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Research Article

Microbial Biosynthesis and Applications of Gentamicin: A Critical Appraisal

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Pages 173-212 | Published online: 02 Dec 2008

REFERENCES

  • K. M. A. Aboshanab, H. Schmidt-Beissner, U.F. Wehmeier, K. Welzel, A. Vente, and W. Piepersberg. Micromonospora echinospora genomic region of the gentamicin biosynthesis gene cluster, strain DSM 43036. GenBank Accession No. (2006) AJ628149..
  • A. A. Abou-Zeid, A. E. I. Eissa, and H. M. Salem. (1974). The fermentative production of gentamicins by Micromonospora purpurea. J. Appl. Chem. Biotechnol 24:655–661.
  • A. A. Abou-Zeid, A. E. I. Eissa, and H. M. Salem. (1976a). Influence of some compounds on gentamicin formation by Micromonospora purpurea. J. Appl. Chem. Biotechnol 26:318–322.
  • A. A. Abou-Zeid, A. E. I. Eissa, and H. M. Salem. (1976b). Production of gentamicin antibiotics by Micromonospora purpurea. Indian J. Exp. Biol 4:200–203.
  • A. A. Abou-Zeid, H. M. Salem, and A. E. I Eissa. (1978). Production of gentamicins by Micromonospora purpurea. Zentralbl. Bakteriol. Naturwiss 133:261–275.
  • P. I. Abrasimovskii, A. V. Valdimirov, and I. E. Bartoschevich. (1990). Phosphate regulation of the processes of growth and biosynthesis of gentamicin in Micromonospora purpurea var. violaceae. Antibiot. Khimioter 35:5–8.
  • E. Adams, W. Roelants, R. De Paepe, E. Roets, and J Hoogmartens. (1998). Analysis of gentamicin by liquid chromatography with pulsed electrochemical detection. J. Pharm. Biomed. Analysis 18:689–698.
  • J. Ahlert, J. Distler, K. Mansauri, and W Pipersberg. (1997). Identification of stsC, the gene encoding the L-glutamine: scyllo-inosose aminotransferase from streptomycin-producing Streptomycetes. Arch. Microbiol 168:102–113.
  • A. I. Al Amoud, B. J. Clark, and H Chrystyn. (2002). Determination of gentamicin in urine samples after inhalation by reversed-phase high-performance liquid chromatography using pre-column derivatisation with o-phthalaldehyde. J. Chromatogr. B 769:89–95.
  • Q Al Awqati. (1995). Regulation of ion channels by ABC transporters that secrete ATP. Science. 269:805–806.
  • J. H. Albracht, and M. S. De Wit. (1987). Separation of gentamicin in raw materials and pharmaceuticals by HPLC. Chromatogram 8:7–8.
  • D. V. Alcid, and S. J. Seligman. (1973). Simplified assay for gentamicin in the presence of other antibiotics. Antimicrob. Agents Chemother 3:559–561.
  • A. A. Al Majed, F. B. Belal, M. A. Abounassif, and N. Y. Khalil. (2003). Fluorimetric determination of gentamicin in dosage forms and biological fluids through derivatization with 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl). Microchim. Acta 141:1–6.
  • J. P. Anhalt. (1977). Assay of gentamicin in serum by high-pressure liquid chromatography. Antimicrob. Agents Chemother 11:651–655.
  • J. P. Anhalt, and S. D. Brown. (1978). High-performance liquid-chromatographic assay of aminoglycoside antibiotics in serum. Clin. Chem 24:1940–1947.
  • J. P. Anhalt, F. D. Sancilio, and T McCorkle. (1978). Gentamicin C-component ratio determination by high-pressure liquid chromatography. J. Chromatogr 153:489–493.
  • J. Ara, Z. Gans, R. Sweeney, and B Wolf. (1995). Dot-ELISA for the rapid detection of gentamicin in milk. J. Clin. Lab Anal 9:320–324.
  • C. Arcelloni, B. Comuzzi, R. Vaiani, and R Paroni. (2001). Quantification of gentamicin in Mueller–Hinton agar by high performance liquid chromatography. J. Chromatogr. B 753:151–156.
  • A. M. Armynot du Chatelet, S. Fourcade, M. A. Atisso, M. Simeon de Bouchberg, M. Yakoun, A. Varet, and C Piedra. (1989). In vitro release of gentamicin from beads, an original galenic form, and in vivo efficacy in abdomino-perineal surgery. Pharmazie 44:131–132.
  • Y. Babin, and S Fortier. (2007). A high-throughput analytical method for determination of aminoglycosides in veal tissues by liquid chromatography/tandem mass spectrometry with automated cleanup. J. AOAC Int 90:1418–1426.
  • P. M. Bapat, and P. P. Wangikar. (2004). Optimization of rifamycin B fermentation in shake flasks via a machine-learning-based approach. Biotechnol. Bioeng 86:201–208.
  • M. L. Barclay, E. J. Begg, S. T. Chambers, and D. R. Boswell. (1995). Improved efficacy with nonsimultaneous administration of first doses of gentamicin and ceftazidime in vitro. Antimicrob. Agents Chemother 39:132–136.
  • S. Bar-Nun, Y. Shnegow, and J. S. Beckmann. (1983). G-418, an elongation inhibitor of 80S ribosomes. Biochim. Biophys. Acta 741:123–127.
  • D. M. Barends, J. S. F. Van der Sandt, and A Hulshoff. (1980). Micro determination of gentamicin in serum by high-performance liquid chromatography with ultraviolet detection. J. Chromatogr 182:201–210.
  • M. Baro, E. Sanchez, A. Delgado, A. Perera, and C Evora. (2002). In vitro–in vivo characterization of gentamicin bone implants. J. Controlled Release. 83:353–364.
  • E. R. Barton-Davis, L. Cordier, D. I. Shoturma, S. E. Leland, and H. L. Sweeney. (1999). Aminoglycoside antibiotics restore dystrophin function to skeletal muscles of mdx mice. J. Clin. Invest 104:375–381.
  • G Beaucaire. (1995). Evaluation of the efficacy and safety of isepamicin compared with amikacin in the treatment of nosocomial pneumonia and septicaemia. J. Chemother 7 (Suppl. 2):165–173.
  • D. M. Bedwell, A. Kaenjak, D. J. Benos, Z. Bebok, J. K. Bubein, J. Hong, A. Touson, J. P. Clancy, and E. J. Sorcher. (1997). Suppression of a CFTR premature stop mutation in a bronchial epithelial cell line. Nat. Med 3:1280–1284.
  • E. J. Begg, and M. L. Barclay. (1995). Aminoglycosides-50 years on. Brit. J. Clin. Pharmacol 39:597–603.
  • C. R. Behl, H. K. Pimplaskar, A. P. Sileno, W. J. Xia, W. J. Gries, J. C. Demeireles, and V. D. Romeo. (1998). Optimization of systemic nasal drug delivery with pharmaceutical excipients. Adv. Drug Deliv. Rev. 29:117–133.
  • S. Belknap. Aminoglycoside antibiotics. In Modern Pharmacology with Clinical Applications, 573–574C. R. Craig, and R. E. Stitzel. Little, Brown and Company, BostonMA, (1997).
  • F. Beltrametti, R. Rossi, E. Selva, and F Marinelli. (2006). Antibiotic production improvement in the rare actinomycete Planobispora rosea by selection of mutants resistant to the aminoglycosides streptomycin and gentamycin and to rifamycin. J. Ind. Microbiol. Biotechnol 33:283–288.
  • R. Bentley, and J. W. Bennett. (2003). What is an antibiotic? Revisited. Adv. Appl. Microbiol 52:303–331.
  • R. Benveniste, and J Davies. (1973). Structure-activity relationships among the aminoglycoside antibiotics: role of hydroxyl and amino groups. Antimicrob. Agents Chemother 4:402–409.
  • G. L. Berestein. (1987). Liposomes as carriers of antimicrobial agents. Antimicrob. Agents Chemother 31:675–678.
  • M. Beretta, M. Betti, and M Polsinelli. (1971). Genetic recombination in Micromonospora. J. Bacteriol 107:415–419.
  • L. S. Berk, J. L. Lewis, and J. C. Nelson. (1974). One hour radioimmunoassay of serum drug concentrations as exemplified by digioxin and gentamicin. Clin. Chem. (NY) 20:1159–1164.
  • C. Bernal, I. Diaz, and N Coello. (2006). Response surface methodology for the optimization of keratinase production in culture medium containing feathers produced by Kocuria rosea. Can. J. Microbiol 52:445–450.
  • M. J. Bibb, P. R. Findlay, and M. W. Johnson. (1984). The relationship between base composition and codon usage in bacterial genes and its use for the simple and reliable identification of protein coding sequences. Gene 30:157–166.
  • R. M. Blanchard, A. F. Martin, T. A. Nieman, D. J. Guerrero, and J. P. Ferraris. (1998). Electrogenerated chemiluminescence using solution phase and immobilized tris (4,7-diphenyl-1,10-phenanthrolinedisulfonic acid)ruthenium(II). Microchim. Acta 130:55–62.
  • M. J. Blanco-Prieto, M. C. Lecaroz, M. J. Renedo, J. Kunkova, and C Gamazo. (2002). In vitro evaluation of gentamicin released from microparticles. Int. J. Pharmaceut 242:203–206.
  • A. Bodalo, J. Bastida, J. L. Gomez, I. Alcarz, and M. L. Asaza. (1996). Immobilization of Pseudomonas sp. BA2 by entrapment in calcium alginate and its application for the production of L-alanine. Enzyme Microb. Technol 19:176–180.
  • M. Bohner, J. Lemaitre, H. P. Merkle, and B Gander. (2000). Control of gentamicin release from a calcium phosphate cement by admixed poly (acrylic acid). J. Pharm. Sci. 89:1262–1270.
  • R. E. Botto, and B Coxon. (1983). Nitrogen-15 nuclear magnetic resonance spectroscopy of neomycin B and related aminoglycosides. J. Am. Chem. Soc 105:1021–1028.
  • L. L. Boulanger, P. Ettestad, J. D. Fogarty, D. T. Dennis, D. Romig, and G Mertz. (2004). Gentamicin and tetracyclines for the treatment of human plague: Review of 75 cases in New Mexico, 1985–1999. Clin. Infect. Dis 38:663–669.
  • G. E. Box, W. G. Hunter, and J. S. Hunter. Statistics for Experimenters. John Wiley and Sons, New York, (1978).
  • British Pharmacopoeia. Biological Assay of Antibiotics II Appendix XIV A. HMSO, London, (1998).
  • A. Broughton, and J. E. Strong. (1976). Radioimmunoassay of iodinated gentamicin. Clin. Chim. Acta 66:125–129.
  • A. Brown, and D Bennett. (1988). Gentamicin-impregnated polymethylmethacrylate beads for the treatment of septic arthritis. Vet. Record 123:625–626.
  • K. M. Bryne, A. S. Kershner, H. Maehr, J. A. Marquez, and C. P. Schaffner. (1977). Separation of gentamicin C-complex into five components by Craig distribution. J. Chromatogr 131:191–203.
  • T. I. Bulina, I. V. Alferova, and L. P. Terekhova. (1997). A new method for the isolation of actinomycetes with the use of microwave irradiation of soil samples. Mikrobiologiya 66:278–282.
  • T. I. Bulina, L. P. Terekhova, and M. V. Tyurin. (1998). The use of electric pulses for the selective isolation of actinomycetes from soil. Mikrobiologiya 67:556–560.
  • L. Bunetel, A. Segui, M. Cormier, and F Langlais. (1990). Comparative study of gentamicin release from normal and low viscosity acrylic bone cement. Clin. Pharmacokinet 19:333–340.
  • K. L. Bunny, R. M. Hall, and H. W. Stokes. (1995). New mobile gene cassettes containing an aminoglycoside resistance gene, aacA7, and a chloramphenicol resistance gene, catB3, in an integron in pBWH301. Antimicrob. Agents Chemother 39:686–693.
  • J. F. Burd, R. C. Wong, J. E. Feeney, R. J. Carrico, and R. C. Boguslaski. (1977). Homogeneous reactant-labeled fluorescent immunoassay for therapeutic drugs exemplified by gentamicin determination in human serum. Clin. Chem 23:1402–1408.
  • Y.-Q. Cai, and S.-F Mou. (2005). Optimizing the quadruple-potential waveform for the determination of gentamicin sulfate by high performance liquid chromatography with pulsed electrochemical detection. Chin. J. Chem 23:1207–1212.
  • C. Carbon, E. Collatz, and G. Humbert. Aminoglycosides (aminocyclitols). In Antimicrobial Agents Annual I, 1–16P. K. Peterson, and J. Verhoef. Elsevier Science, Amsterdam, (1986).
  • J. S. M. S. Carla, and I. C. Roberto. (2001). Optimization of xylitol production by Candida guilliermondi FTI 20037 using response surface methodology. Process Biochem 36:1119–1124.
  • J. C. Carmen, J. L. Nelson, B. L. Beckstead, C. M. Runyan, R. A. Robison, G. B. Schaalje, and W. G. Pitt. (2004). Ultrasonic-enhanced gentamicin transport through colony biofilms of Pseudomonas aeruginosa and Escherichia coli. J. Infect. Chemother 10:193–199.
  • D. Cascaval, A. I. Galaction, N. Nicuta, and A. C. Blaga. (2007). Selective separation of gentamicins from the biosynthetic mixture by reactive extraction. Separat. Purif. Technol 57:264–269.
  • E. Cenni, D. Granchi, and A Pizzoferrato. (2002). Platelet activation after in vitro contact with seven acrylic bone cements. J. Biomat. Sci 13:17–25.
  • G. L. Challis, and D. A. Hopwood. (2003). Synergy and contingency as driving forces for the evolution of multiple secondary metabolite production by Streptomyces species. Proc. Nat. Acad. Sci. USA 100:14555–14561.
