Bioinformatics Identification and Validation of Aging‑Related Molecular Subtype and Prognostic Signature in Sarcoma

References

• Zhu MMT, Shenasa E, Nielsen TO. Sarcomas: immune biomarker expression and checkpoint inhibitor trials. Cancer Treat Rev. 2020;91:102115. doi:10.1016/j.ctrv.2020.102115.
   PubMed Web of Science ®Google Scholar
• Soini EJO, García San Andrés B, Joensuu T. Trabectedin in the treatment of metastatic soft tissue sarcoma: cost-effectiveness, cost-utility and value of information. Ann Oncol. 2011;22(1):215–223. doi:10.1093/annonc/mdq339.
   PubMed Web of Science ®Google Scholar
• Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209–249. doi:10.3322/caac.21660.
   PubMed Web of Science ®Google Scholar
• Zhang X, Li H, Zhou L, Wu D, Zhou S, Yang Y, et al. N6-methyladenosine-related lncRNAs are anticipated biomarkers for sarcoma patients. J Oncol. 2022;2022:1093805. doi:10.1155/2022/1093805.
   PubMed Web of Science ®Google Scholar
• Sbaraglia M, Righi A, Gambarotti M, Dei Tos AP. Ewing sarcoma and Ewing-like tumors. Virchows Arch. 2020;476(1):109–119. doi:10.1007/s00428-019-02720-8.
   PubMed Web of Science ®Google Scholar
• Riggi N, Suvà ML, Stamenkovic I. Ewing’s sarcoma. N Engl J Med. 2021;384(2):154–164. doi:10.1056/NEJMra2028910.
   PubMed Web of Science ®Google Scholar
• Brennan MF, Antonescu CR, Moraco N, Singer S. Lessons learned from the study of 10,000 patients with soft tissue sarcoma. Ann Surg. 2014;260(3):416–421. discussion 421-412. doi:10.1097/SLA.0000000000000869.
   PubMed Web of Science ®Google Scholar
• Zeng Q, Sun S, Li Y, Li X, Li Z, Liang H, et al. Identification of therapeutic targets and prognostic biomarkers among CXC chemokines in the renal cell carcinoma microenvironment. Front Oncol. 2019;9:1555. doi:10.3389/fonc.2019.01555.
   PubMed Web of Science ®Google Scholar
• Li Z, Li Y, Zhong W, Huang P. m6A-related lncRNA to develop prognostic signature and predict the immune landscape in bladder cancer. J Oncol. 2021;2021:7488188. doi:10.1155/2021/7488188.
   PubMed Web of Science ®Google Scholar
• Lin W, Chen Y, Wu B, Chen Y, Li Z. Identification of the pyroptosis‑related prognostic gene signature and the associated regulation axis in lung adenocarcinoma. Cell Death Discov. 2021;7(1):161. doi:10.1038/s41420-021-00557-2.
   PubMed Web of Science ®Google Scholar
• Coley WB. II. Contribution to the knowledge of sarcoma. Ann Surg. 1891;14(3):199–220. doi:10.1097/00000658-189112000-00015.
   PubMedGoogle Scholar
• Yang J, Jiang Q, Liu L, Peng H, Wang Y, Li S, et al. Identification of prognostic aging-related genes associated with immunosuppression and inflammation in head and neck squamous cell carcinoma. Aging. 2020;12(24):25778–25804. doi:10.18632/aging.104199.
   PubMedGoogle Scholar
• Zhang Y, Yan Y, Ning N, Shen Z, Ye Y. A signature of 24 aging‑related gene pairs predict overall survival in gastric cancer. Biomed Eng Online. 2021;20(1):35. doi:10.1186/s12938-021-00871-x.
   PubMed Web of Science ®Google Scholar
• Calcinotto A, Kohli J, Zagato E, Pellegrini L, Demaria M, Alimonti A, et al. Cellular senescence: aging, cancer, and injury. Physiol Rev. 2019;99(2):1047–1078. doi:10.1152/physrev.00020.2018.
   PubMed Web of Science ®Google Scholar
• Elias R, Hartshorn K, Rahma O, Lin N, Snyder-Cappione JE. Aging, immune senescence, and immunotherapy: a comprehensive review. Semin Oncol. 2018;45(4):187–200. doi:10.1053/j.seminoncol.2018.08.006.
   PubMed Web of Science ®Google Scholar
• Xu Q, Chen Y. An aging-related gene signature-based model for risk stratification and prognosis prediction in lung adenocarcinoma. Front Cell Dev Biol. 2021;9:685379. doi:10.3389/fcell.2021.685379.
   PubMed Web of Science ®Google Scholar
• Yuan J, Duan F, Zhai W, Song C, Wang L, Xia W, et al. An aging-related gene signature-based model for risk stratification and prognosis prediction in breast cancer. Int J Womens Health. 2021;13:1053–1064. doi:10.2147/IJWH.S334756.
   PubMed Web of Science ®Google Scholar
• Liu L, Zhao J, Du X, Zhao Y, Zou C, Zhou H, et al. Construction and validation of a novel aging-related gene signature and prognostic nomogram for predicting the overall survival in ovarian cancer. Cancer Med. 2021;10(24):9097–9114. doi:10.1002/cam4.4404.
