Soy Isoflavones—Benefits and Risks from Nature’s Selective Estrogen Receptor Modulators (SERMs)

REFERENCES

• Setchell KDR: Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones. Am J Clin Nutr 68: 1333S–1346S, 1998.
   PubMed Web of Science ®Google Scholar
• Setchell KDR, Cassidy A: Dietary isoflavones: biological effects and relevance to human health. J Nutr 129: 758S–767S, 1999.
   PubMed Web of Science ®Google Scholar
• Setchell KDR, Lawson AM, Mitchell FL, Adlercreutz H, Kirk DN, Axelson M: Lignans in man and in animal species. Nature 287: 740–742, 1980.
   PubMed Web of Science ®Google Scholar
• Setchell KDR, Borriello SP, Hulme P, Kirk DN, Axelson M: Nonsteroidal estrogens of dietary origin: possible roles in hormone-dependent disease. Am J Clin Nutr 40: 569–578, 1984.
   PubMed Web of Science ®Google Scholar
• Shelby MD, Newbold RR, Tully DB, Chae K, Davis VL: Assessing environmental chemicals for estrogenicity using a combination of in vitro and in vivo assays. Environ Health Perspect 104: 1296–1300, 1996.
   PubMed Web of Science ®Google Scholar
• Adlercreutz H, Markkanen H, Watanabe S: Plasma concentrations of phyto-oestrogens in Japanese men. Lancet 342: 1209–1210, 1993.
   PubMed Web of Science ®Google Scholar
• Morton MS, Wilcox G, Wahlqvist ML, Griffiths K: Determination of lignans and isoflavonoids in human female plasma following dietary supplementation. J Endocrinol 142: 251–259, 1994.
   PubMed Web of Science ®Google Scholar
• Lapcik O, Hampl R, al-Maharik N, Salakka A, Wahala K, Adlercreutz H: A novel radioimmunoassay for daidzein. Steroids 62: 315–320, 1997.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Wang GJ, Song TT, Murphy PA, Hendrich S: Urinary disposition of the soybean isoflavones daidzein, genistein and glycitein differs among humans with moderate fecal isoflavone degradation activity. J Nutr 129: 957–962, 1999.
   PubMed Web of Science ®Google Scholar
• Setchell KDR, Zimmer-Nechemias L, Cai J, Heubi JE: Exposure of infants to phyto-oestrogens from soy-based infant formula [see comments]. Lancet 350: 23–27, 1997.
   PubMed Web of Science ®Google Scholar
• Setchell KDR, Brown NM, Desai P, Zimmer-Nechemias L, Wolfe BE, Brashear WT, Kirscher AS, Cassidy A, Heubi J: Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements. J Nutr 131: 1362S–1375S, 2001.
   PubMed Web of Science ®Google Scholar
• Braden A, Hart N, Lamberton J: The estrogenic activity and metabolism of certain isoflavones in sheep. Aust J Agric Res 18: 335–348, 1967.
   Google Scholar
• Lindsay DR, Kelly RW: The metabolism of phyto-oestrogens in sheep. Aust Vet J 46: 219–222, 1970.
   PubMed Web of Science ®Google Scholar
• Lundh T-O, Pettersson H, Keissling K-H: Demethylation and conjugation of formononetin and daidzein in sheep and cow liver microsomes. J Agric Food Chem 36: 22–25, 1988.
   Web of Science ®Google Scholar
• Marrian G, Haslewood G: Equol, a new inactive phenol isolated from the ketohydroxyoestrin fraction of mares urine. Biochem J 26: 1227–1232, 1932.
   PubMedGoogle Scholar
• Common R, Aimsworth L: Identification of equol in the urine of the domestic fowl. Biochim Biophys Acta 53: 403–404, 1961.
   PubMedGoogle Scholar
• Cayen MN, Carter AL, Common RH: The conversion of genistein to equol in the fowl. Biochimica et Biophys Acta 86: 56–64, 1964.
