References
- Bergin J. Agricultural biotechnology: emerging technologies and global markets. Wellesley: BCC Research LLC; 2017 [cited 2006 Sep 15]. p. 1–5. Available from: https://cdn2.hubspot.net/hubfs/308401/BIO100C_Rep-ort_Overview.pdf?t=1506965704675&utm_campaign=BIO100C&utm_source=hs_automation&utm_medium=email&utm_content=48264245&_hsenc=p2ANqtz–qjfA00KQblhA9Wl69G6bqHZU5wDwAYyzVAZpeFBAxpKvV3tzDGpJZB3gkEC0xYhJhp1p-pJCfI6YSZTWmB1TXDO2-PKA2zHwzOTGLOJVqy8in5oy0&_hsmi=48264245
- Napoli C, Lemieux C, Jorgensen R. Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans. Plant Cell. 1990;2:279–289.
- Fire A, Xu S, Montgomery MK, et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 1998;391:806–811.
- Ratcliff F, Harrison BD, Baulcombe DC. A similarity between viral defense and gene silencing in plants. Science. 1997;276:1558–1560.
- Hamilton AJ, Baulcombe DC. A species of small antisense RNA in posttranscriptional gene silencing in plants. Science. 1999;286:950–952.
- Baulcombe D. RNA silencing in plants. Nature. 2004;431:356–363.
- Meister G, Tuschl T. Mechanisms of gene silencing by double-stranded RNA. Nature. 2004;431:343–349.
- Hannon GJ. RNA interference. Nature. 2002;418:244–251.
- Guo Q, Liu Q, Smith NA, et al. RNA silencing in plants: mechanisms, technologies and applications in horticultural crops. Curr Genomics. 2016;17:476–489.
- Saurabh S, Vidyarthi A, Prasad D. RNA interference: concept to reality in crop improvement. Planta. 2014;239:543–564.
- Snead NM, Rossi JJ. Biogenesis and function of endogenous and exogenous siRNAs. Wiley Interdiscip Rev RNA. 2010;1:117–131.
- Xia H, Mao Q, Paulson HL, et al. SiRNA-mediated gene silencing in vitro and in vivo. Nat Biotechnol. 2002;20:1006–1010.
- Lau SE, Mazumdar P, Hee TW, et al. Crude extracts of bacterially-expressed dsRNA protect orchid plants against cymbidium mosaic virus during transplantation from in vitro culture. J Hortic Sci Biotechnol. 2014;89:569–576.
- Numata K, Ohtani M, Yoshizumi T, et al. Local gene silencing in plants via synthetic dsRNA and carrier peptide. Plant Biotechnol J. 2014;12:1027–1034.
- Mitter N, Worrall EA, Robinson KE, et al. Clay nanosheets for topical delivery of RNAi for sustained protection against plant viruses. Nat Plants. 2017; 3:16207.
- Kramer MG, Redenbaugh K. Commercialization of a tomato with an antisense polygalacturonase gene: the FLAVR SAVR™ tomato story. Euphytica. 1994;79:293–297.
- Zhang T, Zhao Y-L, Zhao J-H, et al. Cotton plants export microRNAs to inhibit virulence gene expression in a fungal pathogen. Nat Plants. 2016;2:16153.
- Ghag SB, Shekhawat UKS, Ganapathi TR. Host-induced post-transcriptional hairpin RNA-mediated gene silencing of vital fungal genes confers efficient resistance against Fusarium wilt in banana. Plant Biotechnol J. 2014;12:541–553.
- Hajeri S, Killiny N, El-Mohtar C, et al. Citrus tristeza virus-based RNAi in citrus plants induces gene silencing in Diaphorina citri, a phloem-sap sucking insect vector of citrus greening disease (Huanglongbing). J Biotechnol. 2014;176:42–49.
- Mao Y-B, Cai W-J, Wang J-W, et al. Silencing a cotton bollworm P450 monooxygenase gene by plant-mediated RNAi impairs larval tolerance of gossypol. Nat Biotechnol. 2007;25:1307–1313.
- Liu Y, Wang L, Chen D, et al. Genome-wide comparison of microRNAs and their targeted transcripts among leaf, flower and fruit of sweet orange. BMC Genom. 2014;15:695.
- Carciofi M, Blennow A, Jensen SL, et al. Concerted suppression of all starch branching enzyme genes in barley produces amylose-only starch granules. BMC Plant Biol. 2012;12:223
- Jia H-F, Chai Y-M, Li C-L, et al. Abscisic acid plays an important role in the regulation of strawberry fruit ripening. Plant Physiol. 2011;157:188–199.