   PubMed Web of Science ®Google Scholar
• Lv W, Zhao C, Tan Y, Hu W, Yu H, Zeng N, et al. Identification of an aging-related gene signature in predicting prognosis and indicating tumor immune microenvironment in breast cancer. Front Oncol. 2021;11:796555. doi:10.3389/fonc.2021.796555.
   PubMed Web of Science ®Google Scholar
• Tomczak K, Czerwińska P, Wiznerowicz M. The Cancer Genome Atlas (TCGA): an immeasurable source of knowledge. Contemp Oncol. 2015;19(1a):A68–77. doi:10.5114/wo.2014.47136.
   Google Scholar
• Tacutu R, Thornton D, Johnson E, Budovsky A, Barardo D, Craig T, et al. Human ageing genomic resources: new and updated databases. Nucleic Acids Res. 2018;46(D1):D1083–d1090. doi:10.1093/nar/gkx1042.
   PubMed Web of Science ®Google Scholar
• Mermel CH, Schumacher SE, Hill B, Meyerson ML, Beroukhim R, Getz G, et al. GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers. Genome Biol. 2011;12(4):R41. doi:10.1186/gb-2011-12-4-r41.
   PubMed Web of Science ®Google Scholar
• Chen J, Zhang J, Gao Y, Li Y, Feng C, Song C, et al. LncSEA: a platform for long non-coding RNA related sets and enrichment analysis. Nucleic Acids Res. 2021;49(D1):D969–d980. doi:10.1093/nar/gkaa806.
   PubMed Web of Science ®Google Scholar
• Ayodele O, Razak ARA. Immunotherapy in soft-tissue sarcoma. Curr Oncol. 2020;27(Suppl 1):17–23. doi:10.3747/co.27.5407.
   PubMed Web of Science ®Google Scholar
• Dajsakdipon T, Siripoon T, Ngamphaiboon N, Ativitavas T, Dejthevaporn T. Immunotherapy and biomarkers in sarcoma. Curr Treat Options Oncol. 2022;23(3):415–438. doi:10.1007/s11864-022-00944-6.
   PubMed Web of Science ®Google Scholar
• Kamoun A, de Reyniès A, Allory Y, Sjödahl G, Robertson AG, Seiler R, et al. A consensus molecular classification of muscle-invasive bladder cancer. Eur Urol. 2020;77(4):420–433. doi:10.1016/j.eururo.2019.09.006.
   PubMed Web of Science ®Google Scholar
• Zhu S, Yu W, Yang X, Wu C, Cheng F. Traditional classification and novel subtyping systems for bladder cancer. Front Oncol. 2020;10:102. doi:10.3389/fonc.2020.00102.
   PubMed Web of Science ®Google Scholar
• Li B, Cui Y, Nambiar DK, Sunwoo JB, Li R. The immune subtypes and landscape of squamous cell carcinoma. Clin Cancer Res. 2019;25(12):3528–3537. doi:10.1158/1078-0432.CCR-18-4085.
   PubMed Web of Science ®Google Scholar
• Zhou L, Li Y, Li Z, Huang Q. Mining therapeutic and prognostic significance of STATs in renal cell carcinoma with bioinformatics analysis. Genomics. 2020;112(6):4100–4114. doi:10.1016/j.ygeno.2020.06.032.
   PubMed Web of Science ®Google Scholar
• Wei D, Lan X, Huang Z, Tang Q, Wang Z, Ma Y, et al. Pyroptosis-related gene signature is a Novel prognostic biomarker for sarcoma patients. Dis Markers. 2021;2021:9919842. doi:10.1155/2021/9919842.
   PubMed Web of Science ®Google Scholar
• Li J, Hu C, Du Y, Tang X, Shao C, Xu T, et al. Identification of iron metabolism-related gene signatures for predicting the prognosis of patients with sarcomas. Front Oncol. 2020;10:599816. doi:10.3389/fonc.2020.599816.
   PubMed Web of Science ®Google Scholar
• Chang L, Jia DL, Cao CS, Wei H, Li ZQ. LncRNA PCAT-1 promotes the progression of osteosarcoma via miR-508-3p/ZEB1 axis. Eur Rev Med Pharmacol Sci. 2021;25(6):2517–2527.
   PubMed Web of Science ®Google Scholar
• Li L, Kong XA, Zang M, Dong J, Feng Y, Gui B, et al. Hsa_circ_0003732 promotes osteosarcoma cells proliferation via miR-545/CCNA2 axis. Biosci Rep. 2020;40(6):BSR20191552.
   PubMedGoogle Scholar
• Huo Y, Li Q, Wang X, Jiao X, Zheng J, Li Z, et al. MALAT1 predicts poor survival in osteosarcoma patients and promotes cell metastasis through associating with EZH2. Oncotarget. 2017;8(29):46993–47006. doi:10.18632/oncotarget.16551.
   PubMedGoogle Scholar
• Liu K, Huang J, Ni J, Song D, Ding M, Wang J, et al. MALAT1 promotes osteosarcoma development by regulation of HMGB1 via miR-142-3p and miR-129-5p. Cell Cycle. 2017;16(6):578–587. doi:10.1080/15384101.2017.1288324.
   PubMed Web of Science ®Google Scholar