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Original Research

Chemotherapy Alone vs. Chemotherapy Plus High Dose Multiple Antioxidants in Patients with Advanced Non Small Cell Lung Cancer

, MBBS, PhD, , MD, DM, , MD, DM, , MS, , MD, , MD, , MD, DM, , MBBS, , MBBS, , PhD & , MBBS, FRCP show all
Pages 16-21 | Received 16 Jan 2004, Accepted 25 Nov 2004, Published online: 28 Jun 2013

REFERENCES

  • Cancer burden in the year 2000. The global picture.Eur J Cancer37 :S4– 66,2001 .
  • Non Small Cell Lung Cancer Collaborative Group: Chemotherapy in non small cell lung cancer: a meta analysis using updated data on individual patients from 52 randomized clinical trials.Br Med J311 :899– 909,1995 .
  • Smith W, Khuri FR: The care of the lung cancer patient in the 21st century: a new age.Semin Oncol.31(2 Suppl 4) :11– 15,2004 .
  • Prasad KN, Sinha PK, Ramanujam M, Sakamoto A: Sodium ascorbate potentiates the growth inhibitory effect of certain agents on neuroblastoma cells in culture.Proc Natl Acad Sci U S A76 :829– 832,1979 .
  • Prasad K: Modulation of the effect of tumor therapeutic agents by vitamin C.Life Sci27 :275– 280,1980 .
  • Prasad KN, Hernandez C, Edwards-Prasad J, Nelson J, Borus T, Robinson WA: Modification of the effect of tamoxifen, cis-platin, DTIC, and interferon-alpha 2b on human melanoma cells in culture by a mixture of vitamins.Nutr Cancer22 :233– 245,1994 .
  • Prasad K, Kumar R: Effect of individual antioxidant vitamins alone and in combination on growth and differentiation of human non-tumorigenic and tumorigenic parotid acinar cells in culture.Nutr Cancer26 :11– 19,1996 .
  • Chabner BA, Longo DL: “Cancer Chemotherapy and Biotherapy,” 3rd ed. Philadelphia: Lippincott Williams & Wilkins,2001 .
  • Klastersky J: Side effects of Ifosfamide.Oncology65(Suppl 2) :7– 10,2003 .
  • Hussain AE, Blakley BW, Nicolas M, Balderston J: Assessment of the protective effects of amifostine against cisplatin-induced toxicity.J Otolaryngol32 :294– 297,2003 .
  • Pathak AK, Singh N, Khanna N, Reddy VG, Prasad KN, Kochupillai V: Potentiation of the effect of paclitaxel and carboplatin by antioxidant mixture on human lung cancer H520 Cells.J Am Coll Nutr21 :416– 421,2002 .
  • Carboplatin dosing formulae. Gender bias and the use of creatinine-based methodologies.Eur J Cancer38 :11– 16,2002 .
  • Prasad KN, Kumar A, Kochupillai V, Cole WC: High doses of multiple antioxidant vitamins: essential ingredients in improving the efficacy of standard cancer therapy.J Am Coll Nutr18 :13– 25,1999 .
  • Cancer Therapy Evaluation Program: Common toxicity criteria, version 2.0. Bethesda, Md; National Cancer Institute,1998 .
  • Kaplan EL, Meier P: Non parametric estimation from incomplete observations.J Am Stat Assoc53 :457– 458,1958 .
  • Ettinger DS: Overview and state of the art in the management of lung cancer.Oncology (Huntingt)18(7 Suppl 4) :3– 9,2004 .
  • Haura EB: Treatment of advanced non-small-cell lung cancer: a review of current randomized clinical trials and an examination of emerging therapies.Cancer Control8 :326– 36,2001 .
  • Bonomi P, Kim K, Chang A, Johnson D: Phase III trial comparing etoposide & cisplatin versus taxol with cisplatin-G-CSF versus taxol-cisplatin in advanced non small cell lung cancer. An eastern cooperative oncology group (ECOG) trial (Abstr).Proc Am Soc Clin Oncol : Abstract No 1145,1996 .
