Milk and Diabetes

REFERENCES

• Schrezenmeir J, Leischker A, Laue C, Manns M, Beyer J: Dissociation of MHC phenotypes indicate a genetic difference between type I-diabetes with and without pluriglandular autoimmunicity. Acta Endocrinol 4(Suppl): 126, 1992.
   Google Scholar
• Todd JA, Bell JI, McDevitt HO: HLA-DQ β gene contributes susceptibility and resistance to IDDM. Nature 329: 599–604, 1987.
   PubMed Web of Science ®Google Scholar
• Morel PA, Dorman JS, Todd JA, McDevitt HO, Trucco M: Aspartic acid at position 57 of the HLA-DQ β chain protects against type 1 diabetes: a family study. Proc Natl Acad Sci USA 85: 8111–8116, 1988.
   PubMed Web of Science ®Google Scholar
• Schrezenmeir J, Wallaschofski H, Wick B, Meier A, Laue Ch, Weber P, Beyer J, Tuschky U: HLA Da-Subtypes in pluriglandular autoimmunity. Exp Clin Endocrinol 1(Suppl): 127, 1993.
   Google Scholar
• Scott FW: Cow milk and insulin-dependent diabetes mellitus: is there a relationship? Am J Clin Nutr 51: 489–491, 1990.
   PubMed Web of Science ®Google Scholar
• Dahl-Jorgensen K, Joner G, Hanssen KF: Relationship between cow’s milk consumption and incidence of IDDM in childhood. Diabetes Care 14: 1081–1083, 1991.
   PubMed Web of Science ®Google Scholar
• Fava D, Leslie RDG, Pozzilli P: Relationship between dairy product consumption and incidence of IDDM in childhood in Italy. Diabetes Care 17: 1488–1490, 1994.
   PubMed Web of Science ®Google Scholar
• Reunanen A, Akerblom HK, Kaar ML: Prevalence and ten-year (1970–1979) incidence of insulin-dependent diabetes mellitus in children and adolescents in Finland. Acta Paediatr Scand 71: 893–899, 1982.
   PubMed Web of Science ®Google Scholar
• Muntoni S, Fonte MT, Stoduto S, Marietti G, Bizzarri C, Crino A, Ciampalini P, Multari G, Suppa MA, Matteoli MC, Lucentini L, Sebastiani LM, Visalli N, Pozzilli P, Boscherini B, Muntoni S: Incidence of insulin-dependent diabetes mellitus among Sardinian-heritage children born in Lazio region, Italy. Lancet 349: 160–162, 1997.
   PubMed Web of Science ®Google Scholar
• Borch-Johnsen K, Joner G, Mandrup-Poulsen T, Christy M, Zachau-Christiansen B, Kastrup K, Nerup J: Relation between breast-feeding and incidence of insulin-dependent diabetes mellitus. A hypothesis. Lancet II: 1083–1086, 1994.
   Google Scholar
• Mayer EJ, Hamman RF, Gay EC, Lezotte DC, Savitz DA, Klingensmith GJ: Reduced risk of IDDM among breast-fed children. Diabetes 37: 1625–1632, 1988.
   PubMed Web of Science ®Google Scholar
• Virtanen SM, Rasanen L, Aro A, Lindstrom J, Sippola H, Lounamaa R, Toivanen L, Tuomilehto J, Akerblom HK: Infant feeding in Finnish children less than 7 yr of age with newly diagnosed IDDM. Childhood Diabetes in Finland Study Group. Diabetes Care 14: 415–417, 1991.
   PubMed Web of Science ®Google Scholar
• Kostraba JN, Dorman JS, LaPorte RE, Scott FW, Steenkiste AR, Gloninger M, Drash AL: Early infant diet and risk of IDDM in blacks and whites. A matched case-control study. Diabetes Care 15: 626–631, 1992.
   PubMed Web of Science ®Google Scholar
• Kostraba JN, Cruickshanks KJ, Lawner-Haevner J, Jobim LF, Rewers MJ, Gay EC, Chase HP, Klingensmith G, Hamman RF: Early exposure to cow’s milk and solid foods in infancy, genetic predisposition, and risk of IDDM. Diabetes 42: 288–295, 1993.
   PubMed Web of Science ®Google Scholar
• Perez-Bravo F, Carrasco E, Gutierrez-Lopez MD, Martinez MT, Lopez G, de los Rios MG: Genetic predisposition and environmental factors leading to the development of insulin-dependent diabetes mellitus in Chilean children. J Mol Med 74: 105–109, 1996.
