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Original Research

Influence of Long-Term Administration of Lactulose and Saccharomyces Boulardii on the Colonic Generation of Phenolic Compounds in Healthy Human Subjects

, MS, , BS, , MD, PhD & , PhD
Pages 541-549 | Received 28 Aug 2005, Accepted 11 Jul 2006, Published online: 18 Jun 2013

REFERENCES

  • Gibson GR, Beatty ER, Wang X, Cummings JH: Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin.Gastroenterology108 :975– 982,1995 .
  • Collins MD, Gibson GR: Probiotics, prebiotics, and synbiotics: approaches for modulating the microbial ecology of the gut:Am J Clin Nutr69 :1052S– 1057S,1999 .
  • Saavedra JM, Tschernia A: Recent progress on research of non-digestible galacto-oligosaccharides.Int Dairy J9 :69– 80,1999 .
  • Salminen S, Ouwehand AC, Isolauri E: Clinical Applications of Probiotic Bacteria.Int Dairy J8 :563– 572,1998 .
  • Ziemer CJ, Gibson GR: An Overview of Probiotics, Prebiotics and Synbiotics in the Functional Food Concept: Perspectives and Future Strategies.Int Dairy J8 :473– 479,1998 .
  • Fuller R. Probiotics in human medicine.Gut32 :439– 442,1991 .
  • Gibson GR, Roberfroid MB: Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics.J Nutr125 :1401– 1412,1995 .
  • Bone E, Tamm A, Hill M: The production of urinary phenols by gut bacteria and their possible role in the causation of large bowel cancer.Am J Clin Nutr29 :1448– 1454,1976 .
  • Roberfroid MB, Bornet F, Bouley C, Cummings JH: Colonic Microflora: Nutrition and Health.Nutr Rev53 :127– 130,1995 .
  • Muir JG, Walker KZ, Kaimakamis MA, Cameron MA, Govers MJAP, Lu ZX, Young GP, O’Dea K: Modulation of fecal markers relevant to colon cancer risk: a high-starch Chinese diet did not generate expected beneficial changes relative to a Western-type diet.Am J Clin Nutr68 :372– 379,1998 .
  • Birkett A, Muir J, Phillips J, Jones G, O’Dea K: Resistant starch lowers fecal concentrations of ammonia and phenols in humans.Am J Clin Nutr63 :766– 772,1996 .
  • De Preter V, Geboes K, Verbrugghe K, De Vuyst L, Vanhoutte T, Huys T, Swings J, Pot B, Verbeke K: The in vivo use of the stable isotope labelled biomarkers lactose [15N]-ureide and [2H4]-tyrosine to assess the effects of pro- and prebiotics on the intestinal flora of healthy human volunteers.Br J Nutr92 :439– 446,2004 .
  • Cummings JH, Hill MJ, Bone ES, Branch WJ, Jenkins DJA: The effect of meat protein and dietary fiber on colonic function and metabolism. II. Bacterial metabolites in feces and urine.Am J Clin Nutr32 :2094– 2101,1979 .
  • Ling WH, Korpela R, Mykkänen H, Salminen S, Hänninen O: Lactobacillus Strain GG Supplementation Decreases Colonic Hydrolytic and Reductive Enzyme Activities in Healthy Female Adults.J Nutr124 :18– 23,1994 .
  • Spanhaak S, Havenaar R, Schaafsma G: The effect of consumption of milk fermented by Lactobacillus casei strain Shirota on the intestinal microflora and immune parameters in humans.Eur J Clin Nutr52 :899– 907,1998 .
  • Holgate AM, Read NW: Relationship between small bowel transit time and absorption of a solid meal—influence of metoclopramide, magnesium sulphate and lactulose.Dig Dis Sci28 :812– 819,1983 .
  • Diggory RT, Cuschieri A: The effect of dose and osmolality of lactulose on the oro-caecal transit time determined by the hydrogen breath test and the reproducibility of the test in normal subjects.Ann Clin Res17 :331– 333,1985 .
  • Wutzke KD, Heine WE, Plath C, Leitzmann P, Radke M, Mohr C, Richter I, Gülzow HU, Hobusch D: Evaluation of oro-coecal transit time: a comparison of the lactose-[13C, 15N]ureide 13CO2- and the lactulose H2-breath test in humans.Eur J Clin Nutr51 :11– 19,1997 .
  • Schumann C: Medical, nutritional and technological properties of lactulose. An update.Eur J Nutr41 :117– 125,2002 .
  • Bouhnik Y, Attar A, Joly FA, Riottot M, Dyard F, Flourié B: Lactulose ingestion increases faecal bifidobacterial counts: A randomised double-blind study in healthy humans.Eur J Clin Nutr58 :462– 466,2004 .
  • Marteau PR, de Vrese M, Cellier CJ, Schrezenmeir J: Protection from gastrointestinal diseases with the use of probiotics.Am J Clin Nutr73 :430S– 436S,2001 .
  • Fioramonti J, Theodorou V, Bueno L: Probiotics: what are they? What are their effects on gut physiology? Best Practice & Research Clinical Gastroenterology17 :711– 724,2003 .
  • Ghoos Y, Maes B, Geypens B, Mys G, Hiele M, Rutgeerts P, Vantrappen G: Measurement of gastric emptying rate of solids by means of a carbon labelled octanoic acid breath test.Gastroenterology104 :1640– 1647,1993 .
