Advances in the research of celery, an important Apiaceae vegetable crop

References

• Wu XQ, Zhu DL, Zheng XH, et al. A preliminary study on the varieties and utilization of celery in China. China Seed Industry. 1990;2:9–11.
   Google Scholar
• Kooti W, Ali-Akbari S, Asadi-Samani M, et al. A review on medicinal plant of Apium graveolens. AHM. 2014;1:48–59.
   Google Scholar
• Nagella P, Ahmad A, Kim SJ, et al. Chemical composition, antioxidant activity and larvicidal effects of essential oil from leaves of Apium graveolens. Immunopharmacol Immunotoxicol. 2012;34:205–209.
   PubMed Web of Science ®Google Scholar
• Lori GA, Wolcan SM, Larran S. Fusarium yellows of celery caused by Fusarium oxysporum f. sp. apii in argentina. J Plant Pathol. 2008;90:173–178.
   Web of Science ®Google Scholar
• Orton TJ, Hulbert SH, Durgan ME, et al. UC1, fusarium yellows-resistant celery breeding line [Cultivar development, Fusarium oxysporum]. Hortscience. 1984;19:594.
   Google Scholar
• Quiros CF, D’Antonio V, Greathead AS, et al. UC8-1, UC10-1, and UC26-1: three celery lines resistant to Fusarium yellows. Hort Sci. 1993;28:351–352.
   Google Scholar
• Ochoa O, Quiros CF. Apium wild species: novel sources for resistance to late blight in celery. Plant Breed. 1989;102:317–321.
   Web of Science ®Google Scholar
• Honma S, Lacy ML. Hybridization between pascal celery and parsley. Euphytica. 1980;29:801–805.
   Web of Science ®Google Scholar
• Zhu X, Gao GX, Wang X. Overview of studies on celery late blight disease. China Veg. 2011;17:104–107.
   Google Scholar
• Quiros CF, Douches D, D’Antonio V. Inheritance of annual habit in celery: cosegregation with isozyme and anthocyanin markers. Theor Appl Genet. 1987;74:203–208.
   PubMed Web of Science ®Google Scholar
• Wolf EA, White JM, Stubblefield RS, et al. Florida Slobolt M68’: a spring celery cultivar for Florida. Hort Sci. 1993;28:754–755.
   Google Scholar
• Wang WT, Wu F, Gao GX, et al. A new slow-bolting celery cultivar ‘Juventus’. Acta Hortic Sin. 2012;39:1007–1008.
   Google Scholar
• Zhang Y, Lu CM, Zhao XB. Preliminary study on celery hybridization. J Changjiang Veg. 1998;11:29–30.
   Google Scholar
• Chaubal R, Zanella C, Trimnell MR, et al. Two male-sterile mutants of Zea mays (Poaceae) with an extra cell division in the anther wall. Am J Bot. 2000;87:1193–1201.
   PubMed Web of Science ®Google Scholar
• Kumar V, Apte UB, Bhagwat SG, et al. Phenotypic and molecular characterization of diversified cytoplasmic male sterile lines of rice (Oryza sativa L.). Electron J Plant Breed. 2013;4:1193.
   Google Scholar
• Murai K, Tsunewaki K. Photoperiod-sensitive cytoplasmic male sterility in wheat with Aegilops crassa cytoplasm. Euphytica. 1993;67:41–48.
   Web of Science ®Google Scholar
• Cheng SY, Hou RX, Zhu YY, et al. Identification of cytoplasmic male sterile type of P70-203, a new germplasm of non-heading Chinese cabbage. Genomics Appl Biol. 2009;28:941–945.
   Google Scholar
• Quiros CF, Rugama A, Dong YY, et al. Cytological and genetical studies of a male sterile celery. Euphytica. 1986;35:867–875.
   Web of Science ®Google Scholar
• Gao GX, Jin LZ, Lu ZM, et al. Discovery and botanical characters of celery male sterile material. Tianjin Agric Sci. 2006;12:9–11.