   PubMed Web of Science ®Google Scholar
• Gimeno SG, de Souza JM: IDDM and milk consumption. A case-control study in Sao Paulo, Brazil. Diabetes Care 20: 1256–1260, 1997.
   PubMed Web of Science ®Google Scholar
• Gerstein H: Does cow’s milk cause type I diabetes mellitus? A critical overview of the clinical literature. Diabetes Care 17: 13–19, 1994.
   PubMed Web of Science ®Google Scholar
• Norris JM, Scott FW: A meta-analysis of infant diet and insulin-dependent diabetes mellitus: do biases play a role? Epidemiology 7: 87–92, 1996.
   PubMed Web of Science ®Google Scholar
• Virtanen SM, Rasanen L, Ylonen K, Aro A, Clayton D, Langholz B, Pitkaniemi J, Savilahti E, Lounamaa R, Tuomilehto J, Akerblom HK, and the Childhood Diabetes in Finland Study Group: Childhood diabetes in Finland: early introduction of dairy products associated with increased risk of IDDM in Finnish children. Diabetes 42: 1786–1790, 1993.
   PubMed Web of Science ®Google Scholar
• Akerblom HK, Knip M: Putative environmental factors in Type 1 diabetes. Diabetes Metab Rev 14: 31–67, 1998.
   PubMedGoogle Scholar
• Johansson C, Samuelsson U, Ludvigsson J: A high weight gain early in life is associated with an increased risk of type 1 (insulin-dependent) diabetes mellitus. Diabetologia 37: 91–94, 1994.
   PubMed Web of Science ®Google Scholar
• Fort P, Lanes R, Dahlem S, Recker B, Weyman-Daum M, Pugliese M, Lifshitz F: Breast feeding and insulin-dependent diabetes mellitus in children. J Am Coll Nutr 5: 439–441, 1986.
   PubMed Web of Science ®Google Scholar
• Siemiatycki J, Colle E, Campbell S, Dewar RA, Belmonte MM: Case-control study of IDDM. Diabetes Care 12: 209–216, 1989.
   PubMed Web of Science ®Google Scholar
• Samuelsson U, Johansson C, Ludvigsson J: Breast-feeding seems to play a marginal role in the prevention of insulin-dependent diabetes mellitus. Diabetes Res Clin Pract 19: 203–210, 1993.
   PubMed Web of Science ®Google Scholar
• Norris JM, Beaty B, Klingensmith G, Yu Liping, Hoffman M, Chase HP, Erlich HA, Hamman RF, Eisenbarth GS, Rewers M: Lack of association between early exposure to cow’s milk protein and beta-cell autoimmunity. Diabetes Autoimmunity Study in the Young. JAMA 276: 609–614, 1996.
   PubMed Web of Science ®Google Scholar
• Bodington MJ, McNally PG, Burden AC: Cow’s milk and type 1 childhood diabetes: no increase in risk. Diabet Med 11: 663–665, 1994.
   PubMed Web of Science ®Google Scholar
• Patterson CC, Carson DJ, Hadden DR, Waugh NR, Cole SK: A case-control investigation of perinatal risk factors for childhood IDDM in Northern Ireland and Scotland. Diabetes Care 17: 376–381, 1994.
   PubMed Web of Science ®Google Scholar
• Nigro G, Campea L, De Novellis A, Orsini M: Breast-feeding and insulin-dependent diabetes mellitus. Lancet I: 467, 1985.
   Google Scholar
• Kyvik KO, Green A, Svendsen A, Mortensen K: Breast feeding and the development of type 1 diabetes mellitus. Diabet Med 9: 233–235, 1992.
   PubMed Web of Science ®Google Scholar
• Meloni T, Marinaro AM, Mannazzu MC, Ogana A, La Vecchia C, Negri E, Colombo C: IDDM and early infant feeding. Sardinian case-control study. Diabetes Care 20: 340–342, 1997.
   PubMed Web of Science ®Google Scholar
• Elliott RB, Martin JM: Dietary protein: a trigger of insulin-dependent diabetes in the BB rat? Diabetologia 26: 279–299, 1984.
   Google Scholar
• Daneman D, Fishman L, Clarson C, Martin JM: Dietary triggers of insulin-dependent diabetes in the BB rat? Diabetes Res 5: 93–97, 1987.
   PubMedGoogle Scholar
• Coleman DL, Kuzava JE, Leiter EH: Effect of diet on incidence of diabetes in nonobese diabetic mice. Diabetes 39: 432–436, 1990.
