The Pronucleotide Approach. I. Synthesis, Anti-HIV Activity and Preliminary Stability Studies of Mononucleoside S,S′-Bis(O-acyl-2-oxyethyl) Phosphorodithiolates

N. Schlienger Laboratoire de Chimie Bioorganique, UMR CNRS-USTL 5625, Université Montpellier II, Case courrier 008, Place E. Bataillon, 34095, Montpellier, Cedex 5, France

C. Périgaud Laboratoire de Chimie Bioorganique, UMR CNRS-USTL 5625, Université Montpellier II, Case courrier 008, Place E. Bataillon, 34095, Montpellier, Cedex 5, France

G. Gosselin Laboratoire de Chimie Bioorganique, UMR CNRS-USTL 5625, Université Montpellier II, Case courrier 008, Place E. Bataillon, 34095, Montpellier, Cedex 5, France

I. Lefebvre Laboratoire de Chimie Bioorganique, UMR CNRS-USTL 5625, Université Montpellier II, Case courrier 008, Place E. Bataillon, 34095, Montpellier, Cedex 5, France

A. Pompon Laboratoire de Chimie Bioorganique, UMR CNRS-USTL 5625, Université Montpellier II, Case courrier 008, Place E. Bataillon, 34095, Montpellier, Cedex 5, France

A.-M. Aubertin Laboratoire de Chimie Bioorganique, UMR CNRS-USTL 5625, Université Montpellier II, Case courrier 008, Place E. Bataillon, 34095, Montpellier, Cedex 5, France

A. Kirn Université Louis Pasteur, Institut de Virologie, INSERM U 74, 67000, Strasbourg, France

J.-L. Imbach Laboratoire de Chimie Bioorganique, UMR CNRS-USTL 5625, Université Montpellier II, Case courrier 008, Place E. Bataillon, 34095, Montpellier, Cedex 5, France

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REFERENCES

Lefebvre , I , Périgaud , C. , Pompon , A. , Aubertin , A-M. , Crrardet , J-L. , Kim , A. , Gosselin , G. and Imbach , J-L. 1995 . J. Med Chem , 38 : 3941
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Wiesler , W T , Marshall , W S and Caruthers , M. H. 1993 . Methods in Molecular Biology: Protocolt for, ucleotieds and Analog , Edited by: Agrawal , S. Vol 20 , 191 Totowa : Humana Press Inc. .
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The Pronucleotide Approach. I. Synthesis, Anti-HIV Activity and Preliminary Stability Studies of Mononucleoside S,S′-Bis(O-acyl-2-oxyethyl) Phosphorodithiolates

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The Pronucleotide Approach. I. Synthesis, Anti-HIV Activity and Preliminary Stability Studies of Mononucleoside S,S′-Bis(O-acyl-2-oxyethyl) Phosphorodithiolates

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