348
Views
10
CrossRef citations to date
0
Altmetric
Selected Papers from the 19th International Drying Symposium (IDS 2014), Part 2

Real-Time Monitoring of Gas–Solid Fluidized-Bed Granulation and Coating Process: Evolution of Particle Size, Fluidization Regime Transitions, and Psychometric Parameters

&

REFERENCES

  • Talu, I.; Tardos, G.I.; van Ommen, J.R. Use of stress fluctuations to monitor wet granulation of powders. Powder Technology 2001, 117, 149–162.
  • Chaplin, G.; Pugsley, T.; Winters, C. Monitoring the fluidized bed granulation process based on S-statistic analysis of a pressure time series. AAPS PharmSciTech 2005, 6(2), 198–201.
  • Parise, M.R.; Silva, C.A.M.; Ramazini, M.J.; Taranto, O.P. Identification of defluidization in fluidized bed coating using the Gaussian spectral pressure distribution. Powder Technology 2011, 206, 149–153.
  • Silva, C.A.M.; Parise, M.R.; Silva, F.V.; Taranto, O.P. Control of fluidized bed coating particles using Gaussian spectral pressure distribution. Powder Technology 2011, 212, 445–458.
  • Nunes, J.F.; Silva, C.A.M.; Moris, V.A.S.; Rocha, S.C.S.; Taranto, O.P. Spectral analysis of pressure drop fluctuation in vibrofluidized bed coating. Chemical Engineering Transactions 2011, 24, 649–654.
  • de Martín, L.; van den Dries, K.; van Ommen, J.R. Comparison of three different methodologies of pressure signal processing to monitor fluidized-bed dryers/granulators. Chemical Engineering Journal 2011, 172, 487–499.
  • van Ommen, J.R.; de Korte, R.J.; van den Bleek, C.M. Rapid detection of defluidization using the standard deviation of pressure fluctuations. Chemical Engineering and Processing 2004, 43, 1329–1335.
  • Chirone, R.; Miccio, F.; Scala, F. Mechanism and prediction of bed agglomeration during fluidized bed combustion of a biomass fuel: Effect of the reactor scale. Chemical Engineering Journal 2006, 123, 71–80.
  • Nijenhuis, J.; Korbee, R.; Lensselink, J.; Kiel, J.H.A.; van Ommem, J.R. A method for agglomeration detection and control in full-scale biomass fired fluidized beds. Chemical Engineering Science 2007, 62, 644–654.
  • Bartels, M.; Lin, W.; Nijenhuis, J.; Kapteijn, F.; van Ommen, J.R. Agglomeration in fluidized beds at high temperatures: Mechanisms, detection and prevention. Progress in Energy and Combustion Science 2008, 34, 633–666.
  • Watano, S.; Sato, Y.; Miyanami, K. Control of granule growth in fluidized bed granulation by an image processing system. Chemical and Pharmaceutical Bulletin 1996, 44, 1556–1560.
  • Watano, S. Direct control of wet granulation processes by image processing system. Powder Technology 2001, 117, 163–172.
  • Scheibli, D. The use of FBRM for on-line particle size analysis in a fluid bed granulator. Master's thesis, San José State University, San Jose, CA, Paper 3576, http://scholarworks.sjsu.edu/etd_theses/3576.2007
  • Tok, A.; Goh, X.P.; Ng, W.; Tan, R. Monitoring granulation rate processes using three PAT tools in a pilot-scale fluidized bed. AAPS PharmSciTech 2008, 9, 1083–1091.
  • Hu, X.; Cunningham, J.C.; Winstead, D. Study growth kinetics in fluidized bed granulation with at-line FBRM. International Journal of Pharmaceutics 2008, 347, 54–61.
  • Kukec, S.; Vrecer, F.; Dreu, R. A study of in-situ fluid bed melt granulation using response surface methodology. Acta Pharmaceutica 2012, 62, 497–513.
  • Kukec, S.; Hudovornik, G.; Dreu, R.; Vrecer, F. Study of granule growth kinetics during in situ fluid bed melt granulation using in-line FBRM and SFT probes. Drug Development and Industrial Pharmacy 2014, 40(7), 952–959.
  • Petrak, D. Simultaneous measurement of particle size and particle velocity by the spatial filtering technique. Particle & Particle Systems Characterization 2002, 19, 391–400.
  • Schmidt-Lehr, S.; Moritz, H.U.; Jürgens, K.C. Online control of particle size during fluidized bed granulation. Pharmazeutische Industrie 2007, 69, 478–484.
  • Lipsanen, T.; Närvänen, T.; Räikkönen, H.; Antikainen, O.; Yliruusi, J. Particle size, moisture, and fluidization variations described by indirect in-line physical measurements of fluid bed granulation. AAPS PharmSciTech 2008, 9, 1070–1077.