   PubMed Web of Science ®Google Scholar
• Elliott RB, Reddy SN, Bibby NJ, Kida K: Dietary prevention of diabetes in the non-obese diabetic mouse. Diabetologia 31: 62–64, 1988.
   PubMed Web of Science ®Google Scholar
• Malkani S, Nompleggi D, Hansen JW, Greiner DL, Mordes JP, Rossini AA: Dietary cow’s milk protein does not alter the frequency of diabetes in the BB rat. Diabetes 46: 1133–1140, 1997.
   PubMedGoogle Scholar
• Vaarala O, Saukkonen T, Savilahti E, Klemola T, Akerblom HK: Development of immune response to cow milk proteins in infants receiving cow milk formula or hydrolysed formula. J Allergy Clin Immunol 96: 917–923, 1995.
   PubMed Web of Science ®Google Scholar
• Dahlquist G, Savilahti E, Landin-Olsson M: An increased level of antibodies to beta-lactoglobulin is a risk determinant for early-onset type 1 (insulin-dependent) diabetes mellitus independent of islet cell antibodies and early introduction of cow’s milk. Diabetologia 35: 980–984, 1992.
   PubMed Web of Science ®Google Scholar
• Virtanen SM, Saukkonen T, Savilahti E, Ylonen K, Rasanen L, Aro A, Knip M, Tuomilehto J, Akerblom HK: Diet, cow’s milk protein and the risk of IDDM in Finnish children. Diabetologia 37: 381–387, 1994.
   PubMed Web of Science ®Google Scholar
• Virtanen SM, Hypponen E, Laara E, Vahasalo P, Kulmala P, Savola K, Rasanen L, Aro A, Knip M, Akerblom HK: Cow’s milk consumption, disease-associated autoantibodies and type 1 diabetes mellitus: a follow-up study in siblings of diabetic children. Childhood Diabetes in Finland Study Group. Diabet Med 15: 730–738, 1998.
   PubMed Web of Science ®Google Scholar
• Saukkonen T, Savilahti E, Landin-Olsson M, Dahlquist: IgA bovine serum albumin antibodies are increased in newly diagnosed patients with insulin-dependent diabetes mellitus, but the increase is not an independent risk factor for diabetes. G Acta Paediatr 84: 1258–1261, 1995.
   Google Scholar
• Saukkonen T, Virtanen SM, Karppinen M, Reijonen H, Ilonen J, Rasanen L, Akerblom HK, Savilahti E: Significance of cow’s milk protein antibodies as risk factor for childhood IDDM: interactions with dietary cow’s milk intake and HLA-DQB1 genotype. Childhood Diabetes in Finland Study Group. Diabetologia 41: 72–78, 1998.
   PubMed Web of Science ®Google Scholar
• Vähäsalo P, Knip M, Karjalainen J, Tuomilehto-Wolf E, Lounamaa R, Akerblom HK: Islet cell-specific autoantibodies in children with insulin-dependent diabetes mellitus and their siblings at clinical manifestation of the disease. Childhood Diabetes in Finland Study Group. Eur J Endocrinol 135: 689–695, 1996.
   PubMed Web of Science ®Google Scholar
• Paronen J, Klemetti P, Kantele JM, Savilahti E, Perheentupa J, Akerblom HK, Vaarala O: Glutamate decarboxylase-reactive peripheral blood lymphocytes from patients with IDDM express gut-specific homing receptor alpha4beta7-integrin. Diabetes 46: 583–588, 1997.
   PubMedGoogle Scholar
• Akerblom HK, Vaarala O: Cow milk proteins, autoimmunity and type 1 diabetes. Exp Clin Endocrinol Diab 105: 83–85, 1997.
   PubMed Web of Science ®Google Scholar
• Beppu H, Winter WE, Atkinson MA, Maclaren NK, Fujita K, Takahashi H: Bovine albumin antibodies in NOD mice. Diabetes Res 6: 67–69, 1987.
   PubMedGoogle Scholar
• Glerum M, Robinson BH, Martin JM: Could bovine serum albumin be the initiating antigen ultimately responsible for the development of insulin dependent diabetes mellitus? Diabetes Res 10: 103–107, 1989.
   PubMedGoogle Scholar
• Martin JM, Trink B, Daneman D, Dosch HM, Robinson B: Milk proteins in the etiology of insulin-dependent diabetes mellitus (IDDM). Ann Med 23: 447–452, 1991.
