References
- Coelho-Aguiar JDM, Bon-Frauches AC, Gomes ALT, Veríssimo CP, Aguiar DP, Matias D, Thomasi BBDM, Gomes AS, Brito GADC, Moura-Neto V, et al. The enteric glia: identity and functions. Glia. 2015;63(6):921–35. doi:https://doi.org/10.1002/glia.22795.
- Cheadle GA, Costantini TW, Bansal V, Eliceiri BP, Coimbra R. Cholinergic signaling in the gut: a novel mechanism of barrier protection through activation of enteric glia cells. Surg Infect. 2014;15(4):387–93. doi:https://doi.org/10.1089/sur.2013.103.
- Neunlist M, Aubert P, Bonnaud S, Van Landeghem L, Coron E, Wedel T, Naveilhan P, Ruhl A, Lardeux B, Savidge T, et al. Enteric glia inhibit intestinal epithelial cell proliferation partly through a TGF-β1-dependent pathway. Am J Physiol Gastrointest Liver Physiol. 2007;292(1):G231–41. doi:https://doi.org/10.1152/ajpgi.00276.2005.
- Savidge TC, Newman P, Pothoulakis C, Ruhl A, Neunlist M, Bourreille A, Hurst R, Sofroniew MV. Enteric glia regulate intestinal barrier function and inflammation via release of S-nitrosoglutathione. Gastroenterology. 2007;132(4):1344–58. doi:https://doi.org/10.1053/j.gastro.2007.01.051.
- Turco F, Sarnelli G, Cirillo C, Palumbo I, De Giorgi F, D’Alessandro A, Cammarota M, Giuliano M, Cuomo R. Enteroglial-derived S100B protein integrates bacteria-induced Toll-like receptor signalling in human enteric glial cells. Gut. 2014;63(1):105–15. doi:https://doi.org/10.1136/gutjnl-2012-302090.
- Rosenbaum C, Schick MA, Wollborn J, Heider A, Scholz C-J, Cecil A, Niesler B, Hirrlinger J, Walles H, Metzger M, et al. Activation of myenteric glia during acute inflammation in vitro and in vivo. PLoS One. 2016;11(3):e0151335. doi:https://doi.org/10.1371/journal.pone.0151335.
- Delvalle NM, Fried DE, Rivera-Lopez G, Gaudette L, Gulbransen BD. Cholinergic activation of enteric glia is a physiological mechanism that contributes to the regulation of gastrointestinal motility. Am J Physiol Gastrointest Liver Physiol. 2018;315(4):G473–83. doi:https://doi.org/10.1152/ajpgi.00155.2018.
- McClain J, Grubišić V, Fried D, Gomez-Suarez RA, Leinninger GM, Sévigny J, Parpura V, Gulbransen BD. Ca2+ responses in enteric glia are mediated by connexin-43 hemichannels and modulate colonic transit in mice. Gastroenterology. 2014;146(2):497–507.e1. doi:https://doi.org/10.1053/j.gastro.2013.10.061.
- Bessac A, Cani PD, Meunier E, Dietrich G, Knauf C. Inflammation and gut-brain axis during type 2 diabetes: focus on the crosstalk between intestinal immune cells and enteric nervous system. Front Neurosci. 2018;12:725. doi:https://doi.org/10.3389/fnins.2018.00725.
- Bliss ES, Whiteside E. The gut-brain axis, the human gut microbiota and their integration in the development of obesity. Front Physiol. 2018;9:900. doi:https://doi.org/10.3389/fphys.2018.00900.
- Brasileiro AD, Garcia LP, de Carvalho da Silva S, Rocha LB, Pedrosa AL, Vieira AS, da Silva VJD, Rodrigues ARA. Effects of diabetes mellitus on myenteric neuronal density and sodium channel expression in the rat ileum. Brain Res. 2019;1708:1–9. doi:https://doi.org/10.1016/j.brainres.2018.11.041.