   Google Scholar
• Gao GX, Jin LZ, Lu ZM, et al. A new high yield of quality celery hybrid ‘Jinqi No.1’. J Changjiang Veg. 2009;1:3.
   Google Scholar
• Gao GX, Jin LZ, Lu ZM, et al. A new early-spring celery hybrid ‘Jinqi 2. Acta Hortic Sin. 2008;35:777.
   Google Scholar
• Gao GX, Wang WT, Wu F, et al. Analysis on physiological and biochemical characteristics of cytoplasmic male sterile line and its maintainer line in celery. Tianjin Agric Sci. 2013;19:1–4.
   Google Scholar
• Williams JG, Kubelik AR, Livak KJ, et al. DNA polymorphisms amplified by arbitrary primers are useful as genetic markers. Nucleic Acids Res. 1990;18:6531–6535.
   PubMed Web of Science ®Google Scholar
• Hadrys H, Balick M, Schierwater B. Applications of random amplified polymorphic DNA (RAPD) in molecular ecology. Mol Ecol. 1992;1:55–63.
   PubMed Web of Science ®Google Scholar
• Briard M, Clerc VL, Mausset AE, et al. A comparative study on the use of ISSR, microsatellites and RAPD markers for varietal identification of carrot genotypes. Acta Hort. 2001;546:377–385.
   Google Scholar
• Yang X, Quiros C. Identification and classification of celery cultivars with RAPD markers. Theor Appl Genet. 1993;86:205–212.
   PubMed Web of Science ®Google Scholar
• Liu PY, Zhang BH, Zhao H, et al. Analysis of genetic relationship among celery germplasms by RAPD. Agric Biotechnol. 2014;3:10–13.
   Google Scholar
• Domblides A, Domblides H, Kharchenko V. Discrimination between celery cultivars with the use of RAPD markers. Proc Latv Acad Sci B Nat Exact Appl Sci. 2009;62:219–222.
   Google Scholar
• Ju JF. An analysis of celery genetic diversity by AFLP. Chinese Agric Sci Bull. 2007;23:120–123.
   Google Scholar
• Wang WT, Gu Y, Han QH, et al. ISSR analysis of celery germplasm genetic relationships. China Veg. 2011;4:22–27.
   Google Scholar
• Huestis GM, McGrath JM, Quiros CF. Development of genetic markers in celery based on restriction fragment length polymorphisms. Theor Appl Genet. 1993;85:889–896.
   PubMed Web of Science ®Google Scholar
• Yang X, Quiros CF. Construction of a genetic linkage map in celery using DNA-based markers. Genome. 1995;38:36–44.
   PubMed Web of Science ®Google Scholar
• Lan QK, Li OJ, Zhang JB, et al. Construction of SSR-based molecular fingerprinting and analysis of genetic diversity for celery varieties from Tianjin. Tianjin Agric Sci. 2012;18:7–11.
   Google Scholar
• Morozova O, Marra MA. Applications of next-generation sequencing technologies in functional genomics. Genomics. 2008;92:255–264.
   PubMed Web of Science ®Google Scholar
• Parchman TL, Geist KS, Grahnen JA, et al. Transcriptome sequencing in an ecologically important tree species: assembly, annotation, and marker discovery. BMC Genomics. 2010;11:180.
   PubMed Web of Science ®Google Scholar
• Fu N, Wang Q, Shen HL. De novo assembly, gene annotation and marker development using Illumina paired-end transcriptome sequences in celery (Apium graveolens L.). PLoS One. 2013;8:e57686.
   PubMed Web of Science ®Google Scholar
• Li MY, Wang F, Jiang Q, et al. Identification of SSRs and differentially expressed genes in two cultivars of celery (Apium graveolens L.) by deep transcriptome sequencing. Hortic Res. 2014;1:10.
   PubMed Web of Science ®Google Scholar
• Bhatia P, Ashwath N, Senaratna T, et al. Tissue culture studies of tomato (Lycopersicon esculentum). Plant Cell Tissue Organ Cult. 2004;78:1–21.