   PubMed Web of Science ®Google Scholar
• Saukkonen T, Savilahti E, Vaarala O, Virtala ET, Tuomilehto J, Akerblom HK: Children with newly diagnosed IDDM have increased levels of antibodies to bovine serum albumin but not to ovalbumin. Childhood Diabetes in Finland Study Group. Diabetes Care 17: 970–976, 1994.
   PubMed Web of Science ®Google Scholar
• Levy-Marchal C, Karjalainen J, Dubois F, Karges W, Czernichow P, Dosch HM: Antibodies against bovine albumin and other diabetes markers in French children. Diabetes Care 18: 1089–1094, 1995.
   PubMed Web of Science ®Google Scholar
• Karjalainen J, Martin JM, Knip M, Ilonen J, Robinson BH, Savilahti E, Akerblom HK, Dosch HM: A bovine albumin peptide as a possible trigger of insulin-dependent diabetes mellitus. N Engl J Med 327: 302–307, 1992.
   PubMed Web of Science ®Google Scholar
• Pietropaolo M, Castano L, Babu S, Buelow R, Kuo Y-L S, Martin S, Martin A, Powers AC, Prochazka M, Naggert J, Leiter EH, Eisenbarth GS: Islet cell autoantigen 69kD (ICA69). Molecular cloning and characterization of a novel diabetes-associated autoantigen. J Clin Invest 92: 359–371, 1993.
   PubMed Web of Science ®Google Scholar
• Cheung R, Karjalainen J, Vandermeulen J, Singal DP, Dosch HM: T cells from children with IDDM are sensitized to bovine serum albumin. Scand J Immunol 40: 623–628, 1994.
   PubMed Web of Science ®Google Scholar
• Miyazaki I, Cheung RK, Gaedigk R, Hui MF, Van der Meulen J, Rajotte RV, Dosch HM: T cell activation and anergy to islet cell antigen in type I diabetes. J Immunol 154: 1461–1469, 1995.
   PubMed Web of Science ®Google Scholar
• Karges W, Hammond-McKibben D, Gaedigk R, Shibuya N, Cheung R, Dosch HM: Loss of self-tolerance to ICA69 in nonobese diabetic mice. Diabetes 46: 1548–1556, 1997.
   PubMed Web of Science ®Google Scholar
• Paxson JA, Weber JG, Kulczycki Jr A: Cow’s milk-free diet does not prevent diabetes in NOD mice. Diabetes 46: 1711–1717, 1997.
   PubMed Web of Science ®Google Scholar
• Atkinson MA, Bowman MA, Kao KJ, Campbell L, Dush PJ, Shah SC, Simell O, Maclaren NK: Lack of immune responsiveness to bovine serum albumin in insulin-dependent diabetes. New Engl J Med 329: 1853–1858, 1993.
   PubMed Web of Science ®Google Scholar
• Ivarsson SA, Mansson MU, Jakobsson IL: IgG antibodies to bovine serum albumin are not increased in children with IDDM. Diabetes 44: 1349–1350, 1995.
   PubMed Web of Science ®Google Scholar
• Krokowski M, Caillat-Zucman S, Timsit J, Larger E, Pehuet-Figoni M, Bach JF, Boitard C: Anti-bovine serum albumin antibodies: genetic heterogeneity and clinical relevance in adult-onset IDDM. Diabetes Care 18: 170–173, 1995.
   PubMed Web of Science ®Google Scholar
• Füchtenbusch M, Karges W, Standl E, Dosch HM, Ziegler AG: Antibodies to bovine serum albumin (BSA) in type 1 diabetes and other autoimmune disorders. Exp Clin Endocrinol Diabetes 105: 86–91, 1997.
   PubMed Web of Science ®Google Scholar
• Martin S, Kardorf J, Schulte B, Lampeter EF, Gries FA, Melchers I, Wagner R, Bertrams J, Roep BO, Pfutzner A: Autoantibodies to the islet antigen ICA69 occur in IDDM and in rheumatoid arthritis. Diabetologia 38: 351–355, 1995.
   PubMed Web of Science ®Google Scholar
• Luhder F, Schlosser M, Michaelis D, Ziegler B, Kohnert KD, Ziegler M: No association between anti-bovine serum albumin antibodies and islet cell reactive antibodies in newly diagnosed type 1 diabetic patients. Diabetes Res Clin Pract 26: 35–41, 1994.
