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Articles

Nutritional Importance of Choline for Brain Development

, MD, PhD
Pages 621S-626S | Published online: 18 Jun 2013

REFERENCES

  • Zeisel SH, Blusztajn JK: Choline and human nutrition. Ann Rev Nutr14 :269– 296,1994 .
  • Zeisel SH: Choline: an essential nutrient for humans. Nutrition16 :669– 671,2000 .
  • Institute of Medicine and National Academy of Sciences USA: “Dietary reference intakes for folate, thiamin, riboflavin, niacin, vitamin B12, panthothenic acid, biotin, and choline” Vol. 1. Washington DC: National Academy Press,1998 .
  • Zeisel SH, Mar, M-H, Zhou Z-W, da Costa K-A: Pregnancy and lactation are associated with diminished concentrations of choline and its metabolites in rat liver. J Nutr125 :3049– 3054,1995 .
  • Saito S, Iida A, Sekine A, Miura Y, Sakamoto T, Ogawa C, Kawauchi S, Higuchi S, Nakamura Y: Identification of 197 genetic variations in six human methyltransferase genes in the Japanese population. J Hum Genet46 :529– 537,2001 .
  • Zeisel SH, Wurtman RJ: Developmental changes in rat blood choline concentration. Biochem J198 :565– 570,1981 .
  • Zeisel SH, Epstein MF, Wurtman RJ: Elevated choline concentration in neonatal plasma. Life Sci26 :1827– 1831,1980 .
  • McMahon KE, Farrell PM: Measurement of free choline concentrations in maternal and neonatal blood by micropyrolysis gas chromatography. Clin Chim Acta149 :1– 12,1985 .
  • Braun LD, Cornford EM, Oldendorf WH: Newborn rabbit blood-brain barrier is selectively permeable and differs substantially from the adult. J Neurochem34 :147– 152,1980 .
  • Cornford EM, Braun LD, Oldendorf WH: Developmental modulations of blood-brain barrier permeability as an indicator of changing nutritional requirements in the brain. Pediatr Res16 :324– 328,1982 .
  • Garner SC, Mar M-H, Zeisel SH: Choline distribution and metabolism in pregnant rats and fetuses are influenced by the choline content of the maternal diet. J Nutr125 :2851– 2858,1995 .
  • Zeisel SH, Stanbury JB, Wurtman RJ, Brigida M, Fierro BR: Choline content of mothers’ milk in Ecuador and Boston. New Engl J Med306 :175– 176,1982 .
  • Zeisel SH, Char D, Sheard NF: Choline, phosphatidylcholine and sphingomyelin in human and bovine milk and infant formulas. J Nutr116 :50– 58,1986 .
  • Holmes-McNary M, Cheng WL, Mar MH, Fussell S, Zeisel SH: Choline and choline esters in human and rat milk and infant formulas. Am J Clin Nutr64 :572– 576,1996 .
  • Zeisel SH: Choline: an important nutrient in brain development, liver function and carcinogenesis. J Am Coll Nutr11 :473– 481,1992 .
  • Loy R, Heyer D, Williams CL, Meck WH: Choline-induced spatial memory facilitation correlates with altered distribution and morphology of septal neurons. Adv Exp Med Biol295 :373– 382,1991 .
  • Meck WH, Smith RA, Williams CL: Pre- and postnatal choline supplementation produces long-term facilitation of spatial memory. Dev Psychobiol21 :339– 353,1988 .
  • Meck WH, Smith RA, Williams CL: Organizational changes in cholinergic activity and enhanced visuospatial memory as a function of choline administered prenatally or postnatally or both. Behav Neurosci103 :1234– 1241,1989 .
  • Meck W, Williams C: Simultaneous temporal processing is sensitive to prenatal choline availability in mature and aged rats. Neuroreport8 :3045– 3051,1997 .
  • Meck W, Williams C: Characterization of the facilitative effects of perinatal choline supplementation on timing and temporal memory. Neuroreport8 :2831– 2835,1997 .
  • Meck W, Williams C: Perinatal choline supplementation increases the threshold for chunking in spatial memory. Neuroreport8 :3053– 3059,1997 .
  • Schenk F, Brandner C: Indirect effects of peri- and postnatal choline treatment on place-learning abilities in rat. Psychobiology23 :302– 313,1995 .
  • Brandner C: Perinatal choline treatment modifies the effects of a visuo-spatial attractive cue upon spatial memory in naive adult rats. Brain Res928 :85– 95,2002 .
  • Tees RC: The influences of rearing environment and neonatal choline dietary supplementation on spatial learning and memory in adult rats. Behav Brain Res105 :173– 188,1999 .