   Web of Science ®Google Scholar
• Compton ME, Gray DJ, Gaba VP. Use of tissue culture and biotechnology for the genetic improvement of watermelon. Plant Cell Tissue Organ Cult. 2004;77:231–243.
   Web of Science ®Google Scholar
• Raju CS, Aslam A, Shajahan A. High-efficiency direct somatic embryogenesis and plant regeneration from leaf base explants of turmeric (Curcuma longa L.). Plant Cell Tiss Organ Cult. 2015;122:79–87.
   Web of Science ®Google Scholar
• Williams L, Collin HA. Growth and cytology of celery plants derived from tissue cultures. Ann Bot. 1976;40:333–338.
   Web of Science ®Google Scholar
• Li Y, Shen D, Ni D. Whole plant regeneration from single cell culture of Chinese celery (Apium graveolens L.). J Fudan Univ. 1990;29:380–387.
   Google Scholar
• Han QX, Shen HL, Zhu X, et al. Embryonic callus induction and plant high efficient regeneration system from celery (Apium graveolens L.). China Veg. 2006;11:6–9.
   Google Scholar
• Wan XS, Wang FD, Xia ZA. Studies on culture conditions and plant regeneration of Apium graveolens protoplast. Plant Physiol Commun. 1988;34:2702–2708.
   Google Scholar
• Kim YH, Janick J. Abscisic acid and proline improve desiccation tolerance and increase fatty acid content of celery somatic embryos. Plant Cell Tiss Organ Cult. 1991;4:83–89.
   Web of Science ®Google Scholar
• You YW, Wang YZ, Li X. The effect of gibberellins (GA3) on the dormancy of celery (Apium graveolens L.) and the effect of TDZ on the proliferation of celery. Acta Agric Boreali Sin. 2007;22:61–63.
   Google Scholar
• Huang SY, Chan HS, Wang TT. Induction of somatic embryos of celery by control of gaseous compositions and other physical conditions. Plant Growth Regul. 2006;49:219–227.
   Web of Science ®Google Scholar
• Wang HZ, Du LQ, Li AS, et al. Transformation of the calli of Apium graveolens L. mediated by Agrobacterium tumefaciens. J Zhejiang Agric Univ. 1992;18:45–48.
   Google Scholar
• Zhen SX, Dong WB, Li XB. Study on genetic transformation of celery callus. J Central China Normal Univ Nat Sci Ed. 1996;30:327–329.
   Google Scholar
• Xu ZS, Tan HW, Wang F, et al. CarrotDB: a genomic and transcriptomic database for carrot. Database. 2014;29:1229–1245.
   Google Scholar
• Iorizzo M, Ellison S, Senalik D, et al. A high-quality carrot genome assembly provides new insights into carotenoid accumulation and asterid genome evolution. Nat Genet. 2016;48:657–666.
   PubMed Web of Science ®Google Scholar
• Zhao D, Yan ZM, Zhang SN, et al. Karyotype analysis of main umbelliferous vegetables. Acta Bot Boreali-Occidentalia Sin. 2010;30:1978–1981.
   Google Scholar
• Wang Z, Gerstein M, Snyder M. RNA-Seq: a revolutionary tool for transcriptomics. Nat Rev Genet. 2009;10:57–63.
   PubMed Web of Science ®Google Scholar
• Wei DD, Chen EH, Ding TB, et al. De novo assembly, gene annotation, and marker discovery in stored-product pest Liposcelis entomophila (Enderlein) using transcriptome sequences. PLoS One. 2013;8:e80046.
   PubMed Web of Science ®Google Scholar
• Seo M, Kim K, Yoon J, et al. RNA-seq analysis for detecting quantitative trait-associated genes. Sci Rep. 2016;6:24375.
   PubMed Web of Science ®Google Scholar
• Vilaine F, Palauqui JC, Amselem J, et al. Towards deciphering phloem: a transcriptome analysis of the phloem of Apium graveolens. Plant J. 2003;36:67–81.