  • H. I. Chang, Y.-C. Lau, C. Yan, and A. G. A Coombes. (2008). Controlled release of an antibiotic, gentamicin sulphate, from gravity spun polycaprolactone fibers. J. Biomed. Mater. Res. A 84:230–237.
  • H. I. Chang, Y. Perrie, and A. G. A Coombes. (2006). Delivery of the antibiotic gentamicin sulphate from precipitation cast matrices of polycaprolactone. J. Controlled Release 110:414–421.
  • J Chen. (1990). Effect of stirrer on the fermentative production of gentamicin. Huagong Jixie 17:94–96.
  • J. Chen, J. Chu, S. Zhang, and Y Li. (2001). Screening resting cell system for study of gentamicin biosynthesis. Huadong Ligong Daxue Xuebao 27:135–138.
  • J.-F. Chen, H. Chen, Y.-X. Zhang, Y.-H. Guo, C. Meng, and X.-A Shi. (2006). Optimization of fermentation conditions on sisomicin biosynthesis. Guocheng Gongcheng Xuebao 6:445–449.
  • Y. Chen, Y. Shang, X. Li, X. Wu, and X Xiao. (2008). Development of an enzyme-linked immunoassay for the detection of gentamicin in swine tissues. Food Chem 108:304–309.
  • M. Cherlet, S. D. Baere, and P. D. Backer. (2000). Determination of gentamicin in swine and calf tissues by high-performance liquid chromatography combined with electrospray ionization mass spectrometry. J. Mass Spectrom 35:1342–1350.
  • D. B. Choi, P. M. Yin, O. Y. Choi, and D. Y. Shin. (2005). Strain improvement for high gentamicin production using Micromonosporas purpurea. Korean J. Environ. Health 31:327–331.
  • J. Chu, B. Li, S. Zhang, and Y Li. (2000). On-line ultrasound stimulates the secretion and production of gentamicin by Micromonospora echinospora. Process Biochem 35:569–572.
  • J. Chu, W. Niu, S. Zhang, Y. Zhuang, H. Hu, and Y Li. (2004). Effect of metal ions on the binding of gentamicin to the peptidoglycan of Micromonospora echinospora. Process Biochem 39:1145–1150.
  • J. Chu, S. Zhang, Y. Zhuang, J. Chen, and Y Li. (2002). Factors affecting the biosynthesis and secretion of gentamicin. Process Biochem 38:815–820.
  • W.-H. Chung, K. W. Chung, J. H. Kim, Y.-S. Cho, and S. H. Hong. (2007). Effects of a single intratympanic gentamicin injection on Meniere's disease. Acta Oto-Laryngologica 127:61–66.
  • J. Ciampolini, and K. G. Harding. (2000). Pathophysiology of chronic bacterial osteomyelitis. Why do antibiotics fail so often?. Postgrad. Med. J 76:479–483.
  • P. J. Claes, R. Busson, and H Vanderhaeghe. (1984). Determination of the component ratio of commercial gentamicins by high-performance liquid chromatography using pre-column derivatization. J. Chromatogr 298:445–457.
  • J. P. Clancy, Z. Bebok, F. Ruiz, C. King, J. Jones, L. Walker, H. Greer, J. Hong, L. Wing, M. Macaluso, R. Lyrene, E. J. Sorscher, and D. M. Bedwell. (2001). Evidence that systemic gentamicin suppresses premature stop mutations in patients with cystic fibrosis. Am. J. Respir. Crit. Care Med 163:1683–1692.
  • I. Clarot, P. Chaimbault, F. Hasdenteufel, P. Netter, and A Nicolas. (2004). Determination of gentamicin sulfate and related compounds by high-performance liquid chromatography with evaporative light scattering detection. J. Chromatogr. A 1031:281–287.
  • Consortium CFGA. (1994). Population variation of common cystic fibrosis mutations. The cystic fibrosis genetic analysis consortium. Hum. Mutat 4:167–177.
  • A. G. A. Coombes, S. C. Rizzi, M. Willianson, J. E. Barralet, S. Downes, and W. A. Wallace. (2004). Precipitation casting of polycaprolactone for applications in tissue engineering and drug delivery. Biomaterials 25:315–325.
  • D. J. Cooper, J. L. Daniels, M. D. Yudis, H. M. Marigliano, R.D. Guthrie, and S. T. K. Bukhari. The gentamicin antibiotics. III.. The gross structure of the gentamicin C components. J. Chem. Soc C., (1971) 3126–3129.
  • M. Covi, and G Velluti. (1995). Comparison of the efficacy and safety of isepamicin and amikacin in the treatment of acute lower respiratory tract infections caused by Gram-negative organisms. J. Chemother 7 (Suppl. 2):137–142.
  • H. Curiel, W. Vanderaerden, H. Velez, J. Hoogmartens, and A Van Schepdael. (2007). Analysis of underivatized gentamicin by capillary electrophoresis with UV detection. J. Pharm. Biomed. Anal 44:49–56.
  • G. Dai, J. Wu, Z. Li, Y. Wang, G. Qin, M. Su, P. Li, and T Yuan. (1999). Increasing the yield of gentamicin by N+ implantation of Micromonospora purpurea KR960796 and fermentation condition optimization. Zhengzhou Daxue Xuebao Ziran Kexueban 31:65–69.
  • T. Dairi, T. Ohta, E. Hashimoto, and M Hasegawa. (1992). Self cloning in Micromonospora olivasterospora of fms genes for fortimicin A (astromicin) biosynthesis. Mol. Gen. Genet 232:262–270.
  • G. F. Dall, P. M. S. Simpson, and S. J. Breusch. (2007). In vitro comparison of Refobacin-Palacos R with Refobacin bone cement and Palacos R + G. Acta Orthopaedica 78:404–411.
  • P. J. L. Daniels, C. Luce, T. L. Nagabhushan, R. S. Jaret, D. Schumacher, H. Reimann, and J Ilavasky. (1975). The gentamicin antibiotics. 6. Gentamicin C2b, and aminoglycoside antibiotic produced by Micromonospora purpurea mutant JI-33. J. Antibiot. (Tokyo) 28:35–41.
  • W. Dasu, and T Panda. (2000). Optimization of microbiological parameters for enhanced griseofulvin production using response surface methodology. Bioprocess Eng 22:45–49.
  • S. J. Daum, D. Rosi, and W. A. Goss. (1977). Mutational biosynthesis by idiotrophs of Micromonospora purpurea. II. Conversion of non-amino containing cyclitols to aminoglycoside antibiotics. J. Antibiot. (Tokyo) 30:98–105.
  • J. Davies, and A Jimenez. (1980). A new selective agent for eukaryotic cloning vectors. Am. J. Trop. Med. Hyg 29:1089–1092.
  • J. E. Davies. Aminoglycoside aminocyclitol antibiotics and their modifying enzymes. In: Antibiotics in Laboratory Medicine, 691V. Lorain. ed. Williams and Wilkins, BaltimoreMD, (1986).
  • L. De Beer, R. Stokroos, and H Kingma. (2007). Intratympanic gentamicin therapy for intractable Meniere's disease. Acta Oto-Laryngologica 127:605–612.
  • A. L. Demain, and J. L. Adrio. (2008). Strain improvement for production of pharmaceuticals and other microbial metabolites by fermentation. Progr. Drug Res 65:251–289.
  • Z. Deng, and L Bai. (2006). Antibiotic biosynthetic pathways and pathway engineering? a growing research field in China. Nat. Prod. Rep 23:811–827.
  • M. DiCicco, T. Duong, A. Chu, and S. A. Jansen. (2003). Tobramycin and gentamycin elution analysis between two in situ polymerizable orthopaedic composites. J. Biomed. Mater. Res. B Appl. Biomater 65:137–149.
  • A Dimchev. (1989a). Adaptive response to treatment with N-methyl-N-nitro-N-nitrosoguanidine and potentiation of its mutagenic effect by chloramphenicol in Micromonospora purpureavar. violacea BTCC 60. Epidemiol. Mikrobiol. Infekt. Boles 26:25–30.
  • A Dimchev. (1989b). Gentamicin synthesis with Micromonospora purpureavar. violacea. Biotekhnol Khim 1:24–28.
  • S. Dionisotti, F. Bamonte, F. Scaglione, and E Ongini. (1991). Simple measurement of isepamicin, a new aminoglycoside antibiotic, in guinea pig and human plasma, using high-performance liquid chromatography with ultraviolet detection. Ther. Drug Monit 13:73–78.
  • J. Distler, C. Braun, A. Ebert, and W Piepersberg. (1987). Gene cluster for streptomycin biosynthesis in Streptomyces griseus: Analysis of a central region including the major resistance gene. Mol. Gen. Genet 208:204–210.
  • G. V. Doern, R. H. Glew, D. G. Parker, R. A. Pavuk, and S. D. Brown. (1981). Evaluation of a new latex agglutination inhibition card test for determining serum gentamicin levels. Antimicrob. Agents Chemother 19:930–933.
  • A. J. Domb, and M Maniar. (1993). Absorbable biopolymers derived from dimer fatty acids. J. Polym. Sci. Part A: Polym. Chem 31:1275–1285.
  • G. S. M. J. E. Duchateau, J. Zuidema, and F. W. H. M Merkus. (1986). Bile salts and intranasal drug absorption. Int. J. Pharm. 31:193–199.
  • P. M. Duran, and J. E. Bailey. (1987). Effect of immobilization on the nature of glycolytic oscillation in yeast. Biotechnol. Bioeng 29:892–897.
  • D. J. Earnshaw, and M. J. Gait. (1998). Hairpin ribozyme cleavage catalyzed by aminoglycoside antibiotics and the polyamine spermine in the absence of metal ions. Nucl. Acids Res 26:5551–5561.
  • R. S. Edson, and C. L. Terrell. (1999). The aminoglycosides. Mayo Clinic Proceed 74:519–528.
  • M Elibol. (2004). Process optimization of medium composition for actinorhodin production by Streptomyces coelicolorA3(2) with response surface methodology. Process Biochem 39:1057–1062.
  • M. G. El-Sayed, M. E. Hatem, and A. A. El-Kmay. (1989). Disposition kinetics of gentamicin in normal and endometritic cows using a microbiological assay. Deutsch Tierarztl. Wochenschr 96:412–415.
  • M. A. El-Sokkary, E. Habib, R. Hassan, M. A. El-Eman, and W. A. El-Naggar. (1995a). Effect of some additives on gentamicin production by free and immobilized cells of Micromonospora purpurea. Mansoura J. Pharm. Sci 11:170–187.
  • M. A. El-Sokkary, E. Habib, R. Hassan, M. A. El-Eman, and W. A. El-Naggar. (1995b). Gentamicin production by free and immobilized of M. purpurea. Mansoura J. Pharm. Sci 11:149–169.
  • G. T. Ensing, D. Neut, J. R. van Horn, H. C. van der Mei, and H. J. Busscher. (2006). The combination of ultrasound with antibiotics released from bone cement decreases the viability of planktonic and biofilm bacteria: an in vitro study with clinical strains. J. Antimicrob. Chemother 58:1287–1290.
  • L. Escalante, R. Gonzalez, A. M. Obregon, and S Sanchez. (1992). Carbon catabolite regulation of gentamicin formation. J. Antibiot. (Tokyo) 45:465–469.
  • European Pharmacopoeia.. 1997. Microbiological assay of antibiotics, 3rd ed., 2.7.2. European Department for the Quality of Medicines, Strausbourg.
  • D. C. Eustice, and J. M. Wilhelm. (1984). Mechanisms of action of aminoglycoside antibiotics in eucaryotic protein synthesis. Antimicrob. Agents Chemother 26:53–60.
  • S. Faine, and D. C. Knight. (1968). Rapid microbiological assay of antibiotic in blood and other body fluids. The Lancet 292:375–378.
  • K. Fearon, V. McClendon, B. Bonetti, and D. M. Bedwell. (1994). Premature translation termination mutations are efficiently suppressed in a highly conserved region of yeast Ste6p, a member of the ATP-binding cassette (ABC) transporter family. J. Biol. Chem 269:17802–17808.
  • J. M. Fernandez-Ramos, A. M. Garcia-Campana, F. Ales-Barrero, and J. M. Bosque-Sendra. (2006). Determination of gentamicin in pharmaceutical formulations using peroxyoxalate chemiluminescent detection in flow-injection analysis. Talanta 69:763–768.
  • R. M. Fielding. (1991). Liposomal drug delivery: advantages and limitations from a clinical pharmacokinetics and therapeutic perspective. Clin. Pharmacokinetics 21:155–164.
  • A Fleming. (1929). On the antibacterial action of a Penicillium, with special reference to their use in the isolation of B. influenzae. Brit. J. Exp. Pathol 10:226–236.
  • S. M. Forrest, G. S. Cross, T. Flint, A. Speer, K. J. Robson, and K. E. Davies. (1988). Further studies of gene deletions that cause Duchenne and Becker muscular dystrophies. Genomics 2:109–114.
  • D. Fourmy, M. I. Recht, S. C. Blanchard, and J. D. Puglisi. (1996). Structure of the A site of Escherichia coli 16S ribosomal RNA complexed with an aminoglycoside antibiotic. Science 274:1367–1371.
  • F. Francis, A. Sabu, K. M. Nampoothiri, S. Ramachandran, S. Ghosh, G. Szakacs, and A Pandey. (2003). Use of response surface methodology for optimizing process parameters for the production of α -amylase by Aspergillus oryzae. Biochem. Eng. J 15:107–115.
  • R. A. Frizzell. (1995). Functions of the cystic fibrosis transmembrane conductance regulator protein. Am. J. Respir. Crit. Care Med 151:S54–S58.
