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Research Article

Gustative Roussy Immune Score is a Predictor for Major Pathological Response in Rectal Cancer: A Result from the Preoperative Intraarterial Chemoembolization Combined with Radiotherapy (PCAR) Study

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Pages 527-537 | Received 29 Sep 2023, Accepted 08 Jun 2024, Published online: 05 Jul 2024

References

  • Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–249. doi:10.3322/caac.21660.
  • Qu R, Ma Y, Zhang Z, Fu W. Increasing burden of colorectal cancer in China. Lancet Gastroenterol Hepatol. 2022;7(8):700.
  • Martin ST, Heneghan HM, Winter DC. Systematic review and meta-analysis of outcomes following pathological complete response to neoadjuvant chemoradiotherapy for rectal cancer. Br J Surg. 2012;99(7):918–928. doi:10.1002/bjs.8702.
  • Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature. 2008;454(7203):436–444. doi:10.1038/nature07205.
  • Li Y, Pan Y, Lin X, Hou J, Hu Z, Xu L, et al. Development and validation of a prognostic score for hepatocellular carcinoma patients in immune checkpoint inhibitors therapies: the hepatocellular carcinoma modified Gustave Roussy Immune score. Front Pharmacol. 2021;12:819985. doi:10.3389/fphar.2021.819985.
  • Lenci E, Cantini L, Pecci F, Cognigni V, Agostinelli V, Mentrasti G, et al. The Gustave Roussy immune (GRIm)-score variation is an early-on-treatment biomarker of outcome in advanced non-small cell lung cancer (NSCLC) patients treated with first-line pembrolizumab. J Clin Med. 2021;10(5):1005.
  • Nakazawa N, Sohda M, Ubukata Y, Kuriyama K, Kimura A, Kogure N, et al. Changes in the Gustave Roussy immune score as a powerful prognostic marker of the therapeutic sensitivity of nivolumab in advanced gastric cancer: a multicenter, retrospective study. Ann Surg Oncol. 2022;29(12):7400–7406. doi:10.1245/s10434-022-12226-4.
  • Tian S, Cao Y, Duan Y, Liu Q, Peng P. Gustave Roussy immune score as a novel prognostic scoring system for colorectal cancer patients: a propensity score matching analysis. Front Oncol. 2021;11:737283. doi:10.3389/fonc.2021.737283.
  • Chiloiro G, Romano A, Mariani S, Macchia G, Giannarelli D, Caravatta L, et al. Predictive and prognostic value of inflammatory markers in locally advanced rectal cancer (PILLAR) – a multicentric analysis by the Italian Association of Radiotherapy and Clinical Oncology (AIRO) gastrointestinal study group. Clin Transl Radiat Oncol. 2023;39:100579.
  • Guan B, Huang X, Xia H, Guan G, Xu B. Prognostic value of mesorectal package area in patients with locally advanced rectal cancer following neoadjuvant chemoradiotherapy: a retrospective cohort study. Front Oncol. 2022;12:941786. doi:10.3389/fonc.2022.941786.
  • Portale G, Cavallin F, Valdegamberi A, Frigo F, Fiscon V. Platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio are not prognostic biomarkers in rectal cancer patients with curative resection. J Gastrointest Surg. 2018;22(9):1611–1618. doi:10.1007/s11605-018-3781-2.
  • Yang B, Shan J, Feng Y, Dai N, Li M, Chen C, et al. Transcatheter rectal arterial chemoembolization with oxaliplatin plus S-1 concurrent chemoradiotherapy can improve the pathological remission rate in locally advanced rectal cancer: a comparative study. Radiat Oncol. 2020;15(1):94. doi:10.1186/s13014-020-01540-4.
  • Mezquita L, Auclin E, Ferrara R, Charrier M, Remon J, Planchard D, et al. Association of the lung immune prognostic index with immune checkpoint inhibitor outcomes in patients with advanced non-small cell lung cancer. JAMA Oncol. 2018;4(3):351–357. doi:10.1001/jamaoncol.2017.4771.
  • Ryu HS, Lee JL, Kim CW, Yoon YS, Park IJ, Lim SB, et al. Correlative significance of tumor regression grade and ypT category in patients undergoing preoperative chemoradiotherapy for locally advanced rectal cancer. Clin Colorectal Cancer. 2022;21(3):212–219. doi:10.1016/j.clcc.2022.02.001.
  • Jäger T, Neureiter D, Urbas R, Klieser E, Hitzl W, Emmanuel K, et al. Applicability of American Joint Committee on cancer and College of American Pathologists regression grading system in rectal cancer. Dis Colon Rectum. 2017;60(8):815–826. doi:10.1097/DCR.0000000000000806.
  • Bong JW, Lim SB, Ryu H, Lee JL, Kim CW, Yoon YS, et al. Effect of anaemia on the response to preoperative chemoradiotherapy for rectal cancer. ANZ J Surg. 2021;91(5):E286–E291. doi:10.1111/ans.16547.