   PubMed Web of Science ®Google Scholar
• Vaarala O, Klemetti P, Savilahti E, Reijonen H, Ilonen J, Akerblom HK: Cellular immune response to cow’s milk β-lactoglobulin in patients with newly diagnosed IDDM. Diabetes 45: 178–182, 1996.
   PubMed Web of Science ®Google Scholar
• Lampasona V, Ferrari M, Bosi E, Pastore MR, Bingley PJ, Bonifacio E: Sera from patients with IDDM and healthy individuals have antibodies to ICA69 on western blots but do not immunoprecipitate liquid phase antigen. J Autoimmun 7: 665–674, 1994.
   PubMed Web of Science ®Google Scholar
• Martin S, Lampasona V, Dosch M, Pietropaolo M: Islet cell autoantigen 69 antibodies in IDDM. Diabetologia 39: 747, 1996.
   PubMedGoogle Scholar
• Ronningen KS, Atrazhev A, Luo L, Luo C, Smith DK, Korbutt G, Rajotte RV, Elliott JF: Anti-BSA antibodies do not cross-react with the 69-kDa islet cell autoantigen ICA69. J Autoimmun 11: 223–231, 1998.
   PubMed Web of Science ®Google Scholar
• Savilahti E, Saukkonen TT, Virtala ET, Tuomilehto J, Akerblom HK: Increased levels of cow’s milk and beta-lactoglobulin antibodies in young children with newly diagnosed IDDM. The Childhood Diabetes in Finland Study Group. Diabetes Care 16: 984–989, 1993.
   PubMed Web of Science ®Google Scholar
• Scott FW, Mongeau R, Kardish M, Hartina G, Trick KD, Wojcinski Z: Diet can prevent diabetes in the BB rat. Diabetes 34: 1059–1062, 1985.
   PubMed Web of Science ®Google Scholar
• Issa-Chergui B, Guttmann RD, Seemayer TA, Kelley VE, Colle E: The effect of diet on the spontaneous insulin-dependent diabetis syndrome in the rat. Diabetes Res 9: 81–86, 1988.
   PubMedGoogle Scholar
• Wasmuth HE, Becker F, Seebaum S, Elliott RB, Federlin K: Association of antibodies to β casein with type 1 diabetes. Autoimmunity 21: A328, 1995.
   Google Scholar
• Elliott RB, Wasmuth H, Hill J, Songini M, Bottazzo GF: Diabetes and cow’s milk. Lancet 348: 1657, 1996.
   Web of Science ®Google Scholar
• Cavallo MG, Fava D, Moneti L, Barone F, Pozzilli P: Cell-mediated immune response to β-casein in recent-onset insulin-dependent diabetes: implications for disease pathogenesis. Lancet 348: 926–928, 1996.
   PubMed Web of Science ®Google Scholar
• Inman LR, McAllister CT, Chen L, Hughes S, Newgard CB, Kettman JR, Unger RH, Johnson JH: Autoantibodies to the GLUT-2 glucose transporter of β cells in insulin-dependent diabetes mellitus of recent onset. Proc Natl Acad Sci USA 90: 1281–1284, 1993.
   PubMed Web of Science ®Google Scholar
• Ellis TM, Ottendorfer E, Jodoin E, Salisbury PJ, She JX, Schatz DA, Atkinson MA: Cellular immune responses to beta casein: elevated in but not specific for individuals with type 1 diabetes mellitus. Diabetologia 41: 731–735, 1998.
   PubMed Web of Science ®Google Scholar
• Elliott RB, Wasmuth HE, Bibby NJ, Hill JP: The role of β-casein variants in the induction of insulin-dependent diabetes in the non-obese diabetic mouse and humans. Seminar on milk protein polymorphism, IDF special issue no. 9702. International Dairy Federation, Brussels, 445–453, 1997.
   Google Scholar
• Elliott RB, Harris DP, Hill JP, Bibby NJ, Wasmuth HE: Type I (insulin-dependent) diabetes mellitus and cow milk: casein variant consumption. Diabetologia 42: 292–296, 1999.
   PubMed Web of Science ®Google Scholar
• Migliore-Samour D, Floc’h F and Jollès P: Biologically active casein peptides in immunomodulation. J Dairy Res 56: 357–363, 1989.
   PubMed Web of Science ®Google Scholar
• Gattegno L, Migliore-Samour D, Saffar L, Jollès P: Enhancement of phagocytic activity of human monocytic-macrophagic cells by immunostimulating peptides from human casein. Immunol Lett 18: 27–32, 1988.