  • Verbeke K, De Preter V, Geboes K, Daems T, Van den Mooter G, Evenepoel P, Rutgeerts P: In vivo evaluation of a colonic delivery system using isotope technology.Aliment Pharmacol Ther21 :187– 194,2005 .
  • Bjarnason I, Peters TJ, Veall N: 51Cr-EDTA test for intestinal permeability.Lancet2 :523 ,1984 .
  • Selby P, McElwain TJ, Crofts M, Lopes N, Mundy J: 51Cr-EDTA test for intestinal permeability.Lancet2 :38– 39,1984 .
  • Haycock G, Schwartz G, Wisotsky D: Geometric method for measuring body surface area: a height-weight formula validated in infants, children and adults.J Pediatr93 :62– 66,1978 .
  • Geypens B, Bennink R, Peeters M: Validation of the lactulose-13C-ureide breath test for determination of orocaecal transit time by scintigraphy.J Nucl Med40 :1451– 1455,1999 .
  • Suenaert P, Bulteel V, Den Hond E, Peeters M, Monsuur F, Ghoos Y, Rutgeerts P: In vivo influence of nicotine on human basal and NSAID-induced gut barrier function.Scand J Gastroenterol38 :399– 408,2003 .
  • Cummings JH, Bingham SA: Dietary fibre, fermentation and large bowel cancer.Cancer Surveys6 :601– 621,1987 .
  • Bouhnik Y, Raskine L, Simoneau G, Vicaut E, Neut C, Flourié B, Brouns F, Bornet FR: The capacity of nondigestible carbohydrates to stimulate fecal bifidobacteria in healthy humans: a double-blind, randomized, placebo-controlled, parallel-group, dose-response relation study.Am J Clin Nutr80 :1658– 1664,2004 .
  • Buts JP, Bernasconi P, Van Craynest MP, Maldague P, De Meyer R: Response of human and rat small intestinal mucosa to oral administration of Saccharomyces boulardii.Pediatr Res20 :192– 196,1983 .
  • Jahn HU, Ullrich R, Schneider T, Liehr RM, Schieferdecker HM, Holst H, Zeitz M: Immunological and trophical effects of Saccharomyces boulardii on the small intestine of healthy human volunteers.Digestion57 :95– 104,1996 .
  • Buts JP, Corthier G, Delmée M: Saccharomyces boulardii for Clostridium difficile-associated enteropathies in infants.J Ped Gastroenterol Nutr16 :419– 425,1993 .
  • Caetano JA, Parames MT, Babo MJ: Immunopharmacological effects of Saccharomyces boulardii in healthy human volunteers.Int J Immunopharmacol8 :249– 259,1986 .
  • Kleessen B, Hartmann L, Blaut M: Fructans in diet cause alterations of intestinal mucosal architecture, released mucins and mucosa-associated bifidobacteria in gnotobiotic rats.Br J Nutr89 :597– 606,2003 .
  • Massimino SP, McBurney MI, Field CJ, Thomson ABR, Keelan M, Hayek MG, Sunvold GD: Fermentable dietary fiber increases GLP-1 secretion and improves glucose homeostasis despite increased intestinal glucose transport capacity in healthy dogs.J Nutr128 :1786– 1793,1998 .
  • Reimer RA, Thomson AB, Rajotte RV, Basu TK, Ooraikul B, McBurney MI: A physiological level of rhubarb fiber increases proglucagon gene expression and modulates intestinal glucose uptake in rats.J Nutr127 :1923– 1928,1997 .
  • Tappenden KA, Thomson AB, Wild GE, McBurney MI: Short-chain fatty acids increase proglucagon and ornithine decarboxylase messenger RNAs after intestinal resection in rats.J Parenter Enteral Nutr20 :357– 362,1996 .
  • Gee JM, Lee-Finglas W, Wortley GW, Johnson IT: Fermentable carbohydrates elevate plasma enteroglucagon but high viscosity is also necessary to stimulate small bowel mucosal cell proliferation in rats.J Nutr126 :373– 379,1996 .
  • Reimer RA, McBurney MI: Dietary fiber modulates intestinal proglucagon messenger ribonucleic acid and postprandial secretion of glucagon-like peptide-1 and insulin in rats.Endocrinology137 :3948– 3956,1996 .
  • Drucker DJ, Erlich P, Asa SL, Brubaker PL: Induction of intestinal epithelial proliferation by glucagon-like peptide 2.Proc Natl Acad Sci USA93 :7911– 7916,1996 .
  • Psomas EI, Fletouris DJ, Litopoulou-Tzanetakis E, Tzanetakis N: Assimilation of cholesterol by yeast strains isolated from infant feces and feta cheese.J Dairy Sci86 :3416– 3422,2003 .
  • Taylor GR, Williams CM: Effects of probiotics and prebiotics on blood lipids.Br J Nutr80 :S225– S2330,1998 .
  • Pereira DIA, Gibson GR: Effects of Consumption of Probiotics and Prebiotics on Serum on Serum Lipid levels in Humans.Crit Rev Biochem Molec Biol37 :259– 281,2002 .
  • Delzenne NM, Williams CM: Prebiotics and lipid metabolism.Curr Op Lipidol13 :61– 67,2002 .
  • Beynen AC: Increased concentrations of liver cholesterol in rats fed lactulose.Nahrung33 :89– 90,1989 .
  • Hylemon PB, Glass TL: Biotransformation of bile acids and cholesterol by the intestinal microflora. In David J. Hentges (ed): “Human Intestinal Microflora in Health and Disease.” New York: Academic Press, pp189– 239,1983 .

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