- de Souza SRG, de Miranda Neto MH, Martins Perles JVC, Vieira Frez FC, Zignani I, Ramalho FV, Hermes-Uliana C, Bossolani GDP, Zanoni JN. Antioxidant effects of the quercetin in the jejunal myenteric innervation of diabetic rats. Front Med. 2017;4:8. doi:https://doi.org/10.3389/fmed.2017.00008.
- Clairembault T, Kamphuis W, Leclair-Visonneau L, Rolli-Derkinderen M, Coron E, Neunlist M, Hol EM, Derkinderen P. Enteric GFAP expression and phosphorylation in Parkinson’s disease. J Neurochem. 2014;130(6):805–15. doi:https://doi.org/10.1111/jnc.12742.
- Stenkamp-Strahm C, Patterson S, Boren J, Gericke M, Balemba O. High-fat diet and age-dependent effects on enteric glial cell populations of mouse small intestine. Auton Neurosci. 2013;177(2):199–210. doi:https://doi.org/10.1016/j.autneu.2013.04.014.
- von Boyen GB, Schulte N, Pfluger C, Spaniol U, Hartmann C, Steinkamp M. Distribution of enteric glia and GDNF during gut inflammation. BMC Gastroenterol. 2011;11:3. doi:https://doi.org/10.1186/1471-230X-11-3.
- Qi R, Yang W, Chen J. Role of enteric glial cells in gastric motility in diabetic rats at different stages. J Huazhong Univ Sci Technol Med Sci. 2013;33(4):496–500. doi:https://doi.org/10.1007/s11596-013-1148-1.
- Cornet A, Savidge TC, Cabarrocas J, Deng WL, Colombel JF, Lassmann H, Desreumaux P, Liblau RS. Enterocolitis induced by autoimmune targeting of enteric glial cells: a possible mechanism in Crohn’s disease? Proc Natl Acad Sci USA. 2001;98(23):13306–11. doi:https://doi.org/10.1073/pnas.231474098.
- Cheadle GA, Costantini TW, Lopez N, Bansal V, Eliceiri BP, Coimbra R. Enteric glia cells attenuate cytomix-induced intestinal epithelial barrier breakdown. PLoS One. 2013;8(7):e69042. doi:https://doi.org/10.1371/journal.pone.0069042.
- Esposito G, Capoccia E, Turco F, Palumbo I, Lu J, Steardo A, Cuomo R, Sarnelli G, Steardo L. Palmitoylethanolamide improves colon inflammation through an enteric glia/toll like receptor 4-dependent PPAR-α activation. Gut. 2014;63(8):1300–12. doi:https://doi.org/10.1136/gutjnl-2013-305005.
- Yamane S, Kanno T, Nakamura H, Fujino H, Murayama T. Hydrogen sulfide-mediated regulation of contractility in the mouse ileum with electrical stimulation: roles of L-cysteine, cystathionine β-synthase, and K+ channels. Eur J Pharmacol. 2014;740:112–20. doi:https://doi.org/10.1016/j.ejphar.2014.06.054.
- Velickovic K, Markelic M, Golic I, Otasevic V, Stancic A, Jankovic A, Vucetic M, Buzadzic B, Korac B, Korac A, et al. Long-term dietary L-arginine supplementation increases endothelial nitric oxide synthase and vasoactive intestinal peptide immunoexpression in rat small intestine. Eur J Nutr. 2014;53(3):813–21. doi:https://doi.org/10.1007/s00394-013-0585-8.
- Baudry C, Reichardt F, Marchix J, Bado A, Schemann M, Des Varannes SB, Neunlist M, Moriez R. Diet-induced obesity has neuroprotective effects in murine gastric enteric nervous system: involvement of leptin and glial cell line-derived neurotrophic factor. J Physiol. 2012;590(3):533–44. doi:https://doi.org/10.1113/jphysiol.2011.219717.
