l-arginine production in Corynebacterium glutamicum: manipulation and optimization of the metabolic process

References

• Lee JH, Wendisch VF. Production of amino acids - genetic and metabolic engineering approaches. Bioresour Technol. 2017;245(Pt B):1575–1587.
   PubMedGoogle Scholar
• D'Este M, Alvarado-Morales M, Angelidaki I. Amino acids production focusing on fermentation technologies - a review. Biotechnol Adv. 2018;36(1):14–25.
   PubMed Web of Science ®Google Scholar
• Sepandi M, Abbaszadeh S, Qobady S, et al. Effect of L-arginine supplementation on lipid profiles and inflammatory markers: a systematic review and meta-analysis of randomized controlled trials. Pharmacol Res. 2019;148:104407.
   PubMed Web of Science ®Google Scholar
• Gogoi M, Datey A, Wilson K, et al. Dual role of arginine metabolism in establishing pathogenesis. Curr Opin Microbiol. 2016;29:43–48.
   PubMed Web of Science ®Google Scholar
• Su L, Ma Y, Wu J. Extracellular expression of natural cytosolic arginine deiminase from Pseudomonas putida and its application in the production of L-citrulline. Bioresour Technol. 2015;196:176–183.
   PubMed Web of Science ®Google Scholar
• Huang K, Mu W, Zhang T, et al. Cloning, expression, and characterization of a thermostable L-arginase from Geobacillus thermodenitrificans NG80-2 for L-ornithine production. Biotechnol Appl Biochem. 2016;63(3):391–397.
   PubMed Web of Science ®Google Scholar
• Song W, Sun X, Chen X, et al. Enzymatic production of L-citrulline by hydrolysis of the guanidinium group of L-arginine with recombinant arginine deiminase. J Biotechnol. 2015;208:37–43.
   PubMed Web of Science ®Google Scholar
• Li Y, Wei H, Wang T, et al. Current status on metabolic engineering for the production of L-aspartate family amino acids and derivatives. Bioresour Technol. 2017;245(Pt B):1588–1602.
   PubMedGoogle Scholar
• Zhang B, Yu M, Wei WP, et al. Optimization of L-ornithine production in recombinant Corynebacterium glutamicum S9114 by cg3035 overexpression and manipulating the central metabolic pathway. Microb Cell Fact. 2018;17(1):91.
   PubMedGoogle Scholar
• Zhang B, Yu M, Zhou Y, et al. Systematic pathway engineering of Corynebacterium glutamicum S9114 for L-ornithine production. Microb Cell Fact. 2017;16(1):158.
   PubMedGoogle Scholar
• Sgobba E, Stumpf A, Vortmann M, et al. Synthetic Escherichia coli-Corynebacterium glutamicum consortia for L-lysine production from starch and sucrose. Bioresour Technol. 2018; 260:302–310.
   PubMed Web of Science ®Google Scholar
• Yang H, Zhang C, Lai N, et al. Efficient isopropanol biosynthesis by engineered Escherichia coli using biologically produced acetate from syngas fermentation. Bioresour Technol. 2020;296:122337.
   PubMed Web of Science ®Google Scholar
• Wei Y, Mohsin A, Hong Q, et al. Enhanced production of biosynthesized lycopene via heterogenous MVA pathway based on chromosomal multiple position integration strategy plus plasmid systems in Escherichia coli. Bioresour Technol. 2018;250:382–389.
   PubMed Web of Science ®Google Scholar
• Rui J, You S, Zheng Y, et al. High-efficiency and low-cost production of cadaverine from a permeabilized-cell bioconversion by a Lysine-induced engineered Escherichia coli. Bioresour Technol. 2020; 302:122844.
   PubMed Web of Science ®Google Scholar
• Lee T, Min W, Kim H, et al. Improved production of 3-hydroxypropionic acid in engineered Escherichia coli by rebalancing heterologous and endogenous synthetic pathways. Bioresour Technol. 2020;299:122600.
   PubMed Web of Science ®Google Scholar
• Fang H, Li D, Kang J, et al. Metabolic engineering of Escherichia coli for de novo biosynthesis of vitamin B12. Nat Commun. 2018;9(1):4917.
   PubMedGoogle Scholar
• Guo D, Kong S, Zhang L, et al. Biosynthesis of advanced biofuel farnesyl acetate using engineered Escherichia coli. Bioresour Technol. 2018;269:577–580.
   PubMed Web of Science ®Google Scholar
• Sarria S, Kruyer NS, Peralta-Yahya P. Microbial synthesis of medium-chain chemicals from renewables. Nat Biotechnol. 2017;35(12):1158–1166.
   PubMed Web of Science ®Google Scholar
• Li S, Li Y, Smolke CD. Strategies for microbial synthesis of high-value phytochemicals. Nat Chem. 2018;10(4):395–404.
