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Bean Amylase Inhibitor and Other Carbohydrate Absorption Blockers: Effects on Diabesity and General Health

, MD, MACN, CNS
Pages 266-276 | Published online: 09 Jun 2013

References

  • WHO: “Obesity: Preventing and Managing the Global Epidemic,” Report of WHO Consultation on Obesity, Technical Report Series No 894. Geneva: World Health Organization, pp i– xii, 1– 253, 2000.
  • KingHAubertREHermanWH: Global burden of diabetes, 1995–2025: prevalence, numerical estimates, and projections. Diabetes Care 22: 1414– 1431, 1998.
  • FordESMokdadAHGilesWHGaluskaDASerdulaMK: Geographic variations in the prevalence of obesity, diabetes, and obesity-related behaviors. Obes Res 13: 118– 122, 2005.
  • YaturuSJainSK: Obesity and type 2 diabetes. In BagchiDPreussHG (eds): “Obesity. Epidmiology, Pathophysiology, and Prevention.” Boca RatonFL: CRC Press, pp 139– 154, 2007.
  • BrayGA: The epidemic of obesity and changes in food intake: the Fluoride Hypothesis. Physiol Behav 82: 115– 121, 2004.
  • OhlsonLOLarssonBSvardsuddKWelinLErikssonHWilhelmsenLBjorntorpPTibblinG: The influence of body fat distribution on the incidence of diabetes mellitus. 13.5 years of follow-up of the participants in the study of men born in 1913. Diabetes 34: 1055– 1058, 1985.
  • KayeSAFolsomnARSprafkaJMPrineasRJWallaceRB: Increased incidence of diabetes mellitus in relation to abdominal adiposity in older women. J Clin Epidemiol 44: 329– 334, 1991.
  • LundgrenHBengtssonCBlohmeGLapidusLSjostromL: Adiposity and adipose tissue distribution in relation to incidence of diabetes in women: results from a prospective population study in Gothenburg, Sweden. Int J Obes 13: 413– 423, 1989.
  • Prevalence of overweight and obesity among adults with diagnosed diabetes—United States, 1988–1994 and 1999–2002. MMWR 53: 1066– 1068, 2004.
  • GardnerDCKiazandAAlhassanSKimSStaffordRSBaliseRRKraemerHCKingAC: Comparison of the Atkins, Zone, Ornish, and LEARN diets for change in weight and related risk factors among overweight premenopausal women; the A to Z weight loss study: a randomized trial. JAMA 297: 969– 977, 2007.
  • IacobellisGRibaudoMCLetoGZappaterrenoAVecciEDi MarioULeonettiF: Influence of excess fat on cardiac morphology and function: study in uncomplicated obesity. Obes Res 10: 767– 763, 2002.
  • KenchaiahSEvansJCLevyDWilsonPWBenjaminEJLarsonMGKannelWBVasanRS: Obesity and the risk of heart failure. N Eng J Med 347: 305– 313, 2002.
  • DanaeiGDingELMozaffarianDTaylorBRehmJMurrayCJEzzatiM: The preventable causes of death in the United States: comparative risk assessment of dietary, lifestyle, and metabolic risk factors. PLoS Med Epub Apr 28, 2009.
  • PopkinBMPaeratakulSZhaiFKeyouG: A review of dietary and environmental correlates of obesity with emphasis on developing countries. Obes Res 3: 145S– 153S, 1995.
  • WHO Consultation on Obesity. Geneva: WHO, 1997.
  • TurconiGCenaH: Epidemiology of obesity. In BagchiDPreussHG (eds): “Obesity. Epidmiology, Pathophysiology, and Prevention.” Boca RatonFL: CRC Press, pp 3– 19, 2007.
  • PainGC: Epidemiology of obesity: a global burden for the new millenium. In BagchiDPreussHG (eds): “Obesity. Epidmiology, Pathophysiology, and Prevention.” Boca RatonFL: CRC Press, pp 21– 29, 2007.
  • OgdenCLFlegalKMCarrollMDJohnsonCL: Prevalence and trends in overweight among US children and adolescents, 1999–2000. JAMA 288: 1728– 1732, 2002.