- di Giancamillo A, Vitari F, Bosi G, Savoini G, Domeneghini C. The chemical code of porcine enteric neurons and the number of enteric glial cells are altered by dietary probiotics. Neurogastroenterol Motil. 2010;22(9):e271–8. doi:https://doi.org/10.1111/j.1365-2982.2010.01529.x.
- Pereira RV, Tronchini EA, Tashima CM, Alves EP, Lima MM, Zanoni JN. L-glutamine supplementation prevents myenteric neuron loss and has gliatrophic effects in the ileum of diabetic rats. Dig Dis Sci. 2011;56(12):3507–16. doi:https://doi.org/10.1007/s10620-011-1806-8.
- Ferreira PEB, Beraldi EJ, Borges SC, Natali MRM, Buttow NC. Resveratrol promotes neuroprotection and attenuates oxidative and nitrosative stress in the small intestine in diabetic rats. Biomed Pharmacother. 2018;105:724–33. doi:https://doi.org/10.1016/j.biopha.2018.06.030.
- Panizzon CPDNB, Zanoni JN, Hermes-Uliana C, Trevizan AR, Sehaber CC, Pereira RVF, Linden DR, Neto MHDM. Desired and side effects of the supplementation with l-glutamine and l-glutathione in enteric glia of diabetic rats. Acta Histochem. 2016;118(6):625–31. doi:https://doi.org/10.1016/j.acthis.2016.07.008.
- Piovezana Bossolani GD, Silva BT, Colombo Martins Perles JV, Lima MM, Vieira Frez FC, Garcia de Souza SR, Sehaber-Sierakowski CC, Bersani-Amado CA, Zanoni JN. Rheumatoid arthritis induces enteric neurodegeneration and jejunal inflammation, and quercetin promotes neuroprotective and anti-inflammatory actions. Life Sci. 2019;238:116956. doi:https://doi.org/10.1016/j.lfs.2019.116956.
- do Nascimento Bonato Panizzon CP, de Miranda Neto MH, Ramalho FV, Longhini R, de Mello JCP, Zanoni JN. Ethyl acetate fraction from Trichilia catigua confers partial neuroprotection in components of the enteric innervation of the jejunum in diabetic rats. Cell Physiol Biochem. 2019;53(1):76–86.
- Stockler-Pinto MB, Mafra D, Farage NE, Boaventura GT, Cozzolino SM. Effect of Brazil nut supplementation on the blood levels of selenium and glutathione peroxidase in hemodialysis patients. Nutrition. 2010;26(11–12):1065–9. doi:https://doi.org/10.1016/j.nut.2009.08.006.
- Stockler-Pinto MB, Lobo J, Moraes C, Leal VO, Farage NE, Rocha AV, Boaventura GT, Cozzolino SMF, Malm O, Mafra D, et al. Effect of Brazil nut supplementation on plasma levels of selenium in hemodialysis patients: 12 months of follow-up. J Renal Nutr. 2012;22(4):434–9. doi:https://doi.org/10.1053/j.jrn.2011.08.011.
- Stockler-Pinto MB, Mafra D, Moraes C, Lobo J, Boaventura GT, Farage NE, Silva WS, Cozzolino SF, Malm O. Brazil nut (Bertholletia excelsa, H.B.K.) improves oxidative stress and inflammation biomarkers in hemodialysis patients. Biol Trace Elem Res. 2014;158(1):105–12. doi:https://doi.org/10.1007/s12011-014-9904-z.
- Strunz CC, Oliveira TV, Vinagre JC, Lima A, Cozzolino S, Maranhao RC. Brazil nut ingestion increased plasma selenium but had minimal effects on lipids, apolipoproteins, and high-density lipoprotein function in human subjects. Nutr Res. 2008;28(3):151–5. doi:https://doi.org/10.1016/j.nutres.2008.01.004.
- Cominetti C, de Bortoli MC, Garrido AB Jr., Cozzolino SM. Brazilian nut consumption improves selenium status and glutathione peroxidase activity and reduces atherogenic risk in obese women. Nutr Res. 2012;32(6):403–7. doi:https://doi.org/10.1016/j.nutres.2012.05.005.