   PubMed Web of Science ®Google Scholar
• Tang G, Common RH: Urinary conversion products of certain orally administered isoflavones in the fowl. Biochim Biophys Acta 158: 402–413, 1968.
   PubMed Web of Science ®Google Scholar
• Juniewicz PE, Pallante Morell S, Moser A, Ewing LL: Identification of phytoestrogens in the urine of male dogs. J Steroid Biochem 31: 987–994, 1988.
   PubMedGoogle Scholar
• Monfort SL, Thompson MA, Czekala NM, Kasman LH, Shackleton CH, Lasley BL: Identification of a non-steroidal estrogen, equol, in the urine of pregnant macaques: correlation with steroidal estrogen excretion. J Steroid Biochem 20: 869–876, 1984.
   PubMedGoogle Scholar
• Nilsson A: Demethylation of the plant oestrogen bichanin A in the rat. Nature 92: 358, 1961.
   Google Scholar
• Sfakianos J, Coward L, Kirk M, Barnes S: Intestinal uptake and biliary excretion of the isoflavone genistein in rats. J Nutr 127: 1260–1268, 1997.
   PubMed Web of Science ®Google Scholar
• King RA, Broadbent JL, Head RJ: Absorption and excretion of the soy isoflavone genistein in rats. J Nutr 126: 176–182, 1996.
   PubMed Web of Science ®Google Scholar
• Coldham NG, Howells LC, Santi A, Montesissa C, Langlais C, King LK, Macpherson DD, Sauer MJ: Biotransformation of genistein in the rat: elucidation of metabolite structure by product ion mass fragmentology. J Steroid Biochem Mol Biol 70: 169–184, 1999.
   PubMed Web of Science ®Google Scholar
• Coldham NG, Sauer MJ: Pharmacokinetics of [14C]genistein in the rat: Gender-related differences, potentil mechanisms of biological action, and implications for human health. Toxicol Appl Pharmacol 164: 206–215, 2000.
   PubMed Web of Science ®Google Scholar
• Bennetts HW, Underwood EJ, Shier FL: A specific breeding problem of sheep on subterranean clover pastures in Western Australia. Aust J Agric Res 22: 131–138, 1946.
   Google Scholar
• King RA, Bursill DB: Plasma and urinary kinetics of the isoflavones daidzein and genistein after a single soy meal in humans. Am J Clin Nutr 67: 867–872, 1998.
   PubMed Web of Science ®Google Scholar
• Xu X, Wang HJ, Murphy PA, Cook L, Hendrich S: Daidzein is a more bioavailable soymilk isoflavone than is genistein in adult women. J Nutr 124: 825–832, 1994.
   PubMed Web of Science ®Google Scholar
• Izumi T, Piskula MK, Osawa S, Obata A, Tobe K, Saito M, Kataoka S, Kubota Y, Kikuchi M: Soy isoflavone aglycones are absorbed faster and in higher amounts than their glycosides in humans. J Nutr 130: 1695–1699, 2000.
   PubMed Web of Science ®Google Scholar
• Axelson M, Kirk DN, Farrant RD, Cooley G, Lawson AM, Setchell KD: The identification of the weak oestrogen equol [7-hydroxy-3-(4′-hydroxyphenyl)chroman] in human urine. Biochem J 201: 353–357, 1982.
   PubMed Web of Science ®Google Scholar
• Axelson M, Sjovall J, Gustafsson BE, Setchell KDR: Soya—a dietary source of the non-steroidal oestrogen equol in man and animals. J Endocrinol 102: 49–56, 1984.
   PubMed Web of Science ®Google Scholar
• Walz E: Isoflavone: a Saponin glucoside in soya. Justus Liebigs Ann Chem 489: 118–155, 1931.
   Google Scholar
• Walter E: Genistein (an isoflavone glucoside) and its aglucone, genistin, from soybeans. J Amer Oil Chem Soc 63: 3273–3276, 1941.