  • OgdenCLCarrollMDCurtinLRMcDowellMATabakCJFlegalKM: Prevalence of overweight and obesity in the United States, 1999–2004. JAMA 295: 1549– 1555, 2006.
  • ArsenaultBJCartierACoteMLemieuxITremblayABouchardCPerusseLDespresJP: Body composition, cardiorespiratory fitness, and low-grade inflammation in middle-aged men and women. Am J Cardiol 104: 240– 246, 2009.
  • LeeCGCarrMCMurdochSJMitchellEWoodsNFWenerMHChandlerWLBoykoEJBrunzellJD: Adipokines, inflammation, and visceral adiposity across the menopausal transition: a prospective study. J Clin Endocrinol 94: 1104– 1110, 2009.
  • MittelmanSDVan CittersGWKirkmanELBergmanRN: Extreme insulin resistance of the central adipose depot in vivo. Diabetes 51: 755– 761, 2002.
  • OhmanMKWrightAPWickenheiserKJLuoWEitzmanDT: Visceral adipose tissue and atherosclerosis. Curr Vasc Pharmacol 7: 169– 179, 2009.
  • LowensteinFW: Major nutritional findings from the First Health and Nutrition Examination Survey in the United States of America, 1971–1974. Bibl Nutr Dieta 30: 1– 16, 1981.
  • NelsonLHTuckerLA: Diet composition related to body fat in a multivariate study of 203 men. J Am Diet Assoc 96: 771– 777, 1996.
  • DorfmanSELaurentDGounaridesJSLiXMullarkeyTLRochefordECSari-SarrafFHirschEAHughesTECommerfordSR: Metabolic implications of dietary trans-fatty acids. Obesity 17: 1200– 1207, 2009.
  • EnigMG: Know Your Fats: “The Complete Primer for Understanding the Nutrition of Fats, Oils, and Cholesterol.” Bethesda Press, May 2000.
  • HarperAAstrupA: Can we advise our obese patients to follow the Atkins diet? Obes Rev 5: 93– 94, 2004.
  • OrnishD: Was Dr Atkins right? J Am Diet Assoc 104: 537– 542, 2004.
  • MacdonaldI: Carbohydrates. In ShilsMEOlsonJAShikeM. (eds): “Modern Nutrition in Health and Disease.” Philadelphia: Lea & Febiger, pp 36– 46, 1994.
  • SandersLMLuptonJR: Carbohydrates: In BowmanBARussellRM (eds): “Present Knowledge in Nutrition,” 8th ed. Washington DC: ILSI Press, pp 78– 88, 2001.
  • BellSJVan AusdalWGrochoskiG: Appetite, body weight, health implications of a low-glycemic-load diet. In BagchiDPreussHG (eds): “Obesity. Epidmiology, Pathophysiology, and Prevention.” Boca RatonFL: CRC Press, pp 245– 263, 2007.
  • PreussHGBagchiD: Nutritional therapy of impaired glucose tolerance and diabetes mellitus. In BronnerF (ed): “Nutritional Aspects and Clinical Management of Chronic Disorders and Diseases.” Boca Raton FL: CRC Press, pp 69– 91, 2002.
  • BellSJSearsB: Low-glycemic-load diets: impact on obesity and chronic diseases. CRC Crit Rev Food Sci Nutr 43: 357– 377, 2003.
  • BellSJWolbersJCastertonW: Use of a low-glycemic load diet to promote weight loss. Nutra World 8: 50– 51, 2005.
  • CrawfordVScheckenbachRPreussHG: Effects of niacin-bound chromium supplementation on body composition of overweight African-American women. Diabetes Obes Metab 1: 331– 337, 1999.
  • AndersonRA: Chromium as an essential nutrient for humans. Reg Toxicol Pharmacol 26: S35– S41, 1997.
  • AndersonRA: Nutritional factors influencing the glucose/insulin system: chromium. J Amer Coll Nutr 16: 404– 410, 1997.
  • PreussHG: Effects of glucose/insulin perturbations on aging and chronic disorders of aging: the evidence. J Am Coll Nutr 16: 397– 403, 1997.