   PubMed Web of Science ®Google Scholar
• Jia XL, Wang GL, Xiong F, et al. De novo assembly, transcriptome characterization, lignin accumulation, and anatomic characteristics: novel insights into lignin biosynthesis during celery leaf development. Sci Rep. 2015;5:8259.
   PubMed Web of Science ®Google Scholar
• de Lima JC, Loss-Morais G, Margis R. MicroRNAs play critical roles during plant development and in response to abiotic stresses. Genet Mol Biol. 2012;35:1069–1077.
   PubMed Web of Science ®Google Scholar
• Li X, Bian H, Song D, et al. Flowering time control in ornamental gloxinia (Sinningia speciosa) by manipulation of miR159 expression. Ann Bot. 2013;111:791–799.
   PubMed Web of Science ®Google Scholar
• Sharma D, Tiwari M, Pandey A, et al. MicroRNA858 is a potential regulator of phenylpropanoid pathway and plant development in Arabidopsis. Plant Physiol. 2016;171:944–959.
   PubMed Web of Science ®Google Scholar
• Chen L, Ren Y, Zhang Y, et al. Genome-wide profiling of novel and conserved Populus microRNAs involved in pathogen stress response by deep sequencing. Planta. 2012;235:873–883.
   PubMed Web of Science ®Google Scholar
• Rathjen T, Pais H, Sweetman D, et al. High throughput sequencing of microRNAs in chicken somites. FEBS Lett. 2009;583:1422–1426.
   PubMed Web of Science ®Google Scholar
• Jiang Q, Wang F, Li MY, et al. High-throughput analysis of small RNAs and characterization of novel microRNAs affected by abiotic stress in a local celery cultivar. Sci Hortic. 2014;169:36–43.
   Web of Science ®Google Scholar
• Li MY, Wang F, Xu ZS, et al. High throughput sequencing of two celery varieties small RNAs identifies microRNAs involved in temperature stress response. BMC Genomics. 2014;15:1–9.
   PubMed Web of Science ®Google Scholar
• Jia XL, Li MY, Jiang Q, et al. High-throughput sequencing of small RNAs and anatomical characteristics associated with leaf development in celery. Sci Rep. 2015;5:11093.
   PubMed Web of Science ®Google Scholar
• Bustin SA. Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems. J Mol Endocrinol. 2002;29:23–39.
   PubMed Web of Science ®Google Scholar
• Dheda K, Huggett JF, Chang JS, et al. The implications of using an inappropriate reference gene for real-time reverse transcription PCR data normalization. Anal Biochem. 2005;344:141–143.
   PubMed Web of Science ®Google Scholar
• Rebouças EDL, Costa JJDN, Passos MJ, et al. Real time PCR and importance of housekeepings genes for normalization and quantification of mRNA expression in different tissues. Braz Arch Biol Technol. 2013;56:143–154.
   Web of Science ®Google Scholar
• Li MY, Wang F, Jiang Q, et al. Validation and comparison of reference genes for qPCR normalization of celery (Apium graveolens) at different development stages. Front Plant Sci. 2016;7:313.
   PubMed Web of Science ®Google Scholar
• Everard JD, Cantini C, Grumet R, et al. Molecular cloning of mannose-6-phosphate reductase and its developmental expression in celery. Plant Physiol. 1997;113:1427–1435.
   PubMed Web of Science ®Google Scholar
• Gao Z, Loescher WH. NADPH supply and mannitol biosynthesis. Characterization, cloning, and regulation of the non-reversible glyceraldehyde-3-phosphate dehydrogenase in celery leaves. Plant Physiol. 2000;124:321–330.
   PubMed Web of Science ®Google Scholar
• Yamaoka S, Shimono Y, Shirakawa M, et al. Identification and dynamics of Arabidopsis adaptor protein-2 complex and its involvement in floral organ development. Plant Cell. 2013;25:2958–2969.
