Association between Vitamin D Receptor Polymorphism and Serum Vitamin D Levels in Children with Low-Energy Fractures

REFERENCES

• Landin LA: Fracture patterns in children. Analysis of 8,682 fractures with special reference to incidence, etiology and secular changes in a Swedish urban population 1950–1979. Acta Orthop Scand Suppl 202:1–109, 1983.
   PubMedGoogle Scholar
• Jones IE, Williams SM, Dow N, Goulding A: How many children remain fracture-free during growth? A longitudinal study of children and adolescents participating in the Dunedin Multidisciplinary Health and Development Study. Osteopor Int 13:990–995, 2002.
   PubMed Web of Science ®Google Scholar
• Ma D, Jones G: Soft drink and milk consumption, physical activity, bone mass, and upper limb fractures in children: a population-based case–control study. Calcif Tissue Int 75:286–291, 2004.
   PubMed Web of Science ®Google Scholar
• Wyshak G, Frisch RE: Carbonated beverages, dietary calcium, the dietary calcium/phosphorus ratio, and bone fractures in girls and boys. J Adolesc Health 15:210–215, 1994.
   PubMed Web of Science ®Google Scholar
• Carey DE, Golden NH: Bone health in adolescence. Adolesc Med State Art Rev 26:291–325, 2015.
   PubMedGoogle Scholar
• Manning Ryan L, Teach SJ, Searcy K, Singer SA, Wood R, Wright JL, Hunting KL, Chamberlain JM: The association between weight status and pediatric forearm fractures resulting from ground-level falls. Pediatr Emerg Care 31:835–838, 2015.
   PubMed Web of Science ®Google Scholar
• Yao Y, Zhu L, He L, Duan Y, Liang W, Ne Z, Jin Y, Wu X, Fang Y: A meta-analysis of the relationship between vitamin D deficiency and obesity. Int J Clin Exp Med 8:14977–14984, 2015.
   PubMed Web of Science ®Google Scholar
• Thompson RM, Dean DM, Goldberg S, Kwasny MJ, Langman CB, Janicki JA: Vitamin D insufficiency and fracture risk in urban children. J Pediatr Orthop, 2015. doi:10.1097/BPO.0000000000000697.
   PubMedGoogle Scholar
• Huber AM, Ward LM: The impact of underlying diseases on fracture risk and bone mineral density in children with rheumatic disorders: a review of current literature. Semin Arthritis Rheum 46:49–63, 2016.
   PubMed Web of Science ®Google Scholar
• Mohammadi Z, Fayyazbakhsh E, Ebrfahami F, Amoli MM, Khashayar P, Dini M, Zadeh RN, Keshtkar A, Barikani HR: Association between vitamin D receptor gene polymorphisms (Fok 1 and Bsm1) and osteoporosis: a systematic review. J Diabetes Metab Disord 13(1):98, 2014.
   Google Scholar
• Haussler MR, Whitfield GK, Haussler CA, Hsieh JC, Thompson PD, Seiznick SH, Dominguez CE: The nuclear vitamin D receptor: biological and molecular regulatory properties revealed. J Bone Miner Res 13:325–349, 1998.
   PubMed Web of Science ®Google Scholar
• DeLuca HF, Cantoma MT: Vitamin D: its role and uses in immunology. FASEB J 15:2579–2585, 2001.
   PubMed Web of Science ®Google Scholar
• Szymczak I, Pawliczak R: The active metabolite of vitamin D3 as a potential immunomodulator. Scand J Immunol 83:83–91, 2016.
   PubMed Web of Science ®Google Scholar
• Hii CS, Ferrante A: The non-genomic actions of vitamin D. Nutrients, 8(3):135, 2016.
   PubMed Web of Science ®Google Scholar
• Holick MF: High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc 8:353–373, 2006.
   Google Scholar
• Holick MF, Chen CT: Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr 87(Suppl):1080S–1086S, 2008.
   PubMed Web of Science ®Google Scholar
• Ryan LM, Brandoli C, Freishtat RJ, Wright JL, Tosi L, Chamberlain JM: Prevalence of vitamin D insufficiency in African-American children with forearm fractures: a preliminary study. J Pediatr Orthop 30:106–109, 2010.
   PubMed Web of Science ®Google Scholar
• Karpiński M, Popko J, Żelazowska-Rutkowska B: Prevalence of vitamin D insufficiency in children with low-energy fractures. Endokrynol Ped 2:9–16, 2011.
   Google Scholar
• Schilling S, Wood JN, Levine MA, Langdon D, Christian CW: Vitamin D status in abused and non-abused children younger than 2 years old with fractures. Pediatrics 127:835–841, 2011.
   PubMed Web of Science ®Google Scholar
• Bond L, Clements J, Bertalli N, Evans-Whipp T, McMorris BJ, Patton GC, Toumbourou JW, Catalano RF: A comparison of self-reported puberty using the pubertal development scale and the sexual maturation scale in a school-based epidemiologic survey. J Adolesc 29:709–720, 2006.