- Schott KL, Assmann CE, Teixeira CF, Boligon AA, Waechter SR, Duarte FA, Ribeiro EE, da Cruz IBM. Brazil nut improves the oxidative metabolism of superoxide-hydrogen peroxide chemically-imbalanced human fibroblasts in a nutrigenomic manner. Food Chem Toxicol. 2018;121:519–26. doi:https://doi.org/10.1016/j.fct.2018.09.038.
- Carvalho RF, Huguenin GV, Luiz RR, Moreira AS, Oliveira GM, Rosa G. Intake of partially defatted Brazil nut flour reduces serum cholesterol in hypercholesterolemic patients – a randomized controlled trial. Nutr J. 2015;14:59. doi:https://doi.org/10.1186/s12937-015-0036-x.
- Maranhão PA, Kraemer-Aguiar LG, de Oliveira CL, Kuschnir MC, Vieira YR, Souza MG, Koury JC, Bouskela E. Brazil nuts intake improves lipid profile, oxidative stress and microvascular function in obese adolescents: a randomized controlled trial. Nutr Metab. 2011;8(1):32. doi:https://doi.org/10.1186/1743-7075-8-32.
- Hu Y, McIntosh GH, Le Leu RK, Somashekar R, Meng XQ, Gopalsamy G, Bambaca L, McKinnon RA, Young GP. Supplementation with Brazil nuts and green tea extract regulates targeted biomarkers related to colorectal cancer risk in humans. Br J Nutr. 2016;116(11):1901–11. doi:https://doi.org/10.1017/S0007114516003937.
- National Institute of Health (NIH). Guide for the care and use of laboratory animals. Guide for the care and use of laboratory animals. Washington (DC): National Academies Press (US); 1996.
- Borges SC, da Silva de Souza AC, Beraldi EJ, Schneider LC, Buttow NC. Resveratrol promotes myenteric neuroprotection in the ileum of rats after ischemia-reperfusion injury. Life Sci. 2016;166:54–9. doi:https://doi.org/10.1016/j.lfs.2016.09.016.
- Mendes CE, Palombit K, Tavares-de-Lima W, Castelucci P. Enteric glial cells immunoreactive for P2X7 receptor are affected in the ileum following ischemia and reperfusion. Acta Histochem. 2019;121(6):665–79. doi:https://doi.org/10.1016/j.acthis.2019.06.001.
- Schoffen JPF, Santi Rampazzo AP, Cirilo CP, Zapater MCU, Vicentini FA, Comar JF, Bracht A, Natali MRM. Food restriction enhances oxidative status in aging rats with neuroprotective effects on myenteric neuron populations in the proximal colon. Exp Gerontol. 2014;51:54–64. doi:https://doi.org/10.1016/j.exger.2014.01.001.
- Trevizan AR, Schneider LCL, Araújo EJDA, Garcia JL, Buttow NC, Nogueira-Melo GDA, Sant’Ana DDMG. Acute Toxoplasma gondii infection alters the number of neurons and the proportion of enteric glial cells in the duodenum in Wistar rats. Neurogastroenterol Motil. 2019;31(3):e13523. doi:https://doi.org/10.1111/nmo.13523.
- Zhu HC, Zhao J, Luo CY, Li QQ. Gastrointestinal dysfunction in a Parkinson’s disease rat model and the changes of dopaminergic, nitric oxidergic, and cholinergic neurotransmitters in myenteric plexus. J Mol Neurosci. 2012;47(1):15–25. doi:https://doi.org/10.1007/s12031-011-9560-0.
- Burgess A, Vigneron S, Brioudes E, Labbe JC, Lorca T, Castro A. Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance. Proc Natl Acad Sci USA. 2010;107(28):12564–9. doi:https://doi.org/10.1073/pnas.0914191107.
- Avery JC, Hoffmann PR. Selenium, selenoproteins, and immunity. Nutrients. 2018;10(9):1203. doi:https://doi.org/10.3390/nu10091203.
