 25, 1284–1291. doi:https://doi.org/10.1109/JBHI.2020.3021143
   PubMed Web of Science ®Google Scholar
• Zhan, A.; Mohan, S.; Tarolli, C.; Schneider, R. B.; Adams, J. L.; Sharma, S.; Elson, M. J.; Spear, K. L.; Glidden, A. M.; Little, M. A.; et al. Using Smartphones and Machine Learning to Quantify Parkinson Disease Severity the Mobile Parkinson Disease Score. JAMA Neurol. 2018, 75, 876–880. doi:https://doi.org/10.1001/jamaneurol.2018.0809
   PubMed Web of Science ®Google Scholar
• Beleites, C.; Neugebauer, U.; Bocklitz, T.; Krafft, C.; Popp, J. Sample Size Planning for Classification Models. Anal. Chim. Acta. 2013, 760, 25–33. doi:https://doi.org/10.1016/j.aca.2012.11.007
   PubMed Web of Science ®Google Scholar
• Othman, N.; Lee, K. Y.; Radzol, A.; Mansor, W.; Ramlan, N. Linear Discriminant Analysis for Detection of Salivary NS1 from SERS Spectra. IEEE Reg. 10 Int. Conf. TENCON 2017 2017, 2017, 2876–2879. doi:https://doi.org/10.1109/TENCON.2017.8228352
   Google Scholar
• Guo, S.; Rösch, P.; Popp, J.; Bocklitz, T. Modified PCA and PLS: Towards a Better Classification in Raman Spectroscopy–Based Biological Applications. J. Chemom. 2020, 34, e3202. doi:https://doi.org/10.1002/cem.3202.
   Web of Science ®Google Scholar
• Workman, J.; Mark, H. A Survey of Chemometric Methods Used in Spectroscopy. Spectroscopy 2020, 35, 9–14.
   Web of Science ®Google Scholar
• Meza Ramirez, C. A.; Greenop, M.; Ashton, L.; Ur Rehman, I. Applications of Machine Learning in Spectroscopy. Appl. Spectrosc. Rev. 2020. doi:https://doi.org/10.1080/05704928.2020.1859525.
   Google Scholar
• Deckert-Gaudig, T.; Taguchi, A.; Kawata, S.; Deckert, V. Tip-Enhanced Raman Spectroscopy - From Early Developments to Recent Advances. Chem. Soc. Rev. 2017, 46, 4077–4110. doi:https://doi.org/10.1039/c7cs00209b
   PubMed Web of Science ®Google Scholar
• Kurouski, D. Tip-Enhanced Raman Spectroscopy: An Emerging Technique for Probing Biology and Electrochemistry at the Nanoscale. Spectroscopy 2018, 33, 38–46.
   Web of Science ®Google Scholar
• Mahapatra, S.; Li, L.; Schultz, J. F.; Jiang, N. Tip-Enhanced Raman Spectroscopy: Chemical Analysis with Nanoscale to Angstrom Scale Resolution. J. Chem. Phys. 2020, 153, 010902. doi:https://doi.org/10.1063/5.0009766
   PubMed Web of Science ®Google Scholar
• De Angelis, F.; Gentile, F.; Mecarini, F.; Das, G.; Moretti, M.; Candeloro, P.; Coluccio, M. L.; Cojoc, G.; Accardo, A.; Liberale, C. Breaking the Diffusion Limit with Super-Hydrophobic Delivery of Molecules to Plasmonic Nanofocusing SERS Structures. Nat. Photon. 2011, 5, 2–7. https://doi.org/10.1038/NPHOTON.2011.222.
   Web of Science ®Google Scholar
• Song, W.; Psaltis, D.; Crozier, K. B. Superhydrophobic Bull's-Eye for Surface-Enhanced Raman Scattering. Lab Chip. 2014, 14, 3907–3911. doi:https://doi.org/10.1039/c4lc00477a
   PubMed Web of Science ®Google Scholar
• Martines, E.; Seunarine, K.; Morgan, H.; Gadegaard, N.; Wilkinson, C. D. W.; Riehle, M. O. Superhydrophobicity and Superhydrophilicity of Regular Nanopatterns. Nano Lett. 2005, 5, 2097–2103. doi:https://doi.org/10.1021/nl051435t
   PubMed Web of Science ®Google Scholar
• Lovera, P.; Creedon, N.; Alatawi, H.; Mitchell, M.; Burke, M.; Quinn, A. J.; Riordan, A. O. Low-Cost Silver Capped Polystyrene Nanotube Arrays as Super-Hydrophobic Substrates for SERS Applications. Nanotechnology 2014, 25, 175502. doi:https://doi.org/10.1088/0957-4484/25/17/175502
   PubMed Web of Science ®Google Scholar
• Hakonen, A.; Wang, F.; Andersson, P. O.; Wingfors, H.; Rindzevicius, T.; Schmidt, M. S.; Soma, V. R.; Xu, S.; Li, YQi.; Boisen, A.; Wu, HAn. Hand-Held Femtogram Detection of Hazardous Picric Acid with Hydrophobic Ag Nanopillar SERS Substrates and Mechanism of Elasto-Capillarity. ACS Sens. 2017, 2, 198–202. doi:https://doi.org/10.1021/acssensors.6b00749
   PubMed Web of Science ®Google Scholar
• Li, J. F.; Huang, Y. F.; Ding, Y.; Yang, Z. L.; Li, S. B.; Zhou, X. S.; Fan, F. R.; Zhang, W.; Zhou, Z. Y.; Wu, D. Y.; et al. Shell-Isolated Nanoparticle-Enhanced Raman Spectroscopy. Nature 2010, 464, 392–395. doi:https://doi.org/10.1038/nature08907
   PubMed Web of Science ®Google Scholar
• Valstar, M. H.; de Bakker, B. S.; Steenbakkers, R. J. H. M.; de Jong, K. H.; Smit, L. A.; Klein Nulent, T. J. W.; van Es, R. J. J.; Hofland, I.; de Keizer, B.; Jasperse, B.; et al. The Tubarial Salivary Glands: A Potential New Organ at Risk for Radiotherapy. Radiother. Oncol. 2021, 154, 292–298. doi:https://doi.org/10.1016/j.radonc.2020.09.034
   PubMed Web of Science ®Google Scholar