Effects of Canola Oil Consumption on Lipid Profile: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials

References

• Global Atlas on Cardiovascular Disease Prevention and Control. Mendis S PP, Norrving B editors. World Health Organization, Geneva; 2011.
   Google Scholar
• Uusitupa M, Hermansen K, Savolainen MJ, Schwab U, Kolehmainen M, Brader L, et al. Effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome - a randomized study (SYSDIET). J Int Med. 2013;274(1):52–66.
   PubMed Web of Science ®Google Scholar
• Alpert JS. Nutritional advice for the patient with heart disease: what diet should we recommend for our patients? Circulation. 2011;124(10):e258–e260.
   PubMed Web of Science ®Google Scholar
• Hammad S, Pu SH, Jones PJ. Current evidence supporting the link between dietary fatty acids and cardiovascular disease. Lipids. 2016;51(5):507–517.
   PubMed Web of Science ®Google Scholar
• Negele L, Schneider B, Ristl R, Stulnig TM, Willfort-Ehringer A, Helk O, Widhalm K. Effect of a low-fat diet enriched either with rapeseed oil or sunflower oil on plasma lipoproteins in children and adolescents with familial hypercholesterolaemia. Results of a pilot study. Eur J Clin Nutr. 2015;69(3):337–343.
   PubMed Web of Science ®Google Scholar
• Jolfaie N, Rouhani M, Surkan P, Siassi F, Azadbakht L. Rice bran oil decreases total and LDL cholesterol in humans: a systematic review and meta-analysis of randomized controlled clinical trials. Horm Metab Res. 2016;48(07):417–426.
   PubMedGoogle Scholar
• Enns JE, Zahradka P, Guzman RP, Baldwin A, Foot B, Taylor CG. Randomized controlled trial to evaluate the effect of canola oil on blood vessel function in peripheral arterial disease: Rationale and design of the Canola-PAD Study. Open Access J Clin Trials. 2014;6:117–125.
   Google Scholar
• Okuyama H, Langsjoen PH, Ohara N, Hashimoto Y, Hamazaki T, Yoshida S, Kobayashi T, Langsjoen AM. Medicines and vegetable oils as hidden causes of cardiovascular disease and diabetes. Pharmacology. 2016;98(3-4):134–170.
   PubMed Web of Science ®Google Scholar
• Jones PJH, Senanayake VK, Pu SH, Jenkins DJ, Connelly PW, Lamarche B, et al. DHA-enriched high-oleic acid canola oil improves lipid profile and lowers predicted cardiovascular disease risk in the canola oil multicenter randomized controlled trial. Am J Clin Nutr. 2014;100(1):88–97.
   PubMed Web of Science ®Google Scholar
• Iggman D, Gustafsson IB, Berglund L, Vessby B, Marckmann P, Risérus U. Replacing dairy fat with rapeseed oil causes rapid improvement of hyperlipidaemia: a randomized controlled study. J Int Med. 2011;270(4):356–364.
   PubMed Web of Science ®Google Scholar
• Salar A, Faghih S, Pishdad GR. Rice bran oil and canola oil improve blood lipids compared to sunflower oil in women with type 2 diabetes: a randomized, single-blind, controlled trial. J Clin lipidol. 2016;10(2):299–305.
   PubMed Web of Science ®Google Scholar
• Nydahl M, Gustafsson I, Ohrvall M, Vessby B. Similar effects of rapeseed oil (canola oil) and olive oil in a lipid-lowering diet for patients with hyperlipoproteinemia. J Am Coll Nutr. 1995;14(6):643–651.
   PubMed Web of Science ®Google Scholar
• Heggen E, Granlund L, Pedersen JI, Holme I, Ceglarek U, Thiery J, Kirkhus B, Tonstad S. Plant sterols from rapeseed and tall oils: effects on lipids, fat-soluble vitamins and plant sterol concentrations. Nutr Metab Cardiovasc Dis. 2010;20(4):258–265.
   PubMed Web of Science ®Google Scholar
• Pedersen A, Baumstark MW, Marckmann P, Gylling H, Sandström B. An olive oil-rich diet results in higher concentrations of LDL cholesterol and a higher number of LDL subfraction particles than rapeseed oil and sunflower oil diets. J Lipid Res. 2000;41(12):1901–1911.