   Google Scholar
• Murphy PA: Phytoestrogen content of processed soybean products. Food Technol 43: 60–64, 1982.
   Google Scholar
• Farmakalidis E, Murphy P: Isolation of 6"-O-acetyldaidzein and 6"-O-acetylgenistein from toasted defatted soy flakes. J Agric Food Chem 33: 385–389, 1985.
   Web of Science ®Google Scholar
• Coward L, Barnes NC, Setchell KDR, Barnes S: Genistein and daidzein, and their β-glycosides conjugates: anti-tumor isoflavones in soybean foods from American and Asian diets. J Agric Food Chem 41: 1961–1967, 1993.
   Web of Science ®Google Scholar
• Song T, Barua K, Buseman G, Murphy PA: Soy isoflavone analysis: quality control and a new internal standard. Am J Clin Nutr 68: 1474S–1479S, 1998.
   PubMed Web of Science ®Google Scholar
• Adlercreutz H, Martin F: Biliary excretion and intestinal metabolism of progesterone and estrogens in man. J Steroid Biochem 13: 231–244, 1980.
   PubMedGoogle Scholar
• Setchell KDR, Brown NM, Zimmer-Nechemias L, Brashear WT, Wolfe B, Kirschner AS, Cassidy A, Heubi JE: Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability. Am J Clin Nutr, in press, 2001.
   Google Scholar
• Day AJ, DuPont MS, Ridley S, Rhodes M, Rhodes MJ, Morgan MR, Williamson G: Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver beta-glucosidase activity. FEBS Lett 436: 71–75, 1998.
   PubMed Web of Science ®Google Scholar
• Ioku K, Pongpiriyadacha Y, Konishi Y, Takei Y, Nakatani N, Terao J: beta-Glucosidase activity in the rat small intestine toward quercetin monoglucosides. Biosci Biotechnol Biochem 62: 1428–1431, 1998.
   PubMed Web of Science ®Google Scholar
• McMahon LG, Nakano H, Levy MD, Gregory JF, 3rd: Cytosolic pyridoxine-beta-D-glucoside hydrolase from porcine jejunal mucosa. Purification, properties, and comparison with broad specificity beta-glucosidase. J Biol Chem 272: 32025–32033, 1997.
   PubMedGoogle Scholar
• Mykkanen H, Tikka J, Pitkanen T, Hanninen O: Fecal bacterial enzyme activities in infants increase with age and adoption of adult-type diet. J Pediatr Gastroenterol Nutr 25: 312–316, 1997.
   PubMed Web of Science ®Google Scholar
• Setchell KDR, Welsh M, Lim C: HPLC analysis of phytoestrogens in soy protein preparations with ultraviolet, electrochemical, and thermospray mass spectrometric detection. J Chromatogr 385: 267–274, 1987.
   PubMed Web of Science ®Google Scholar
• Setchell KDR: Absorption and metabolism of soy isoflavones—from food to dietary supplements and adults to infants. J Nutr 130: 654S–655S, 2000.
   PubMed Web of Science ®Google Scholar
• Kelly GE, Nelson C, Waring MA, Joannou GE, Reeder AY: Metabolites of dietary (soya) isoflavones in human urine. Clin Chim Acta 223: 9–22, 1993.
   PubMed Web of Science ®Google Scholar
• Joannou GE, Kelly GE, Reeder AY, Waring M, Nelson C: A urinary profile study of dietary phytoestrogens. The identification and mode of metabolism of new isoflavonoids. J Steroid Biochem Mol Biol 54: 167–184, 1995.
   PubMed Web of Science ®Google Scholar
• Hollman PC, van Trijp JM, Mengelers MJ, de Vries JH, Katan MB: Bioavailability of the dietary antioxidant flavonol quercetin in man. Cancer Lett 114: 139–140, 1997.
   PubMed Web of Science ®Google Scholar
• Dwyer JT, Goldin BR, Saul N, Gualtieri L, Barakat S, Adlercreutz H: Tofu and soy drinks contain phytoestrogens [see comments]. J Am Diet Assoc 94: 739–743, 1994.