  • P. Frutos, E. Diez-Pena, G. Frutos, and J. M. Barrales-Rienda. (2002). Release of gentamicin sulphate from a modified commercial bone cement. Effect of (2-hydroxyethyl methacrylate) comonomer and poly (N-vinyl-2-pyrrolidone) additive on release mechanism and kinetics. Biomaterials 23:3787–3797.
  • K. F. Fu, and H. C. Neu. (1976). In vitro study of netilmicin compared with other aminoglycosides. Antimicrob. Agents Chemother 10:526–534.
  • T. Fujimoto, Y. Tsuda, R. Tawa, and S Hirose. (1989). Fluorescence polarization immunoassay of gentamicin or netilmicin in blood spotted on filter paper. Clin. Chem 35:867–869.
  • I. Gado, J. Berdy, I. Koczka, I. Horvath, M. Jaray, and G Zlatos. (1975). Gentamicin antibiotics. Hung. Teljes 10:972.
  • C. Gamazo, M. J. Blanco-Prieto, M. C. Lecároz, A. I. Vitas, B. Gander, J. M. Irache, and S Prior. (2004). New therapeutic approaches for the treatment of Brucella infections: Gentamicin entrapment into drug delivery systems. Curr. Med. Chem.—Anti Infective Agents 3:43–56.
  • J. Gavalda, P. L. Onrubia, M. T. M. Gomez, X. Gomis, J. L. Ramirez, O. Len, D. Rodriguez, M. Crespo, I. Ruiz, and A Pahissa. (2003). Efficacy of ampicillin combined with ceftriaxone and gentamicin in the treatment of experimental endocarditis due to Enterococcus faecalis with no high-level resistance to aminoglycosides. J. Antimicrob. Chemother 52:514–517.
  • T. A. Getek, M. L. Vestal, and T. G. Alexander. (1991). Analysis of gentamicin sulfate by high-performance liquid chromatography combined with thermospray mass spectrometry. J. Chromatogr. A 554:191–203.
  • S. Gheduzzi, J. J. Webb, and A. W. Miles. (2006). Mechanical characterisation of three percutaneous vertebroplasty biomaterials. J. Mater. Sci. Mater. Med 17:421–426.
  • E. F. Gillard, J. S. Chamberlain, E. G. Murphy, C. L. Duff, B. Smith, A. H. Burghes, M. W. Thompson, J. Sutherland, I. Oss, S. E. Bodrug, H. J. Klamut, P. N. Ray, and R. G. Woron. (1989). Molecular and phenotypic analysis of patients with deletions within the deletion-rich region of Duchenne muscular dystrophy (DMD) gene. Am. J. Hum. Genet 45:368–372.
  • R. A. Giuliano, G. A. Verpooten, and M. E. de Broe. (1986). Renal cortical kinetics of gentamicin after implantation of gentamicin-polymethylmethacrylate beads in rats. Antimicrob. Agents Chemother 30:385–389.
  • R. Gonzalez, L. Islas, A. M. Obregon, L. Escalante, and S Sanchez. (1995). Gentamicin formation inMicromonospora purpurea: stimulatory effect of ammonium. J. Antibiot 48:479–483.
  • M. Goodfellow, and S. T. Williams. (1983). Ecology of actinomycetes. Annu. Rev. Microbiol 37:189–192.
  • B. Gosmann, and H. J. Rehm. (1986). Oxygen uptake of microorganisms entrapped in Ca-alginate. Appl. Microbiol. Biotechnol 23:163–167.
  • S. Goto, A. Tsuji, T. Murai, M. Nishida, H. Tsukano, and H Watanabe. (1998). Therapeutic effect of antimicrobial drugs against experimental infections due to Yersinia pestis in mice. J. Infect. Chemother 4:16–19.
  • I. V. Grachev, T. N. Laznikova, and N. V. Orlova. (1976). Value of pH for growth of gentamicin-producing organism and biosynthesis of the antibiotic. Antibiotiki (Moscow) 21:102–105.
  • A. E. Graham, E. Speicher, and B Williamson. (1997). Analysis of gentamicin sulfate and a study of its degradation in dextrose solution. J. Pharm. Biomed. Anal. 15:537–543.
  • J. K. Griffiths, R. Balakrishnan, G. Widmer, and S Tzipori. (1998). Paromomycin and geneticin inhibit intracellular Cryptosporidium parvum without trafficking through the host cell cytoplasm: implications for drug delivery. Infect. Immun 66:3874–3883.
  • R.-W. Guo, J. Chu, Y.-P. Zhuang, and S.-L Zhang. (2005). Effect of agitator type on the mycelial morphology and gentamicin production in Micromonospora echinospora. Chin. J. Antibiot 27:456–461.
  • P.D. Haaland. Experimental Design in Biotechnology. Marcel Dekker, New York, (1989).
  • W. Haasnoot, P. Stouten, G. Cazemier, A. Lommen, J. F. M. Nouws, and H. J. Keukens. (1999). Immunochemical detection of aminoglycosides in milk and kidney. Analyst 124:301–305.
  • D. Haltrich, B. Lavssamayer, and W Steiner. (1994). Xylanase formation by Sclerotium rolfsii effect of growth substrates and development of a culture medium using statistical designed experiments. Appl. Microbiol. Biotechnol 42:522–530.
  • J. W. Hamilton. (2001). Gentamicin in pharmacogenetic approach to treatment of cystic fibrosis. Lancet 358:2014–2016.
  • S. H. Han, and C. S. Shin. (1992). Effect of magnesium sulfate on sisomicin fermentation. Korean J. Appl. Microbiol. Biotechnol 5:96–99.
  • S. D. Hanes, and V. L. Herring. (2001). Gentamicin enzyme-linked immunosorbent assay for microdialysis samples. Ther. Drug Monit 23:689–693.
  • C. Hascicek, N. Gonul, and N Erk. (2003). Mucoadhesive microspheres containing gentamicin sulfate for nasal administration: preparation and in vitro characterization. Il Farmaco 58:11–16.
  • A. Hassoun, R. Spera, and J. Dunkel. Tularemia and once-daily gentamicin. Antimicrob. Agents Chemother. (2006) 50824–824.
  • M. Hayakawa, T. Sadakata, T. Kajiura, and H Nonomura. (1991). New methods for the highly selective isolation of Micromonospora and Microbispora from soil. J. Ferment. Bioeng 72:320–326.
  • G. Q. He, Q. H. Chen, X. J. Ju, and N. D. Shi. (2004). Improved elastase production by Bacillus sp. EL31410—further optimization and kinetics studies of culture medium for batch fermentation. J. Zhejiang Univ. Sci 5:149–156.
  • L. K. Hein, M. Bawden, V. J. Muller, D. Sillence, J. J. Hopwood, and D. A. Brooks. (2004). α -L Iduronidase premature stop codons and potential read-through in mucopolysaccharidosis type I patients. J. Mol. Biol 338:453–462.
  • D. N. Heller, S. B. Clark, and H. F. Righter. (2000). Confirmation of gentamicin and neomycin in milk by weak cation-exchange extraction and electrospray ionization/ion trap tandem mass spectrometry. J. Mass Spectrom 35:39–49.
  • D. N. Heller, J. O. Peggins, C. B. Nochetto, M. L. Smith, and Moulton K. Chiesa OA. (2005). LC/MS/MS measurement of gentamicin in bovine plasma, urine, milk, and biopsy samples taken from kidneys of standing animals. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci 821:22–30.
  • J. G. E. Hendriks, G. T. Ensing, J. R. van Horn, J. Lubbers, H. C. van der Mei, and H. J. Busscher. (2003). Increased release of gentamicin from acrylic bone cements under influence of low-frequency ultrasound. J. Controlled Release 92:369–374.
  • S. L. Henry, and K. P. Galloway. (1995). Local antibacterial therapy for the management of orthopedic infections—pharmacokinetic considerations. Clin. Pharmacokinet 9:36–45.
  • J. R. Hildebrand. (2002). Arzneimittelfälschungen in den USA. Pharm. Ind 64:147–150.
  • M. Himabindu, and A Jetty. (2006). Optimization of nutritional requirements for gentamicin production by Micromonospora echinospora. Indian J. Exp. Biol 44:842–848.
  • M. Himabindu, R. Potumarthi, K. Vishalakshi, and A Jetty. (2006). Optimization of critical medium components for the maximal production of gentamicin by Micromonospora echinospora ATCC 15838 using response surface methodology. Appl. Biochem. Biotechnol 134:143–154.
  • M. Himabindu, R. Potumarthi, and A Jetty. (2007a). Enhancement of gentamicin production by mutagenesis and non-nutritional stress conditions in Micromonospora echinospora. Process Biochem 42:1352–1356.
  • M. Himabindu, R. Potumarthi, and A. Jetty. Evaluation of immobilization conditions for enhanced production of gentamicin in repeated batch operations by Micromonospora echinospora. Int. J. Chem. Reactor Eng. (2007b) 5A38. (Available online at http://www.bepress.com/ijcre/vol5/A38)..
  • M. Himabindu, R. Potumarthi, and A Jetty. (2008). Gentamicin production by Micromonospora echinospora (Me-22) in stirred tank reactor: Effect of various parameters. J. Basic Microbiol 48:53–58.
  • G. Hirsbrunner, and A Steiner. (1998). Treatment of infectious arthritis of the radiocarpal joint of cattle with gentamicin-impregnated collagen sponges. Vet. Record 142:399–402.
  • D. M. Hocknull, and M. D. Lilly. (1990). The use of free and immobilized Arthrobacter simplex in organic solvent/aqueous two liquid phase reactors. Appl. Microbiol. Biotechnol 33:148–153.
  • E. P. Hoffman, R. H. J. Brown, and L. M. Kunkel. (1987). Dystrophin: the protein product of the Duchenne muscular dystrophy locus. Cell 51:919–928.
  • S. J. Holcombe, R. K. Schneider, L. R. Bramlage, and R. M. Embertson. (1997). Use of antibiotic impregnated polymethyl methacrylate in horses with open or infected fractures or joints: 19 cases (1987–1995). J. Am. Vet. Med. Assoc 211:889–893.
  • R. K. Holmes, and J. P. Sanford. (1974). Enzymatic assay for gentamicin and related aminoglycoside antibitotics. J. Infect. Dis 129:519–527.
  • H. A. Holt, L. O. White, K. A. Bedford, K. E. Bowker, D. S. Reeves, and A. P. MacGowan. (1994). An evaluation of three new immunoassays for determination of serum gentamicin concentrations. J. Antimicrob. Chemother 34:747–754.
  • C. E. Holy, J. E. Davies, and M. S. Shoichet. Bone tissue engineering on biodegradable polymers: preparation of a novel poly (lactide co-glycolide) foam.. In Biomaterials, Carriers for Drug Delivery, and Scaffolds for Tissue Engineering, 272–274N. A. Peppas, D. J. Mooney, A. G. Mikos, and L. Brannon-Peppas. eds. A.I.Ch.E. Press, New York, (1997).
  • C. E. Holy, C. Cheng, J. E. Davies, and M. S. Shoichet. (2001). Optimizing the sterilization of PLGA scaffolds for use in tissue engineering. Biomaterials 22:25–31.
  • D. A. Hopwood, H. M. Wright, M. J. Bibb, and S. N. Cohen. (1977). Genetic recombination through protoplast fusion in Streptomyces. Nature (London) 268:171–174.
  • S. Hoshihiko, C. Noiri, K. Matsunaga, K. Katsumata, E. Satoh, and K Nagoka. (1988). Nucleotide sequence of the ribostamycin phosphotransferase gene and its control region in Streptomyces ribosidificus. Gene 68:285–296.
  • P. A. Hoskisson, G. P. Sharples, and G Hobbs. (2003). The importance of amino acids as carbon source for Micromonospora echinospora (ATCC 15837). Lett. Appl. Microbiol 36:268–271.
  • M. Howard, R. A. Frizzell, and D. M. Bedwell. (1996). Aminoglycoside antibiotics restore CFTR function by overcoming premature stop mutations. Nat. Med 2:467–469.
  • M. T. Howard, B. H. Shirts, L. M. Petros, K. M. Flanigan, R. F. Gesteland, and J. F. Atkins. (2000). Sequence specificity of aminoglycoside induced stop codon read-through: potential implications for treatment of Duchenne muscular dystrophy. Ann. Neurol 48:164–169.
  • S. C. Hsu, and J. L. Lockwood. (1975). Powdered chitin agar as a selective medium for enumeration of actinomycetes in water and soil. Appl. Microbiol 29:422–426.
  • H. Hu, and K Ochi. (2001). Novel approach for improving the productivity of antibiotic-producing strains by inducing combined resistant mutations. Appl. Environ. Microbiol 67:1885–1892.
  • H. Hu, Q. Zhang, and K Ochi. (2002). Activation of antibiotic biosynthesis by specific mutations in the rpoB gene (encoding the RNA polymerase β subunit) o. Streptomyces lividans. J. Bacteriol 184:3984–3991.
  • W. S. Hu, A. F. Brana, and A. L. Demain. (1984). Carbon source regulation of cephem antibiotic production by resting cells of Streptomyces clavuligerus and its reversal by protein synthesis inhibitors. Enzyme Microb. Technol 6:155–160.
  • L. Huan, Zhang Z. Liu-Junke, and Y Xue. (1987). Mutation breeding by near UV light in the presence of 8-methoxysopralen on gentamicin producer. Kangshengsu 12:120–125.
  • F. Huang, Y. Li, J. Yu, and J. B. Spencer. (2002). Biosynthesis of aminoglycoside antibiotics: cloning, expression and characterisation of an aminotransferase involved in the pathway to 2-deoxystreptamine. Chem. Commun 23:2860–2861.
  • C. G. Hyun, S. S. Kim, J. K. Sohng, J. J. Hahn, J. W. Kim, and J. W. Suh. (2000). An efficient approach for cloning dNDP-glucose synthase gene from actinomycetes and its application in Streptomyces spectabilis, a spectinomycin producer. FEMS Microbiol. Lett 183:183–189.