   PubMed Web of Science ®Google Scholar
• Södergren E, Gustafsson IB, Basu S, Nourooz-Zadeh J, Nälsén C, Turpeinen A, Berglund L, Vessby B. A diet containing rapeseed oil-based fats does not increase lipid peroxidation in humans when compared to a diet rich in saturated fatty acids. Eur J Clin Nutr. 2001;55(11):922–931.
   PubMed Web of Science ®Google Scholar
• Nigam P, Bhatt S, Misra A, Chadha DS, Vaidya M, Dasgupta J, Pasha QM. Effect of a 6-month intervention with cooking oils containing a high concentration of monounsaturated fatty acids (olive and canola oils) compared with control oil in male Asian Indians with nonalcoholic fatty liver disease. Diabetes Technol Ther. 2014;16(4):255–261.
   PubMed Web of Science ®Google Scholar
• Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, McQuay HJ. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 1996;17(1):1–12.
   PubMedGoogle Scholar
• Trialists CT. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90056 participants in 14 randomised trials of statins. Lancet. 2005;366(9493):1267–78.
   PubMed Web of Science ®Google Scholar
• Mihaylova B, Emberson J, Blackwell L, Keech A, Simes J, Barnes EH, Voysey M, Gray A, Collins R, Baigent C. The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials. Lancet. 2012;380(9841):581–590.
   PubMed Web of Science ®Google Scholar
• Hoffman R, Gerber M. Can rapeseed oil replace olive oil as part of a Mediterranean-style diet? Br J Nutr. 2014;112(11):1882–1895.
   PubMed Web of Science ®Google Scholar
• Mensink RP, Zock PL, Kester AD, Katan MB. Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. Am J Clin Nutr. 2003;77(5):1146–1155.
   PubMed Web of Science ®Google Scholar
• Ramprasath VR, Jones PJ, Buckley DD, Woollett LA, Heubi JE. Decreased plasma cholesterol concentrations after PUFA-rich diets are not due to reduced cholesterol absorption/synthesis. Lipids. 2012;47(11):1063–1071.
   PubMed Web of Science ®Google Scholar
• Sacks FM, Katan M. Randomized clinical trials on the effects of dietary fat and carbohydrate on plasma lipoproteins and cardiovascular disease. Am J Med. 2002;113(Suppl9B):13S–24S.
   PubMedGoogle Scholar
• Takeuchi H, Nakamoto T, Mori Y, Kawakami M, Mabuchi H, Ohishi Y, Ichikawa N, Koike A, Masuda K. Comparative effects of dietary fat types on hepatic enzyme activities related to the synthesis and oxidation of fatty acid and to lipogenesis in rats. Biosci Biotechnol Biochem. 2001;65(8):1748–1754.
   PubMed Web of Science ®Google Scholar
• Daumerie CM, Woollett LA, Dietschy JM. Fatty acids regulate hepatic low density lipoprotein receptor activity through redistribution of intracellular cholesterol pools. Proc Natl Acad Sci USA. 1992;89(22):10797–10801.
   PubMed Web of Science ®Google Scholar
• Gillingham LG, Gustafson JA, Han S-Y, Jassal DS, Jones PJ. High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects. Br J Nutr. 2011;105(03):417–427.
   PubMedGoogle Scholar
• Ellegård L, Andersson H, Bosaeus I. Rapeseed oil, olive oil, plant sterols, and cholesterol metabolism: an ileostomy study. Eur J Clin Nutr. 2005;59(12):1374–1378.
   PubMed Web of Science ®Google Scholar
• SzydłOwska-Czerniak A. Rapeseed and its products—sources of bioactive compounds: a review of their characteristics and analysis. Crit Rev Food Sci Nutr. 2013;53(4):307–330.
   PubMed Web of Science ®Google Scholar
• Ras RT, Geleijnse JM, Trautwein EA. LDL-cholesterol-lowering effect of plant sterols and stanols across different dose ranges: a meta-analysis of randomised controlled studies. Br J Nutr. 2014;112(02):214–219.