   PubMed Web of Science ®Google Scholar
• Wang GL, Wang F, Xu ZS, et al. Cloning and expression profile analysis of the AgMu2 gene of adaptor complex from celery. Acta Hortic Sin. 2014;41:1369–1378.
   Google Scholar
• Yan J, Yu L, Xu S, et al. Apigenin accumulation and expression analysis of apigenin biosynthesis relative genes in celery. Sci Hortic. 2014;165:218–224.
   Web of Science ®Google Scholar
• Jia XL, Wang GL, Wang F, et al. Anatomic structure and expression profiles of related genes: novel insights into leaf development in celery. J Plant Growth Regul. 2015;34:519–531.
   Web of Science ®Google Scholar
• Li Y, Xu ZS, Tan GF, et al. Cloning and expressional response analysis of AgHSFB2 under different temperature treatments in celery. J Nanjing Agric Univ. 2015;38:360–368.
   Google Scholar
• Guo WJ, Meetam M, Goldsbrough PB. Examining the specific contributions of individual Arabidopsis metallothioneins to copper distribution and metal tolerance. Plant Physiol. 2008;146:1697–1706.
   PubMed Web of Science ®Google Scholar
• Divol F, Vilaine F, Thibivilliers S, et al. Systemic response to aphid infestation by Myzus persicae in the phloem of Apium graveolens. Plant Mol Biol. 2005;57:517–540.
   PubMed Web of Science ®Google Scholar
• Chen YY, Li MY, Li Y, et al. Isolation and characterization of the Agmt2 gene and its response to abiotic and metalstress in Apium graveolens. Sci Hortic. 2015;186:1–6.
   Web of Science ®Google Scholar
• Li Y, Chen YY, Wang F, et al. Isolation and characterization of the Agvip1 gene and response to abiotic and metal ions stresses in three celery cultivars. Mol Biol Rep. 2014;41:6003–6011.
   PubMed Web of Science ®Google Scholar
• Abebe T, Guenzi AC, Martin B, et al. Tolerance of mannitol-accumulating transgenic wheat to water stress and salinity. Plant Physiol. 2003;131:1748–1755.
   PubMed Web of Science ®Google Scholar
• Zhifang G, Loescher WH. Expression of a celery mannose 6-phosphate reductase in Arabidopsis thaliana, enhances salt tolerance and induces biosynthesis of both mannitol and a glucosyl-mannitol dimer. Plant Cell Environ. 2003;26:275–283.
   Web of Science ®Google Scholar
• Song GQ, Sink KC, Ma Y, et al. A novel mannose-based selection system for plant transformation using celery mannose-6-phosphate reductase gene. Plant Cell Rep. 2010;29:163–172.
   PubMed Web of Science ®Google Scholar
• Sickler CM, Edwards GE, Kiirats O, et al. Response of mannitol-producing Arabidopsis thaliana to abiotic stress. Funct Plant Biol. 2007;34:382–391.
   PubMed Web of Science ®Google Scholar
• Chan Z, Grumet R, Loescher W. Global gene expression analysis of transgenic, mannitol-producing, and salt-tolerant Arabidopsis thaliana indicates widespread changes in abiotic and biotic stress-related genes. J Exp Bot. 2011;62:4787–4803.
   PubMed Web of Science ®Google Scholar
• Noiraud N, Maurousset L, Lemoine R. Identification of a mannitol transporter, AgMAT1, in celery phloem. Plant Cell. 2001;13:695–705.
   PubMed Web of Science ®Google Scholar
• Noiraud N, Delrot S, Lemoine R. The sucrose transporter of celery. Identification and expression during salt stress. Plant Physiol. 2000;122:1447–1456.
   PubMed Web of Science ®Google Scholar
• Katagiri F. A global view of defense gene expression regulation – a highly interconnected signaling network. Curr Opin Plant Biol. 2004;7:506–511.
   PubMed Web of Science ®Google Scholar
• Stoop JMH, Williamson JD, Pharr DM. Mannitol metabolism in plants: a method for coping with stress. Trends Plant Sci. 1996;1:139–144.