  • J. Ilavsky, A. P. Bayan, W. Charney, and H. Reimann. New antibiotic from Micromonospora purpurea JI-20. US Patent. 3903072.. (1975).
  • L. Illum, N. F. Farraj, H. Critchley, and S. S. Davis. (1988). Nasal administratrion of gentamicin using a novel microsphere delivery system. Int. J. Pharm 46:261–265.
  • T. Inaoka, K. Takahashi, H. Yada, M. Yoshida, and K Ochi. (2004). RNA polymerase mutation activates the production of a dormant antibiotic 3,3′-neotrehalosadiamine via an autoinduction mechanism in Bacillus subtilis. J. Biol. Chem 279:3885–3892.
  • N. Isoherranen, and S Soback. (2000). Determination of gentamicin after trimethylsilylimidazole and trifluoroacetic anhydride derivatization using gas chromatography and negative ion chemical ionization ion trap mass spectrometry. Analyst 125:1573–1576.
  • L. P. Ivanitskaya, E. M. Singal, M. V. Bibikova, and S. N. Vostrov. (1978). Directed isolation of Micromonospora generic cultures on a selective medium with gentamicin. Antibiotiki (Moscow) 23:690–692.
  • N. Iwase, F. Kudo, N. Yamauchi, and K Kakinuma. (1998). Substrate specificity of 2-deoxy-scyllo-inosose synthase, the starter enzyme for 2-deoxystreptamine biosynthesis, towards deoxyglucose-6-phosphates and proposed mechanism. Biosci. Biotechnol. Biochem 62:2396–2407.
  • R Janknegt. (1990). Aminoglycoside therapy: current use and future prospects. Pharm. Weekly Sci 12:81–90.
  • S. M. Jankovic, and V Ninkovic. (1998). Monitoring of serum concentrations of antibiotics by microbiological method: a one-year experience. Med. Pregl 51:333–342.
  • M. Jarai, S. Piukovich, and L Szoke. (1982). Process for the production of gentamicin C by Micromonospora purpurea. Hung. Patent Appl 184:991.
  • P. A. Jauert, L. E. Jensen, and D. T. Kirkpatrick. (2005). A novel yeast genomic DNA library on a geneticin-resistance vector. Yeast 22:653–657.
  • H. J. Jeong, E. S. Jang, B. I. Han, K. H. Lee, M. S. Ock, H. H. Kong, D. I. Chung, S. Y. Seol, D. T. Cho, and H. S. Yu. (2007). Acanthamoeba: Could it be an environmental host of Shigella. Exp. Parasitol 115:181–186.
  • W. Jianlong, L. Ping, and Q Yi. (1997). Biodegradation of phthalic acid esters by immobilized microbial cells. Environ. Int 23:775–782.
  • A. Jimenez, and J Davies. (1980). Expression of a transposable antibiotic resistance element in Saccharomyces. Nature (London) 287:869–871.
  • Y. Jin, J.-W. Jang, C.-H. Han, and M.-H Lee. (2005). Development of ELISA and immunochromatographic assay for the detection of gentamicin. J. Agric. Food Chem 53:7639–7643.
  • J. E. Johnson, S. Crawford, and J. H. Jorgensen. (1982). Evaluation of the macro-vue latex agglutination test for quantitation of gentamicin in human serum. J. Clin. Microbiol 16:299–302.
  • R. N. Jones. (1995). Isepamicin (SCH21420, 1-N-HAPA gentamicin B): microbiological characteristics including antimicrobial potency of spectrum of activity. J. Chemother 7 (Suppl. 2):7–16.
  • U. Joosten, A. Joist, T. Frebel, B. Brandt, S. Diederichs, and C von Eiff. (2004). Evaluation of an in situ setting injectable calcium phosphate as a new carrier material for gentamicin in the treatment of chronic osteomyelitis: Studies in vitro and in vivo. Biomaterials 25:4287–4295.
  • H. Jork, and F. R. Kunz. (1988). Isolation of gentamicin C compounds from culture filtrate of Micromonospora purpurea. J. Chromatogr 450:115–119.
  • E. Kaale, S. Leonard, A. Van Schepdael, E. Roets, and J Hoogmartens. (2000). Capillary electrophoresis analysis of gentamicin sulphate with UV detection after pre-capillary derivatization with 1,2-phthalic dicarboxaldehyde and mercaptoacetic acid. J. Chromatogr. A 895:67–79.
  • E. Kaale, Y. Long, H. A. Fonge, C. Govaerts, K. Desmet, A. Van Schepdael, and J Hoogmartens. (2005). Gentamicin assay in human serum by solid-phase extraction and capillary electrophoresis. Electrophoresis 26:640–647.
  • E. Kaale, E. Van Goidsenhoven, A. Van Schepdael, E. Roets, and J Hoogmartens. (2001). Electrophoretically mediated microanalysis of gentamicin with in-capillary derivatization and UV detection. Electrophoresis 22:2746–2754.
  • P. Kabasakalian, S. Kalliney, and A. W. Magatti. (1977). Determination of gentamicin complex components in fermentation broth by in-situ fluorometric measurements of 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole derivatives. Anal. Chem 49:953–955.
  • P. J. Kadar. (1972). Thin-layer chromatograph of basic water-soluble antibiotics on resin-coated chromatoplates. J. Antibiot. (Tokyo) 25:677–678.
  • P. J. Kadar, and H Ilona. (1980). Aminoglycoside antibiotics: thin-layer chromatography, bioautographic detection and quantitative assay. J. Chromatogr 195:251–256.
  • J. L. Kadurugamuwa, A. J. Clarke, and T. S. Beveridge. (1993). Surface action of gentamicin o. Pseudomonas aeruginosa. J. Bacteriol 175:5798–5805.
  • D. A. Kafetzis, H. C. Maltezou, M. Mavrikou, C. Siafas, I. Paraskakis, D. Delis, and C Bartsokas. (2000). Isepamicin versus amikacin for the treatment of acute pyelonephritis in children. Int. J. Antimicrob. Agents 14:51–55.
  • L. A. Kaine, and K. A. Wolnick. (1994). Forensic investigation of gentamicin sulfates by anion-exchange ion chromatography with pulsed electrochemical detection. J. Chromatogr. A 674:255–261.
  • R. Karimi, and M Ehrenberg. (1994). Dissociation rate of cognate peptidyl tRNA from the A-site of hyper-accurate and error-prone ribosomes. Eur. J. Biochem 226:355–360.
  • H. Kase, Y. Odakura, and K Nakayama. (1982). Sagamicin and the related aminoglycosides: fermentation and biosynthesis. I. Biosynthetic studies with the blocked mutants of Micromonospora sagamiensis. J. Antibiot. (Tokyo) 35:1–9.
  • K. M. Keeling, D. A. Brooks, J. J. Hopwood, P. Li, J. N. Thompson, and D. M. Bedwell. (2001). Gentamicin-mediated suppression of Hurler syndrome stop mutations restores a low level of α -L-iduronidase activity and reduces lysosomal glycosaminoglycan accumulation. Hum. Mol. Genet 10:291–299.
  • G. H. Kelemen, E. Cundliffe, and I Financsek. (1991). Cloning and characterization of gentamicin-resistance genes from Micromonospora purpurea and Micromonospora rosea. Gene 98:53–60.
  • G. H. Kelemen, I. Financsek, and M Jarai. (1989). Efficient transformation of Micromonospora purpurea with pIJ702 plasmid. J. Antibiot. (Tokyo) 42:325–328.
  • M. K. Kharel, D. B. Basnet, H. C. Lee, K. Liou, J. S. Woo, B.-G. Kim, and J. K. Sohng. Isolation and characterization of tobramycin biosynthetic gene cluster from Streptomyces tenebrarius. FEMS Microbiol. Lett.. (2004a) 230:185–190.
  • M. K. Kharel, D. B. Basnet, H. C. Lee, K. Liou, Y. H. Moon, J.-J. Kim, J. S. Woo, and J. K. Sohng. (2004b). Molecular cloning and characterization of a 2-deoxystreptamine biosynthetic gene cluster in gentamicin-producing Micromonospora echinospora ATCC15835. Mol. Cells 18:71–78.
  • M. K. Kharel, B. Subba, H. C. Lee, K. Liou, and J. K. Sohng. (2005). Characterization of L-glutamine:2-deoxy-scyllo-inosose aminotransferase (tbmB) from Streptomyces tenebrarius. Bioorg. Med. Chem. Lett 15:89–92.
  • S. M. Kheira, and M. M. A El-Sokkary. (2003). Effect of aminoglycosides and β -lactam antibiotics on the production of gentamicin by Micromonospora purpurea DSM 43036. New Egyptian J. Microbiol 6:197–210.
  • F. A. Kidd, S. D. Wullschleger, K. Dawley, and C. P. P Reid. (1982). Use of gentamicin in axenic culturing of ectomycorrhizal plants. Appl. Environ. Microbiol 44:506–508.
  • H. Kienapfel, R. Hildebrand, T. Neumann, R. Specht, M. Koller, I. Celik, H. H. Mueller, P. Griss, K. J. Klose, and C Georg. (2004). The effect of Palamed® G bone cement on early migration of tibial components in total knee arthroplasty. Inflammat. Res 53:S159–S163.
  • P. J. Kijak, J. Jackson, and B Shaikh. (1997). Determination of gentamicin in bovine milk using liquid chromatography with post-column derivatization and fluorescence detection. J. Chromatogr. B Biomed. Sci. Appl 691:377–382.
  • D. H. Kim, J. H. Suh, J. Y. Ju, S. K. Yum, and C. S. Shin. (1998). Analysis of sisomicin binding sites in Micromonospora inyoensis cell wall. FEMS Microbiol. Lett 166:9–13.
  • K. S. Kim, N. Y. Cho, H. S. Pai, and D. D. Y Ryu. (1983). Mutagenesis of Micromonospora rosaria by using protoplasts and mycelial fragments. Appl. Environ. Microbiol 46:689–693.
  • K. S. Kim, H. S. Pai, S. Y. Lee, and D. D. Y Ryu. (1990). Effect of intercalating dyes on the production of antibiotics by Micromonospora rosaria and Micromonospora purpurea. Enzyme Microb. Technol 12:564–570.
  • S. Kim, J. Song, and H. T. Choi. (2004). Genetic transformation and mutant isolation in Ganoderma lucidum by restriction enzyme-mediated integration. FEMS Microbiol. Lett 233:201–204.
  • S. Kimura, K. Ito, T. Miyagi, T. Hiranuma, K. Yoshioka, S. Ozasa, M. Matsukura, M. Ikezawa, M. Matsuo, Y. Takeshima, and T Miike. (2005). A novel approach to identify Duchenne muscular dystrophy patients for aminoglycoside antibiotics therapy. Brain Dev 27:400–405.
  • B. G. Knecht, A. Strasser, R. Dietrich, E. Märtlbauer, R. Niessner, and M. G. Weller. (2004). Automated microarray system for the simultaneous detection of antibiotics in milk. Anal. Chem 76:646–654.
  • Y Kobayashi. (2001). Clinical observation and treatment of leptospirosis. J. Infect. Chemother 7:59–68.
  • T. Kokubu, I. Karube, and S Suzuki. (1981). Protease production by immobilized mycelium of Steptomyces fradiae. Biotechnol. Bioeng 23:29–39.
  • A. Y. Kolosova, A. N. Blintsov, J. V. Samsonova, and A. M. Egorov. (1998). Development of an enzyme-linked immunosorbent assay for gentamicin in human blood serum. Fresenius J. Anal. Chem 361:329–330.
  • T. Korzybski. Antibiotics: Origin, Nature and Properties. American Society for Microbiology, Washington, DC.. (1978).
  • K. Kraisintu, R. T. Parfitt, and M. G. Rowan. (1982). A high-performance liquid chromatographic method for the determination and control of the composition of gentamicin sulphate. Int. J. Pharmaceut 10:67–75.
  • T. P. Krasnova, T. N. Laznikova, S. V. Dmitrieva, A. V. Valdimirov, and N. V. Orlova. (1979a). Comparative study of an active strain of Micromonospora purpurea and its poorly active mutant in relation to gentamicin biosynthesis. Antibiotiki (Moscow) 23:12–18.
  • T. P. Krasnova, I. V. Bukin, and N. V. Orlova. (1979b). Role of the components in the methylation system in the cobalamin-dependent gentamycin biosynthesis by a Micromonospora purpurea culture. Antibiotiki (Moscow) 23:12–18.
  • T. P. Krasnova, I. V. Bukin, and N. V. Orlova. (1979c). Study of the role of some methylation system components in the cobalamin-dependent biosynthesis of gentamycin by Micromonospora purpurea. Antibiotiki (Moscow) 24:808–815.
  • T. P. Krasnova, T. N. Laznikova, and N. V. Orlova. (1977). Effect of cobalt on the growth of a Micromonospora purpurea var. violacea 1935 culture and on the biosynthesis of gentamicin. Antibiotiki (Moscow) 22:201–206.
  • T. P. Krasnova, T. N. Laznikova, E. V. Likina, and N. V. Orlova. (1978). Role of cobalt in the biosynthesis of the components of the gentamicin complex. Antibiotiki (Moscow) 23:12–18.
  • F. Kudo, H. Tamegai, T. Fujiwara, U. Tagami, K. Hirayama, and K Kakinuma. (1999). Molecular cloning of the gene for the key carbocycle-forming enzyme in the biosynthesis of 2-deoxystreptamine-containing aminocyclitol antibiotics and its comparison with dehydroquinate synthase. J. Antibiot. (Tokyo) 52:559–571.
  • F. Kudo, N. Yamauchi, R. Suzuki, and K Kakinuma. (1997). Kinetic isotope effect and reaction mechanism of 2-deoxy-scyllo-inosose syntase derived from butirosin-producing Bacillus circulans. J. Antibiot. (Tokyo) 50:424–428.