   PubMedGoogle Scholar
• Kratz M, Gülbahçe E, von Eckardstein A, Cullen P, Cignarella A, Assmann G, Wahrburg U. Dietary mono- and polyunsaturated fatty acids similarly affect LDL size in healthy men and women. J Nutr. 2002;132(4):715–718.
   PubMed Web of Science ®Google Scholar
• Seppänen-Laakso T, Laakso I, Lehtimäki T, Rontu R, Moilanen E, Solakivi T, Seppo L, Vanhanen H, Kiviranta K, Hiltunen R. Elevated plasma fibrinogen caused by inadequate α-linolenic acid intake can be reduced by replacing fat with canola-type rapeseed oil. Prostaglandins Leukot Essent Fatty Acids. 2010;83(1):45–54.
   PubMed Web of Science ®Google Scholar
• Gebauer SK, Psota TL, Harris WS, Kris-Etherton PM. n− 3 fatty acid dietary recommendations and food sources to achieve essentiality and cardiovascular benefits. Am J Clin Nutr. 2006;83(6):S1526–1535S.
   PubMed Web of Science ®Google Scholar
• Pu S, Rodríguez-Pérez C, Ramprasath VR, Segura-Carretero A, Jones PJ. Dietary high oleic canola oil supplemented with docosahexaenoic acid attenuates plasma proprotein convertase subtilisin kexin type 9 (PCSK9) levels in participants with cardiovascular disease risk: A randomized control trial. Vasc Pharmacol. 2016;87:60–65.
   PubMed Web of Science ®Google Scholar
• Vega-López S, Ausman LM, Jalbert SM, Erkkilä AT, Lichtenstein AH. Palm and partially hydrogenated soybean oils adversely alter lipoprotein profiles compared with soybean and canola oils in moderately hyperlipidemic subjects. Am J Clin Nutr. 2006;84(1):54–62.
   PubMed Web of Science ®Google Scholar
• Wardlaw GM, Snook JT, Lin M-C, Puangco MA, Kwon JS. Serum lipid and apolipoprotein concentrations in healthy men on diets enriched in either canola oil or safflower oil. Am J Clin Nutr. 1991;54(1):104–110.
   PubMed Web of Science ®Google Scholar
• Ooi EM, Watts GF, Ng TW, Barrett PH. Effect of dietary Fatty acids on human lipoprotein metabolism: a comprehensive update. Nutrients. 2015;7(6):4416–4425.
   PubMed Web of Science ®Google Scholar
• Saedi S, Noroozi M, Khosrotabar N, Mazandarani S, Ghadrdoost B. How canola and sunflower oils affect lipid profile and anthropometric parameters of participants with dyslipidemia. MJIRI. 2017;31:23–28.
   PubMedGoogle Scholar
• Kruse M, von Loeffelholz C, Hoffmann D, Pohlmann A, Seltmann AC, Osterhoff M, Hornemann S, Pivovarova O, Rohn S, Jahreis G, Pfeiffer AF. Dietary rapeseed/canola‐oil supplementation reduces serum lipids and liver enzymes and alters postprandial inflammatory responses in adipose tissue compared to olive‐oil supplementation in obese men. Mol Nutr Food Res. 2015;59(3):507–519.
   PubMed Web of Science ®Google Scholar
• Jenkins DJ, Kendall CW, Vuksan V, Faulkner D, Augustin LS, Mitchell S, Ireland C, Srichaikul K, Mirrahimi A, Chiavaroli L, et al. Effect of lowering the glycemic load with canola oil on glycemic control and cardiovascular risk factors: a randomized controlled trial. Diabetes Care. 2014;37(7):1806–1814.
   PubMed Web of Science ®Google Scholar
• Baxheinrich A, Stratmann B, Lee-Barkey YH, Tschoepe D, Wahrburg U. Effects of a rapeseed oil-enriched hypoenergetic diet with a high content of α-linolenic acid on body weight and cardiovascular risk profile in patients with the metabolic syndrome. Br J Nutr. 2012;108(4):682–691.
   PubMed Web of Science ®Google Scholar
• Noroozi M, Zavoshy R, Hashemi HJ. The effects of low-calorie diet with canola oil on blood lipids in hyperlipidemic patients. J Food Nutr Res. 2009;48(4):626–631.
