866
Views
196
CrossRef citations to date
0
Altmetric
Reviews

Impact of the Discovery of Human Zinc Deficiency on Health

, MD, PhD, MACN
Pages 257-265 | Received 11 Aug 2009, Published online: 09 Jun 2013

References

  • PrasadASHalstedJANadimiM: Syndrome of iron deficiency anemia, hepatosplenomegaly, hypogonadism, dwarfism and geophagia. Am J Med 31: 532– 546, 1961.
  • PrasadASMialeAFaridZSandsteadHHSchulertA: Zinc metabolism in patients with the syndrome of iron deficiency anemia hypogonadism, and dwarfism. J Lab Clin Med 61: 537– 549, 1963.
  • CavdarAOArcasoyACinSBabacanEGozdasogluS: Geophagia in Turkey; iron and zinc in geophagia cases. In PrasadASCavdarAOBrewerGJAggettPJ (eds): “Zinc Deficiency in Human Subjects.” New York: Alan R. Liss, Inc., pp 71– 97, 1983.
  • PrasadAS: “Biochemistry of Zinc.” New York: Plenum Press, 1993.
  • PrasadASMeftahSAbdallahJKaplanJBrewerGJBachJFDardenneM: Serum Thymulin in human zinc deficiency. J Clin Invest 82: 1202– 1210, 1988.
  • BeckFWJPrasadASKaplanJFitzgeraldJTBrewerGJ: Changes in cytokines production and T cell subpopulations in experimentally induced zinc-deficient humans. Am J Physiol 272: E1002– E1007, 1997.
  • BrownKHPeersonJMAllenLHRiveraJ: Effect of supplemental zinc on the growth and serum zinc concentrations of prepubertal children: a meta-analysis of randomized, controlled trials. Am J Clin Nutr 75: 1062– 1071, 2002.
  • OverbeckSRinkLHaaseH: Modulating the immune response by oral zinc supplementation: A single approach for multiple diseases. Arch Immunol Ther Exp 56: 15– 30, 2008.
  • PrasadAS: Clinical, immunological, anti-inflammatory and antioxidant roles of zinc. Exp Gerontology 43: 370– 377, 2008.
  • FrakerPJHaasSLueckeRW: Effect of zinc deficiency on the immune response of the young adult A/J mouse. J Nutr 107: 1889– 1895, 1977.
  • FrakerPJDePasquale-JardieuPZwickiCMLueckeRW: Regeneration of T-cell helper function in zinc deficient adult mice. Proc Natl Acad Sci USA 75: 5660– 5664, 1978.
  • FrostPRabbaniPSmithJPrasadAS: Cell mediated cytotoxicity and tumor growth in zinc deficient mice. Proc Soc Exp Biol Med 167: 333– 337, 1981.
  • PrasadASBeckFWJBaoBSnellDFitzgeraldJT: Duration and severity of symptoms and levels of plasma interleukin-1 receptor antagonist, soluble tumor necrosis factor receptor, and adhesion molecules in patients with common cold treated with zinc acetate. J Inf Dis 197: 795– 802, 2008.
  • CoovadiaHMBobatR: Zinc deficiency and supplementation in HIV/AIDS. Nutr Res 22: 179– 191, 2002.
  • ZazzoJFRouveixBRajagopalanPLevacherMGirardPM: Effect of zinc on the immune status of zinc-depleted AIDS related complex patients. Clin Nutr 8: 259– 261, 1989.
  • MocchegianiEVecciaSAncaraniFScaliseGFabrisN: Benefit of oral zinc supplementation as an adjunct to zidovudine (AZT) therapy against opportunistic infections in AIDS. Int J Immunopharmacol 17: 719– 727, 1995.
  • BobatRCoovadiaHStephenCNaidookLMcKerrowNBlackREMossWJ: Safety and efficacy of zinc supplementation for children with HIV-1 infection in South Africa: a randomized double-blind placebo-controlled trial. Lancet 366: 1862– 1867, 2005.
  • FawziWWVillamorEMsamangaGIAntelmanGAboudSUrassaWHunterD: Trial of zinc supplements in relation to pregnancy outcomes, hematologic indicators, and T cell counts among HIV-1- infected women in Tanzania. Am J Clin Nutr 81: 161– 167, 2005.
  • KoWSGuoCHHsuGSChiouYLYenMSYaunSR: The effect of zinc supplementation on the treatment of chronic hepatitis C patients with interferon and ribavirin. Clin Biochem 38: 614– 620, 2005.
  • TakagiHNagamineTAbeTTakayamaHSatoKOtsukaTKakizakiSHashimotoYMatsumotoTKojimaATakezawaJSuzukiKSatoSMoriM: Zinc supplementation enhances the response to interferon therapy in patients with chronic hepatitis C. J Viral Hepat 8: 367– 371, 2001.
  • KumelGSchraderSZentgrafHDausHBrendelM: The mechanism of the antiherpetic activity of zinc sulphate. J Gen Virol 71: 2989– 2997, 1990.
  • KorantBDKauerJCButterworthBE: Zinc ions inhibit replication of rhinoviruses. Nature 248: 588– 590, 1974.
