EHD2 Overexpression Suppresses the Proliferation, Migration, and Invasion in Human Colon Cancer

References

• Ferlay J, Colombet M, Soerjomataram I, Mathers C, Parkin DM, Piñeros M, et al. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 2019;144(8):1941–1953. doi:10.1002/ijc.31937.
   PubMed Web of Science ®Google Scholar
• Islami F, Goding Sauer A, Miller KD, Siegel RL, Fedewa SA, Jacobs EJ, et al. Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States. CA Cancer J Clin. 2018;68(1):31–54. doi:10.3322/caac.21440.
   PubMed Web of Science ®Google Scholar
• Siegel RL, Miller KD, Fedewa SA, Ahnen DJ, Meester RGS, Barzi A, et al. Colorectal cancer statistics, 2017. CA Cancer J Clin. 2017;67(3):177–93. doi:10.3322/caac.21395.
   PubMed Web of Science ®Google Scholar
• Novello M, Mandarino FV, Di Saverio S, Gori D, Lugaresi M, Duchi A, et al. Post-operative outcomes and predictors of mortality after colorectal cancer surgery in the very elderly patients. Heliyon. 2019;5(8):e02363. doi:10.1016/j.heliyon.2019.e02363.
   PubMed Web of Science ®Google Scholar
• Di Saverio S, Birindelli A, Segalini E, Novello M, Larocca A, Ferrara F, et al. “To stent or not to stent?”: immediate emergency surgery with laparoscopic radical colectomy with CME and primary anastomosis is feasible for obstructing left colon carcinoma. Surg Endosc. 2018;32(4):2151–2155. doi:10.1007/s00464-017-5763-y.
   PubMed Web of Science ®Google Scholar
• Bender U, Rho YS, Barrera I, Aghajanyan S, Acoba J, Kavan P. Adjuvant therapy for stages II and III colon cancer: risk stratification, treatment duration, and future directions. Curr Oncol. 2019;26(Suppl 1):S43–S52. doi:10.3747/co.26.5605.
   PubMedGoogle Scholar
• Carethers JM. Clinical and genetic factors to inform reducing colorectal cancer disparitites in African Americans. Front Oncol. 2018;8:531. doi:10.3389/fonc.2018.00531.
   PubMed Web of Science ®Google Scholar
• Lentini A, Abbruzzese A, Provenzano B, Tabolacci C, Beninati S. Transglutaminases: key regulators of cancer metastasis. Amino Acids. 2013;44(1):25–32. doi:10.1007/s00726-012-1229-7.
   PubMed Web of Science ®Google Scholar
• Chung CL, Tai SB, Hu TH, Chen JJ, Chen CL. Roles of myosin-mediated membrane trafficking in TGF-β signaling. IJMS. 2019;20(16):3913. doi:10.3390/ijms20163913.
   Google Scholar
• Shaughnessy R, Echard A. Rab35 GTPase and cancer: linking membrane trafficking to tumorigenesis. Traffic. 2018;19(4):247–252. doi:10.1111/tra.12546.
   PubMed Web of Science ®Google Scholar
• Revelo NH, ter Beest M, van den Bogaart G. Membrane trafficking as an active regulator of constitutively secreted cytokines. J Cell Sci. 2020;133(5):jcs234781. doi:10.1242/jcs.234781.
   Web of Science ®Google Scholar
• Guilherme A, Soriano NA, Bose S, Holik J, Bose A, Pomerleau DP, et al. EHD2 and the novel EH domain binding protein EHBP1 couple endocytosis to the actin cytoskeleton. J Biol Chem. 2004;279(11):10593–10605. doi:10.1074/jbc.M307702200.
   PubMed Web of Science ®Google Scholar
• Simone LC, Naslavsky N, Caplan S. Scratching the surface: actin’ and other roles for the CT terminal Eps15 homology domain protein, EHD2. Histol Histopathol. 2014;29(3):285.
   PubMed Web of Science ®Google Scholar
• Nicolson GL. Cell membrane fluid-mosaic structure and cancer metastasis. Cancer Res. 2015;75(7):1169–1176. doi:10.1158/0008-5472.CAN-14-3216.
   PubMed Web of Science ®Google Scholar
• Doherty KR, Demonbreun AR, Wallace GQ, Cave A, Posey AD, Heretis K, et al. The endocytic recycling protein EHD2 interacts with myoferlin to regulate myoblast fusion. J Biol Chem. 2008;283(29):20252–20260. doi:10.1074/jbc.M802306200.
   PubMed Web of Science ®Google Scholar
• Yang X, Ren H, Yao L, Chen X, He A. Role of EHD2 in migration and invasion of human breast cancer cells. Tumour Biol. 2015;36(5):3717–3726. doi:10.1007/s13277-014-3011-9.
   PubMedGoogle Scholar
• Liu J, Ni W, Qu L, Cui X, Lin Z, Liu Q, et al. Decreased expression of EHD2 promotes tumor metastasis and indicates poor prognosis in hepatocellular carcinoma. Dig Dis Sci. 2016;61(9):2554–2567. doi:10.1007/s10620-016-4202-6.
   PubMed Web of Science ®Google Scholar
• Bignotti E, Tassi RA, Calza S, Ravaggi A, Romani C, Rossi E, et al. Differential gene expression profiles between tumor biopsies and short-term primary cultures of ovarian serous carcinomas: identification of novel molecular biomarkers for early diagnosis and therapy. Gynecol Oncol. 2006;103(2):405–416. doi:10.1016/j.ygyno.2006.03.056.