   PubMed Web of Science ®Google Scholar
• Svedberg S, De Haas J, Leimenstoll G, Paul F, Teschemacher H: Demonstration of β-casomorphin immunoreactive materials in in vitro digests of bovine milk and in small intestine contents after bovine milk ingestion in adult humans. Peptides 6: 825–830, 1985.
   PubMed Web of Science ®Google Scholar
• Meisel H: Biochemical properties of regulatory peptides derived from milk proteins. Biopolymers 43: 119–128, 1997.
   PubMed Web of Science ®Google Scholar
• Hartwig A, Teschemacher H, Lehmann W, Gauly M, Erhardt G: Influence of genetic polymorphisms in bovine milk on the occurence of bioactive peptides. Seminar on milk protein polymorphism, IDF special issue no. 9702. International Dairy Federation, Brussels, 459–460, 1997.
   Google Scholar
• Vaarala O, Paronen J, Otonkoski T, Akerblom HK: Cow milk feeding induces antibodies to insulin in children—a link between cow milk and insulin-dependent diabetes mellitus? Scand J Immunol 47: 131–135, 1998.
   PubMed Web of Science ®Google Scholar
• Atkinson MA, Maclaren NK, Luchetta R: Insulitis and diabetes in NOD mice reduced by prophylactic insulin therapie. Diabetes 39: 933–937, 1990.
   PubMed Web of Science ®Google Scholar
• Zhang ZJ, Davidson L, Eisenbarth G, Weiner HL: Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin. Proc Natl Acad Sci USA 88: 10252–10256, 1991.
   PubMed Web of Science ®Google Scholar
• Bergerot I, Fabien N, Maguer V, Thivolet C: Oral administration of human insulin to NOD mice generates CD4+ T cells that suppress adoptive transfer of diabetes. J Autoimmun 7: 655–663, 1994.
   PubMed Web of Science ®Google Scholar
• Ploix C, Bergerot I, Fabien N, Perche S, Moulin V, Thivolet C: Protection against autoimmune diabetes with oral insulin is associated with the presence of IL-4 type 2T-cells in the pancreas and pancreatic lymph nodes. Diabetes 47: 39–44, 1998.
   PubMed Web of Science ®Google Scholar
• Akerblom HK, Savilahti E, Vaarala O: Cow’s milk protein and insulin-dependent diabetes mellitus. Scand J Nutr 40: 98–103, 1996.
   Google Scholar
• Pettitt DJ, Forman MR, Hanson RL, Knowler WC, Bennett PH: Breastfeeding and incidence of non-insulin-dependent diabetes mellitus in Pima Indians. Lancet 350: 166–168, 1997.
   PubMed Web of Science ®Google Scholar
• Lucas A, Lucas PJ, Baum JD: Pattern of milk flow in breast-fed infants. Lancet II: 57–58, 1979.
   Google Scholar
• Wright P: Development of feeding behaviour in early infancy: implications for obesity. Health Bull 39: 197–205, 1981.
   Google Scholar
• Hamosh M: Does infant nutrition affect adiposity and cholesterol levels in the adult? J Pediatr Gastroenterol Nutr 7: 10–16, 1988.
   PubMed Web of Science ®Google Scholar
• Simmons D: NIDDM and breastfeeding. Lancet 350: 157–158, 1997.
   Google Scholar
• Rich-Edwards JW, Colditz GA, Stampfer MJ, Willett WC, Gillman MW, Hennekens CH, Speizer FE, Manson JE: Birthweight and the risk for type 2 diabetes mellitus in adult women. Ann Intern Med 130: 278–284, 1999.
   PubMed Web of Science ®Google Scholar
• Hales CN, Barker DJ, Clark PM, Cox LJ, Fall C, Osmond C, Winter PD: Fetal and infant growth and impaired glucose tolerance at age 64. BMJ 303: 1019–1022, 1991.
   PubMed Web of Science ®Google Scholar
• Kluthe R, Schubert A: Obesity in Europe. Ann Int Med 103: 1037–1042, 1985.
   PubMed Web of Science ®Google Scholar
• Morris MC: Dietary fats and blood pressure. J Cardivasc Risk 1: 21–30, 1994.
   PubMedGoogle Scholar
• Moers A, Schrezenmeir J: Palmitic but not stearic acid inhibits NO-production in endothelials cells. Exp Clin Endocrino Exp Clin Endocrinol Diabetes 105(Suppl)2: 78–80, 1997.