   PubMed Web of Science ®Google Scholar
• Carskadon MA, Acebo CH: A self-administered rating scale for pubertal development. J Adolesc Health 14:190–195, 1993.
   PubMed Web of Science ®Google Scholar
• Dick MD, Rose JR, Pulkkinen L, Kaprio J: Measuring puberty and understanding its impact: a longitudinal study of adolescent twins. J Youth Adolesc 30:385–399, 2001.
   Web of Science ®Google Scholar
• Cole TJ, Berlizzi MC, FelegalKM, Dietz WH: Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 320:1240–1243, 2000.
   PubMed Web of Science ®Google Scholar
• Cole TJ, Green PJ: Smoothing reference centile curves: the LMS method and penalized likelihood. Stat Med 11:1305–1319, 1992.
   PubMed Web of Science ®Google Scholar
• Cole TJ: The evidential value of developmental age imaging for assessing age of majority. Ann Hum Biol 42:379–388, 2015.
   PubMed Web of Science ®Google Scholar
• Györffy B, Vásárhelyi B, Krikovszky D, Madacsy L, Tordai A, Tulassy T, Szabo A: Gender-specific association of vitamin D receptor polymorphism combinations with type 1 diabetes mellitus. Eur J Endocrinol 147:803–808, 2002.
   PubMed Web of Science ®Google Scholar
• Marshall WA, Tanner JM: Variations in pattern of pubertal changes in girls. Arch Dis Child 44:291–303, 1969.
   PubMed Web of Science ®Google Scholar
• Marshall WA, Tanner JM: Variations in pattern of pubertal changes in boys. Arch Dis Child 45:13–23, 1970.
   PubMed Web of Science ®Google Scholar
• Lyons RA, Sellstrom E, Delahunty AM, Loeb M, Varilo S: Incidence and cause of fractures in European districts. Arch Dis Child 82:452–455, 2000.
   PubMed Web of Science ®Google Scholar
• Hansson G, Hirsch G: Fractures in children. J Pediatr Orthop Part B 6:77–78, 1997.
   PubMed Web of Science ®Google Scholar
• Goulding A, Jones IE, Taylor RW, Manning PJ, Williams SM: More broken bones: a 4-year double cohort study of young girls with and without forearm fractures. J Bone Miner Res 15:2011–2018, 2000.
   PubMed Web of Science ®Google Scholar
• Goulding A, Grant AM, Williams SM: Bone and body composition of children and adolescents with repeated forearm fractures. J Bone Miner Res 20:2090–2096, 2005.
   PubMed Web of Science ®Google Scholar
• Goulding A, Rockell JEP, Black RE, Grant AM, Jones IE, Williams SM: Children who avoid drinking cow's milk are at increased risk for prepubertal bone fractures. J Am Diet Assoc 104:250–253, 2004.
   PubMedGoogle Scholar
• Clark EM, Ness AR, Tobias JH: Bone fragility contributes to the risk of fracture in children, even after moderate and severe trauma. J Bone Miner Res 23:173–179, 2008.
   PubMed Web of Science ®Google Scholar
• Ferrari SL, Chevalley T, Bonjour JP, Rizoli R: Childhood fractures are associated with decreased bone mass gain during puberty: an early marker of persistent bone fragility? J Bone Miner Res 21:501–507, 2006.
   PubMed Web of Science ®Google Scholar
• Abrams SA, Griffin JI, Hawthorne KM, Chen Z, Gunn SK, Wilde M, Darlington G, Shypailo RJ, Ellis KJ: Vitamin D receptor Fok1 polymorphisms affect calcium absorption, kinetics, and bone mineralization rates during puberty. J Bone Miner Res 20:945–953, 2005.
   PubMed Web of Science ®Google Scholar
• Macdonald HM, McGuigan EF, Stewart A, Black AJ, Frazer WD, Ralston S, Reid DM: Large-scale population-based study shows no evidence of association between common polymorphism of the VDR gene and BMD in British women. J Bone Miner Res. 21:151–162, 2006.
   PubMed Web of Science ®Google Scholar
• Ji GR, Yao M, Sun CY Li ZH, Han Z: BsmI, TaqI, ApaI and FokI polymorphisms in the vitamin D receptor (VDR) gene and risk of fracture in Caucasians: a meta-analysis. Bone 47:681–686, 2010.
   PubMed Web of Science ®Google Scholar
• Uitterlinden AG, Ralston SH, Brandi ML, Brandi ML, Carey AH, Grinberg D, Langdahl BL, Lis P, Lorenc R, Obermeyer-Pietsch B, Reeve J, Reid DM, Amedei A, Bassiti A, Bustamante M, Husted LB, Diez-Perez A, Dobnig H, Dunning AM, Enjuanes A, Fahrleitner-Pammer A, Fang Y, Karczmarewicz E, Kruk MA, van Leeuwen JP, Mavilia C, van Meurs JB, Mangion J, McGuigan FE, Pols HA, Renner W, Rivadeneira F, van Schoor NM, Scollen S, Sherlock RE, Ioannidis JP: The association between common vitamin D receptor gene variations and osteoporosis: a participant-level meta-analysis. Ann Intern Med 145:255–264, 2006.