  • DeFronzoRAFerinimmiE: Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 14: 173– 194, 1991.
  • ReavenG: The metabolic syndrome or the insulin resistance syndrome? Different names, different concepts, and different goals. Endocrinol. Metab Clin North Am 33: 283– 303, 2004.
  • SzantoSYudkinJ: The effect of dietary sucrose on blood lipids, serum insulin, platelet adhesiveness, and body weight in human volunteers. Postgrad Med J 45: 602– 607, 1969.
  • YudkinJ: The low carbohydrate diet in the treatment of obesity. Postgrad Med 51: 151– 154, 1972.
  • ReiserSHandlerHBGardnerLBHallfrischJGMichaelisOEPratherES: Isocaloric exchange of dietary starch and sucrose in humans. II. Effect on fasting blodd insulin, glucose, and glucagon and on insulin and glucose response to a sucrose load. Am J Clin Nutr 32: 2206– 2216, 1979.
  • YudkinJ: Sugar and obesity. Lancet 2: 794, 1983.
  • YudkinJ: Sucrose, coronary heart disease, diabetes, and obesity. Do hormones provide a link? Am Heart J 115: 493– 498, 1988.
  • No author: Is the Atkins diet on to something? No, it's not a healthy way to eat. But the high-protein, low-carbohydrate diet may hold a few important lessons about weight loss and healthy eating. Harvard Health Lett 28: 1– 2, 2003.
  • WolfBWOoleverTMLaiCSBolognesiCRadmardRMaharryKSGarlebKAHertzlerSRFirkinsJL: Effects of a beverage containing an enzymatically induced-viscosity dietary fiber, with or without fructose, on the postprandial glycemic response to a high glycemic index food in humans. Eur J Clin Nutr 57: 1120– 1127, 2003.
  • HarringtonS: The role of sugar-sweetened beverage consumption in adolescent obesity: a review of the literature. J Sch Nurs 24: 3– 12, 2008.
  • DuboisLFarmerAGirardMPetersonK: Regular sugar-sweetened beverage consumption between meals increases risk of overweight among preschool-aged children. J Am Diet Assoc 107: 934– 935, 2007.
  • DuffeyKJPopkinBM: Shifts in patterns and consumption of beverages between 1965 and 2002. Obesity 15: 2739– 2747, 2007.
  • ReavenGMChenNHollenbeckCChenYDI: Effect of age on glucose tolerance and glucose uptake in healthy individuals. J Am Ger Soc 37: 735– 740, 1989.
  • BroughtonDLTaylorRL: Review: deterioration of glucose tolerance with age: the role of insulin resistance. Age Aging 20: 221– 225, 1991.
  • ShimokataHMullerDCFlegJLSorkinJZiembaAWAndresR: Age as independent determinant of glucose tolerance. Diabetes 40: 44– 51, 1991.
  • DeFronzoR: Glucose intolerance and aging. Diabetes Care 4: 493– 501, 1981.
  • LeeK: Usefulness of the metabolic syndrome criteria as predictors of insulin resistance among obese Korean women. Public Health Nutr 26: 1– 6, 2009.
  • WadaHSatohNKitaokaSOnoKMorimotoTKawamuraTNakanoTFujitaMKitaTShimatsuAHasegawaK: Soluble VEGF receptor-2 is increased in sera of subjects with metabolic syndrome in association with insulin resistance. Atherosclerosis Jul 30, 2009 [Epub ahead of print].
  • PreussHGBagchiDClouatreD: Insulin resistance; a factor in aging. In GhenMJCorsoNJoiner-BeyHKlatzRDratzA (eds): “The Advanced Guide to Longevity Medicine.” Landrum SC: Ghen, pp 239– 250, 2001.
  • MasoroEJ: Assessment of nutritional components in prolongation of life and health by diet. Proc Soc Exper Biol Med 193: 31– 34, 1990.
  • MasoroEJ: Nutrition as a modulator of the aging process. Physiologist. 27: 98– 101, 1984.
