LncRNA LINC00958 Activates mTORC1/P70S6K Signalling Pathway to Promote Epithelial-Mesenchymal Transition Process in the Hepatocellular Carcinoma

References

• Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. doi:10.3322/caac.21492.
   PubMed Web of Science ®Google Scholar
• Altekruse SF, Devesa SS, Dickie LA, McGlynn KA, Kleiner DE. Histological classification of liver and intrahepatic bile duct cancers in SEER registries. J Registry Manag. 2011;38(4):201–5.
   PubMedGoogle Scholar
• Cheng D, Deng J, Zhang B, He X, Meng Z, Li G, et al. LncRNA HOTAIR epigenetically suppresses miR-122 expression in hepatocellular carcinoma via DNA methylation. EBioMedicine. 2018;36:159–70. doi:10.1016/j.ebiom.2018.08.055.
   PubMed Web of Science ®Google Scholar
• Wallace MC, Preen D, Jeffrey GP, Adams LA. The evolving epidemiology of hepatocellular carcinoma: a global perspective. Expert Rev Gastroenterol Hepatol. 2015;9(6):765–79. doi:10.1586/17474124.2015.1028363.
   PubMed Web of Science ®Google Scholar
• Chen M, Xu Z, Zhang Y, Zhang X. LINC00958 promotes the malignancy of nasopharyngeal carcinoma by sponging microRNA-625 and thus upregulating NUAK1. Onco Targets Ther. 2019;12:9277–90. doi:10.2147/OTT.S216342.
   PubMed Web of Science ®Google Scholar
• Huang S, Zhan Z, Li L, Guo H, Yao Y, Feng M, et al. LINC00958-MYC positive feedback loop modulates resistance of head and neck squamous cell carcinoma cells to chemo- and radiotherapy in vitro. Onco Targets Ther. 2019;12:5989–6000. doi:10.2147/OTT.S208318.
   PubMed Web of Science ®Google Scholar
• Xiong D, Wu W, Kan L, Chen D, Dou X, Ji X, et al. LINC00958 and HOXC13-AS as key candidate biomarkers in head and neck squamous cell carcinoma by integrated bioinformatics analysis. PeerJ. 2020;8:e8557-e8557. doi:10.7717/peerj.8557.
   Web of Science ®Google Scholar
• Seitz AK, Christensen LL, Christensen E, Faarkrog K, Ostenfeld MS, Hedegaard J, et al. Profiling of long non-coding RNAs identifies LINC00958 and LINC01296 as candidate oncogenes in bladder cancer. Sci Rep. 2017;7(1):395. doi:10.1038/s41598-017-00327-0.
   PubMed Web of Science ®Google Scholar
• Bessman MJ, Frick DN, O’Handley SF. The MutT proteins or “Nudix” hydrolases, a family of versatile, widely distributed, “housecleaning” enzymes. J Biol Chem. 1996;271(41):25059–25062. doi:10.1074/jbc.271.41.25059.
   PubMed Web of Science ®Google Scholar
• Xu W, Dunn CA, Jones CR, D’Souza G, Bessman MJ. The 26 Nudix hydrolases of Bacillus cereus, a close relative of Bacillus anthracis. J Biol Chem. 2004;279(23):24861–24865. doi:10.1074/jbc.M403272200.
   PubMed Web of Science ®Google Scholar
• Song MG, Bail S, Kiledjian M. Multiple Nudix family proteins possess mRNA decapping activity. RNA. 2013;19(3):390–399. doi:10.1261/rna.037309.112.
   PubMed Web of Science ®Google Scholar
• Takagi Y, Setoyama D, Ito R, Kamiya H, Yamagata Y, Sekiguchi M. Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2. J Biol Chem. 2012;287(25):21541–21549. doi:10.1074/jbc.M112.363010.
   PubMed Web of Science ®Google Scholar
• Shumar SA, Kerr EW, Geldenhuys WJ, Montgomery GE, Fagone P, Thirawatananond P, et al. Nudt19 is a renal CoA diphosphohydrolase with biochemical and regulatory properties that are distinct from the hepatic Nudt7 isoform. J Biol Chem. 2018;293(11):4134–4148. doi:10.1074/jbc.RA117.001358.
   PubMed Web of Science ®Google Scholar
• Tang X, Zhang W, Ye Y, Li H, Cheng L, Zhang M, et al. LncRNA hotair contributes to sorafenib resistance through suppressing miR-217 in hepatic carcinoma. Biomed Res Int. 2020;2020:1–10. doi:10.1155/2020/9515071.