   PubMed Web of Science ®Google Scholar
• King R, Bignell C: Concentrations of isoflavone phytoestrogens and glucosides in Australian soya beans and soya foods. Aust J Nutr Diet 57: 70–78, 2000.
   Google Scholar
• Reinli K, Block G: Phytoestrogen content of foods—A compendium of literature values. Nutr Cancer 26: 123–148, 1996.
   PubMed Web of Science ®Google Scholar
• Pillow P, Duphorne C, Chang S, Contois J, Strom S, Spitz M, Hursting S: Development of a database for assessing dietary phytoestrogen intake. Nutr Cancer 33: 3–19, 1999.
   PubMed Web of Science ®Google Scholar
• Lu L-J, Broemelin L, Marshall M, Sadagopa Ramanujam V: A simplified method to quantify isoflavones in commercial soybean diets and human urine after legume consumption. Cancer Epidemiol Biomarkers Prev 4: 497–503, 1995.
   PubMed Web of Science ®Google Scholar
• Franke AA, Custer LJ, Wang W, Shi CY: HPLC analysis of isoflavonoids and other phenolic agents from foods and from human fluids. Proc Soc Exp Biol Med 217: 263–273, 1998.
   PubMed Web of Science ®Google Scholar
• Messina M: Isoflavone intakes by Japanese were overestimated. Am J Clin Nutr 62: 645, 1995.
   PubMed Web of Science ®Google Scholar
• Wilcox B, Fuchigami K, Wilcox D, Kendall C, Suzuki M, Todoriki H, DJA J: Isoflavone intake in Japanese and Japanese-Canadians. Am J Clin Nutr 61: 901 (Abstract), 1995.
   Google Scholar
• Nagata C, Takatsuka N, Kurisu Y, Shimizu H: Decreased serum total cholesterol concentration is associated with high intake of soy products in Japanese men and women. J Nutr 128: 209–213, 1998.
   PubMed Web of Science ®Google Scholar
• Wakai K, Egami I, Kato K, Kawamura T, Tamakoshi A, Y L, Nakayama T, Wada M, Ohno Y: Dietary intake and sources of isoflavones among Japanese. Nutr Cancer 33: 139–145, 1999.
   PubMed Web of Science ®Google Scholar
• Chen Z, Zheng W, Custer LJ, Dai Q, Shu XO, Jin F, Franke AA: Usual dietary consumption of soy foods and its correlation with the excretion rate of isoflavonoids in overnight urine samples among Chinese women in Shanghai. Nutr Cancer 33: 82–87, 1999.
   PubMed Web of Science ®Google Scholar
• Purba Mb, Lukito W, Wahlqvist ML, Kouris-Blazos A, Hadisaputro S, Lestiani L, Wattanapenpaiboon N, Kamso S: Food intake and eating patterns of Indonesian elderly before the 1998 economic crisis. Asia Pacific J Clin Nutr 8: 200–206, 1999.
   PubMedGoogle Scholar
• Maskarinec G, Singh S, Meng L, Franke AA: Dietary soy intake and urinary isoflavone excretion among women from a multiethnic population. Cancer Epidemiol Biomarkers Prev 7: 613–619, 1998.
   PubMed Web of Science ®Google Scholar
• Jones A, Price K, Fenwick G: Development and application of high-performance liquid chromatographic method for the analysis of phytoestrogens. J Sci Food Agric 46: 357–364, 1989.
   Web of Science ®Google Scholar
• Kuiper GG, Lemmen JG, Carlsson B, Corton JC, Safe SH, van der Saag PT, van der Burg B, Gustafsson JA: Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 139: 4252–4263, 1998.
   PubMed Web of Science ®Google Scholar
• Jordan VC, Morrow M: Tamoxifen, raloxifene, and the prevention of breast cancer. Endocr Rev 20: 253–278, 1999.