  • HopkinK: Aging in focus. Caloric restriction may put the brakes on aging. J NIH Research 7: 47– 50, 1995.
  • YudkinJS: Sugar and disease. Nature 239: 197– 199, 1972.
  • YudkinJS: Patterns and trends in carbohydrate consumption and their relation to disease. Proc Nutr Soc 23: 149– 162, 1964.
  • YudkinJS: Adipose tissue, insulin action and vascular disease: inflammatory signals. Int J Obes Metab Disord 27: S25– S28, 2003.
  • YudkinJS: Insulin resistance and the metabolic syndrome –the pitfalls of epidemiology. Diabetologia 50: 1576– 1586, 2007.
  • MasoroEJMcCarterRJMKatzMSMcMahanCA: Dietary restriction alters characteristics of glucose fuel use. J Gerontol 47: B202– B208, 1992.
  • CerulliJLomaestroBMMaloneM: Update on the pharmacotherapy of obesity. Ann Pharmacol 32: 88– 102, 1998.
  • CarekPJDickersonLM. Current concepts in the pharmacological management of obesity. Drugs 57: 883– 904, 1999.
  • FDA: Early communications about ongoing safety review Orlistat (marketed as Alli and Xenical). 8/24/09. http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviers/DrugSafetyInformationforHeathcareProfessionals/ucm179166.htm.
  • PawlakDBKushnerJALudwigDS: Effects of dietary glycaemic index on adiposity, glucose homeostasis, and plasma lipids in animals. Lancet 364: 778– 785, 2004.
  • BrehmBJSeeleyRJDanielsSRD'AllessioDA: A randomized trial comparing a very low carbohydrate diet and a calorie-restricted low fat diet on body weight and cardiovascular risk factors in healthy women. J Fam Pract 52: 515– 516, 2003.
  • MecklingKAGauthierMGrubbRSanfordJ: Effects of a hypocaloric, low carbohydrate diet on weight loss, blood lipids, blood pressure, glucose tolerance, and body composition in free-living overweight women. Canad J Physiol Pharmacol 80: 1095– 1105, 2002.
  • McAuleyKAHopkinsCMSmithKJMcLayRTWilliamsSMTaylorRWMannJI: Comparison of high-fat and high-protein diets with a high-carbohydrate diet in insulin-resistant obese women. Diabetologia 48: 8– 16, 2005.
  • ThomasDEElliotEJBaurL: Low glycaemic loads for overweight and obesity. Cochrane Database Syst Rev Jul 18;CD005105.
  • GanjiVKiesCV: Psyllium husk fiber supplementation to soybean and coconut oil diets of humans: effect of fat digestibility and faecal fatty acid excretion. Eur J Clin Nutr 48: 595– 597, 1994.
  • WadsteinJThomEHeldmanEGudmunssonSLiljaB: Biopolymer L112, a chitosan with fat binding properties and potential as a weight reducing agent. In MuzzarelliRAA (ed): “Chitosan Per Os; From Dietary Supplement to Drug Carrier.” GrottammareItaly: Atec, pp 65– 76, 2000.
  • PreussHGKaatsGR: Chitosan as a dietary supplement for weight loss. A review. Curr Nutr Rev 2: 297– 311, 2006.
  • PreussHGGottliebB: Lower your carbs – without a low-carb diet. In “The Natural Fat-Loss Pharmacy.” New York: Broadway Books, pp 105– 124, 2007.
  • FukagawaNKAndersonJWHagemanGYoungVRNinakerKL: High-carbohydrate, high-fiber diets increase peripheral insulin sensitivity in healthy young and old adults. Am J Clin Nutr 52: 524– 528, 1990.
  • JenkinsDJKendallCWMarchieAJenkinsALAugustinLSLudwigDSBarnardNDAndersonJW: Type 2 diabetes and the vegetarian diet. Am J Clin Nutr. 78 (3 Suppl): 610S– 616S, 2003.
  • ZeinMAreasJKnapkaJGleimGDiPetteDHollandBPreussHG: Influence of oat bran on sucrose-induced blood pressure elevations in SHR. Life Sci 47: 1121– 1128, 1990.