   Web of Science ®Google Scholar
• Stricker H, Duchini F, Facchini M, Mombelli G. Canola oil decreases cholesterol and improves endothelial function in patients with peripheral arterial occlusive disease–a pilot study. Artery Res. 2008;2(2):67–73.
   Google Scholar
• Karvonen HM, Aro A, Tapola NS, Salminen I, Uusitupa MI, Sarkkinen ES. Effect of [alpha]-linolenic acid [ndash] rich Camelina sativa oil on serum fatty acid composition and serum lipids in hypercholesterolemic subjects. Metab Clin Exp. 2002;51(10):1253–1260.
   PubMed Web of Science ®Google Scholar
• Junker R, Kratz M, Neufeld M, Erren M, Nofer JR, Schulte H, Nowak-Göttl U, Assmann G, Wahrburg U. Effects of diets containing olive oil, sunflower oil, or rapeseed oil on the hemostatic system. Thromb Haemost. 2001;85(2):280–286.
   PubMed Web of Science ®Google Scholar
• Sarkkinen ES, Uusitupa MI, Gylling H, Miettinen TA. Fat-modified diets influence serum concentrations of cholesterol precursors and plant sterols in hypercholesterolemic subjects. Metabolism. 1998;47(6):744–750.
   PubMed Web of Science ®Google Scholar
• Chambers KM. Assessment of the nutritional properties of regular and low linolenic acid canola oil in non-insulin-dependent (type II) diabetes mellitus subjects. 1998.
   Google Scholar
• Sundram K, Hayes K, Siru OH. Both dietary 18: 2 and 16: 0 may be required to improve the serum LDL/HDL cholesterol ratio in normocholesterolemic men. J Nutr Biochem. 1995;6(4):179–187.
   Web of Science ®Google Scholar
• McKenney JM, Proctor JD, Wright JT, Kolinski RJ, Elswick R, Coaker JS. The effect of supplemental dietary fat on plasma cholesterol levels in lovastatin‐treated hypercholesterolemic patients. Pharmacotherapy. 1995;15(5):565–572.
   PubMed Web of Science ®Google Scholar
• Uusitupa M, Schwab U, Mäkimattila S, Karhapää P, Sarkkinen E, Maliranta H, Agren J, Penttilä I. Effects of two high-fat diets with different fatty acid compositions on glucose and lipid metabolism in healthy young women. Am J Clin Nutr. 1994;59(6):715–1316.
   Web of Science ®Google Scholar
• Gustafsson I-B, Vessby B, Ohrvall M, Nydahl M. A diet rich in monounsaturated rapeseed oil reduces the lipoprotein cholesterol concentration and increases the relative content of n-3 fatty acids in serum in hyperlipidemic subjects. Am J Clin Nutr. 1994;59(3):667–674.
   PubMed Web of Science ®Google Scholar
• Seppänen-Laakso T, Vanhanen H, Laakso I, Kohtamäki H, Viikari J. Replacement of margarine on bread by rapeseed and olive oils: effects on plasma fatty acid composition and serum cholesterol. Ann Nutr Metab. 1993;37(4):161–174.
   PubMed Web of Science ®Google Scholar
• Lichtenstein AH, Ausman LM, Carrasco W, Jenner JL, Gualtieri LJ, Goldin BR, Ordovas JM, Schaefer EJ. Effects of canola, corn, and olive oils on fasting and postprandial plasma lipoproteins in humans as part of a National Cholesterol Education Program Step 2 diet. Arterioscler Thromb Vasc Biol. 1993;13(10):1533–1542.
   Google Scholar
• Valsta LM, Jauhiainen M, Aro A, Katan MB, Mutanen M. Effects of a monounsaturated rapeseed oil and a polyunsaturated sunflower oil diet on lipoprotein levels in humans. Arterioscler Thromb Vasc Biol. 1992;12(1):50–57.
   Google Scholar
• Baudet M, Jacotot B. Dietary fats and lecithin-cholesterol acyltransferase activity in healthy humans. Ann Nutr Metab. 1988;32(5-6):352–359.
   PubMed Web of Science ®Google Scholar