   Google Scholar
• Meisel H: Biochemical properties of regulatory peptides derived from milk proteins. Biopolymers 43: 119–128, 1997.
   PubMed Web of Science ®Google Scholar
• Mullally MM, Meisel H, FitzGerald RJ: Synthetic peptides corresponding to alpha-lactalbumin and beta-lactoglobulin sequences with angiotensin-I-converting enzyme inhibitory activity. Biol Chem Hoppe Seyler 377: 259–260, 1996.
   PubMed Web of Science ®Google Scholar
• Yamamoto N, Akino A, Takano T: Antihypertensive effect of the peptides derived from casein by an extracellular proteinase from Lactobacillus helveticus CP790. J Dairy Sci 77: 917–922, 1994.
   PubMed Web of Science ®Google Scholar
• Snowdon DA: Animal product consumption and mortality because of all causes combined, coronary heart disease, stroke, diabetes, and cancer in Seventh-day Adventists. Am J Clin Nutr 48: 739–748, 1988.
   PubMed Web of Science ®Google Scholar
• Appel LJ, Moore TJ, Obarzanek E, Vollmer WM, Svetkey LP, Sacks FM, Bray GA, Vogt TM, Cutler JA, Windhauser MM, Lin PH, Karanja N: A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N Engl J Med 336: 1117–1124, 1997.
   PubMed Web of Science ®Google Scholar
• Dwyer JT: Health aspects of vegetarian diets. Am J Clin Nutr 48: 712–738, 1988.
   PubMed Web of Science ®Google Scholar
• Sacks FM, Kass EH: Low blood pressure in vegetarians: effects of specific foods and nutrients. Am J Clin Nutr 48: 795–800, 1988.
   PubMed Web of Science ®Google Scholar
• Cappuccio FP, Elliott P, Allender PS, Pryer J, Follman DA, Cutler JA: Epidemiologic association between dietary calcium intake and blood pressure: a meta-analysis of published data. Am J Epidemiol 142: 935–945, 1995.
   PubMed Web of Science ®Google Scholar
• Ackley S, Barrett-Connor E, Suarez L: Dairy products, calcium, and blood pressure. Am J Clin Nutr 38: 457–461, 1983.
   PubMed Web of Science ®Google Scholar
• Abbott RD, Curb JD, Rodriguez BL, Sharp DS, Burchfiel CM, Yano K: Effect of dietary calcium and milk consumption on risk of thromboembolic stroke in older middle-aged men. The Honolulu Heart Programm. Stroke 27: 813–818, 1996.
   PubMed Web of Science ®Google Scholar
• Sekiya S, Kobayashi Y, Kita E, Imamura Y, Toyama S: Antihypertensive effects of tryptic hydrolysate of casein on normotensive and hypertensive volunteers. J Jpn S N F Science 45: 513–517, 1992.
   Google Scholar
• Donnelly R: Angiotensin-converting enzyme inhibitors and insulin sensitivity metabolic effects in hypertension, diabetes, and heart failure. J Cariovasc Pharmacol 20: 38–44, 1992.
   Google Scholar
• Uehara M, Kishikawa H, Isami S, Kisanuki K, Ohkubo Y, Miyamura N, Miyata T, Yano T, Shichiri M: Effects on insulin sensitivity of angiotensin converting enzyme inhibitors with or without a sulphydryl group: bradykinin may improve insulin resistance in dogs and humans. Diabetologia 37: 300–307, 1994.
   PubMed Web of Science ®Google Scholar
• Aro A, Pelkonen R, Leino U: Glucose and insulin responses to meals containing milk, lactose, glucose or fructose in subjects with non-insulin-dependent diabetes. Diabete Metab 13: 603–606, 1987.
   PubMed Web of Science ®Google Scholar
• Gannon MC, Nuttall FQ, Krezowski PA, Billington CJ, Parker S: The serum insulin and plasma glucose responses to milk and fruit products in type 2 (non-insulin-dependent) diabetic patients. Diabetologia 29: 784–791, 1986.
   PubMed Web of Science ®Google Scholar
• Schrezenmeir J, Tato F, Tato S, Küstner E, Krause U, Hommel G, Asp N-G, Kasper H, Beyer J: Comparison of glycemic response and insulin requirements after mixed meals of equal carbohydrate content in healthy, type-1 and type-2 diabetic man. Klin Wochenschr 67: 985–994, 1989.
   PubMedGoogle Scholar
• Schrezenmeir J: Hyperinsulinemia, hyperproinsulinemia, and insulin resistance in the metabolic syndrome. Experientia 5: 426–432, 1996.