   PubMed Web of Science ®Google Scholar
• Brzozowski AM, Pike AC, Dauter Z, Hubbard RE, Bonn T, Engstrom O, Ohman L, Greene GL, Gustafsson JA, Carlquist M: Molecular basis of agonism and antagonism in the oestrogen receptor. Nature 389: 753–758, 1997.
   PubMed Web of Science ®Google Scholar
• Pike AC, Brzozowski AM, Hubbard RE, Bonn T, Thorsell AG, Engstrom O, Ljunggren J, Gustafsson JA, Carlquist M: Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist. Embo J 18: 4608–4618, 1999.
   PubMed Web of Science ®Google Scholar
• McKenna N, Xu J, Nawaz Z, Tsai S, Tsai M-J, O’Malley B: Nuclear receptor coactivators: multiple complexes, multiple functions. J Steroid Biochem Mol Biol 69: 3–12, 1999.
   PubMed Web of Science ®Google Scholar
• Klinge C: Estrogen receptor interaction with co-activators and co-repressors. Steroids 65: 227–251, 2000.
   PubMed Web of Science ®Google Scholar
• Brzezinski A, Debi A: Phytoestrogens: the “natural” selective estrogen receptor modulators? European J Obstetrics Gynecol Reprod Biol 85: 47–51, 1999.
   PubMed Web of Science ®Google Scholar
• Cummings SR, Eckert S, Krueger KA, Grady D, Powles TJ, Cauley JA, Norton L, Nickelsen T, Bjarnason NH, Morrow M, Lippman ME, Black D, Glusman JE, Costa A, Jordan VC: The effect of raloxifene on risk of breast cancer in postmenopausal women: results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation [see comments]. JAMA 281: 2189–2197, 1999.
   PubMed Web of Science ®Google Scholar
• Anderson JW, Johnstone BM, Cook-Newell ME: Meta-analysis of the effects of soy protein intake on serum lipids [see comments]. N Engl J Med 333: 276–282, 1995.
   PubMed Web of Science ®Google Scholar
• Anthony M, Clarkson T, Hughes C: Plant and mammalian estrogen effects on plasma lipids of female monkeys. Circulation 90: 1–235, 1994.
   PubMed Web of Science ®Google Scholar
• Anthony MS, Clarkson TB: Comparison of soy phytoestrogens and conjugated equine estrogens on atherosclerosis progression in post-menopausal monkeys. Circulation 97: 829 (Abstract), 1998.
   Google Scholar
• Honore EK, Williams JK, Anthony MS, Clarkson TB: Soy isoflavones enhance coronary vascular reactivity in atherosclerotic female macaques. Fertil Steril 67: 148–154, 1997.
   PubMed Web of Science ®Google Scholar
• Crouse JR, 3rd, Morgan T, Terry JG, Ellis J, Vitolins M, Burke GL: A randomized trial comparing the effect of casein with that of soy protein containing varying amounts of isoflavones on plasma concentrations of lipids and lipoproteins. Arch Intern Med 159: 2070–2076, 1999.
   PubMed Web of Science ®Google Scholar
• Cassidy A, Bingham S, Setchell KDR: Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women [see comments]. Am J Clin Nutr 60: 333–340, 1994.
   PubMed Web of Science ®Google Scholar
• Wong W, O’Brian Smith E, Stuff J, Hachey D, Heird W, Pownell H: Cholesterol-lowering effect of soy protein in normocholesterolemic and hypercholesterolemic men. Am J Clin Nutr 68: 1385S–1389S, 1998.
   PubMed Web of Science ®Google Scholar
• Merz-Demlow B, Duncan A, Wangen K, Xu X, Carr T, Phipps W, Kurzer M: Soy isoflavones improve plasma lipids in normocholesterolemic, premenopausal women. Am J Clin Nutr 71: 1462–1469, 1999.