  • W. Kusser, K. Zimmer, and F Fiedler. (1985). Characteristics of the binding of aminoglycoside antibiotics to teichoic acids: A potential model system for interaction of aminoglycosides with polyanions. Eur. J. Biochem 151:601–605.
  • E. Küster, and S. T. Williams. (1964). Selection of media for isolation of streptomycetes. Nature (London) 202:928–929.
  • W. Y. Lau, K. W. Chu, G. P. Poon, and K. K. Ho. (1988). Prophylactic antibiotics in elective colorectal sugery. Br. J. Surg. 75:782–785.
  • T. N. Laznikova, I. V. Gracheva, and N. V. Orlova. (1977). Effect of different forms of nitrogen in the biosynthesis of gentamicin by a Micromonospora purpurea var. violacea 1935 culture. Antibiotiki (Moscow) 22:579–581.
  • T. N. Laznikova, T. P. Krasnova, E. V. Lipina, and N. V. Orlova. (1978). Dependence of the component makeup of the gentamicin complex on Micromonospora purpurea var. violacea 1935 cultivation conditions. Antibiotiki (Moscow) 23:499–503.
  • P. Leal Del Rosal. The efficacy and safety of isepamicin compared with amikacin in the treatment of intra-abdominal infections. J. Chemother. (1995) 7 (Suppl. 2):143–148.
  • M. C. Lecaroz, M. J. Blanco-Prieto, M. A. Campanero, H. Salman, and C Gamazo. (2007). Poly (D,L-lactide coglycolide) particles containing gentamicin: Pharmacokinetics and pharmacodynamics in Brucella melitensis-infected mice. Antimicrob. Agents Chemother 51:1185–1190.
  • M. C. Lecaroz, M. A. Campanero, C. Gamazo, and M. J. Blanco-Prieto. (2006). Determination of gentamicin in different matrices by a new sensitive high-performance liquid chromatography-mass spectrometric method. J. Antimicrob. Chemother 58:557–563.
  • C. Lecaroz, C. Gamazo, and M. J. Blanco-Prieto. (2006a). Biodegradable micro- and nanoparticles as long-term delivery vehicles for gentamicin. J. Microencapsulat 23:782–792.
  • C. Lecaroz, C. Gamazo, and M. J. Blanco-Prieto. (2006b). Nanocarriers with gentamicin to treat intracellular pathogens. J. Nanosci. Nanotechnol 6:3296–3302.
  • H. A. Lechevalier, and M. P. Lechevalier. (1967). Biology of actinomycetes. Annu. Rev. Microbiol 21:71–100.
  • B. K. Lee, J. B. Bailey, R. G. Condon, J. A. Marquez, G. H. Wagman, and M. J. Weinstein. (1977). Biotransformation of sisomicin to gentamicin C2b. Antimicrob. Agents Chemother 12:335–358.
  • B. K. Lee, R. G. Condon, A. Murawski, and G. H. Wagman. (1975). Incorporation of L-methionine-methyl-14C into gentamicins. III. Chromatographic separation and degradation of components of methyl-14C-gentamicin complex. J. Antibiot. (Tokyo) 28:163–166.
  • B. K. Lee, T. L. Nagabhushan, R. G. Condon, A. B. Cooper, and J. A. Waitz. (1978). Antibiotic biosynthesis by cofermentation of blocked mutants of two Micromonospora species. Antimicrob. Agents Chemother 14:73–77.
  • B. K. Lee, R. T. Testa, G. H. Wagman, C. M. Liu, L. McDaniel, and C Schaffner. (1973). Incorporation of L-methionine-methyl-14C into gentamicins. J. Antibiot. (Tokyo) 26:728–731.
  • M. J. Lee, and D. D. Y Ryu. (1979). Production of gentamicin by Micromonospora purpurea. Studies on fermentation variables. Misaengmul Hakhoe Chi 17:152–159.
  • S. S. Lee, Y. C. Liu, S. R. Wann, W. R. Lin, T. H. Tsai, H. H. Lin, Y. S. Chen, and M. Y. Yen. (1999). Once daily isepamicin treatment in complicated urinary tract infections. J. Microbiol. Immunol. Infect 32:105–110.
  • W. Lesniak, J. Mc Laren, W. R. Harris, V. L. Pecoraro, and J Schacht. (2003). An isocratic separation of underivatized gentamicin components, 1H NMR assignment and protonation pattern. Carbohydr. Res 338:2853–2862.
  • G. Lewis, and S Janna. (2004). The in vitro elution of gentamicin sulfate from a commercially available gentamicin-loaded acrylic bone cement, VersaBond™AB. J. Biomed. Mater. Res. B Appl. Biomater 71:77–83.
  • G. Lewis, and S Janna. (2006). Estimation of the optimum loading of an antibiotic powder in an acrylic bone cement: Gentamicin sulfate in SmartSet HV. Acta Orthopaedica 77:622–627.
  • R. G. Leyh, C. Bartels, and H.-H Sievers. (1999). Adjuvant treatment of deep sternal wound infection with collagenous gentamicin. Ann. Thorac. Surg 68:1648–1651.
  • B. Li, J. Chu, Y. Li, S. Zhang, Y. Li, X. Gui, Y. Zhou, L. Zhang, and S. Sun. Effect of cell wall synthesis of producing strain on gentamicin biosynthesis. Zhongguo Kengshengsu Zazhi. (1997a) 22:246–249, 297.
  • B. Li, J. Chu, Y. Li, S. Zhang, Y. Zhou, X. Gui, L. Zhang, and S. Sun. Effect of online ultrasonic treatment on gentamicin biosynthesis.. Zhongguo Kengshengsu Zazhi. (1997b) 22:250–253, 257.
  • B. L. Li, J. Chu, Y. R. Li, S. L. Zhang, Y.-B. Zhou, X.-L. Gui, L.-X. Zhang, and S.-D Sun. (1998). Effect of intracellular bonding mode of gentamicin on its fermentation potency. Zhongguo Yiyao Gongye Zazhi 29:54–57.
  • H. Li, and J Chang. (2005). Preparation, characterization and in vitro release of gentamicin from PHBV/wollastonite composite microspheres. J. Controlled Release 107:463–473.
  • Y. V. Li, L. P. Terekhova, and M. G. Gapochka. (2002). Isolation of actinomycetes from soil using extremely high frequency radiation. Microbiology 71:105–108.
  • A Liao. (2002). Mutagenesis and screening of gentamicin producer of Micromonospora echinosporavar. 23–18. Zhongguo Kengshengsu Zazhi 27:199–201.
  • S. T. Lim, G. P. Martin, D. J. Berry, and M. B. Brown. (2000). Preparation and evaluation of the in vitro drug release properties and mucoadhesion of novel microspheres of hyaluronic acid and chitosan. J. Controlled Release 66:281–292.
  • L. Linde, S. Boelz, M. Nissim-Rafinia, Y. S. Oren, M. Wilschanski, Y. Yaacov, D. Virgilis, G. Neu-Yilik, A. E. Kulozik, E. Kerem, and B Kerem. (2007). Nonsense-mediated mRNA decay affects nonsense transcript levels and governs response of cystic fibrosis patients to gentamicin. J. Clin. Invest 117:683–692.
  • M. Lindlöf, A. Kiuru, H. Kääriäinen, H. Kalimo, H. Lang, H. Pihko, J. Rapola, H. Somer, M. Somer, M. L. Savontaus, and A de la Chapelle. (1989). Gene deletion in X-linked muscular dystrophy. Am. J. Hum. Genet 44:397–401.
  • F. Liu, Y. Fu, and H Yan. (2003). Screening the high mutants of gentamicin by 12C ion beam radiation and their productivity in fermentation tank. Zhongguo Kengshengsu Zazhi 28:517–519.
  • N. M. Llewellyn, and J. B. Spencer. (2006). Biosynthesis of 2-deoxysptreptamine-containing aminoglycoside antibiotics. Nat. Prod. Rep. 23:864–874.
  • D. Loebenberg, M. Counelis, and J. A. Waitz. (1975). Antibiotic G-418, a new Micromonospora-produced aminoglycoside with activity against protozoa and helminths: antiparasitic activity. Antimicrob. Agents Chemother 7:811–815.
  • D. Löffler, and T. A. Ternes. (2003). Analytical method for the determination of the aminoglycoside gentamicin in hospital wastewater via liquid chromatography-electrospray-tandem mass spectrometry. J. Chromatogr. A 1000:583–588.
  • E. E. M. G. Loomans, J. van Wiltenburg, M. Koets, and A van Amerongen. (2003). Neamin as an immunogen for the development of a generic ELISA detecting gentamicin, kanamycin, and neomycin in milk. J. Agric. Food Chem 51:587–593.
  • O. Lortholary, M. Tod, Y. Cohen, and O Petitjean. (1995). Aminoglycosides. Med. Clin. N. Am 79:761–787.
  • V. V. Losev, E. S. Bylinkina, and T. N. Laznikova. (1981a). Effect of aeration and agitation conditions on gentamycin biosynthesis. Antibiotiki (Moscow) 23:570–575.
  • V. V. Losev, P. V. Kotlenska, D. P. Tsoneva, and T. N. Laznikova. (1981b). Oxidative-reductive activity of the mycelium as a criterion for assessing inoculate quality in gentamycin biosynthesis. Antibiotiki (Moscow) 26:496–500.
  • L. A. Lucher, Y. M. Chen, and J. B. Walker. (1989). Reactions catalyzed by purified L-glutamine: keto-scyllo-inositol aminotransferase, an enzyme required for biosynthesis of aminocyclitol antibiotics. Antimicrob. Agents Chemother 33:452–459.
  • G. M. Luedemann, and M. J. Weinstein. Gentamycin and method of production.. US Patent 3,091,572. (Granted to Schering Corporation, Bloomfield, N.J, May 28, 1963.). (1963).
  • P. Lutwyche, C. Cordeiro, D. J. Wiseman, M. St-Louis, M. Uh, M. J. Hope, M. S. Webb, and B. B. Finlay. (1998). Intracellular delivery and antibacterial activity of gentamicin encapsulated in pH-sensitive liposomes. Antimicrob. Agents Chemother 42:2511–2520.
  • H. Maehr, C.-M. Liu, T. Hermann, B. L. T. Prosser, J. M. Smallheer, and N. J. Palleroni. (1980). Microbial products. IV. X-14847, a new aminoglycoside from Micromonospora echinospora. J. Antibiot. (Tokyo) 33:1431–1436.
  • H. Maehr, and C. P. Schaffner. (1967). The separation and differentiation of the gentamicin complex. J. Chromatogr 30:572–578.
  • W. A. Mahon, J. Ezer, and T. W. Wilson. (1973). Radioimmunoassay for measurement of gentamicin in blood. Antimicrob. Agents Chemother 3:585–589.
  • W. A. Mahon, R. I. Feldman, and G. H. Scherr. (1977). Hemagglutination inhibition assay for gentamicin. Antimicrob. Agents Chemother 11:359–361.
  • S. K. Maitra, T. T. Yoshikawa, J. L. Hansen, I. Nilsson-Ehle, W. J. Palin, M. C. Schotz, and L. B. Guze. (1977). Serum gentamicin assay by high-performance liquid chromatography. Clin. Chem 23:2275–2278.
  • J. A. Maloney, and W. M. Awni. (1990). High-performance liquid chromatographic determination of isepamicin in plasma, urine and dialysate. J. Chromatogr 526:487–496.
  • A. S. Mankin, and S. W. Liebman. (1999). Baby, don't stop!. Nat. Genet 23:8–10.
  • V. Manyanga, K. Kreft, B. Divjak, J. Hoogmartens, and E Adams. (2008). Improved liquid chromatographic method with pulsed electrochemical detection for the analysis of gentamicin. J. Chromatogr 1189:347–354.
  • L. E. Maquat. (2004). Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics. Nat. Rev. Mol. Cell Biol 5:89–99.
  • P. Matsushima, and R. H. Blatz. (1988). Genetic transformation of Micromonospora rosaria by the Streptomyces plasmid pIJ702. J. Antibiot. (Tokyo) 41:583–585.
  • B. Mattiasson, K. Svensson, C. Borrebaeck, S. Jonsson, and G Kronvall. (1978). Non-equilibrium enzyme immunoassay of gentamicin. Clin. Chem 24:1770–1773.
  • J. W. Mayhew, and S. L. Gorbach. (1978). Assay of gentamicin and tobramycin in sera of patients by gas-liquid chromatography. Antimicrob. Agents Chemother 14:851–855.
  • B. J. McGrath, E. M. Bailey, K. C. Lamp, and M. J. Rybak. (1992). Pharmacodynamics of once-daily amikacin in various combinations with cefepime, aztreonam and ceftazidime against Pseudomonas aeruginosa in an in vitro infection model. Antimicrob. Agents Chemother 36:2741–2745.
  • H.-Y. Mei, A. A. Galan, N. S. Halim, D. P. Mack, D. W. Moreland, K. B. Sanders, H. N. Truong, and A. W. Czarnik. (1995). Inhibition of an HIV-1 Tat-derived peptide binding to TAR RNA by aminoglycoside antibiotics. Bioorg. Med. Chem. Lett 5:2755–2760.
  • J. R. Mendell, C. H. Buzin, J. Feng, J. Yan, C. Serrano, D. S. Sangani, C. Wall, T. W. Prior, and S. S. Sommer. (2001). Diagnosis of Duchenne dystrophy by enhanced detection of small mutations. Neurology 28:645–650.
  • M. Mihelic-Rapp, and W Giebel. (1996). A new immunohistochemical method for the detection of gentamicin in inner ear fluid compartments. Eur. Arch. Otorhinolaryngol 253:411–416.
  • N. E. Mikkelsen, K. Johansson, A. Virtanen, and L. A. Kirsebom. (2001). Aminoglycoside binding displaces a divalent metal ion in a tRNA-neomycin B complex. Nat. Struct. Biol 8:510–514.