  • Rodrigues D, Simões J, Teixeira L, Aires F, Fernandes C, Rey C, et al. Baseline anaemia increases locally advanced rectal cancer mortality in older patients undergoing preoperative chemoradiation. Support Care Cancer. 2021;29(3):1403–1411. doi:10.1007/s00520-020-05618-3.
  • Cosper PF, McNair C, González I, Wong N, Knudsen KE, Chen JJ, et al. Decreased local immune response and retained HPV gene expression during chemoradiotherapy are associated with treatment resistance and death from cervical cancer. Int J Cancer. 2020;146(7):2047–2058. doi:10.1002/ijc.32793.
  • Nicolas AM, Pesic M, Engel E, Ziegler PK, Diefenhardt M, Kennel KB, et al. Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer. Cancer Cell. 2022;40(2):168–184 e13. doi:10.1016/j.ccell.2022.01.004.
  • Liu H, Tang L, Li Y, Xie W, Zhang L, Tang H, et al. Nasopharyngeal carcinoma: current views on the tumor microenvironment’s impact on drug resistance and clinical outcomes. Mol Cancer. 2024;23(1):20. doi:10.1186/s12943-023-01928-2.
  • Diakos CI, Charles KA, McMillan DC, Clarke SJ. Cancer-related inflammation and treatment effectiveness. Lancet Oncol. 2014;15(11):e493-503–e503. doi:10.1016/S1470-2045(14)70263-3.
  • Zhang X, Li J, Peng Q, Huang Y, Tang L, Zhuang Q, et al. Association of markers of systemic and local inflammation with prognosis of patients with rectal cancer who received neoadjuvant radiotherapy. Cancer Manag Res. 2019;11:191–199. doi:10.2147/CMAR.S187559.
  • Dudani S, Marginean H, Tang PA, Monzon JG, Raissouni S, Asmis TR, et al. Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as predictive and prognostic markers in patients with locally advanced rectal cancer treated with neoadjuvant chemoradiation. BMC Cancer. 2019;19(1):664. doi:10.1186/s12885-019-5892-x.
  • Lai S, Huang L, Luo S, Liu Z, Dong J, Wang L, et al. Systemic inflammatory indices predict tumor response to neoadjuvant chemoradiotherapy for locally advanced rectal cancer. Oncol Lett. 2020;20(3):2763–2770. doi:10.3892/ol.2020.11812.
  • Gawiński C, Mróz A, Roszkowska-Purska K, Sosnowska I, Derezińska-Wołek E, Michalski W, et al. A prospective study on the roles of the lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) in patients with locally advanced rectal cancer. Biomedicines. 2023;11(11):3048. doi:10.3390/biomedicines11113048.
  • Eraslan E, Adas YG, Yildiz F, Gulesen AI, Karacin C, Arslan UY. Systemic immune-inflammation index (SII) predicts pathological complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. J Coll Physicians Surg Pak. 2021;31 (4):399–404. doi:10.29271/jcpsp.2021.04.399.
  • Wang Y, Chen L, Zhang B, Song W, Zhou G, Xie L, et al. Pretreatment inflammatory-nutritional biomarkers predict responses to neoadjuvant chemoradiotherapy and survival in locally advanced rectal cancer. Front Oncol. 2021;11:639909. doi:10.3389/fonc.2021.639909.
  • Arıkan R, Alkış H, Işık S, Yaşar A, Çelebi A, Majidova N, et al. Evaluation of predictive and prognostic importance of lung immune prognostic index in locally advanced rectal cancer patients treated with neoadjuvant chemoradiotherapy. Cureus. 2023;15(6):e40548. doi:10.7759/cureus.40548.
  • Soeters PB, Wolfe RR, Shenkin A. Hypoalbuminemia: pathogenesis and clinical significance. JPEN J Parenter Enteral Nutr. 2019;43(2):181–193. doi:10.1002/jpen.1451.
  • Claps G, Faouzi S, Quidville V, Chehade F, Shen S, Vagner S, et al. The multiple roles of LDH in cancer. Nat Rev Clin Oncol. 2022;19(12):749–762. doi:10.1038/s41571-022-00686-2.
  • Hwang M, Canzoniero JV, Rosner S, Zhang G, White JR, Belcaid Z, et al. Peripheral blood immune cell dynamics reflect antitumor immune responses and predict clinical response to immunotherapy. J Immunother Cancer. 2022;10(6):e004688. doi:10.1136/jitc-2022-004688.
  • Feng JF, Wang L, Yang X, Chen S. Gustave Roussy Immune Score (GRIm-Score) is a prognostic marker in patients with resectable esophageal squamous cell carcinoma. J Cancer. 2020;11(6):1334–1340.
  • Li SJ, Zhao L, Wang HY, Zhou HN, Ju J, Du H, et al. Gustave Roussy Immune Score based on a three-category risk assessment scale serves as a novel and effective prognostic indicator for surgically resectable early-stage non-small-cell lung cancer: a propensity score matching retrospective cohort study. Int J Surg. 2020;84:25–40.
  • Minichsdorfer C, Gleiss A, Aretin MB, Schmidinger M, Fuereder T. Serum parameters as prognostic biomarkers in a real world cancer patient population treated with anti PD-1/PD-L1 therapy. Ann Med. 2022;54(1):1339–1349.