   Web of Science ®Google Scholar
• Williamson JD, Stoop JM, Massel MO, et al. Sequence analysis of a mannitol dehydrogenase cDNA from plants reveals a function for the pathogenesis-related protein ELI3. Proc Natl Acad Sci USA. 1995;92:7148–7152.
   PubMed Web of Science ®Google Scholar
• Jennings DB, Daub ME, Pharr DM, et al. Constitutive expression of a celery mannitol dehydrogenase in tobacco enhances resistance to the mannitol-secreting fungal pathogen Alternaria alternata. Plant J. 2002;32:41–49.
   PubMed Web of Science ®Google Scholar
• Divol F, Vilaine F, Thibivilliers S, et al. Involvement of the xyloglucan endotransglycosylase/hydrolases encoded by celery XTH1 and Arabidopsis XTH33 in the phloem response to aphids. Plant Cell Environ. 2007;30:187–201.
   PubMed Web of Science ®Google Scholar
• Pauli G, Bessot JC, Dietemann-Molard A, et al. Celery sensitivity: clinical and immunological correlations with pollen allergy. Clin Allergy. 1985;15:273–279.
   PubMedGoogle Scholar
• Jankiewitz A, Aulepp H, Fötisch K, et al. Serological investigation of 30 celery-allergic patients with particular consideration of the thermal stability of IgE-binding celery allergens. Allergo J. 1998;7:87–95.
   Google Scholar
• Gendel SM, Jenkins JA. Allergen sequence databases. Mol Nutr Food Res. 2006;50:633–637.
   PubMed Web of Science ®Google Scholar
• Breiteneder H, Hoffmann-Sommergruber K, O’Riordain G, et al. Molecular characterization of Api g 1, the major allergen of celery (Apium graveolens), and its immumological and structural relationships to a group of 17-kDa tree pollen allergens. Eur J Biochem. 1995;233:484–489.
   PubMedGoogle Scholar
• Wangorsch A, Ballmer-Weber BK, Rösch P, et al. Mutational epitope analysis and cross-reactivity of two isoforms of Api g 1, the major celery allergen. Mol Immunol. 2007;44:2518–2527.
   PubMed Web of Science ®Google Scholar
• Gadermaier G, Hauser M, Egger M, et al. Sensitization prevalence, antibody cross-reactivity and immunogenic peptide profile of Api g 2, the non-specific lipid transfer protein 1 of celery. PLoS One. 2011;6:e24150.
   PubMed Web of Science ®Google Scholar
• Vejvar E, Himly M, Briza P, et al. Allergenic relevance of nonspecific lipid transfer proteins 2: identification and characterization of Api g 6 from celery tuber as representative of a novel IgE-binding protein family. Mol Nutr Food Res. 2013;57:2061–2070.
   PubMed Web of Science ®Google Scholar
• Scheurer S, Wangorsch A, Haustein D, et al. Cloning of the minor allergen Api g4 profilin from celery (Apium graveolens) and its cross-reactivity with birch pollen profilin Bet v 2. Clin Exp Allergy. 2000;30:962–971.
   PubMed Web of Science ®Google Scholar
• Bublin M, Radauer C, Wilson IB, et al. Cross-reactive N-glycans of Api g 5, a high molecular weight glycoprotein allergen from celery, are required for immunoglobulin E binding and activation of effector cells from allergic patients. FASEB J. 2003;17:1697–1699.
   PubMed Web of Science ®Google Scholar
• Dewitt AM, Andersson K, Peltre G, et al. Cloning, expression and immunological characterization of full-length timothy grass pollen allergen Phl p 4, a berberine bridge enzyme-like protein with homology to celery allergen Api g 5. Clin Exp Allergy. 2006;36:77–86.
   PubMed Web of Science ®Google Scholar
• Bolwell GP, Bozak K, Zimmerlin A. Plant cytochrome P450. Phytochemistry. 1994;37:1491–1506.