  • N. E. Mikkelsen, B. Mathias, A. Virtanan, and L. A. Kirsebom. Inhibition of RNase P RNA cleavage by aminoglycosides.. Proc. Natl. Acad. Sci. USA. (1999) 96:6155–6160..
  • G. H. Miller, P. T. S. Chiu, and J. A. Waitz. (1978). Biological activity of Sch 21420, the 1-N-S-α -hydroxy-β -aminopropionyl derivative of gentamicin B. J. Antibiot. (Tokyo) 31:688–696.
  • F. Mingqi, Z. Min, and B Huaxiang. (1998). Study on rational selection of high productivity strain of gentamicin C(1a). Chin. J. Antibiot 23:410–414.
  • D. Moazed, and H. F. Noller. (1987). Interaction of antibiotics with functional sites in 16S ribosomal RNA. Nature (London) 327:389–394.
  • M. S. Moon, S. J. Jun, S. H. Lee, C. S. Cheong, K. S. Kim, and B. S. Lee. (2005). A semisynthesis of isepamicin by fragmentation method. Tetrahedron Lett 46:607–609.
  • J. R. Morgan, and K. E. Williams. (1980). Preparation and properties of liposome-associated gentamicin. Antimicrob. Agents Chemother 17:544–548.
  • Y. Morikawa, I. Karabe, and S Suzuki. (1980). Continuous production of bacitracin by immobilized living whole cells of Bacillus sp. Biotechnol. Bioeng 22:1015–1023.
  • C. Mugabe, A. O. Azghani, and A Omri. (2005). Liposome-mediated gentamicin delivery: development and activity against resistant strains of Pseudomonas aeruginosa isolated from cystic fibrosis patients. J. Antimicrob. Chemother 55:269–271.
  • W. Mwengee, T. Butler, S. Mgema, G. Mhina, Y. Almasi, C. Bradley, J. B. Formanik, and C. G. Rochester. (2006). Treatment of plague with gentamicin or doxycycline in a randomized clinical trial in Tanzania. Clin. Infect. Dis 42:614–621.
  • T. L. Nagabhushan, A. B. Cooper, H. Tsai, P. J. L. Daniels, and G. H. Miller. (1978). The syntheses and biological properties of 1-N-(S-4-amino-2-hydroxybutyryl)-gentamicin B and 1-N-(S-3-amino-2-hydroxypropionyl)-gentamicin B. J. Antibiot. (Tokyo) 31:681–687.
  • T. L. Nagabhushan, W. N. Turner, P. J. L. Daniels, and J. B. Morton. (1975). The gentamicin antibiotics. 7. Structures of the gentamicin antibiotics A1, A3 and A4. J. Org. Chem 40:2830–2834.
  • K. Nagaoka, and A. L. Demain. (1975). Mutational biosynthesis of a new antibiotic, streptomutin A, by an idiotroph of Streptomyces griseus. J. Antibiot. (Tokyo) 28:627–635.
  • F. Nakamura, R. Ohta, Y. Machida, and T Nagai. (1996). In vitro and in vivo nasal mucoadhesion of some water-soluble polymers. Int. J. Pharm 134:173–181.
  • C. L. Nelson, S. G. Hickmon, and R. A. Skinner. (1997). Treatment of experimental osteomyelitis by surgical debridement and the implantation of bioerodable, polyanhydride gentamicin beads. J. Orthop. Res 15:249–255.
  • D. Neut, H. van de Belt, J. R. van Horn, H. C. van der Mei, and H. J. Busscher. (2003). Residual gentamicin-release from antibiotic-loaded polymethylmethacrylate beads after 5 years of implantation. Biomaterials 24:1829–1831.
  • J Nielsen. (1998). The role of metabolic engineering in the production of secondary metabolites. Curr. Opin. Microbiol 1:330–336.
  • K. G. Nilsson, and T Dalen. (1998). Inferior performance of Boneloc bone cement in total knee arthroplasty. Acta Orthop. Scand 69:479–483.
  • L Nilsson. (1978). New rapid bioassay of gentamicin based on luciferase assay of extracellular ATP in bacterial cultures. Antimicrob. Agents Chemother 14:812–816.
  • L Nilsson. (1980). Factors affecting gentamicin assay. Antimicrob. Agents Chemother 17:918–921.
  • W. Niu, H. Hu, J. Chu, and Y Li. (2003). Preliminary study of the mechanism of gentamicin bound by peptidoglycan of the cell wall of Micromonospora echinospora var. Zhongguo Kengshengsu Zazhi 28:65–69.
  • H. F. Noller. (1991). Ribosomal RNA and translation. Annu. Rev. Biochem 60:191–227.
  • A. M. Obregon, L. Escalante, R. Gonzalez, R. Rodriguez, and S Sanchez. (1994). Physiological studies on gentamicin: phosphate repression of antibiotic formation. J. Antibiot. (Tokyo) 47:1442–1446.
  • K Ochi. (1987). Metabolic initiation of differentiation and secondary metabolism by Streptomyces griseus: significance of the stringent response (ppGpp) and GTP content in relation to A factor. J. Bacteriol 169:3608–3616.
  • K. Ochi. (2007). From microbial differentiation to ribosome engineering. Biosci. Biotechnol. Biochem 71:1373–1386.
  • K. Ochi, S. Okamoto, Y. Tozawa, T. Inaoka, T. Hosaka, J. Xu, and K. Kurosawa. Ribosome engineering and secondary metabolite production.. Adv. Appl. Microbiol.. (2004) 56:ϑ155–184.
  • H. Ogawa, S. Imai, A. Satoh, and M Kojima. (1983). An improved method for the preparation of Streptomycetes and Micromonospora protoplasts. J. Antibiot. (Tokyo) 36:184–186.
  • R. Okachi, I. Kawamoto, S. Takasawa, M. Yamamoto, S. Sato, T. Sato, and T. Nara. (1974). A new antibiotic XK-62–2 (Sagamicin). I. Isolation, physicochemical and antibacterial properties. J. Antibiot. (Tokyo) 27:793–800.
  • Y. Okamoto-Hosoya, T. Hosaka, and K Ochi. (2003). An aberrant protein synthesis activity is linked with antibiotic overproduction in rpsL mutants of Streptomyces coelicolor A3(2). Microbiology 149:3299–3309.
  • S. Omura, and Y. Tanaka. Biosynthesis of tylosin and its regulation by ammonium and phosphate. In Regulation of Secondary Metabolite Formation, 305–332. Kleinkauf, H., Von, D. H., Dornauer, H., and Nesemann, G., eds. VCH Verlagsgesellschaft mbH, Weinheim. (1985).
  • J. Ørskov. Investigations into the Morphology of the Ray Fungi, 134–136. Levin and Munksgaard, Copenhagen. (1923).
  • M. R. Owen, A. P. Moores, and R. J. Coe. (2004). Management of MRSA septic arthritis in a dog using a gentamicin-impregnated collagen sponge. J. Small Anim. Practice 45:609–612.
  • J. W. Park, J. S. J. Hong, N. Parajuli, H. S. Koh, S. R. Park, M.-O. Lee, S.-K. Lim, and Y. J. Yoon. (2007). Analytical profiling of biosynthetic intermediates involved in the gentamicin pathway of Micromonospora echinospora by high-performance liquid chromatography using electrospray ionization mass spectrometric detection. Anal. Chem 79:4860–4869.
  • G. W. Peng, M. A. F. Gadalla, and A Peng. (1977). High pressure liquid chromatographic method for determination of gentamicin in plasma. Clin. Chem 23:1838–1844.
  • M. A. Pesce, and S. H. Bodourian. (1981). Enzyme immunoassay of gentamicin with use of a centrifugal analyzer. Clin. Chem 27:1460–1462.
  • U. Peschke, H. Schmidt, H.-Z. Zhang, and W Piepersberg. (1995). Molecular characterization of the lincomycin production gene cluster of Streptomyces lincolnensis 78–11. Mol. Microbiol 16:1137–1156.
  • I. Phillips, A. Smith, and K Shannon. (1977). Antibacterial activity of netilmicin, a new aminoglycoside antibiotic compared with that of gentamicin. Antimicrob. Agents Chemother 11:402–406.
  • W. G. Pitt, M. O. McBride, J. K. Lunceford, R. J. Roper, and R. D. Sagers. (1994). Ultrasonic enhancement of antibiotic action on gram-negative bacteria. Antimicrob. Agents Chemother 38:2577–2582.
  • A. Posyniak, J. Zmudzki, and J Niedzielska. (2001). Sample preparation for residue determination of gentamicin and neomycin by liquid chromatography. J. Chromatogr. A 914:59–66.
  • P. B. N. Prasad, A. C. S. Rao, S. C. Mathur, Y. Kumar, and S. K. Talwar. (1998). Comparative HPTLC and HPLC studies on quantitative determination of gentamicin sulphate in bulk drugs. Indian Drugs 35:744–747.
  • M. Preu, D. Guyot, and M. Petz. Development of a gas chromatography-mass spectrometry method for the analysis of aminoglycoside antibiotics using experimental design for the optimisation of the derivatisation reactions.. J. Chromatogr. A. (1998) 818:95–108.
  • S. Prior, C. Gamazo, J. M. Irache, H. P. Merkle, and B Gander. (2000). Gentamicin encapsulation in PLA/PLGA microspheres in view of treating Brucella infections. Int. J. Pharmaceut 196:115–125.
  • S. Prior, B. Gander, C. Lecároz, J. M. Irache, and C Gamazo. (2004). Gentamicin-loaded microspheres for reducing the intracellular Brucella abortus load in infected monocytes. J. Antimicrob. Chemother 53:981–988.
  • T. Prior, C. Bartolo, and D Pearl. (1995). Spectrum of small mutations in the dystrophin coding region. Am. J. Hum. Genet 57:22–33.
  • P. Purohit, and S Stern. (1994). Interactions of a small RNA with antibiotic and RNA ligands of the 30S subunit. Nature (London) 370:659–662.
  • W. J. Reiblein, P. D. Watkins, and G. H. Wagman. (1973). Binding of gentamicin and other aminoglycoside antibiotics to mycelium of various actinomycetes. Antimicrob. Agents Chemother 4:602–606.
  • K. L. Jr Reinhart, and R. M. Stroshane. (1976). Biosynthesis of aminocyclitol antibiotics. J. Antibiot. (Tokyo) 29:319–353.
  • L. Rodrigues, J. Teixeira, R. Oliviera, and H. C. van der Mei. (2006). Response surface optimization of the medium components for the production of biosurfactants by probiotic bacteria. Process Biochem 41:1–10.
  • M. Rodriguez-Saiz, M. Lembo, L. Bertetti, R. Muraca, J. Velasco, A. Malcangi, J. L. de la Fuente, and J. L. Barredo. (2004). Strain improvement for cephalosporin production by Acremonium chrysogenum using geneticin as a suitable transformation marker. FEMS Microbiol. Lett 235:43–49.
  • J. Rogers, A. H. Chang, U. von Ahsen, R. Schroeder, and J Davies. (1996). Inhibition of the self-cleavage reaction of the human hepatitis delta virus ribozyme by antibiotics. J. Mol. Biol 259:916–925.
  • D. Rosi, W. A. Goss, and S. J. Daum. (1977). Mutational biosynthesis by idiotrophs of Micromonospora purpurea. I. Conversion of aminocyclitols to new aminoglycoside antibiotics. J. Antibiot. (Tokyo) 30:88–97.
  • A. Rosner, and H Aviv. (1980a). Gentamicin bioautography assay vs. the microbiological disk test. J. Antibiot. (Tokyo) 33:600–603.
  • A. Rosner, and H Aviv. (1980b). Radioimmunoassay of gentamicin in Micromonospora medium extracts. Antimicrob. Agents Chemother 17:510–511.
  • J. P. Rosselet, J. Maruez, E. Meseck, A. Murawski, A. Hamden, C. Joyner, R. Schmidt, D. Miglion, and H. L. Herzog. (1963). Isolation, purification and characterization of gentamicin. Antimicrob. Agents Chemother 196:14–16.
  • T. J. Rowbotham, and T Cross. (1977). Rhodococcus coprophilus sp. nov.: an aerobic nocardioform actinomycete belonging to the “rhodochrous” complex. J. Gen. Microbiol 100:123–138.
  • B. Rutledge, D. Huyette, D. Day, and J Anglen. (2003). Treatment of osteomyelitis with local antibiotics delivered via bioabsorbable polymer. Clin. Orthop. Relat. Res 411:280–287.
  • D. Salauze, and J Davies. (1991). Isolation and characterization of an aminoglycoside phosphotransferase from neomycin-producing Micromonospora chalchea; comparison with that of Streptomyces fradiae and other producers of 4,6-disubstituted 2-deoxystreptamine antibiotics. J. Antibiot. (Tokyo) 44:1432–1443.
  • L. A. R. Sallam, A.-M. H. El-Refai, A.-H.A Hamdi, H. A. El-Minofi, and I. S. Abd-El-Salam. (2005). Studies on the application of immobilization technique for the production of cyclosporin A by a local strain of Aspergillus terreus. J. Gen. Appl. Microbiol 51:143–149.
  • E. N. Sanchez, E. M. Alhadeff, M. H. M. Rocha-Leao, R. C. Fernandes, and N. PereiraJr.. (1996). Performance of a continuous bioreactor with immobilized yeast cells in the ethanol fermentation of molasses stillage medium. Biotechnol. Lett 18:91–94.
  • N. A. Sandrak. (1977). Degradation of cellulose by Micromonospores. Mikrobiologiia 46:478–481.
  • A. Satoh, H. Ogawa, and Y Satomura. (1975). Effects of sclerin on production of th. Streptomyces. Agric. Biol. Chem 39:1593–1598.