   Web of Science ®Google Scholar
• Peng N, He J, Li J, Huang H, Huang W, Liao Y, et al. Long noncoding RNA MALAT1 inhibits the apoptosis and autophagy of hepatocellular carcinoma cell by targeting the microRNA-146a/PI3K/Akt/mTOR axis. Cancer Cell Int. 2020;20(1):165. doi:10.1186/s12935-020-01231-w.
   PubMed Web of Science ®Google Scholar
• Ofman R, Speijer D, Leen R, Wanders RJA. Proteomic analysis of mouse kidney peroxisomes: identification of RP2p as a peroxisomal nudix hydrolase with acyl-CoA diphosphatase activity. Biochem J. 2006;393(Pt 2):537–543. doi:10.1042/BJ20050893.
   PubMedGoogle Scholar
• Gasmi L, McLennan AG. The mouse Nudt7 gene encodes a peroxisomal nudix hydrolase specific for coenzyme A and its derivatives. Biochem J. 2001;357(1):33–38. doi:10.1042/bj3570033.
   PubMedGoogle Scholar
• Lee JM, Dedhar S, Kalluri R, Thompson EW. The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J Cell Biol. 2006;172(7):973–981. doi:10.1083/jcb.200601018.
   PubMed Web of Science ®Google Scholar
• Nieto MA, Huang RY, Jackson RA, Thiery JE. EMT: 2016. Cell. 2016;166(1):21–45. doi:10.1016/j.cell.2016.06.028.
   PubMed Web of Science ®Google Scholar
• Li M, Wu J, Zhang P. Research progress of application of E-cadherin, N-Cadherin and Vimentin in tumor metastasis. 2016;28:132–136. doi:10.3760/cma.j.issn.1006-9801.2016.02.017.
   Google Scholar
• Li Q, Dai Z, Xia C, Jin L, Chen X. Suppression of long non-coding RNA MALAT1 inhibits survival and metastasis of esophagus cancer cells by sponging miR-1-3p/CORO1C/TPM3 axis. Mol Cell Biochem. 2020;470(1–2):165–174. doi:10.1007/s11010-020-03759-x.
   PubMed Web of Science ®Google Scholar
• Guo G, Dai S, Chen Q. Long noncoding RNA LINC00261 reduces proliferation and migration of breast cancer cells via the NME1-EMT pathway. CMAR. 2020;12:3081–3089. doi:10.2147/CMAR.S237197.
   Google Scholar
• Lee G, Zheng Y, Cho S, Jang C, England C, Dempsey JM, et al. Post-transcriptional regulation of de novo lipogenesis by mTORC1-S6K1-SRPK2 signaling. Cell. 2017;171(7):1545–1558. doi:10.1016/j.cell.2017.10.037.
   PubMed Web of Science ®Google Scholar
• Hung C-M, Garcia-Haro L, Sparks CA, Guertin DA. mTOR-dependent cell survival mechanisms. Cold Spring Harbor Perspect Biol . 2012;4(12):a008771. doi:10.1101/cshperspect.a008771.
   PubMed Web of Science ®Google Scholar
• Fingar DC, Salama S, Tsou C, Harlow E, Blenis J. Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev. 2002;16(12):1472–1487. doi:10.1101/gad.995802.
   PubMed Web of Science ®Google Scholar
• Dowling RJO, Topisirovic I, Alain T, Bidinosti M, Fonseca BD, Petroulakis E, et al. mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs. Science. 2010;328(5982):1172–1176. doi:10.1126/science.1187532.
   PubMed Web of Science ®Google Scholar
• Kim ST, Kim SY, Klempner SJ, Yoon J, Kim N, Ahn S, et al. Rapamycin-insensitive companion of mTOR (RICTOR) amplification defines a subset of advanced gastric cancer and is sensitive to AZD2014-mediated mTORC1/2 inhibition. Ann Oncol. 2017;28(3):547–554. doi:10.1093/annonc/mdw669.
   PubMed Web of Science ®Google Scholar
• Shea MP, O’Leary KA, Wegner KA, Vezina CM, Schuler LA. High collagen density augments mTOR-dependent cancer stem cells in ERα+ mammary carcinomas, and increases mTOR-independent lung metastases. Cancer Lett. 2018;433:1–9. doi:10.1016/j.canlet.2018.06.025.
   PubMed Web of Science ®Google Scholar