   PubMed Web of Science ®Google Scholar
• Li M, Yang X, Zhang J, Shi H, Hang Q, Huang X, et al. Effects of EHD2 interference on migration of esophageal squamous cell carcinoma. Med Oncol. 2013;30(1):396. doi:10.1007/s12032-012-0396-4.
   PubMed Web of Science ®Google Scholar
• Kim Y, Kim MH, Jeon S, Kim J, Kim C, Bae JS, et al. Prognostic implication of histological features associated with EHD2 expression in papillary thyroid carcinoma. PLoS One. 2017;12(3):e0174737. doi:10.1371/journal.pone.0174737.
   PubMed Web of Science ®Google Scholar
• Liu C, Liu S, Wang L, Wang Y, Li Y, Cui Y. Effect of EH domain containing protein 2 on the biological behavior of clear cell renal cell carcinoma. Hum Exp Toxicol. 2019;38(8):927–937. doi:10.1177/0960327119842241.
   PubMed Web of Science ®Google Scholar
• Lv J, Fan N, Wang Y, Wang X, Gao C. Identification of differentially expressed proteins of normal and cancerous human colorectal tissues by liquid chromatograph-mass spectrometer based on iTRAQ approach. Cancer Invest. 2015;33(9):420–428. doi:10.3109/07357907.2015.1055757.
   PubMed Web of Science ®Google Scholar
• Sobin LH, Compton CC. TNM seventh edition: what's new, what's changed: communication from the International Union Against Cancer and the American Joint Committee on Cancer. Cancer. 2010;116(22):5336–5339. doi:10.1002/cncr.25537.
   PubMed Web of Science ®Google Scholar
• Chandrashekar DS, Bashel B, Balasubramanya SAH, Creighton CJ, Ponce-Rodriguez I, Chakravarthi BVSK, et al. UALCAN: a portal for facilitating tumor subgroup gene expression and survival analyses. Neoplasia. 2017;19(8):649–658. doi:10.1016/j.neo.2017.05.002.
   PubMed Web of Science ®Google Scholar
• Fei W, Liu S, Hu X. High FOXRED1 expression predicted good prognosis of colorectal cancer. Am J Cancer Res. 2016;6(11):2722.
   PubMed Web of Science ®Google Scholar
• Liu Z, Guan C, Lu C, Liu Y, Ni R, Xiao M, et al. High NUSAP1 expression predicts poor prognosis in colon cancer. Pathol Res Pract. 2018;214(7):968–973. doi:10.1016/j.prp.2018.05.017.
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25(4):402–408. doi:10.1006/meth.2001.1262.
   PubMed Web of Science ®Google Scholar
• Maritzen T, Schachtner H, Legler DF. On the move: endocytic trafficking in cell migration. Cell Mol Life Sci. 2015;72(11):2119–2134. doi:10.1007/s00018-015-1855-9.
   PubMed Web of Science ®Google Scholar
• Naslavsky N, Caplan S. EHD proteins: key conductors of endocytic transport. Trends Cell Biol. 2011;21(2):122–31. doi:10.1016/j.tcb.2010.10.003.
   PubMed Web of Science ®Google Scholar
• Yang HQ, Jana K, Rindler MJ, Coetzee WA. The trafficking protein, EHD2, positively regulates cardiac sarcolemmal KATP channel surface expression: role in cardioprotection. Faseb J. 2018;32(3):1613–1625. doi:10.1096/fj.201700027R.
   PubMed Web of Science ®Google Scholar
• Rotem-Yehudar R, Galperin E, Horowitz M. Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29. J Biol Chem. 2001;276(35):33054–33060. doi:10.1074/jbc.M009913200.
   PubMed Web of Science ®Google Scholar
• Benjamin S, Weidberg H, Rapaport D, Pekar O, Nudelman M, Segal D, et al. EHD2 mediates trafficking from the plasma membrane by modulating Rac1 activity. Biochem J. 2011;439(3):433–445.
   PubMedGoogle Scholar
• Pastushenko I, Blanpain C. EMT transition states during tumor progression and metastasis. Trends Cell Biol. 2019;29(3):212–226. doi:10.1016/j.tcb.2018.12.001.
   PubMed Web of Science ®Google Scholar
• Gan WJ, Wang JR, Zhu XL, He XS, Guo PD, Zhang S, et al. RARγ-induced E-cadherin downregulation promotes hepatocellular carcinoma invasion and metastasis. J Exp Clin Cancer Res. 2016;35(1):164. doi:10.1186/s13046-016-0441-9.
   PubMed Web of Science ®Google Scholar
• Shi Y, Liu X, Sun Y, Wu D, Qiu A, Cheng H, et al. Decreased expression and prognostic role of EHD2 in human breast carcinoma: correlation with E-cadherin. J Mol Hist. 2015;46(2):221–231. doi:10.1007/s10735-015-9614-7.
   PubMed Web of Science ®Google Scholar
• Van Roy F, Berx G. The cell-cell adhesion molecule E-cadherin. Cell Mol Life Sci. 2008;65(23):3756–3788. doi:10.1007/s00018-008-8281-1.
   PubMed Web of Science ®Google Scholar