  • T. W. Schafer, A. Pascale, G. Shimonaski, and P. E. Came. (1972). Evaluation of gentamicin for use in virology and tissue culture. Appl. Microbiol 23:565–570.
  • A. Schatz, E. Bugie, and S. A. Waksman. (1944). Streptomycin, a substance exhibiting antibiotic activity against gram positive and gram negative bacteria. Proc. Soc. Exp. Biol. Med 55:66.
  • R. Schiffelers, G. Storm, and I. B. Woudenberg. (2001). Liposome-encapsulated aminoglycosides in pre-clinical and clinical studies. J. Antimicrob. Chemother 48:333–344.
  • M. Schlaap, and W Friess. (2003). Collagen/PLGA microparticle composites for local controlled delivery of gentamicin. J. Pharmaceut. Sci 92:2145–2151.
  • G. Schmidt-Kastner, and H Reimann. (1976). The production of sisomicin. Infection 4:S292–S293.
  • J. Schnieders, U. Gbureck, R. Thull, and T Kissel. (2006). Controlled release of gentamicin from calcium phosphate-poly(lactic acid-co-glycolic acid) composite bone cement. Biomaterials 27:4239–4249.
  • G. Seidl, and H. P. Nerad. (1998). Gentamicin C: Separation of C1, C1a, C2, C2a and C2b components by HPLC using isocratic ion-exchange chromatography and post-column derivatisation. Chromatographia 25:169–171.
  • I. Sermet-Gaudelus, M. Renouil, A. Fajac, L. Bidou, B. Parbaille, S. Pierrot, N. Davy, E. Bismuth, P. Reinert, G. Lenoir, J. F. Lesure, J. P. Rousset, and A. Edelman. In vitro prediction of stop-codon suppression by intravenous gentamicin in patients with cystic fibrosis: a pilot study.. BMC Med. (2007) 5:5. doi: 10.1186/1741–7015-5–5. (Available online at http://www.biomedcentral.com/1741–7015/5/5).
  • E. J. Shaw, R. A. A. Watson, J. Landon, and D. S. Smith. (1977). Estimation of serum gentamicin by quenching fluoroimmunoassay. J. Clin. Pathol 30:526–531.
  • E. J. Shaw, R. A. A. Watson, and D. S. Smith. (1979). Continuous-flow fluoroimmunoassay of serum gentamicin, with automatic sample blank correction. Clin. Chem 25:322–324.
  • Z. Shi, K. G. Neoh, E. T. Kang, and W Wang. (2006). Antibacterial and mechanical properties of bone cement impregnated with chitosan nanoparticles. Biomaterials 27:2440–2449.
  • M. Shibata, M. Uyeda, Y. Kido, M. Kinoshita, Y. Kosugi, Y. Hashimoto, Y. Takeshita, and E Mori. (1980). Gentamicin components, produced by a new isolate of Micromonospora. Agric. Biol. Chem 44:2507–2509.
  • C. S. Shin, B. W. Ahn, S. H. Lee, S. U. Kim, and S. H. Bok. (1988). Liberation of sisomicin from cells by sodium chloride. Appl. Microbiol. Biotechnol 28:37–38.
  • C. S. Shin, and S. H. Han. (1995). Effect of magnesium sulfate on product inhibition of sisomicin production. J. Microbiol. Biotechnol 5:96–99.
  • C. S. Shin, S. Y. Kim, and J. Y. Ju. (1994). Characteristic of sisomicin fermentation supplemented with MgSO4 in stirred and air-lift fermenters. Biotechnol. Lett 16:251–256.
  • D.-Y. Shin, S.-S. Park, D. H. Lim, Y. W. Lee, J.-H. Moon, I. S. Choi, D.-H. Suk, and D. B. Choi. Studies on production of gentamicin from Micromonosporas purpurea using crude soybean oil.. Process Biochem.. (2008) (In press) doi:10.1016/j.procbio.2008.04.010..
  • Y. Shinto, A. Uchida, F. Korkusuz, N. Araki, and K Ono. (1992). Calcium hydroxyapatite ceramic used as a delivery system for antibiotics. J. Bone Joint Surg. (Br) 74B:600–604.
  • I. G. Shirokikh, and O. V. Merzaeva. (2005). Actinomycete complexes in the rhizosphere of winter rye on soddy podozolic soil. Microbiology 74:230–235.
  • W. E. Siegenthaler, A. Bonetti, and R Luthy. (1986). Aminoglycoside antibiotics in infectious diseases: An overview. Am. J. Med 6B:2–13.
  • D. Singh, S. Saraf, V. K. Dixit, and S Saraf. (2008). Formulation optimization of gentamicin loaded Eudragit RS100 microspheres using factorial design study. Biol. Pharm. Bull 31:662–667.
  • M. Sivakumar, and K. P. Rao. (2002). Preparation, characterization and in vitro release of gentamicin from coralline hydroxyapatite-gelatin composite microspheres. Biomaterials 23:3175–3181.
  • A. L. Smith, J. A. Waitz, D. H. Smith, E. M. Oden, and B. B. Emerson. (1974). Comparison of enzymatic and microbiological gentamicin assays. Antimicrob. Agents Chemother 6:316–319.
  • J. Solera, A. Espinosa, E. Martínez-Alfaro, L. Sánchez, P. Geijo, E. Navarro, J. Escribano, and J. A. Fernández. (1997). Treatment of human brucellosis with doxycycline and gentamicin. Antimicrob. Agents Chemother 41:80–84.
  • I. Soriano, and C Evora. (2000). Formulation of calcium phosphates/poly (d,l-lactide) blends containing gentamicin for bone implantation. J. Controlled Release 68:121–134.
  • C. M. T. Spahn, and C. D. Prescott. (1996). Throwing a spanner in the works: antibiotics and the translation apparatus. J. Mol. Med 74:423–439.
  • D. W. Spelman, M. McDonald, and W. J. Spicer. (1989). Aminoglycoside antibiotic agents: a review. Therapeutics 151:346–349.
  • T. K. Stage, K. J. Hertel, and O. C. Uhlenbeck. (1995). Inhibition of the hammerhead ribozyme by neomycin. RNA 1:95–101.
  • P. F. Stanbury, A. Whitaker, and S. J. Hall. (1995). Principles of Fermentation Technology, 2nd ed. Pergamon Press, Oxford.
  • J. C. Standefer, and G. C. Saunders. (1978). Enzyme immunoassay for gentamicin. Clin. Chem 24:1903–1907.
  • R. Stanzak, P. Matsushima, R. H. Baltz, and R. N. Rao. (1986). Cloning and expression in Streptomyces lividans of clustered erythromycin biosynthesis genes from Streptomyces erythreus. Biotechnology 4:229–232.
  • D. A. Stead. (2000). Current methodologies for the analysis of aminoglycosides. J. Chromatogr. B 747:69–93.
  • D. A. Stead, and R. M. Richards. (1996). Sensitive fluorimetric determination of gentamicin sulfate in biological matrices using solid-phase extraction, pre-column derivatization with 9-fluorenylmethyl chloroformate and reversed-phase high-performance liquid chromatography. J. Chromatogr. B 675:295–302.
  • D. Stephens, L. Li, D. Robinson, S. Chen, H.-C. Chang, R. M. Liu, Y. Tian, E. J. Ginsburg, X. Gao, and T Stultz. (2000). Investigation of the in vitro release of gentamicin from a polyanhydride matrix. J. Controlled Release 63:305–317.
  • R. J. Strobel, and W. M. Nakatsukasa. (1993). Response surface for optimizing Saccharopolyspora spinosa, a novel macrolide producer. J. Ind. Microbiol 11:121–127.
  • W Sturm. (1995). Isepamicin versus amikacin in the treatment of urinary tract infections. J. Chemother 7 (Suppl. 2):149–154.
  • M. J. Stutts, C. M. Canessa, J. C. Olsen, M. Hamrick, J. A. Cohn, B. C. Rossier, and R. C. Boucher. (1995). CFTR as a cAMP-dependent regulator of sodium channels. Science 269:847–850.
  • I. I. Sutar, H. G. Vartak, M. C. Srinivasan, and H Sivaraman. (1986). Production of alkaline protease by immobilized mycelium of Conidiobolus. Enzyme Microb. Technol 8:632–634.
  • M. A. Sveshnikova, N. T. Chormonova, N. V. Lavrova, L. P. Terekhova, and T. P. Preobrazhenskaia. (1976). Isolation of soil actinomycetes on selective media with novobiocin. Antibiotiki (Moscow) 21:784–787.
  • Z Szabo. (1984). Occurrence of gentamicin-producing micromonosporae in Lake Balaton (W. Hungary). Z. Allg. Mikrobiol 24:649–653.
  • H. Tamegai, E. Nango, M. Kuwahara, H. Yamamoto, Y. Ota, H. Kuriki, T. Eguchi, and K Kakinuma. (2002). Identification of L-glutamine:2-deoxy-scyllo-inosose aminotransferase required for the biosynthesis of butorisin in Bacillus circulans. J. Antibiot. (Tokyo) 55:707–714.
  • N. Tamehiro, T. Hosaka, J. Xu, H. Hu, N. Otake, and K Ochi. (2003). Innovative approach for improvement of an antibiotic-overproducing industrial strain of Streptomyces albus. Appl. Environ. Microbiol 69:6412–6417.
  • C.-H. Tann, J. S.-H. Chiu, and M. D. Green. (1991). Improved process for preparing isepamicin. European Patent 0405802A2 (Granted to Schering Corporation, New Jersey, USA.)
  • M. E. Temple, and M. C. Nahata. (2000). Treatment of listeriosis. Ann. Pharmacother 34:656–661.
  • M. L. A. Teruel, E. Gontier, C. Bienaime, J. E. N. Saucedo, and J.-N Barbotin. (1997). Response surface analysis of chlortetracycline and tetracycline production with κ -carrageenan immobilize. Streptomyces aureofaciens. Enzyme Microb. Technol 21:314–320.
  • R. T. Testa, and B. C. Tilley. (1975). Biotransformation, a new approach to aminoglycoside biosynthesis. I. Sisomicin. J. Antibiot. (Tokyo) 28:573–579.
  • R. T. Testa, and B. C. Tilley. Biotransformation, a new approach to aminoglycoside biosynthesis: II. Gentamicin.. J. Antibiot. (Tokyo). (1976) 29:140–146.
  • R. T. Testa, and B. C. Tilley. (1979). Biosynthesis of sisomicin and gentamicin. Jpn. J. Antibiot 32 (Suppl. 32):S47–S59.
  • R. T. Testa, G. H. Wagman, P. J. L. Daniels, and M. J. Weinstein. (1974). Mutamicins; biosynthetically created new sisomicin analogs. J. Antibiot. (Tokyo) 27:917–921.
  • C. Thawai, S. Tanasupawat, T. Itoh, K. Suwanborirux, and T Kudo. (2004). Micromonospora aurantionigra sp. nov., isolated from a peat swamp forest in Thailand. Actinomycetologica 18:8–14.
  • K. Thoma, R. Alex, and J Randzio. (1992). Biodegradable controlled release implants based on β -tricalcium phosphate ceramic. 2. Testing of gentamicin controlled release pellets in vitro and in vivo. Eur. J. Pharm. Biopharm 38:107–112.
  • A. Thomas, and S Tappin. (1974). Separation of gentamicin complex by ion-exchange column chromatography. J. Chromatogr 97:280–283.
  • J. B. Tok, J. Cho, and R. R. Rando. (1999). Aminoglycoside antibiotics are able to specifically bind the 5'-untranslated region of thymidylate synthase messenger RNA. Biochemistry 38:199–206.
  • Y. Tsay, L. Wilson, and E Keefe. (1980). Quantitation of serum gentamicin concentration by a solid-phase immunofluorescence method. Clin. Chem 26:1610–1612.
  • T. Uematsu, A. Mizuno, Y. Suzuki, R. Sato, T. Yamazaki, and M Nakashima. (1988). Evaluation of a fluorescence polarization immunoassay procedure for quantitation of isepamicin, a new aminoglycoside antibiotic. Ther. Drug Monit 10:459–462.
  • M. I. Ugwoke, G. Kaufmann, N. Verbeke, and R Kinget. (2000). Intranasal bioavability of apomorphine from carboxymethylcellulose-based drug delivery systems. Int. J. Pharm. 202:125–131.
  • United States Pharmacopeia, 2003. Gentamicin Sulphate, Official Monograph, United States Pharmacopeia 26, United States Pharmacopeial Convention, Rockville, MD.
  • United States Pharmacopeia XXIII, 1995. NF 18. The United States Pharmaceutical Convention, Rockville.
  • J. Unwin, S. Standage, D. Alexander, T. HostedJr., A. C. Horan, and E. M. H Wellington. (2004). Gene cluster in Micromonospora echinospora ATCC15835 for the biosynthesis of the gentamicin C complex. J. Antibiot. (Tokyo) 57:436–445.
  • T. Urban, and C Jarstrand. (1979a). Nitroblue tetrazolium (NBT) reduction by bacteria employed for rapid determination of antibiotic concentrations in serum. Acta Pathol. Microbiol. Scand 86B:159–164.
  • T. Urban, and C Jarstrand. (1979b). Nitroblue tetrazolium (NBT) reduction by bacteria. Some properties of the reaction and its possible use. Acta Pathol. Microbiol. Scand 87B:227–233.
  • D. Ursic, J. D. Kemp, and J. P. Helgeson. (1981). A new antibiotic with known resistance factors, G418 inhibits plant cells. Biochem. Biophys. Res. Commun 101:1031–1037.
  • M. B. Vainshtein, V. A. Nikitin, V. A. Driniaev, and L. E. Eremina. (1989). Effect of the oxidation-reduction potential of the medium on the production of gentamicin. Antibiot. Khimioter 34:16–19.