   PubMed Web of Science ®Google Scholar
• Morant M, Bak S, Møller BL, et al. Plant cytochromes p450: tools for pharmacology, plant protection and phytoremediation. Curr Opin Biotechnol.. 2003;14:151–162.
   PubMed Web of Science ®Google Scholar
• Page V, Schwitzguébel JP. Metabolism of sulphonated anthraquinones in rhubarb, maize and celery: the role of cytochromes P450 and peroxidases. Plant Cell Rep. 2009;28:1725–1735.
   PubMed Web of Science ®Google Scholar
• Larbat R, Hehn A, Hans J, et al. Isolation and functional characterization of CYP71AJ4 encoding for the first P450 monooxygenase of angular furanocoumarin biosynthesis. J Biol Chem. 2009;284:4776–4785.
   PubMed Web of Science ®Google Scholar
• Tian C, Wang F, Jiang Q, et al. Cloning and expression pattern analysis of CELI gene in celery. J Nanjing Agric Univ. 2014;37:39–45.
   Google Scholar
• Heyen BJ, Alsheikh MK, Smith EA, et al. The calcium-binding activity of a vacuole-associated, dehydrin-like protein is regulated by phosphorylation. Plant Physiol. 2002;130:675–687.
   PubMed Web of Science ®Google Scholar
• Nijveldt RJ, van Nood E, van Hoorn DE, et al. Flavonoids: a review of probable mechanisms of action and potential applications. Am J Clin Nutr. 2001;74:418–425.
   PubMed Web of Science ®Google Scholar
• Romanová D, Vachálková A, Cipák L, et al. Study of antioxidant effect of apigenin, luteolin and quercetin by DNA protective method. Neoplasma. 2001;48:104–107.
   PubMed Web of Science ®Google Scholar
• Kim HP, Son KH, Chang HW, et al. Anti-inflammatory plant flavonoids and cellular action mechanisms. J Pharmacol Sci. 2004;96:229–245.
   PubMed Web of Science ®Google Scholar
• Marzocchella L, Fantini M, Benvenuto M, et al. Dietary flavonoids: molecular mechanisms of action as anti-inflammatory agents. Recent Pat Inflamm Allergy Drug Discov. 2011;5:200–220.
   PubMedGoogle Scholar
• Popović M, Kaurinović B, Trivić S, et al. Effect of celery (Apium graveolens) extracts on some biochemical parameters of oxidative stress in mice treated with carbon tetrachloride. Phytother Res. 2006;20:531–537.
   PubMed Web of Science ®Google Scholar
• Sugihara N, Arakawa T, Ohnishi M, et al. Anti- and pro-oxidative effects of flavonoids on metal-induced lipid hydroperoxide-dependent lipid peroxidation in cultured hepatocytes loaded with alpha-linolenic acid. Free Radic Biol Med. 1999;27:1313–1323.
   PubMed Web of Science ®Google Scholar
• Patil RH, Babu RL, Naveen KM, et al. Apigenin inhibits PMA-induced expression of pro-inflammatory cytokines and AP-1 factors in A549 cells. Mol Cell Biochem. 2015;403:95–106.
   PubMed Web of Science ®Google Scholar
• Chen CY, Peng WH, Tsai KD, et al. Luteolin suppresses inflammation-associated gene expression by blocking NF-kB and AP-1 activation pathway in mouse alveolar macrophages. Life Sci. 2007;81:1602–1614.
   PubMed Web of Science ®Google Scholar
• King JC, Lu QY, Li G, et al. Evidence for activation of mutated p53 by apigenin in human pancreatic cancer. Biochim Biophys Acta. 2012;1823:593–604.
   PubMed Web of Science ®Google Scholar
• Zhang YH, Park YS, Kim TJ, et al. Endothelium-dependent vasorelaxant and antiproliferative effects of apigenin. Gen Pharmacol. 2000;35:341–347.
   PubMedGoogle Scholar
• Wan LL, Xia J, Ye D, et al. Effects of quercetin on gene and protein expression of NOX and NOS after myocardial ischemia and reperfusion in rabbit. Cardiovasc Ther. 2009;27:28–33.