   Google Scholar
• Wangen K, Duncan A, Xu X, Kurzer M: Soy isoflavones improve plasma lipids in normocholesterolemic and mildly hypercholesterolemic postmenopausal women. Am J Clin Nutr 73: 225–231, 2000.
   Web of Science ®Google Scholar
• Nestel PJ, Yamashita T, Sasahara T, Pomeroy S, Dart A, Komesaroff P, Owen A, Abbey M: Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women. Arterioscl Thromb Vascul Biol 17: 3392–3398, 1997.
   PubMed Web of Science ®Google Scholar
• Hodgson JM, Puddey IB, Beilin LJ, Mori TA, Croft KD: Supplementation with isoflavonoid phytoestrogens does not alter serum lipid concentrations: a randomized controlled trial in humans. J Nutr 128: 728–732, 1998.
   PubMed Web of Science ®Google Scholar
• Nestel PJ, Pomeroy S, Kay S, Komesaroff P, Behrsing J, Cameron JD, West L: Isoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal women. J Clin Endocrinol Metab 84: 895–898, 1999.
   PubMed Web of Science ®Google Scholar
• Kapiotis S, Hermann M, Held I, Seelos C, Ehringer H, Gmeiner BM: Genistein, the dietary-derived angiogenesis inhibitor, prevents LDL oxidation and protects endothelial cells from damage by atherogenic LDL. Arterioscl Thromb Vasc Biol 17: 2868–2874, 1997.
   PubMed Web of Science ®Google Scholar
• Tikkanen MJ, Wahala K, Ojala S, Vihma V, Adlercreutz H: Effect of soybean phytoestrogen intake on low density lipoprotein oxidation resistance. Proc Natl Acad Sci U S A 95: 3106–3110, 1998.
   PubMed Web of Science ®Google Scholar
• Jenkins DJA, Kendall CWC, Garsetti M, Rosenberg-Zand RS, Jackson C-J, Agarwal S, Rao AV, Diamandis EP, Parker T, Faulkner D, Vuksan V, Vidgen E: Effect of soy protein foods on low-density lipoprotein oxidation and ex vivo sex hormone receptor activity—A controlled crossover trial. Metabolism 49: 537–543, 2000.
   PubMed Web of Science ®Google Scholar
• Scheiber MD, Liu JH, Subbiah MTR, Rebar RW, Setchell KDR: Dietary soy supplementation reduces LDL oxidation and bone turnover in healthy post-menopausal women. Menopause, in press, 2001.
   Google Scholar
• Wiseman H, O’Reilly J, Adlercreutz H, Mallet A, Bowey E, Rowland I: Isoflavone phytoestrogens consumed in soy decrease F2-isoprostane concentrations and increase resistance of low-density lipoprotein to oxidation in humans. Am J Clin Nutr 72: 395–400, 2000.
   PubMed Web of Science ®Google Scholar
• Figtree GA, Griffiths H, Lu Y-Q, Webb CM, MacLeod K, Collins P: Plant-derived estrogens relax coronary arteries in vitro by a calcium antagonistic mechanism. Journal of American College of Cardiology 35: 1977–1985, 2000.
   PubMed Web of Science ®Google Scholar
• Sadowska-Krowicka H, Mannick EE, Oliver PD, Sandoval M, Zhang XJ, Eloby-Childess S, Clark DA, Miller MJ: Genistein and gut inflammation: role of nitric oxide. Proc Soc Exp Biol Med 217: 351–357, 1998.
   PubMed Web of Science ®Google Scholar
• Salzman A, Preiser J-C, Setchell K, Szabo C: Isoflavone-mediated inhibition of tyrosine kinase: a novel anti-inflammatory approach. J Medicinal Food 2: 179–181, 1999.
   PubMedGoogle Scholar
• Blair HC, Jordan SE, Peterson TG, Barnes S: Variable effects of tyrosine kinase inhibitors on avian osteoclastic activity and reduction of bone loss in ovariectomized rats. J Cell Biochem 61: 629–637, 1996.
