Immunomodulatory Effects of ResistAid™: A Randomized, Double-Blind, Placebo-Controlled, Multidose Study

REFERENCES

• Twigg , H L . 2005 . Humoral immune defense (antibodies): recent advances . Proc Am Thoracic Soc , 2 : 417 – 421 .
   PubMedGoogle Scholar
• Albers , R , Antoine , J M , Bourdet-Sicard , R , Calder , P C , Gleeson , M , Lesourd , B , Samartin , S , Sanderson , I R , Van Loo , J , Vas Dias , F W and Watzl , B . 2005 . Markers to measure immunomodulation in human nutrition intervention studies . Br J Nutr , 94 : 452 – 481 .
   PubMed Web of Science ®Google Scholar
• Cummings , J H , Antoine , J M , Azpiroz , F , Bourdet-Sicard , R , Brandtzaeg , P , Calder , P C , Gibson , G R , Guarner , F , Isolauri , E , Pannemans , D , Shortt , C , Tuijtelaars , S and Watzl , B . 2004 . PASSCLAIM—gut health and immunity . Eur J Clin Nutr , 43 ( suppl 2 ) : 118 – 173 .
   Google Scholar
• 1991 . Diphtheria, tetanus, and pertussis: recommendations for vaccine use and other preventive measures. Recommendations of the Immunization Practices Advisory Committee . MMWR Morb Mortal Wkly Rep , 40 : 1 – 28 .
   PubMedGoogle Scholar
• Sanofi Pasteur . Tetanus toxoid for booster use only. Rep. U.S. Food and Drug Administration, 01 Dec 2005. Web 23 Sept 2013 . Accessed at: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM166873.pdf
   Google Scholar
• Schauer , U , Stemberg , F , Rieger , C H , Büttner , W , Borte , M , Schubert , S , Möllers , H , Riedel , F , Herz , U , Renz , H and Herzog , W . 2003 . Levels of antibodies specific to tetanus toxoid, Haemophilus influenza type B, and pneumococcal capsular polysaccharide in healthy children . Clin Diagn Lab Immunol , 10 : 202 – 207 .
   PubMedGoogle Scholar
• Cox , R J , Haaheim , L R , Ericsson , J C , Madhun , A S and Brokstad , K A . 2006 . The humoral and cellular responses induced locally and systemically after parenteral influenza vaccination in man . Vaccine , 24 : 6557 – 6580 .
   Google Scholar
• Brokstad , K A , Cox , R J , Olofsson , J , Jonsson , R and Haaheim , L R . 1995 . Parenteral influenza immunization induces a rapid systemic and local immune response . J Infect Dis , 171 : 198 – 203 .
   PubMed Web of Science ®Google Scholar
• Kelly , G S . 1999 . Larch arabinogalactan: clinical relevance of a novel immune-enhancing polysaccharide . Altern Med Rev , 4 : 96 – 103 .
   PubMedGoogle Scholar
• D’Adamo , P D . 1990 . Larch arabinoglactan . J Naturopath Med , 6 : 33 – 37 .
   Google Scholar
• US Food and Drug Administration . Department of Health and Human Services: “CFR—Code of Federal Regulations Title 21—Food and Drugs . Section 170.3. Accessed at: <http://cfr.vlex.com/source/code-federal-regulations-food-drus-1070/section/01.02.71>
   Google Scholar
• Hauer , J and Anderer , F A . 1993 . Mechanism if stimulation of human natural killer cell cytotoxicity by arabinogalactan from Larix occidentalis . Cancer Immunol Immunother , 36 : 237 – 244 .
   PubMed Web of Science ®Google Scholar
• Grieshop , C M , Flickinger , E A and Fahey , G C . 2002 . Oral administration of arabinogalactan affects immune status and fecal microbial populations in dogs . J Nutr , 132 : 478 – 482 .
   PubMed Web of Science ®Google Scholar
• Kim , L S , Waters , R F and Burkholder , P M . 2002 . Immunological activity of larch arabinogalactan and echinacea: a preliminary, randomized, double-blind, placebo-controlled trial . Altern Med Rev , 7 : 138 – 149 .
   PubMedGoogle Scholar
• Udani , J , Singh , B B , Barrett , M L and Singh , V J . 2010 . Proprietary arabinogalactan extract increases antibody response to pneumonia vaccine: a randomized double-blind, placebo-controlled, pilot study in healthy volunteers . J Nutr , 9 : 32
   Google Scholar
• Spahn , T W and Kucharzik , T . 2004 . Modulating the intestinal immune system: the role of lymphotoxin and GALT organs . Gut , 53 : 456 – 465 .