   PubMed Web of Science ®Google Scholar
• Regnaultroger C. The potential of botanical essential oils for insect pest control. Integr Pest Manag Rev. 1997;2:25–34.
   Google Scholar
• Burt S. Essential oils: their antibacterial properties and potential applications in foods – a review. Int J Food Microbiol. 2004;94:223–253.
   PubMed Web of Science ®Google Scholar
• Helaly AD, Baek JP, Mady E, et al. Phytochemical analysis of some celery accessions. JMAP. 2015;4:1–7.
   Google Scholar
• Sowbhagya HB. Chemistry, technology, and nutraceutical functions of celery (Apium graveolens L.): an overview. Crit Rev Food Sci Nutr.. 2014;54:389–398.
   PubMed Web of Science ®Google Scholar
• Sellami IH, Bettaieb I, Bourgou S, et al. Essential oil and aroma composition of leaves, stalks and roots of celery (Apium graveolens var. dulce) from Tunisia. J Essent Oil Res. 2012;24:513–521.
   Web of Science ®Google Scholar
• Lu ZG, Li W, Wang PJ. Chemical composition and ability of scavenging radical of essential oil and residue from the celery seed. AMR. 2011;183–185:18–21.
   Google Scholar
• Li N, Zu YG, Wang W. Antimicrobial and antioxidant effect of celery seed essential oil. China Condiment. 2012;37:28–31.
   Google Scholar
• Momin RA, Nair MG. Mosquitocidal, nematicidal, and antifungal compounds from Apium graveolens L. seeds. J Agric Food Chem. 2001;49:142–145.
   PubMed Web of Science ®Google Scholar
• Shad AA, Shah HU, Bakht J, et al. Nutraceutical potential and bioassay of Apium graveolens L. grown in Khyber Pakhtunkhwa-Pakistan. J Med Plants Res. 2011;5:5160–5166.
   Google Scholar
• Huang W, Wang GL, Li H, et al. Transcriptional profiling of genes involved in ascorbic acid biosynthesis, recycling, and degradation during three leaf developmental stages in celery. Mol Genet Genomics. 2016;291:2131–2143.
   PubMed Web of Science ®Google Scholar
• Domagała-Światkiewicz I, Gastoł M. Comparative study on mineral content of organic and conventional carrot, celery and red beet juices. Acta Sci Pol Hortorum Cultus. 2012;11:173–183.
   Web of Science ®Google Scholar
• Dong LH, Zhao FQ. Determination and analysis of the content of trace elements in two celery varieties. J Taishan Med Coll. 2004;25:141–141.
   Google Scholar
• Choi WS, Chang SH, Kim JE, et al. Hypolipidemic effects of scoparone and its coumarin analogues in hyperlipidemia rats induced by high fat diet. J Korean Soc Appl Biol Chem. 2013;56:647–653.
   Google Scholar
• Yu H, Li JL. Study on the effect of celery on lipid-lowering and health care. Guizhou Med J. 2004;28:560–561.
   Google Scholar
• Shehata MMSM, Soltan SSA. The effects of purslane and celery on hypercholesterolemic mice. World J Dairy Food Sci. 2012;7:212–221.
   Google Scholar
• Beier RC, Oertli EH. Psoralen and other linear furocoumarins as phytoalexins in celery. Phytochemistry. 1983;22:2595–2597.
   Web of Science ®Google Scholar
• Zhang J, Li T, Wang J, et al. Analysis of fatty acid in two kinds of celery seed oil by GC/MS. China Oils Fats. 2004;29:70–71.
   Google Scholar
• Li AM, Wang YL, Zhao SL, et al. Analysis of nutritional components of several wild celery varieties. Special Wild Econ Anim Plant Res. 1997;3:18–19.
   Google Scholar
• Chi CC, Zhai EL, Li CY, et al. Comparative study of hematinic function of celery sodium iron chlorophyllin and other hematinics. Food Sci. 2013;34:289–292.
   Google Scholar