- Chi-Ham CL, Clark KL, Bennett AB. The intellectual property landscape for gene suppression technologies in plants. Nat Biotechnol. 2010;28:32–36.
- Fire A, Kostas S, Montgomery M, et al. Genetic inhibition by double-stranded RNA. United States patent US 7,622,622. 2009.
- Baulcombe DC, Hamilton AJ, et al. Gene silencing. United States Patent US 8,097,710. 2012.
- Baulcombe DC, Hamilton AJ. Short RNA producing gene silencing in cells. United States Patent US 8,759,102. 2014.
- Baulcombe DC, Hamilton AJ. Gene silencing. United States Patent US 8,779,236. 2014.
- Waterhouse PM, Wang MB, Graham MC. Methods and means for obtaining modified phenotypes. European Patent EP 1,068,311. 1999.
- The information on legal events for EP1068311 was retrieved from Google Patent database. 1998—[cited 2017 Oct 31]. Available from: https://www.google.com.my/patents/EP1068311B1?cl=en&dq=EP1068311-&hl=en&sa=X&ved=0ahUKEwiwyeeq-dXXAhVMwI8KHSWJCfgQ6AEIJTAA#legal-events
- Tenllado F, Díaz-Ruíz JR. Double-stranded RNA-mediated interference with plant virus infection. J Virol. 2001;75:12288–12297.
- Gan D, Zhang J, Jiang H, et al. Bacterially expressed dsRNA protects maize against SCMV infection. Plant Cell Rep. 2010;29:1261–1268.
- Tenllado F, Martínex-García B, Vargas M, et al. Crude extracts of bacterially expressed dsRNA can be used to protect plants against virus infections. BMC Biotechnol. 2003;3:25.
- Killiny N, Hajeri S, Tiwari S, et al. Double-stranded RNA uptake through topical application, mediates silencing of five CYP4 genes and suppresses insecticide resistance in Diaphorina citri. PLoS One. 2014;9:e110536.
- Joga MR, Zotti MJ, Smagghe G, et al. RNAi efficiency, systemic properties, and novel delivery methods for pest insect control: what we know so far. Front Physiol. 2016;7:553.
- Blake WJ, Cunningham DS, Maceachran D. Cell-free production of ribonucleic acid. WO2016160936 (Patent application). 2016.
- Ma X, Zhu Q, Chen Y, et al. CRISPR/Cas9 platforms for genome editing in plants: developments and applications. Mol Plant. 2016;9:961–974.
- Arora L, Narula A. Gene editing and crop improvement using CRISPR-Cas9 system. Front Plant Sci. 2017;8:1931.
- Charpentier E, Doudna JA. Biotechnology: rewriting a genome. Nature. 2013;495:50–51.
- Devgen NV. Monsanto company announce research and technology agreements, Press Release, Monsanto Technology LLC, St Louis, MO. 2007—[cited 2017 Nov 7]. Available from: https://monsanto.com/news-releases/devgen-n-v-and-monsanto-company-announce-research-and-technology-agreements/
- Forage Genetics International (FGI) and Monsanto announce Alfalfa commercial and research agreements to support innovation for alfalfa growers, Press Release, Monsanto Technology LLC, St Louis, MO. 2016—[cited 2017 Nov 8]. Available from: https://monsanto.com/news-releases/forage-genetics-international-fgi-and-monsanto-announce-alfalfa-commercial-and-research-agreements-to-support-innovation-for-alfalfa-growers/
- Event Name: KK179. ISAAA. 2013—[cited 2017 Nov 1]. Available from: http://www.isaaa.org/gmapprovaldatabase/event/default.asp?EventID=356&Event=KK179
- DuPont and Rosetta Green sign research agreement for drought tolerance in corn and soybeans. 2011 — [cited 2017 Nov 8]. Available from: http://oklahomafarmreport.com/wire/news/2011/12/00092_DuPontRos-etta12152011_093347.php
- KWS and Rosetta Green sign a research and collaboration agreement for developing improved sugar beet. 2012—[cited 2017 Nov 8]. Available from: https://www.seedquest.com/news.php?type=news&id_article=28449&id_region=&id_category=176,&id_crop=63
- Bayer, Rosetta Green reach deal to improve cotton yields. 2012—[cited 2017 Nov 8]. Available from: https://www.genomeweb.com/rnai/bayer-rosetta-green-reach-deal-improve-cotton-yields
- Research agreements with Dow Agrosciences. Press release, Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., Munich, Germany. 2012—[cited 2017 Nov 8]. Available from: https://www.fraunhofer.de/en/press/research-news/2012/january/research-agreement-with-dow-agrosciences.html
- Dow AgroSciences published new data on use of RNAi against corn pest. 2015 — [cited 2017 Nov 8]. Available from: https://www.genomeweb.com/gene-silencinggene-editing/dow-agrosciences-publishes-new-data-use-rnai-against-corn-pest
- The list of business deals and partnerships was compiled from various online resources. Keywords used for Google search engine were “firm”, “RNAi”, “RNA silencing”, “licensing agreements”, “business deals”, “acquisition” and “partnership”. [cited 2017 Oct 20].