  • PreussHGGondalJABustosEBushehriNLiebermanSBrydenNAPolanskyMMAndersonRA: Effect of chromium and guar on sugar-induced hypertension in rats. Clin Neph 44: 170– 177, 1995.
  • UdaniJHardyMKavoussiB: Dietary supplement carbohydrate digestion inhibitors: A review of the literature. In BagchiDPreussHG (eds): “Obesity. Epidmiology, Pathophysiology, and Prevention.” Boca RatonFL: CRC Press, pp 279– 298, 2007.
  • MeissDE: Phaseolus vulgaris and alpha amylase inhibition. In BagchiDPreussHG (eds): “Obesity. Epidmiology, Pathophysiology, and Prevention.” Boca RatonFL: CRC Press, pp 423– 432, 2007.
  • BrudnakMA: Weight-loss drugs and supplements: are there safer alternatives? Med Hypotheses 58: 28– 33, 2002.
  • GuytonACHallJE: “Textbook of Medical Physiology,” 9th ed. Philadelphia: WB Saunders, Chap 2, 1996.
  • AndohATsujikawaTFujiyamaY: Role of dietary fiber and short chain fatty acids in the colon. Curr Pharm Des 9: 347– 358, 2003.
  • HigginsJAHigbeeDRDonahooWTBrownILBellMLBessesenDH: Resistant starch consumption promotes lipid oxidation. Nutr Metabolism 1: 8, 2004.
  • KeenanMJZhouJMcCutcheonKLRaggioAMBatemanHGToddEJonesCKTulleyRTMeltonSMartinRJHegstedM: Effects of resistant starch, a non digestible fermentable fiber, on reducing body fat. Obesity 14: 1523– 1534, 2006.
  • GrabitskeHASlavinJL: Low-digestible carbohydrates in practice. J Am Diet Assoc 108: 1677– 1681, 2008.
  • ObiroWCZhangTJiangB: The nutraceutical role of the Phasoleus vulgaris a-amylase inhibitor. Br J Nutr 100: 1– 12, 2008.
  • MarshalJJLaudaCM: Purification and properties of phaseolamin, an inhibitor of alpha-amylase from the kidney bean, Phaseolus vulgaris. J Bio Chem 250: 8030– 8037, 1975.
  • LajoloFMFilhoFFMenezesEW: Amylase inhibitors in Phaseolus vulgaris beans. Food Technol. Sept: 119– 121, 1991.
  • NakaguchiTArakawaTPhiloJSWenJIshimotoMYamaguchiH: Structural characterization of an alpha-amylase inhibitor from a wild common bean (Phaseolus vulgaris): insight into the common structural features of leguminous alpha-amylase inhibitors. J Biochem. 121: 350– 354, 2004.
  • PayanF: Structural basis for the inhibition of mammalian and insect alpha-amylase by plant protein inhibitors. Biochim Biophy Acta 1696: 171– 180, 2004.
  • SantimoneMKoukiekoloRMoreauYLe BerreVRougePMarchis-MourenGDesseauxV: Porcine pancreatic alpha-amylase inhibition by the kidney bean (Phaseolus vulgaris) inhibitor (alpha-Al1) and structural changes in the alpha-amylase complex. Biochim Biophy Acta 1696: 181– 190, 2004.
  • Bo-LinnGWSanta AnaCAMorawskiSGFordtranJS: Starch blockers – their effect on calorie absorption from a high-starch meal. New Eng J Med 307: 1413– 1416, 1982.
  • HollenbeckCBCoulstonAMQuanRBeckerTRVremanHJStevensonDKReavenGM: Effects of a commercial starch blocker preparation on carbohydrate digestion and absorption: in vivo and in vitro studies. Am J Clin Nutr 38: 498– 503, 1983.
  • GarrowJSScottPFHeelsSNairKSHallidayD: A study or ‘starch blockers” in many using 13C-enriched starch as a tracer. Hum Nutr Clin Nutr. 37: 301– 305, 1983.
  • CarlsonGLLiBUBassPOlsenWA: A bean alpha-amylase inhibitor formulation (starch blocker) is ineffective in man. Science 219: 393– 395, 1983.