   PubMed Web of Science ®Google Scholar
• Uitterlinden AG, Fang Y, Van Meurs JB, Pols HA, Van Leeuwen JP: Genetics and biology of vitamin D receptor polymorphisms. Gene 338:143–156, 2004.
   PubMed Web of Science ®Google Scholar
• Fang Y, Rivadeneira F, Meurs JB, Pols JB, Ioannidis JP, Uitterlinder AG: Vitamin D receptor gene BsmI and TaqI polymorphism and fracture risk: a meta-analysis. Bone 39:938–945, 2006.
   PubMed Web of Science ®Google Scholar
• Horst-Sikorska W, Kalak R, Wawrzyniak A: Association analysis of the polymorphisms of the VDR gene with bone mineral density and the occurrence of fractures. J Bone Miner Metab 25:310–319, 2007.
   PubMed Web of Science ®Google Scholar
• Bener A, Al-Ali M, Hoffmann F: Vitamin D deficiency in healthy children in a sunny country: associated factors. Int J Food Sci Nutr 60(Suppl 5):60–70, 2009.
   PubMed Web of Science ®Google Scholar
• Steele B, Serota A, Helfet DL, Peterson M, Lyman S, Lane JM: Vitamin D deficiency: a common occurrence in both high- and low-energy fractures. HSS J 4:143–148, 2008.
   PubMedGoogle Scholar
• Peters BS, dos Santos LC, Fisberg M, Wood RJ, Martini LA: Prevalence of vitamin D insufficiency in Brazilian adolescents. Ann Nutr Metab 54:15–21, 2009.
   PubMed Web of Science ®Google Scholar
• Turner AG, Anderson PH, Morris HA: Vitamin D and bone health. Scand J Clin Lab Invest 72(Suppl 243):65–72, 2012.
   Google Scholar
• Becker C, Crow S, Toman J, Lipton C, McMahon DJ, Macaulay W, Siris E: Characteristics of elderly patients admitted to an urban tertiary care hospital with osteoporotic fractures: correlations with risk factors, fracture type, gender and ethnicity. Osteoporos Int 17:410–416, 2006.
   PubMed Web of Science ®Google Scholar
• Glowacki J, Hurwitz S, Thornhill TS, Kelly M, LeBoff MS: Osteoporosis and vitamin D deficiency among postmenopausal women with osteoarthritis undergoing total hip arthroplasty. J Bone Joint Surg Am 85:2371–2377, 2003.
   PubMed Web of Science ®Google Scholar
• Janssen H, Samson MM, Verhaar HJ: Vitamin D deficiency, muscle function, and falls in elderly people. Am J Clin Nutr 75:611–615, 2002.
   PubMed Web of Science ®Google Scholar
• Hitz MF, Jensen JEB, Eskildsen PC: Bone mineral density and bone markers in patients with a recent low-energy fracture: effect of 1 y of treatment with calcium and vitamin D. Am J Clin Nutr 86:251–259, 2007.
   PubMed Web of Science ®Google Scholar
• Pawley N, Bishop NJ: Prenatal and infant predictors of bone health: the influence of vitamin D. Am J Clin Nutr 80:1748S–1751S, 2004.
   PubMed Web of Science ®Google Scholar
• Lehtonen-Veromaa MKM, Mottonen TT, Nuotio IO, Irjala K, Viikari J: Vitamin D and attainment of peak bone mass among peripubertal Finnish girls: a 3-y prospective study. Am J Clin Nutr 76:1446–1453, 2002.
   PubMed Web of Science ®Google Scholar
• Li K, Shi Q, Yang L, Li X, Liu L, Wang L, Li Q, Wang G, Li CY, Gao TW: The association of vitamin D receptor gene polymorphisms and serum 25-hydroxyvitamin D levels with generalized vitiligo. Br J Dermatol 167:815–821, 2012.
   PubMed Web of Science ®Google Scholar
• Santos BR, Mascarenhas LPG, Satler F, Boguszewski MC, Spritzer PM: Vitamin D deficiency in girls from south Brazil: a cross-sectional study on prevalence and association with vitamin D receptor gene variants. BMC Pediatrics 12:62, 2012.
   PubMed Web of Science ®Google Scholar
• Clark EM, Ness AR, Tobias JH: Vigorous physical activity increases fracture risk in children irrespective of bone mass: a prospective study of the independent risk factors for fractures in healthy children. J Bone Miner Res 23:1012–1022, 2008.
   PubMed Web of Science ®Google Scholar
• Manias K, McCabe D, Bishop N: Fractures and recurrent fractures in children; varying effects of environmental factors as well as bone size and mass. Bone 39:652–657, 2006.
   PubMed Web of Science ®Google Scholar