   PubMed Web of Science ®Google Scholar
• Kelly , G . 1999 . Larch arabinogalactan: clinical relevance of a novel immune-enhancing polysaccharide . Altern Med Rev , 4 : 96 – 103 .
   PubMedGoogle Scholar
• World Medical Association: . “ Ethical Principles for Medical Research Involving Human Subjects ” . World Medical Association Declaration of Helsinki . 1 Oct. 2008. Web. 23 Sept. 2013. Accessed at: <http://www.wma.net/en/30publications/10policies/b3/17c.pdf>
   Google Scholar
• Price Christopher , H , Hedtke , D , Richards , G N and Tempesta , M S . Methods for the Extraction of Phytochemicals from Fibrous Plants in the Absence of Solvent , Larex International, Inc . assignee. Patent 5756098. 26 May 1998. Print
   Google Scholar
• Hazard Analysis and Critical Control Points - FDA Code 2009 . Annex 4. N.p., n.d. Web. 23 Sept. 2013. Accessed at: http://www.fda.gov/Food/GuidanceRegulation/RetailFoodProtection/FoodCode/ucm188363.htm
   Google Scholar
• Agency Response Letter GRAS Notice No. GRN 000084. CFSAN/Office of Premarket Approval, 19 Feb. 2002. Web. 23 Sept. 2013. Accessed at: <http://www.fda.gov/Food/IngredientsPackagingLabeling/GRAS/NoticeInventory/ucm154598.htm>
   Google Scholar
• Agency Response Letter GRAS Notice No. GRN 000047. CFSAN/Office of Premarket Approval, 06 June 2000. Web. 23 Sept. 2013. Accessed at: <http://www.fda.gov/Food/IngredientsPackagingLabeling/GRAS/NoticeInventory/ucm153766.htm>
   Google Scholar
• “Advisory Committees.” 2009 Meeting Materials, Vaccines and Related Biological Products Advisory Committee. U.S. Food and Drug Administration, 15 Dec. 2009. Web. 23 Sept. 2013. Accessed at: <http://www.fda.gov/AdvisoryCommittees/CommitteesMeetingMaterials/BloodVaccinesandOtherBiologics/VaccinesandRelatedBiologicalProductsAdvisoryCommittee/ucm129568.htm>
   Google Scholar
• Haahr , M . Random.org: True random number service . Web resource, 2006. Accessed at: http://www.random.org
   Google Scholar
• Robinson , R R , Feirtag , J and Slavin , J L . 2001 . Effects of dietary arabinogalactan on gastrointestinal and blood parameters in healthy human subjects . J Am Coll Nutr , 20 : 279 – 285 .
   PubMed Web of Science ®Google Scholar
• De Vrese , M and Schrezenmeir , J . 2008 . Probiotics, prebiotics, and synbiotics . Adv Biochem Engin/Biotechnol , 111 : 1 – 66 .
   PubMed Web of Science ®Google Scholar
• Vos , A P , Knol , J , Stahl , B , M’rabet , L and Garssen , J . 2010 . Specific prebiotic oligosaccharides modulate the early phase of a murine vaccination response . Int Immunopharmacol , 10 : 619 – 625 .
   PubMed Web of Science ®Google Scholar
• van't Land , B , Schijf , M , van Esch , B , van Bergenhenegouwen , J , Bastiaans , J , Schouten , B , Boon , L and Garssen , J . 2010 . Regulatory T-cells have a prominent role in immune modulated vaccine response by specific oligosaccharides . Vaccine , 28 : 5711 – 5717 .
   PubMed Web of Science ®Google Scholar
• Bunout , D , Hirsch , S , Pía de la Maza , M , Muñoz , C , Haschke , F , Steenhout , P , Klassen , P , Barrera , G , Gattas , V and Petermann , M . 2002 . Effects of prebiotics on the immune response to vaccination in the elderly . Parenter Enteral Nutr , 26 : 372 – 376 .
   PubMed Web of Science ®Google Scholar
• Thomas , C and Moridani , M . 2010 . Interindividual variations in the efficacy and toxicity of vaccines . Toxicology , 278 : 204 – 210 .
   Web of Science ®Google Scholar