  • LayerPCarlsonGLDiMagnoEP: Partially purified white bean amylase inhibitor reduces starch digestion in vitro and inactivates intraduodenal amylase in humans, Gastroenterology 88: 1895– 1902, 1985.
  • LayerPZinsmeisterARDiMagnoEP: Effects of decreasing intraluminal amylase activity on starch digestion and postprandial gastrointestinal function in humans. Gastroenterology 88: 1895– 1902, 1985.
  • LayerPRizzaRAZinsmeisterARCarlsonGLDiMagnoEP: Effect of a purified amylase inhibitor on carbohydrate tolerance in normal subjects and patients with diabetes mellitus. Mayo Clin Proc 61: 442– 447, 1986.
  • BruggeWRRosenfeldMS: Impairment of starch absorption by a potent amylase inhibitor. Am J Gastroenterol 82: 718– 722, 1987.
  • BoivinMZinsmeisterARGoVLDiMagnoEP: Effect of a purified amylase inhibitor on carbohydrate metabolism after a mixed meal in healthy humans. May Clin Proc 62: 249– 255, 1987.
  • JainNKBoivinMZinsmeisterARBrownMLMalageladaJEDiMagnoEP: Effect of ileal perfusion of carbohydrates and amylase inhibitor on gastrointestinal hormones and emptying. Gastroenterology 96: 377– 387, 1989.
  • BoivinMFlourieBRizzaRAGoVLDiMagnoEP: Gastrointestinal and metabolic effects of amylase inhibition in diabetics. Gastroenterology 94: 387– 394, 1988.
  • TormoMAGil-ExojoIRomero de TejadaACampilloJE: Hypoglycemic and anorexigenic activities of an alpha-amylase inhibitor from white kidney beans (Phaseolus vulgaris) in Wistar rats. Br J Nutr 92: 785– 790, 2004.
  • DeglaireAMoughanPJBosCTomeD: Commercial Phaesolus vulgaris extract (starch stopper) increases ileal endogenous amino acid and crude protein losses in the growing rat. J Agric Food Chem 54: 5197– 5202, 2006.
  • PreussHGEchardBTalpurNTalpurFStohsS: Inhibition of starch and sucrose gastrointestinal absorption in rats by various dietary supplements alone and combined. Acute studies Int J Med Sci 4: 196– 202, 2007.
  • PreussHGEchardBTalpurNTalpurFStohsS: Inhibition of starch and sucrose gastrointestinal absorption in rats by various dietary supplements alone and combined. Subchronic studies. Int J Med Sci 4: 209– 215, 2007.
  • VinsonJAAl KharratHShutaD: Investigation of an amylase inhibitor on human glucose absorption after starch consumption. Open Nutraceutical J 2: 88– 91, 2009.
  • ThomE: A randomized, double-blind, placebo-controlled trial of a new weight-reducing agent of natural origin. J Int Med Res 28: 229– 233, 2000.
  • CellenoLPerriconeNVPreussHG: Effect of a dietary supplement containing standardized Phaseolus vulgaris extract on the body composition of overweight men and women. Int J Med Sci 4: 45– 52, 2007.
  • UdaniJHardyMMadsenDC: Blocking carbohydrate absorption and weight loss: a clinical trial using Phase 2 brand proprietary fractionated white bean extract. Altern Med Rev 9: 63– 69, 2004.
  • UdaniJSinghBB: Blocking carbohydrate absorption and weight loss: a clinical trial using a proprietary fractionated white bean extract. Altern Ther Health Med 13: 32– 37, 2007.
  • Food and Agricultural Organization/World Health Organization Expert Consultation on Carbohydrates in Human Nutrition. Carbohydrates in Human Nutrition: A Report of a Joint FAO/WHO Expert Consultation. FAO Food and Nutrition Paper no. 66. Rome: FAO, 1998.
  • SmithTBrownJCLivesyG: Energy balance and thermogenesis in rats consuming non starch polysaccharides of various fermentabilities. Am J Clin 68: 802– 819, 1998.