  • Fischer WalkerCBlackRE: Zinc and the risk for infectious disease. Ann Rev Nutr 24: 255– 275, 2004.
  • HaqueKMBinderHJ: Zinc in the treatment of acute diarrhea: current status and assessment. Gastroenterology 130: 2201– 2205, 2006.
  • SazawalSBlackRBhanMKBhandariNSinhaAJallaS: Zinc supplementation in young children with acute diarrhea in India. N Engl J Med 333: 839– 844, 1995.
  • WalkerCLFBhuttaZABhandariNTekaTShahidFTanejaSBlackRE: Zinc during and in convalescence from diarrhea has no demonstrable effect on subsequent morbidity and anthropometic status among infants <6 mo of age. Am J Clin Nutr 85: 887– 894, 2007.
  • GhishanFK: Transport of electrolytes, water, and glucose in zinc deficiency. J Pediatr Gastroenterol Nutr 3: 608– 612, 1984.
  • RahmanMJSarkarPRoySKAhmadSMChistiJAzimTMatthanMSackDAnderssonJRaqibR: Effects of zinc supplementation as adjunct therapy on the systemic immune responses in shigellosis. Am J Clin Nutr 81: 495– 502, 2005.
  • RaqibRRoySKRahmanMJAzimTAmeersSChristiJAnderssonJ: Effect of zinc supplementation on immune and inflammatory responses in pediatric patients with shigellosis. Am J Clin Nutr 79: 444– 450, 2004.
  • GeorgeJBhatiaVNBalakrishnanSRamuG: Serum zinc/copper ratio in subtypes of leprosy and effect of oral zinc therapy on reactional states. Int J Lepr Other Mycobact Dis 59: 20– 24, 1991.
  • MathurNBumbRAMangalHN: Oral zinc in recurrent Erythema Nodosum Leprosum reaction. Lepr India 55: 547– 552, 1983.
  • MathurNKBumbRAMangalHNSharmaML: Oral zinc as an adjunct to dapsone in lepromatous leprosy. Int J Lepr Other Mycobact Dis 52: 331– 338, 1984.
  • KaryadiEWestCESchultinkWNelwanRHGrossRAminZDolmansWMSchlebuschHVandeermeerJW: A double-blind, placebo-controlled study of vitamin A and zinc supplementation in persons with tuberculosis in Indonesia: effects on clinical response and nutritional status. Am J Clin Nutr 75: 720– 727, 2002.
  • FrakerPJDe Pasquale-JardieuRZwicklLueckeRW: Regeneration of T-cell helper function in zinc-deficient adult mice. Proc Natl Acad Sci USA 75: 5660– 5664, 1978.
  • KashimuraHSuzukiKHassanMIkezawaKSawahataTWatanabeTNakaharaAMutohHTanakaN: Polaprezinc, a muscosal protective agent, in combination with lansoprazole, amoxycillin and clarithromycin increases the cure rate of Helicobacter pylori infection. Aliment Pharmacol Ther 13: 483– 487, 1999.
  • PrasadASBeckFWJBaoBFitzgeraldJTSnellDCSteinbergJDCardozoLJ: Zinc supplementation decreases incidence of infections in the elderly: Effect of zinc on generation of cytokines and oxidative stress. Am J Clin Nutr 85: 837– 844, 2007.
  • BaoBPrasadASBeckFWJSnellDCSunejaASarkarFHDoshiNFitzgeraldJTSwerdlowP: Zinc supplementation decreases oxidative stress, incidence of infection, and generation of inflammatory cytokines in sickle cell disease. Translational Res 152: 67– 80, 2008.
  • Age-Related Eye Disease Study Research group (AREDS Report No. 8): A randomized, placebo controlled, clinical trial of high-dose supplemented with vitamins C and E, beta-carotene, for age-related macular degeneration and vision loss. Arch Ophthalmol 119: 1417– 1436, 2001.
  • AREDS Report No. 13: Association of mortality with ocular disorders and an intervention of high dose anti-oxidants and zinc in the age-related eye disease study. Arch Ophthalmol 122: 716– 726, 2004.
  • VeverkaDVWilsonCMartinezMAWengerRTamosuinasA: Use of zinc supplements to reduce upper respiratory infections in United States Air Force Academy Cadets. Comp Therapies in Clinical Practice 15: 91– 95, 2009.
  • MeydaniSNBarnettJBDallalGEFineBCJacquesPFLekaLSHamerDH: Serum zinc and pneumonia in nursing home elderly. Am J Clin Nutr 86: 1167– 1173, 2007.
  • HaaseHRinkL: Signal transduction in moncytes: The role of zinc ions. Biometals 20: 579– 585, 2007.
  • HiranoTMurakamiMFukadaTNishidaKYamasakiSSuzukiT: Roles of zinc and zinc signaling in immunity: Zinc as an intracellular signaling molecules. Advances in Immunology 97: 149– 176, 2008.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.