   Google Scholar
• Himsworth HP: Diet and incidence of diabetes mellitus. Clin Sci Mol Med 2: 117–118, 1935.
   Google Scholar
• West KM, Kalbfleisch J: Influence of nutritional factors on the prevalence of diabetes. Diabetes 20: 99–108, 1971.
   PubMed Web of Science ®Google Scholar
• Precht D, Molkentin J: Trans fatty acids: implications for health, analytical methods, incidence in edible fats and intake. Nahrung 39: 343–374, 1995.
   PubMedGoogle Scholar
• Jahreis G, Fritsche J, Steinhart H: Monthly variations of milk composition with special regard to fatty acids depending on season and farm management systems—conventional versus ecological. Fett/Lipid 98: 356–359, 1996.
   Google Scholar
• Jiang J, Bjoerck L, Fonden R, Emanuelson M: Occurence of conjugated cis-9, trans-11-octadecadienoic acid in bovine milk: effects of feed and dietary regimen. J Dairy Sci 79: 438–445, 1996.
   PubMed Web of Science ®Google Scholar
• Jahreis G, Fritsche J, Steinhart H: Conjugated linoleic acid in milk fat: high variation depending on production system. Nutr Res 17: 1479–1484, 1997.
   Web of Science ®Google Scholar
• Ha YL, Grimm NK, Pariza MW: Anticarcinogens from fried ground beef: heat altered derivatives of linoleic acid. Carcinogenesis 8: 1881–1887, 1987.
   PubMed Web of Science ®Google Scholar
• Ip C, Chin SF, Scimeca JA, Pariza MW: Mammary cancer prevention by conjugated dienoic derivative of linoleic acid. Cancer Res 51: 6118–6124, 1991.
   PubMed Web of Science ®Google Scholar
• Lee KN, Kritchevsky D, Pariza MW: Conjugated linoleic acid and atherosclerosis in rabbits. Atherosclerosis 108: 19–25, 1994.
   PubMed Web of Science ®Google Scholar
• Katan MB, Zock PL, Mensink RP: Effects of fats and fatty acids on blood lipids in humans: an overview. Am J Clin Nutr 60, 6(Suppl): 1017S–1022S, 1994.
   Web of Science ®Google Scholar
• Mensink RP, Katan MB: Effect of dietary trans fatty acids on high-density and low-density lipoprotein cholesterol levels in healthy subjects. N Engl J Med 323: 439–445, 1990.
   PubMed Web of Science ®Google Scholar
• Christiansen E, Schnider S, Palmvig B, Tauber-Lassen E, Pedersen O: Intake of a diet high in trans monounsaturated fatty acids or saturated fatty acids. Effects on postprandial insulinemia and glycemia in obese patients with NIDDM. Diabetes Care 20: 881–887, 1997.
   PubMed Web of Science ®Google Scholar
• Houseknecht KL, Vanden Heuvel JP, Moya-Camarena SY, Portocarrero CP, Peck LW, Nickel KP, Belury MA: Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat. Biochem Biophys Res Commun 244: 678–682, 1998.
   PubMed Web of Science ®Google Scholar
• Belury MA, Kempa-Steczko A: Conjugated linoleic acid modulates hepatic lipid composition in mice. Lipids 32: 199–204, 1997.
   PubMed Web of Science ®Google Scholar
• Zhou YP, Grill VE: Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J Clin Invest 93: 870–876, 1994.
   PubMed Web of Science ®Google Scholar
• Zhou YP, Grill V: Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans. J Clin Endocrinol Metab 80: 1584–1590, 1995.
   PubMed Web of Science ®Google Scholar
• Zhou YP, Ling ZC, Grill VE: Inhibitory effects of fatty acids on glucose-regulated B-cell function: association with increased islet triglyceride stores and altered effect of fatty acid oxidation on glucose metabolism. Metabolism 45: 981–986, 1996.
   PubMed Web of Science ®Google Scholar
• Alstrup KK, Gregersen S, Jensen HM, Thomsen JL, Hermansen K: Differential effects of cis and trans fatty acids on insulin release from isolated mouse islets. Metabolism 48: 22–29, 1999.
   PubMed Web of Science ®Google Scholar
• Schrezenmeir J, Laue Ch. Apoptosis and proliferation of islet cells—in vitro model for diabetogenesis. Exp Clin Endocrinol Diabetes 105, 3(Suppl): 95, 1997.
   Google Scholar