  • KoikeTKoizumiYTangLTakaharaKSaitouY: The anti-obesity effect and the safety of taking “Phaseolamin™ 1600 diet”. J New Rem Clin 54: 1– 16, 2005.
  • WuXXuXShenJPreussHG: Enhanced weight loss from a dietary supplement containing standardized Phaseolus vulgaris extract in overweight men and women (Submitted for publication).
  • ChokshiD: Toxicity studies of Blokal, a dietary supplement containing Phase 2 starch neutralizer (Phase 2), standardized extract of the common white kidney bean (Phaseolus vulgaris). Int J Toxicol 25: 361– 371, 2006.
  • ChokshiD: Subchronic oral toxicity of a standardized white kidney bean (Phaseolus vulgaris) extract in rats. Food Chem /Toxicol 45: 32– 40, 2007.
  • HansawasdiCKawabataJKasaiT: Alpha-amylase inhibitors from roselle (Hibiscus sabdariffa Linn.) tea. Biosci Biotechnol Biochem 64: 1041– 1043, 2000.
  • HansawadiCKawabataJKasaiT: Hibiscus acid as an inhibitor of starch digestion in the Caco-2 cell model system. Biosci Biotechnol Biochem 65: 2087– 2089, 2001.
  • SachdewaAKhemaniLD: Effects of Hibiscus rosa sinensis Linn. ethanol flower extract on blood glucose and lipid profile in streptozotocin induced diabetes in rats. J Ethnopharmacol, 89, 61– 66, 2003.
  • LankischMLayerPRizzaRADiMagnoEP: Acute postprandial gastrointestinal and metabolic effects of wheat amylase inhibitor (WAI) in normal, obese, and diabetic humans. Pancreas 17: 176– 181, 1998.
  • SeriKSanaiKMatsuoNKawakuboKXueCInoueS: L-arabinose selectively inhibits intestinal sucrase in an uncompetitive manner and suppresses glycemic response after sucrose ingestion in animals. Metabolism 45: 1368– 1374, 1996.
  • OsakiSKimuraTSugimotoTHizukuriSIritaniN: L-arabinose feeding prevents increases due to dietary sucrose in lipogenic enzymes and triacylglycerol levels in rats. J Nutr 131: 796– 799, 2001.
  • InoueSSanaiKSeriK. Effect of L-arabinose on blood glucose level after ingestion of sucrose-containing food in humans. J Jpn Soc Nutr Food Sci 53: 243– 247, 2000.
  • YoshikawaMMuarakamiTKadoyaMLiYMurakamiNYamaharaJMatsudaH: The inhibitors of glucose absorption from the leaves of Gymnema sylvestre R. BR. (Asclepiadaceae): structures of gymnemosides a and b. Chem Pharm Bull 45: 1671– 1676, 1997.
  • ShimizuKIinoANakajimaJTanakaKNakajyoSUrakawaNAtsuchiMWadaTYamashitaC: Suppression of glucose absorption by some fractions extracted from Gymnema sylvestre leaves. J Vet Med Sci 59: 245– 251, 1997.
  • HirshAJYaoSYYoungJDCheesemanCI: Inhibition of glucose absorption in the rat jejunum: a novel action of alpha-D-glucosidase inhibitors. Gastroenterology 113: 205– 211, 1997.
  • KwonOEckPChenSCorpeCPLeeJ-HKruhlakMLevineM: Inhibition of the intestinal glucose transporter GLUT2 by flavonoids. The FASEB J 21: 366– 377, 2007.
  • SugimotoKSuzukiJNakagawaKHayachiSEnomotoTFujitaTYamajiRRyoichi InuiHNakanoY: Eucalyptus leaf extract inhibits intestinal fructose absorption, and suppresses adiposity due to dietary sucrose in rats. Br J Nutr 93: 957– 963, 2005.
  • BurkittDP: Western diseases and their emergence related to diet. S Afr Med J 61: 1013– 1015, 1982.
  • BurkittDPTrowellHC: Nutritional intake, adiposity, and diabetes. Br Med J 1: 1083– 1084, 1979.

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