- Apples that don’t go brown now available in US supermarkets. Press release, CSIRO, Canberra, Australia. 2017—[cited 2017 November 7]. Available from: https://www.csiro.au/en/News/News-releases/2017/Apples-that-dont-go-brown
- Arctic apple developed in B.C. approved for sale in Canada. Press release, CSIRO, Canberra, Australia. 2015—[cited 2017 Nov 7]. Available from: http://www.cbc.ca/news/canada/british-columbia/arctic-apple-deve loped-in-b-c-approved-for-sale-in-canada-1.3003875
- Sinha G. Interest resparks in RNAi. Nat Biotechnol. 2012;30:1012.
- Bachman PM, Huizinga KM, Jensen PD, et al. Ecological risk assessment for DvSnf7 RNA: a plant-incorporated protectant with targeted activity against western corn rootworm. Regul Toxicol Pharmacol. 2016;81:77–88.
- The list of deregulated transgenic plants was retrieved from a USDA database. [cited 2017 Nov 1]. Available from: https://www.aphis.usda.gov/aphis/ourfocus/biotechnology/permits-notifications-petitions/petitions/petition-status
- Tekmira receives milestone payment from Monsanto. 2014—[cited 2017 Nov 7]. Available from: https://seekingalpha.com/news/1836985-tekmira-receives-milestone-payment-from-monsanto
- Regalado A. The next great GMO debate. 2015—[cited 2017 Nov 7]. Available from: https://www.technologyreview.com/s/540136/the-next-great-gmo-debate/
- Barfield T. Bayer sells crop science units to ease Monsanto takeover. 2017—[cited 2017 Nov 7]. Available from: https://phys.org/news/2017-10-bayer-crop-science-ease-monsanto.html
- GreenLight Biosciences raises $18m series D for RNAi biopesticide. 2017—[cited 2017 Nov 7]. Available from: https://agfundernews.com/greenlight-biosciences-raises-18m-series-d-rnai-biopesticide.html
- The data was compiled from press releases from the company websites and online news, keywords used were “RNAi”, “RNA silencing”, “licensing agreement”, “acquisition”, “research partnership” and “collaboration”.
- Prado JR, Segers G, Voelker T, et al. Genetically engineered crops: from idea to product. Annu Rev Plant Biol. 2014;65:769–790.
- European Parliament. Directive 2001/18/EC of the European Parliament and of the Council of 12 March 2001 on the deliberate release into the environment of genetically modified organisms. 2001—[cited 2017 Nov 15]. Available from: http://eur-lex.europa.eu/legal-content/en/TXT/?uri=CELEX%3A32001L0018
- Plants with novel traits. [cited 2017 Nov 15]. Available from: http://www.inspection.gc.ca/plants/plants-with-novel-traits/eng/1300137887237/1300137939635
- Genetically Modified (GM) Foods and Other Novel Foods. [cited 2017 Nov 15]. Available from: https://www.canada.ca/en/health-canada/services/food-nutrition/genetically-modified-foods-other-novel-foods.html
- Office of Science and Technology Policy. Coordinated Framework for Regulation of Biotechnology. 1986—[cited 2017 November 15]. Available from: https://www.aphis.usda.gov/brs/fedregister/coordinated_framework.pdf
- Jaffe G. Regulating transgenic crops: a comparative analysis of different regulatory processes. Transgenic Res. 2004;13:5–19.
- Pesticide Experimental Use Permit; Receipt of Application; Comment Request. 2017—[cited 2017 Nov 15]. Available from: https://www.federalregister.gov/documents/2017/06/08/2017-11942/pesticide-experimental-use-permit-receipt-of-application-comment-request
- EPA. (2013). White paper on RNAi technology as a pesticide: problem formulation for human health and ecological risk assessment. p. 39. Washington, DC: United States Environmental Protection Agency.
- FIFRA Scientific Advisory Panel Meeting. (2014). A set of scientific issues being considered by the Environmental Protection Agency regarding RNAi technology: problem formulation for human health and ecological risk assessment. p. 75. Washington, DC: United States Environmental Protection Agency.
- Paces J, Nic M, Novotny T, et al. Literature review of baseline information to support the risk assessment of RNAi-based GM plants. EFSA Supp Publ. 2017;314. EN-1246.