  • Tees RC: The influences of sex, rearing environment, and neonatal choline dietary supplementation on spatial and nonspatial learning and memory in adult rats. Dev Psychobiol35 :328– 342,1999 .
  • Tees RC, Mohammadi E, Adam TJ: Altering the impact of early rearing on the rat’s spatial memory with pre- and postnatal choline supplementation. Soc Neurosci Abstr17 :1401 ,1999 .
  • Ricceri L, Berger-Sweeney J: Postnatal choline supplementation in preweanling mice: sexually dimorphic behavioral and neurochemical effects. Behav Neurosci112 :1387– 1392,1998 .
  • Jones JP, Meck W, Williams CL, Wilson WA, Swartzwelder HS: Choline availability to the developing rat fetus alters adult hippocampal long-term potentiation. Brain Res Dev Brain Res118 :159– 167,1999 .
  • Albright CD, Tsai AY, Friedrich CB, Mar MH, Zeisel SH: Choline availability alters embryonic development of the hippocampus and septum in the rat. Brain Res Dev Brain Res113 :13– 20,1999 .
  • Albright CD, Friedrich CB, Brown EC, Mar MH, Zeisel SH: Maternal dietary choline availability alters mitosis, apoptosis and the localization of TOAD-64 protein in the developing fetal rat septum. Brain Res Dev Brain Res115 :123– 129,1999 .
  • Albright CD, Mar MH, Friedrich CB, Brown EC, Zeisel SH: Maternal choline availability alters the localization of p15Ink4B and p27Kip1 cyclin-dependent kinase inhibitors in the developing fetal rat brain hippocampus. Dev Neurosci23 :100– 106,2001 .
  • Craciunescu C, Albright C, Mar M-H, Song J, Zeisel S: Choline availability during embryonic development alters progenitor cell mitosis in developing mouse hippocampus. J Nutr133 :3614– 3618,2003 .
  • Dani S, Hori A, Walter G (eds): “Principles of Neural Aging.” Amsterdam: Elsevier,1997 .
  • van Praag H, Kempermann G, Gage FH: Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus [see comments]. Nat Neurosci2 :266– 270,1999 .
  • Markakis EA, Gage FH: Adult-generated neurons in the dentate gyrus send axonal projections to field CA3 and are surrounded by synaptic vesicles. J Comp Neurol406 :449– 460,1999 .
  • Selhub J, Seyoum E, Pomfret EA, Zeisel SH: Effects of choline deficiency and methotrexate treatment upon liver folate content and distribution. Cancer Res51 :16– 21,1991 .
  • Varela-Moreiras G, Selhub J, da Costa K, Zeisel SH: Effect of chronic choline deficiency in rats on liver folate content and distribution. J Nutr Biochem3 :519– 522,1992 .
  • Kim Y-I, Miller JW, da Costa K-A, Nadeau M, Smith D, Selhub J, Zeisel SH, Mason JB: Folate deficiency causes secondary depletion of choline and phosphocholine in liver. J Nutr124 :2197– 2203,1995 .
  • Zeisel SH, Zola T, daCosta K, Pomfret EA: Effect of choline deficiency on S-adenosylmethionine and methionine concentrations in rat liver. Biochem J259 :725– 729,1989 .
  • Anonymous: Betaine for homocystinuria. Med Lett Drug Therap39 :12 :1997 .
  • Kang S: Treatment of hyperhomocyst(e)inemia: physiological basis. J Nutr126 :1273S– 1275S,1996 .
  • Pomfret EA, da Costa K, Zeisel SH: Effects of choline deficiency and methotrexate treatment upon rat liver. J Nutr Biochem1 :533– 541,1990 .
  • Akesson B, Fehling C, Jagerstadt M, et al.: Effect of experimental folate deficiency on lipid metabolism in liver and brain. Brit J Nutr47 :505– 520,1982 .
  • Willoughby M, Jewell F: Folate status throughout pregnancy and in postpartum period. Brit Med J4 :356 ,1968 .
  • Qvist I, Abdulla M, Jagerstad M, Svensson S: Iron, zinc and folate status during pregnancy and two months after delivery. Acta Obstet Gynecol Scand65 :15– 22,1986 .
  • Oppenheim RW: Cell death during the development of the nervous system. Ann Rev Neurosci14 :453– 501,1991 .
  • Thompson CB: Apoptosis in the pathogenesis and treatment of disease. Science267 :1456– 1462,1995 .
  • Merry D, Korsmeyer S: Bcl-2 gene family in the nervous system. Annu Rev Neurosci20 :245– 267,1997 .
  • Schwartzman RA, Cidlowski JA: Apoptosis: The biochemistry and molecular biology of programmed cell death. Endoc Rev14 :133– 151,1993 .