  • Ehlers, H.; Liu, A.; Räikkönena, H.; Hataraa, J.; Antikainena, O.; Airaksinena, S.; Heinämäkia, J.; Loub, H.; Yliruusi, J. Granule size control and targeting in pulsed spray fluid bed granulation. International Journal of Pharmaceutics 2009, 377, 9–15.
  • Närvänen, T.; Lipsanen, T.; Antikainen, O.; Räikkönen, H.; Heinämäki, J.; Yliruusi, J. Gaining fluid bed process understanding by in-line particle size analysis. Journal of Pharmaceutical Sciences 2009, 98, 1110–1117.
  • Burggraeve, A.; van den Kerkhof, T.; Hellings, M.; Remon, J.P.; Vervaet, C.; de Beer, T. Evaluation of in-line spatial filter velocimetry as PAT monitoring tool for particle growth during fluid bed granulation. European Journal of Pharmaceutics and Biopharmaceutics 2010, 76, 138–146.
  • Huang, J.; Goolcharran, C.; Utz, J.; Hernandez-abad, P.; Ghosh, K.; Nagi, A. A PAT approach to enhance process understanding of fluid bed granulation using inline particle size characterization and multivariate analysis. Journal Pharmaceutical Innovation 2010, 5, 58–68.
  • Dieter, P.; Stefan, D.; Günter, E.; Michael, K. In-line particle sizing for real-time process control by fiber-optical spatial filtering technique (SFT). Advanced Powder Technology 2011, 22, 203–208.
  • Kage, H.; Takahashi, T.; Yoshida, T.; Ogura, H.; Matsuno, Y. Coating efficiency of seed particles in a fluidized bed by atomization of a powder suspension. Powder Technology 1996, 86, 243–250.
  • Dewettinck, K.; De Visscher, A.; Deroo, L.; Huyghebaert, A. Modeling the steady-state thermodynamic operation point of top-spray fluidized bed processing. Journal of Food Engineering 1999, 39, 131–143.
  • Hede, P.D.; Bach, P.; Jensen, A.D. Top-spray fluid bed coating: Scale-up in terms of relative droplet size and drying force. Powder Technology 2008, 184, 318–332.
  • Burggraeve, A.; Monteyne, T.; Remon, J.P.; Vervaet, C.; De Beer, T. Process analytical tools for monitoring, understanding and control of pharmaceutical fluidized bed granulation: A review. European Journal of Pharmaceutics and Biopharmaceutics 2013, 83, 2–15.
  • Silva, C.A.M.; Butzge, J.J.; Nitz, M.; Taranto, O.P. Monitoring and control of coating and granulation processes in fluidized beds: A review. Advanced Powder Technology 2014, 25, 195–210.
  • Aghbashlo, M.; Sotudeh-Gharebagh, R.; Zarghami, R.; Mujumdar, A.S.; Mostoufi, N. Measurement techniques to monitor and control fluidization quality in fluidized bed dryers: A review. Drying Technology 2014, 32, 1005–1051.
  • Hansuld, E.M.; Briens, L. A review of monitoring methods for pharmaceutical wet granulation. International Journal of Pharmaceutics 2014, 472, 192–201.
  • Folttmann, F.; Knop, K.; Kleinebudde, P.; Pein, M. In-line spatial filtering velocimetry for particle size and film thickness determination in fluidized-bed pellet coating processes. European Journal of Pharmaceutics and Biopharmaceutics 2014, 88, 931–938.
  • Burgess, D.J.; Duffy, E.; Etzler, F.; Hickey, A.J. Particle size analysis: AAPS workshop report, Cosponsored by the Food and Drug Administration and the United States Pharmacopeia. The AAPS Journal 2004, 6, 1–12.
  • Silva, A.F.T.; Burggraeve, A.; Denon, Q.; van der Meeren, P.; Sandler, N.; van den Kerkhof, T.; Hellings, M.; Vervaet, C.; Remon, J.P.; Lope, J.A.; De Beer, T. Particle sizing measurements in pharmaceutical applications: Comparison of in-process methods versus off-line methods. European Journal of Pharmaceutics and Biopharmaceutics 2013, 85(3), Part B, 1006–1018.
  • Steigmiller, D. Application of process analytical technology for investigation of fluid bed granulation and active coating during process development and scale-up. Dissertation, University of Bonn, Berlin, 2012.
  • Roßteuscher-Carl, K.; Fricke, S.; Hacker, M.C.; Schulz-Siegmund, M. In-line monitoring of particle size in a fluid bed granulator: Investigations concerning positioning and configuration of the sensor. International Journal of Pharmaceutics 2014, 466, 31–37.
  • Hede, P.D. Fluid bed coating and granulation. Master's thesis. CHEC: Department of Chemical Engineering, Technical University of Denmark, Lyngby, 2005.
  • Hede, P.D. Fluid bed coating and agglomeration: Scale-up and process optimization. Ph.D. thesis. CHEC: Department of Chemical Engineering, Technical University of Denmark, Lyngby, 2008.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.