  • P. Vidgren, M. Vidgren, J. Arppe, T. Hakuli, E. Laine, and P Paronen. (1992). In vitro evaluation of spray-dried mucoadhesive microspheres for nasal administration. Drug. Dev. Ind. Pharm 18:581–597.
  • P. Vidgren, M. Vidgren, P. Vainio, J. Nuutinen, and P Paronen. (1991). Double-labelling technique in the evaluation of nasal mucoadhesion of disodium cromoglycate microspheres. Int. J. Pharm 73:131–136.
  • A. Vigano, and N Principi. (1995). A randomised comparison of isepamicin and amikacin in the treatment of bacterial infections in paediatric patients. J. Chemother 7 (Suppl. 2):95–101.
  • V. A. Vinci, and G. Byng. (1999). Manual of Industrial Microbiology and Biotechnology. ASM Press, Washington, DC.
  • R. Vogel, K. DeFillipo, and V Reif. (2001). Determination of isepamicin sulfate and related compounds by high performance liquid chromatography using evaporative light scattering detection. J. Pharm. Biomed. Anal 24:405–412.
  • U. Von Ahsen, J. Davies, and R Schroeder. (1991). Antibiotic inhibition of group I ribozyme function. Nature (London 353:368–370.
  • G. H. Wagman, J. A. Marquez, J. V. Bailey, D. Cooper, J. Weinstein, R. Tkach, and P Daniels. (1972). Chromatographic separation of some minor components of the gentamicin complex. J. Chromatogr 70:171–173.
  • G. H. Wagman, J. A. Marquez, and M. J. Weinstein. (1968). Chromatographic separation of the components of the gentamicin complex. J. Chromatogr 34:210–215.
  • G. H. Wagman, R. T. Testa, and J. A. Marquez. (1970). Antibiotic 6640. II. Fermentation, isolation and properties. J. Antibiot. (Tokyo) 23:555–558.
  • G. H. Wagman, and M. J. Weinstein. (1966). A chemically defined fermentation medium for the growth of Micromonospora purpurea. Biotechnol. Bioeng 8:259–273.
  • J. A. Waitz, G. H. Miller, E. L. Jr Moss, and P. J. S Chiu. (1978). Chemotherapeutic evaluation of 5-episisomicin (Sch 22591), a new semisynthetic aminoglycoside. Antimicrob. Agents Chemother 13:41–48.
  • J. A. Waitz, E. J. Moss, E. M. Oden, G. H. Wagman, and M. J. Weinstein. (1972). Biological activity of Sch 14342, an aminoglycoside antibiotic coproduced in the gentamicin fermentation. Antimicrob. Agents Chemother 2:464–469.
  • J. A. Waitz, F. Sabatelli, F. Menzel, and E. L. Jr Moss. (1974). Antibiotic 6418, a new Micromonospora-produced aminoglycoside with activity against protozoa and helminths: biological activity. Antimicrob. Agents Chemother 6:579–582.
  • Y. Wakisaka, Y. Kawamura, Y. Yasuda, K. Kenzo, and Y Nishimoto. (1982). A selective isolation procedure for Micromonospora. J. Antibiot. (Tokyo) 35:822–836.
  • G. H. I. M. Walenkamp, and T. B. Vree. (1981). Treatment of a patient with impaired renal function with gentamicin-PMMA beads. Arch. Orthop. Traumat. Surg 99:137–141.
  • S. E. Walker, and P. E. Coates. (1981). High-performance liquid chromatographic methods for determination of gentamicin in biological fluids. J. Chromatogr 223:131–138.
  • C. T. Walsh. (2000). Molecular mechanisms that confer antibacterial drug resistance. Nature (London) 406:775–781.
  • Q.-H. Wan, and X. C. Le. (1999). Capillary electrophoretic immunoassays for digoxigenin and gentamicin with laser-induced fluorescence polarization detection. J. Chromatogr. B 734:31–38.
  • S. Wanandy, N. Brouwer, Q. Liu, A. Mahon, S. Cork, P. Karuso, S. Vemulpad, and J Jamie. (2005). Optimisation of the fluorescein diacetate antibacterial assay. J. Microbiol. Methods 60:21–30.
  • G. Wang, T. Hosaka, and K Ochi. (2008). Dramatic activation of antibiotic production in Streptomyces coelicolor by cumulative drug resistance mutations. Appl. Environ. Microbiol 74:2834–2840.
  • H. Wang, J. Ren, and Y Zhang. (1993). Use of p-dimethyl- aminobenzalhyde as a coloured reagent for determination of gentamicin. Talanta 40:851–853.
  • H. Y. Wang, L. D. Liu, Y. Sun, L. Ma, and J Li. (2000). Determination of gentamycin by synchronous derivative fluorimetry. Talanta 52:201–209.
  • S. Wang, P. W. Huber, M. Cui, A. W. Czarnik, and H. Y. Mei. (1998). Binding of neomycin to the TAR element of HIV-1 RNA induces dissociation of Tat protein by an allosteric mechanism. Biochemistry 37:5549–5557.
  • R. A. A. Watson, J. Landon, E. J. Shaw, and D. S. Smith. (1976). Polarization fluoroimmunoassay of gentamicin. Clin. Chim. Acta 73:51–55.
  • T. Q. Wei, V. P. Chu, A. R. Craig, J. E. Duffy, D. M. Obzansky, D. Kilgore, I. S. Masulli, C. M. Sanders, and J. C. Thompson. (1999). Automated homogeneous immunoassay for gentamicin on the dimension clinical chemistry system. Clin. Chem 45:388–393.
  • R. Weigand, and R. J. Coombes. (1983). Gentamicin determination by high-performance liquid chromatography. J. Chromatogr 281:381–385.
  • M. J. Weinstein, G. M. Luedemann, E. M. Oden, G. H. Wagman, J. P. Rosselet, J. A. Marquez, C. T. Coniglio, W. Charney, H. L. Herzog, and J Black. (1963a). Gentamicin, new antibiotic complex from Micromonospora. J. Med. Chem 6:463–464.
  • M. J. Weinstein, G. M. Luedemann, E. M. Oden, and G. H. Wagman. (1963b). Gentamicin, a new broad spectrum antibiotic complex. Antimicrob. Agents Chemother 3:1–7.
  • M. J. Weinstein, G. M. Luedemann, E. M. Oden, and G. H. Wagman. (1965). Biological properties of gentamicin A. Antimicrob. Agents Chemother 5:810–815.
  • M. J. Weinstein, G. M. Luedemann, G. Ridge, and G. H. Wagman. (1974). Sisomicin and methods for its production.. US Patent 3, 832, 286.
  • M. J. Weinstein, J. A. Marquez, R. T. Testa, G. H. Wagman, E. M. Oden, and J. A. Waitz. (1970). Antibiotic 6640, a new Micromonospora-produced aminoglycoside antibiotic. J. Antibiot. (Tokyo) 23:551–554.
  • M. J. Weinstein, G. H. Wagman, E. M. Oden, and J. A. Marquez. (1967). Biological activity of the antibiotic components of the gentamicin complex. J. Bacteriol 94:789–790.
  • F. Wienen, and U Holzgrabe. (2003). A new micellar electrokinetic capillary chromatography method for separation of the components of the aminoglycoside antibiotics. Electrophoresis 24:2948–2957.
  • J. W. Williams, J. S. Langer, and D. B. Northrop. (1975). A spectrophotometric assay for gentamicin. J. Antibiot. (Tokyo) 28:982–987.
  • M. R. Williamson, H. I. Chang, and A. G. A Coombes. (2004). Gravity spun polycaprolactone fibers: Controlling release of a hydrophilic macromolecule (ovalbumin) and a lipophilic drug (progesterone). Biomaterials 25:5053–5060.
  • M. R. Williamson, and A. G. A Coombes. (2003). Gravity spinning of polycaprolactone fibres for applications in tissue engineering. Biomaterials 25:459–465.
  • M. Wilschanski, Y. Yahav, Y. Yaacov, H. Blau, L. Bentur, J. Rivlin, M. Aviram, T. Bdolah-Abram, Z. Bebok, L. Shushi, B. Kerem, and E Kerem. (2003). Gentamicin-induced correction of CFTR function in patients with cystic fibrosis and CFTR stop mutations. New Engl. J. Med 349:1433–1441.
  • W. Wilson, G. Richard, and D Hughes. (1973). Thin-layer chromatographic identification of the gentamicin complex. J. Chromatogr 78:442–444.
  • N. Woodworf, E. McNamara, E. Smyth, and R. C. George. (1992). High-level resistance to gentamicin in Enterococcus faecium. J. Antimicrob. Chemother 29:395–403.
  • J. J. Wright. (1976). Synthesis of 1-N-ethylsisomicin: a broad spectrum semi-synthetic aminoglycoside antibiotic. J. Chem. Soc. Chem. Commun 6:206–208.
  • W. Xia, and J Chang. (2006). Well-ordered mesoporous bioactive glasses (MBG): A promising bioactive drug delivery system. J. Controlled Release 110:522–530.
  • X. Xiong, J. Chu, and Y Li. (2002). Effect of microwave and several other factors on secretion of gentamicin. Zhongguo Kengshengsu Zazhi 33:164–167.
  • N. Yamauchi, and K Kakinuma. (1992). Confirmation of in vitro synthesis of 2-deoxy-scyllo-inosose, the earliest intermediate in the biosynthesis if 2-deoxystreptamine, using cell free preparations of Streptomyces fradiae. J. Antibiot. (Tokyo) 45:774–780.
  • N. Yamauchi, and K Kakinuma. (1995). Enzymatic carbocycle formation in microbial secondary metabolism. The mechanism of 2-deoxy-scyllo-inosose synthase reaction as a crucial step in the 2-deoxystreptamine biosynthesis in Streptomyces fradiae. J. Org. Chem 60:5614–5619.
  • K. Yanai, S. Hoshigo, and T. Murakami. Gentamicin biosynthesis genes. Jpn. Kokai Tokkyo Koho JP 2004180638-A 1. 2004.(Granted on July 2, 2004 to Meiji Seika Kaisha Ltd, Japan.)
  • H. H. Yang, Q. Z. Zhu, H. Y. Qu, X. L. Chen, M. T. Ding, and J. G. Xu. (2002). Flow injection fluorescence immunoassay for gentamicin using sol-gel-derived mesoporous biomaterial. Anal. Biochem 308:71–76.
  • L Yang. (1999). Selection of Micromonospora purpurea by UV-mutagenesis and studies on fermentation conditions. Qingdao Huogong Xueyuan Xuebao 20:48–51.
  • X. Yang, L. Wu, A. Deng, J. Zhang, and L Zhu. (1995). Study on determination of gentamicin in serum by enhanced chemiluminesent immunoassay based on immobilized antibody and biotin-avidin system. Hua Xi Yi Ke Da Xue Xue Bao 26:234–236.
  • Z. Yang, H. Yuan, W. Tong, P. Zou, W. Chen, and X Zhang. (1996). Osteogenesis in extraskeletally implanted porous calcium phosphate ceramics: variability among different kinds of animal. Biomaterials 17:2131–2137.
  • R. C. Yao, and D. F. Mahoney. (1984). Enzyme-linked immunosorbent assay for the detection of fermentation metabolites: aminoglycoside antibiotics. J. Antibiot. (Tokyo) 37:1462–1468.
  • J. C. Yombi, P. Wallemacq, T. Leal, J. L. Gala, and B Vandercam. (2005). Key pharmacokinetic parameters of isepamicin in febrile neutropenic cancer patients and in women with acute pelvic inflammatory disease. J. Chemother 17:521–526.
  • S. Yoshizawa, D. Fourmy, and J. D. Puglisi. (1998). Structural origins of gentamicin antibiotic action. EMBO J 17:6437–6448.
  • S. Yoshizawa, D. Fourmy, and J. D. Puglisi. (1999). Recognition of the codon-anticodon helix by ribosomal RNA. Science 285:1722–1725.
  • L. L. Yuan, H. Wei, and S. F. Y Li. (2005). Direct determination of gentamicin components by capillary electrophoresis with potential gradient detection. Electrophoresis 26:196–201.
  • M. L. Zapp, S. Stern, and M. R. Green. (1993). Small molecules that selectively block RNA binding of HIV-1 Rev protein inhibits Rev function and viral production. Cell 74:969–978.
  • P. L. Zeitlin. (1999). Novel pharmacologic therapies for cystic fibrosis. J. Clin. Investigat 103:447–452.
  • T. R. Zembower, G. A. Noskin, M. J. Postelnick, C. Nguyen, and L. R. Peterson. (1998). The utility of aminoglycosides in an era of emerging drug resistance. Int. J. Antimicrob. Agents, 10:95–105.
  • G. M. Zenova, and D. G. Zvyaginstsev. (2002). Actinomycetes of the genus Micromonospora in meadow ecosystems. Microbiology 71:648–653.
  • B. Zhang, X. Lin, J. Zhang, J. Huang, S. Chen, B. Ye, and Y Song. (1985). Neutron irradiation breeding of antibiotics and oranges. Hejishu 15:34–35.
  • D.-L. Zhang, J. Chu, and Y.-R. Li. (2002). Influence of dissolved oxygen and phosphate on the synthesis and secretion of gentamicin. Zhongguo Kengshengsu Zazhi, 28:145–147, 189.
  • Y. X. Zhang, K. Perry, V. A. Vinci, K. Powell, W. P. Stemmer, and S. B. del Cardayre. (2002). Genome shuffling leads to rapid phenotypic improvement in bacteria. Nature 415:644–646.
  • J. Zhou, Q. Zhou, S. Zhao, X. Chen, C. Jiang, and Z Sheng. (1987). Cell fusion of the Micromonospora purpurea, gentamicin block mutant. Kangshengsu 12:399–401.
  • M. Zhou, and M. D. Donovan. (1996). Intranasal mucociliar clearance of putative bioadhesive polymer gels. Int. J. Pharm 135:115–125.

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