- Kiełczykowska M, Kocot J, Paździor M, Musik I. Selenium – a fascinating antioxidant of protective properties. Adv Clin Exp Med. 2018;27(2):245–55. doi:https://doi.org/10.17219/acem/67222.
- Steinbrenner H, Al-Quraishy S, Dkhil MA, Wunderlich F, Sies H. Dietary selenium in adjuvant therapy of viral and bacterial infections. Adv Nutr. 2015;6(1):73–82. doi:https://doi.org/10.3945/an.114.007575.
- Hadrup N, Loeschner K, Mandrup K, Ravn-Haren G, Frandsen HL, Larsen EH, Lam HR, Mortensen A. Subacute oral toxicity investigation of selenium nanoparticles and selenite in rats. Drug Chem Toxicol. 2019;42(1):76–83. doi:https://doi.org/10.1080/01480545.2018.1491589.
- Kim JE, Choi SI, Lee HR, Hwang IS, Lee YJ, An BS, Lee SH, Kim HJ, Kang BC, Hwang DY. Selenium significantly inhibits adipocyte hypertrophy and abdominal fat accumulation in OLETF rats via induction of fatty acid β-oxidation. Biol Trace Elem Res. 2012;150(1–3):360–70. doi:https://doi.org/10.1007/s12011-012-9519-1.
- Wang X, Zhang W, Chen H, Liao N, Wang Z, Zhang X, Hai C. High selenium impairs hepatic insulin sensitivity through opposite regulation of ROS. Toxicol Lett. 2014;224(1):16–23. doi:https://doi.org/10.1016/j.toxlet.2013.10.005.
- Cardoso BR, Duarte GBS, Reis BZ, Cozzolino SMF. Brazil nuts: nutritional composition, health benefits and safety aspects. Food Res Int. 2017;100(Pt 2):9–18. doi:https://doi.org/10.1016/j.foodres.2017.08.036.
- Little TJ, Russo A, Meyer JH, Horowitz M, Smyth DR, Bellon M, Wishart JM, Jones KL, Feinle-Bisset C. Free fatty acids have more potent effects on gastric emptying, gut hormones, and appetite than triacylglycerides. Gastroenterology. 2007;133(4):1124–31. doi:https://doi.org/10.1053/j.gastro.2007.06.060.
- Muller M, Canfora EE, Blaak EE. Gastrointestinal transit time, glucose homeostasis and metabolic health: modulation by dietary fibers. Nutrients. 2018;10(3):275.
- Grubisic V, Verkhratsky A, Zorec R, Parpura V. Enteric glia regulate gut motility in health and disease. Brain Res Bull. 2018;136:109–17. doi:https://doi.org/10.1016/j.brainresbull.2017.03.011.
- Sharkey KA. Emerging roles for enteric glia in gastrointestinal disorders. J Clin Invest. 2015;125(3):918–25. doi:https://doi.org/10.1172/JCI76303.
- Aubé A-C, Cabarrocas J, Bauer J, Philippe D, Aubert P, Doulay F, Liblau R, Galmiche JP, Neunlist M. Changes in enteric neurone phenotype and intestinal functions in a transgenic mouse model of enteric glia disruption. Gut. 2006;55(5):630–7. doi:https://doi.org/10.1136/gut.2005.067595.
- Bassotti G, Villanacci V, Cathomas G, Maurer CA, Fisogni S, Cadei M, Baron L, Morelli A, Valloncini E, Salerni B. Enteric neuropathology of the terminal ileum in patients with intractable slow-transit constipation. Hum Pathol. 2006;37(10):1252–8. doi:https://doi.org/10.1016/j.humpath.2006.04.027.
- Bassotti G, Villanacci V, Fisogni S, Rossi E, Baronio P, Clerici C, Maurer CA, Cathomas G, Antonelli E. Enteric glial cells and their role in gastrointestinal motor abnormalities: introducing the neuro-gliopathies. World J Gastroenterol. 2007;13(30):4035–41. doi:https://doi.org/10.3748/wjg.v13.i30.4035.