  • Henderson C: Programmed cell death in the developing nervous system. Neuron17 :579– 795,1996 .
  • Vekrellis K, McCarthy M, Watson A, Whitfield J, Rubin L, Ham J: Bax promotes neuronal cell death and is downregulated during the development of the nervous system. Development124 :1239– 1249,1997 .
  • Holmes-McNary M, Baldwin J, Zeisel SH: Opposing regulation of choline deficiency-induced apoptosis by p53 and NF-k B. J Biol Chem276 :41197– 41204,2001 .
  • Holmes-McNary MQ, Loy R, Mar M-H, Albright CD, Zeisel SH: Apoptosis is induced by choline deficiency in fetal brain and in PC12 cells. Devel Brain Res101 :9– 16,1997 .
  • Yen CL, Mar MH, Meeker RB, Fernandes A, and Zeisel SH: Choline deficiency induces apoptosis in primary cultures of fetal neurons. FASEB J15 :1704– 1710,2001 .
  • Yen CL, Mar MH, Zeisel SH: Choline deficiency-induced apoptosis in PC12 cells is associated with diminished membrane phosphatidylcholine and sphingomyelin, accumulation of ceramide and diacylglycerol, and activation of a caspase. FASEB J13 :135– 142,1999 .
  • Kuan CY, Roth KA, Flavell RA, Rakic P: Mechanisms of programmed cell death in the developing brain. Trends Neurosci23 :291– 297,2000 .
  • Fisher MC, Zeisel SH, Mar MH, Sadler TW: Inhibitors of choline uptake and metabolism cause developmental abnormalities in neurulating mouse embryos. Teratology64 :114– 122,2001 .
  • Fisher MC, Zeisel SH, Mar MH, Sadler TW: Perturbations in choline metabolism cause neural tube defects in mouse embryos in vitro. Faseb J16 :619– 621,2002 .
  • Paulsen M, Ferguson-Smith AC: DNA methylation in genomic imprinting, development, and disease. J Pathol195 :97– 110,2001 .
  • Lachner M, Jenuwein T: The many faces of histone lysine methylation. Curr Opin Cell Biol14 :286– 298,2002 .
  • Reinhart B, Eljanne M, Chaillet JR: Shared role for differentially methylated domains of imprinted genes. Mol Cell Biol22 :2089– 2098,2002 .
  • Babinger P, Kobl I, Mages W, Schmitt R: A link between DNA methylation and epigenetic silencing in transgenic Volvox carteri. Nucleic Acids Res29 :1261– 1271,2001 .
  • Hendrich B, Bird A: Identification and characterization of a family of mammalian methyl-CpG binding proteins. Mol Cell Biol18 :6538– 6547,1998 .
  • Jones PA, Takai D: The role of DNA methylation in mammalian epigenetics. Science293 :1068– 1070,2001 .
  • Amir RE, Van den Veyver IB, Wan M, Tran CQ, Francke U, Zoghbi HY: Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat Genet23 :185– 188,1999 .
  • Garcia MJ, Martinez-Delgado B, Cebrian A, Martinez A, Benitez J, Rivas C: Different incidence and pattern of p15INK4b and p16INK4a promoter region hypermethylation in Hodgkin’s and CD30-Positive non-Hodgkin’s lymphomas. Am J Pathol161 :1007– 1013,2002 .
  • Diccianni MB, Omura-Minamisawa M, Batova A, Le T, Bridgeman L, Yu AL: Frequent deregulation of p16 and the p16/G1 cell cycle-regulatory pathway in neuroblastoma. Int J Cancer80 :145– 154,1999 .
  • Alonso-Aperte E, Varela-Moreiras G: Brain folates and DNA methylation in rats fed a choline deficient diet or treated with low doses of methotrexate. Int J Vitam Nutr Res66 :232– 236,1996 .
  • Christman JK, Sheikhnejad G, Dizik M, Abileah S, Wainfan E: Reversibility of changes in nucleic acid methylation and gene expression induced in rat liver by severe dietary methyl deficiency. Carcinogenesis14 :551– 557,1993 .
  • Tsujiuchi T, Tsutsumi M, Sasaki Y, Takahama M, Konishi Y: Hypomethylation of CpG sites and c-myc gene overexpression in hepatocellular carcinomas, but not hyperplastic nodules, induced by a choline-deficient L-amino acid-defined diet in rats. Jpn J Cancer Res90 :909– 913,1999 .
  • Wolff GL, Kodell RL, Moore SR, Cooney CA: Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice. Faseb J12 :949– 957,1998 .
  • Waterland RA, Jirtle RL: Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol23 :5293– 5300,2003 .
  • Zeisel SH, Mar MH, Howe JC, Holden JM: Concentrations of choline-containing compounds and betaine in common foods. J Nutr133 :1302– 1307,2003 .

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