   PubMed Web of Science ®Google Scholar
• Arjmandi BH, Alekel L, Hollis BW, Amin D, Stacewicz-Sapuntzakis M, Guo P, Kukreja SC: Dietary soybean protein prevents bone loss in an ovariectomized rat model of osteoporosis. J Nutr 126: 161–167, 1996.
   PubMed Web of Science ®Google Scholar
• Draper CR, Edel MJ, Dick IM, Randall AG, Martin GB, Prince RL: Phytoestrogens reduce bone loss and bone resorption in oophorectomized rats. J Nutr 127: 1795–1799, 1997.
   PubMed Web of Science ®Google Scholar
• Anderson JJ, Ambrose WW, Garner SC: Biphasic effects of genistein on bone tissue in the ovariectomized, lactating rat model. Proc Soc Exp Biol Med 217: 345–350, 1998.
   PubMed Web of Science ®Google Scholar
• Ishida H, Uesugi T, Hirai K, Toda T, Nukaya H, Yokotsuka K, Tsuji K: Preventive effects of the plant isoflavones, daidzin and genistin, on bone loss in ovariectomized rats fed a calcium-deficient diet. Biol Pharm Bull 21: 62–66, 1998.
   PubMed Web of Science ®Google Scholar
• Brzezinski A, Adlercreutz H, Shaoul Rea: Short-term effects of phytoestrogen-rich diet on postmenopausal women. Menopause 4: 89–94, 1997.
   Web of Science ®Google Scholar
• Potter SM, Baum JA, Teng H, Stillman RJ, Shay NF, Erdman JW, Jr.: Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women. Am J Clin Nutr 68: 1375S–1379S, 1998.
   PubMed Web of Science ®Google Scholar
• Alekel L, St Germain A, Peterson C, Hanson K, Stewart J, Toda T: Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women. Am J Clin Nutr 72: 844–852, 2000.
   PubMed Web of Science ®Google Scholar
• Horiuchi T, Onouchi T, Takahashi M, Ito H, Orimo H: Effect of soy protein on bone metabolism in postmenopausal women. Osteoporosis 11: 721–724, 2000.
   PubMed Web of Science ®Google Scholar
• Barrett J: Phytoestrogens. Friends or foes? A [news]. Environ Health Perspect 104: 478–482, 1996.
   PubMed Web of Science ®Google Scholar
• Sheehan DM: Isoflavone content of breast milk and soy formulas: benefits and risks [letter; comment]. Clin Chem 43: 850; discussion 852, 1997.
   Google Scholar
• Setchell KDR, Gosselin SJ, Welsh MB, Johnston JO, Balistreri WF, Kramer LW, Dresser BL, Tarr MJ: Dietary estrogens—a probable cause of infertility and liver disease in captive cheetahs. Gastroenterology 93: 225–233, 1987.
   PubMed Web of Science ®Google Scholar
• Faber K, Hughes C: The effect of neonatal exposure to diethylstilbestrol, genistein, and zearalenone on pituitary responsiveness and sexually dimorphic nucleus volume in the castrated adult rat. Biol Reprod 45: 649–653, 1991.
   PubMed Web of Science ®Google Scholar
• Whitten PL, Lewis C, Russell E, Naftolin F: Potential adverse effects of phytoestrogens. J Nutr 125: 771S–776S, 1995.
   PubMed Web of Science ®Google Scholar
• Medlock KL, Branham WS, Sheehan DM: The effects of phytoestrogens on neonatal rat uterine growth and development. Proc Soc Exp Biol Med 208: 307–313, 1995.
   PubMed Web of Science ®Google Scholar
• Brown NM, Setchell KDR: Animal models impacted by phytoestrogens in commercial chow: implications for pathways influenced by hormones. Lab Invest, 81: 735–747, 2001.
   PubMed Web of Science ®Google Scholar
• Thigpen JE, Setchell KD, Ahlmark KB, Locklear J, Spahr T, Caviness GF, Goelz MF, Haseman JK, Newbold RR, Forsythe DB: Phytoestrogen content of purified, open- and closed-formula laboratory animal diets. Lab Anim Sci 49: 530–536, 1999.