- Cossais F, Durand T, Chevalier J, Boudaud M, Kermarrec L, Aubert P, Neveu I, Naveilhan P, Neunlist M. Postnatal development of the myenteric glial network and its modulation by butyrate. Am J Physiol Gastrointest Liver Physiol. 2016;310(11):G941–51. doi:https://doi.org/10.1152/ajpgi.00232.2015.
- John JA, Shahidi F. Phenolic compounds and antioxidant activity of Brazil nut (Bertholletia excelsa). J Funct Foods. 2010;2(3):196–209. doi:https://doi.org/10.1016/j.jff.2010.04.008.
- de Oliveira MR. The effects of ellagic acid upon brain cells: a mechanistic view and future directions. Neurochem Res. 2016;41(6):1219–28. doi:https://doi.org/10.1007/s11064-016-1853-9.
- Wang GQ, He XM, Zhu GF, Li DD, Shi JS, Zhang F. Ellagic acid supports neuron by regulating astroglia Nrf2. Biotechnol Appl Biochem. 2019;66(5):738–43. doi:https://doi.org/10.1002/bab.1791.
- Abdo H, Mahe MM, Derkinderen P, Bach-Ngohou K, Neunlist M, Lardeux B. The omega-6 fatty acid derivative 15-deoxy-Δ12,14-prostaglandin J2 is involved in neuroprotection by enteric glial cells against oxidative stress. J Physiol. 2012;590(11):2739–50. doi:https://doi.org/10.1113/jphysiol.2011.222935.
- De Quelen F, Chevalier J, Rolli-Derkinderen M, Mourot J, Neunlist M, Boudry G. N-3 polyunsaturated fatty acids in the maternal diet modify the postnatal development of nervous regulation of intestinal permeability in piglets. J Physiol. 2011;589(17):4341–52. doi:https://doi.org/10.1113/jphysiol.2011.214056.
- Rahn J, Lennicke C, Kipp AP, Müller AS, Wessjohann LA, Lichtenfels R, Seliger B. Altered protein expression pattern in colon tissue of mice upon supplementation with distinct selenium compounds. Proteomics. 2017;17(11):1600486. doi:https://doi.org/10.1002/pmic.201600486.
- von Boyen GB, Steinkamp M, Reinshagen M, Schafer KH, Adler G, Kirsch J. Proinflammatory cytokines increase glial fibrillary acidic protein expression in enteric glia. Gut. 2004;53(2):222–8. doi:https://doi.org/10.1136/gut.2003.012625.
- Verma S, Hoffmann FW, Kumar M, Huang Z, Roe K, Nguyen-Wu E, Hashimoto AS, Hoffmann PR. Selenoprotein K knockout mice exhibit deficient calcium flux in immune cells and impaired immune responses. J Immunol. 2011;186(4):2127–37. doi:https://doi.org/10.4049/jimmunol.1002878.
- Adebayo OL, Sandhir R, Adenuga GA. Protective roles of selenium and zinc against postnatal protein-undernutrition-induced alterations in Ca2+-homeostasis leading to cognitive deficits in Wistar rats. Int J Dev Neurosci. 2015;43(1):1–7. doi:https://doi.org/10.1016/j.ijdevneu.2015.03.007.
- Broadhead MJ, Bayguinov PO, Okamoto T, Heredia DJ, Smith TK. Ca2+ transients in myenteric glial cells during the colonic migrating motor complex in the isolated murine large intestine. J Physiol. 2012;590(2):335–50. doi:https://doi.org/10.1113/jphysiol.2011.219519.
- McMenamin CA, Clyburn C, Browning KN. High-fat diet during the perinatal period induces loss of myenteric nitrergic neurons and increases enteric glial density, prior to the development of obesity. Neuroscience. 2018;393:369–80. doi:https://doi.org/10.1016/j.neuroscience.2018.09.033.