  • Gatzemeier U, Pawel J vo, Gottfried M, Velde GPM te, Mattson K, DeMarinis F, Harper P, Salvati F, Robinet G, Lucenti A, Bogaerts J, Winograd B, Gallant G: Phase III comparative study of high dose cisplatin versus a combination of paclitaxel and cisplatin in patients with advanced non small cell lung cancer (Abstr).Proc Am Soc Clin Oncol : Abstract No 1748,1998 .
  • Belani CP, Natale RB, Lee JS, Socinski M, Robert F, Waterhouse D, Rowland K, Ansari R, Lilenbaum R, Sridhar K: Randomized phase III trial comparing cisplatin/etoposide versus carboplatin/paclitaxel in advanced and metastatic non small cell lung cancer (Abstr).Proc Am Soc Clin Oncol : Abstract No 1751,1998 .
  • Kelly K, Crowley J, Bunn PA, Livingston RB, Gandara DR: A randomized phase III trial of paclitaxel plus carboplatin versus vinorelbin plus cisplatin in untreated advanced non small cell lung cancer: a southwest oncology group (SWOG) trial (Abstr).Proc Am Soc Clin Oncol : Abstract No 1777,1999 .
  • Seifter E, Rettura A, Padawar J, Levenson SM: Vitamin A and β-carotene as adjunctive therapy to tumor excision, radiation therapy and chemotherapy. In Prasad KN (ed): “Vitamins, Nutrition and Cancer.” Basel: Karger, pp1– 19,1984 .
  • Jaakkola K, Lahteenmaki P, Laakso J, Harju E, Tykka H, Mahlberg K: Treatment with antioxidant and other nutrients in combination with chemotherapy and irradiation in patients with small-cell lung cancer.Anticancer Res12 :599– 606,1992 .
  • Drisko JA, Chapman J, Hunter VJ: The use of antioxidants with first-line chemotherapy in two cases of ovarian cancer.J Am Coll Nutr.22 :118– 23,2003 .
  • Lockwood K, Moesgaard S, Hanioka T, Folkers K: Apparent partial remission of breast cancer in ‘high risk’ patients supplemented with nutritional antioxidants, essential fatty acids and coenzyme Q10.Mol Aspects Med15(Suppl) :231– 240,1994 .
  • Clemens MR, Waladkhani AR, Bublitz K, Ehninger G, Gey KF: Supplementation with antioxidants prior to bone marrow transplantation.Wien Klin Wochenschr109 :771– 776,1997 .
  • Lamm DL, Riggs DR, Shriver JS, et al: Megadose vitamins in bladder cancer: A double-blind clinical trial.J Urol151 :21– 26,1994 .
  • Wang YM, Madanat FF, Kimball JC, Gleiser CA, Ali MK, Kaufman MW, van Eys J: Effect of vitamin E against adriamycin-induced toxicity in rabbits.Cancer Res40 :1022– 1027,1980 .
  • Delanian S: Striking regression of radiation-induced fibrosis by a combination of pentoxifylline and tocopherol.Brit J Radiol71 :892– 894,1998 .
  • Cole WC, Prasad KN: Heterogeneity of commercial β-carotene preparations: correlation with biological activities. In Prasad KN, Cole WC (eds): “Cancer and Nutrition.” Amsterdam: IOS Press, pp99– 104,1998 .
  • Carini R, Poli G, Dianzani MU, Maddix SP, Slater TF, Cheeseman KH: Comparative evaluation of the amount of the antioxidant activity of alpha-tocopherol, alpha-tocopherol polyethylene glycol 1000 succinate and alpha-tocopherol succinate in isolated hepatocytes and liver microsomal suspensions.Biochem Pharmacol39 :1597– 1601,1990 .
  • Wycherly BJ, Moak MA, Christensen MJ: High dietary intake of sodium selenite induces oxidative DNA damage in rat liver.Nutr Cancer48 :78– 83,2004 .

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