Cholesterol Conjugated Uniform and Gapmer Phosphorothioate Oligonucleotides Targeted Against PKC-α and C-raf Gene Expression

Muthiah Manoharan Isis Pharmaceuticals, 2292 Faraday Avenue, Carlsbad, CA, 92008, USA

Kathleen L. Tivel Isis Pharmaceuticals, 2292 Faraday Avenue, Carlsbad, CA, 92008, USA

Gopal Inamati Isis Pharmaceuticals, 2292 Faraday Avenue, Carlsbad, CA, 92008, USA

Brett P. Monia Isis Pharmaceuticals, 2292 Faraday Avenue, Carlsbad, CA, 92008, USA

Nick Dean Isis Pharmaceuticals, 2292 Faraday Avenue, Carlsbad, CA, 92008, USA

P. Dan Cook Isis Pharmaceuticals, 2292 Faraday Avenue, Carlsbad, CA, 92008, USA

REFERENCES

Monia , B. P. , Johnston , J. F. , Geiger , T. , Muller , M. and Fahbro , D. 1996 . Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase . Nature Med. , 2 : 668 – 675 .
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Dean , N. M. , McKay , R. , Miraglia , L. , Geiger , T. , Muller , M. , Fabbro , D. and Bennett , C. F. 1996 . Antisense oligonucleotides as inhihitors of signal transduction: Development from research tools to therapeutic agents . Biochem. Soc. Trans. , 24 : 623 – 629 .
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Cholesterol Conjugated Uniform and Gapmer Phosphorothioate Oligonucleotides Targeted Against PKC-α and C-raf Gene Expression

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Cholesterol Conjugated Uniform and Gapmer Phosphorothioate Oligonucleotides Targeted Against PKC-α and C-raf Gene Expression

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