   PubMedGoogle Scholar
• Wang F, Zeltwanger S, Hu S, Hwang T-C: Deletion of phenylalanine 508 causes attenuated phosphorylation-dependent activation of CFTR chloride channels. J Physiol 524: 637–648, 2000.
   PubMedGoogle Scholar
• Camper-Kirby DC, Welch S, Walker A, Shiraishi I, Setchell KDR, Schaefer E, Kajstura J, Anversa P, Sussman M: Myocardial Akt activation and gender: nuclear activity in females versus males. Circ Res, 88: 1020–1027, 2001.
   PubMed Web of Science ®Google Scholar
• Divi RL, Doerge DR: Inhibition of thyroid peroxidase by dietary flavonoids. Chem Res Toxicol 9: 16–23, 1996.
   PubMed Web of Science ®Google Scholar
• Divi RL, Chang HC, Doerge DR: Anti-thyroid isoflavones from soybean: isolation, characterization, and mechanisms of action. Biochem Pharmacol 54: 1087–1096, 1997.
   PubMed Web of Science ®Google Scholar
• Hertog MG, Hollman PC, Katan MB, Kromhout D: Intake of potentially anticarcinogenic flavonoids and their determinants in adults in The Netherlands. Nutr Cancer 20: 21–29, 1993.
   PubMed Web of Science ®Google Scholar
• Churella H, Borschel M, Thomas R, Breen M, Jacobs M: Growth and protein status of term infants fed soy formulas differing in protein content. J Am Coll Nutr 13: 262–267, 1994.
   PubMed Web of Science ®Google Scholar
• Lasekan JB, Ostrom KM, Jacobs JR, Blatter MM, Ndife LI, Gooch WM, 3rd, Cho S: Growth of newborn, term infants fed soy formulas for 1 year. Clin Pediatr (Phila) 38: 563–571, 1999.
   PubMed Web of Science ®Google Scholar
• Setchell KDR, Radd S: Soy and other legumes: Bean around a long time but are they the ‘Superfood’ of the millenium and what are the safety issues for their constitutent phytoestrogens. Asia Pacific J Clin Nutr 9: S13–S22, 2000.
   Google Scholar
• Strom BL, Schinnar R, Zeigler EE, Bamhart KT, Sammel MD, Macones GA, Stalings VA, Drulis JM, Nelson SE, Hanson SA: Exposure to soy-based formula in infancy and endocrinological and reproductive outcomes in young adulthood. JAMA 286: 807–814, 2001.
   PubMed Web of Science ®Google Scholar
• Barnes S: Effect of genistein on in vitro and in vivo models of cancer. J Nutr 125: 777S–783S, 1995.
   PubMed Web of Science ®Google Scholar
• Barnes S, Grubbs C, Setchell KDR, Carlson J: Soybeans inhibit mammary tumors in models of breast cancer. Prog Clin Biol Res 347: 239–253, 1990.
   PubMedGoogle Scholar
• Adlercreutz H, Mousavi Y, Clark J, Hockerstedt K, Hamalainen E, Wahala K, Makela T, Hase T: Dietary phytoestrogens and cancer: in vitro and in vivo studies. J Steroid Biochem Mol Biol 41: 331–337, 1992.
   PubMed Web of Science ®Google Scholar
• Lamartiniere CA, Moore JB, Brown NM, Thompson R, Hardin MJ, Barnes S: Genistein suppresses mammary cancer in rats. Carcinogenesis 16: 2833–2840, 1995.
   PubMed Web of Science ®Google Scholar
• Constantinou AI, Krygier AE, Mehta RR: Genistein induces maturation of cultured human breast cancer cells and prevents tumor growth in nude mice. Am J Clin Nutr 68: 1426S–1430S, 1998.
   PubMed Web of Science ®Google Scholar