   PubMed Web of Science ®Google Scholar
• Ginesy M, Belotserkovsky J, Enman J, et al. Metabolic engineering of Escherichia coli for enhanced arginine biosynthesis. Microb Cell Fact. 2015;14:29.
   PubMed Web of Science ®Google Scholar
• Okuda S, Sherman DJ, Silhavy TJ, et al. Lipopolysaccharide transport and assembly at the outer membrane: the PEZ model. Nat Rev Microbiol. 2016;14(6):337–345.
   PubMed Web of Science ®Google Scholar
• Becker J, Wittmann C. A field of dreams: Lignin valorization into chemicals, materials, fuels, and health-care products. Biotechnol Adv. 2019;37(6):107360.
   PubMed Web of Science ®Google Scholar
• Jeandet P, Sobarzo-Sanchez E, Clement C, et al. Engineering stilbene metabolic pathways in microbial cells. Biotechnol Adv. 2018;36(8):2264–2283.
   PubMed Web of Science ®Google Scholar
• Kim HT, Khang TU, Baritugo KA, et al. Metabolic engineering of Corynebacterium glutamicum for the production of glutaric acid, a C5 dicarboxylic acid platform chemical. Metab Eng. 2019;51:99–109.
   PubMed Web of Science ®Google Scholar
• Cleto S, Jensen JVK, Wendisch VF, et al. Corynebacterium glutamicum metabolic engineering with CRISPR interference (CRISPRi). ACS Synth Biol. 2016;5(5):375–385.
   PubMed Web of Science ®Google Scholar
• Hashiro S, Mitsuhashi M, Chikami Y, et al. Construction of Corynebacterium glutamicum cells as containers encapsulating dsRNA overexpressed for agricultural pest control. Appl Microbiol Biotechnol. 2019;103(20):8485–8496.
   PubMed Web of Science ®Google Scholar
• Zhang J, Yang F, Yang Y, et al. Optimizing a CRISPR-Cpf1-based genome engineering system for Corynebacterium glutamicum. Microb Cell Fact. 2019;18(1):60.
   PubMedGoogle Scholar
• Jiang Y, Qian F, Yang J, et al. CRISPR-Cpf1 assisted genome editing of Corynebacterium glutamicum. Nat Commun. 2017;8:15179.
   PubMed Web of Science ®Google Scholar
• Zhang B, Yu M, Zhou Y, et al. Improvement of L-ornithine production by attenuation of argF in engineered Corynebacterium glutamicum S9114. AMB Express. 2018;8(1):26.
   PubMedGoogle Scholar
• Park SH, Kim HU, Kim TY, et al. Metabolic engineering of Corynebacterium glutamicum for L-arginine production. Nat Commun. 2014;5(1):9.
   Google Scholar
• Lubitz D, Jorge JM, Pérez-García F, et al. Roles of export genes cgmA and lysE for the production of L-arginine and L-citrulline by Corynebacterium glutamicum. Appl Microbiol Biotechnol. 2016;100(19):8465–8474.
   PubMed Web of Science ®Google Scholar
• Zhan M, Kan B, Dong J, et al. Metabolic engineering of Corynebacterium glutamicum for improved L-arginine synthesis by enhancing NADPH supply. J Ind Microbiol Biotechnol. 2019;46(1):45–54.
   PubMed Web of Science ®Google Scholar
• Man Z, Xu M, Rao Z, et al. Systems pathway engineering of Corynebacterium crenatum for improved L-arginine production. Sci Rep. 2016;6:28629.
   PubMed Web of Science ®Google Scholar
• Guo J, Man Z, Rao Z, et al. Improvement of the ammonia assimilation for enhancing L-arginine production of Corynebacterium crenatum. J Ind Microbiol Biotechnol. 2017;44(3):443–451.
   PubMed Web of Science ®Google Scholar
• Man Z, Rao Z, Xu M, et al. Improvement of the intracellular environment for enhancing L-arginine production of Corynebacterium glutamicum by inactivation of H2O2-forming flavin reductases and optimization of ATP supply. Metab Eng. 2016;38:310–321.
   PubMed Web of Science ®Google Scholar
• Xu M, Rao Z, Yang J, et al. The effect of a LysE exporter overexpression on L-arginine production in Corynebacterium crenatum. Curr Microbiol. 2013;67(3):271–278.
   PubMed Web of Science ®Google Scholar
• Xu M, Li J, Shu Q, et al. Enhancement of L-arginine production by increasing ammonium uptake in an AmtR-deficient Corynebacterium crenatum mutant. J Ind Microbiol Biotechnol. 2019;46(8):1155–1166.
   PubMed Web of Science ®Google Scholar
• Zhang J, Xu M, Ge X, et al. Reengineering of the feedback-inhibition enzyme N-acetyl-l-glutamate kinase to enhance l-arginine production in Corynebacterium crenatum. J Ind Microbiol Biotechnol. 2017;44(2):271–283.
   PubMed Web of Science ®Google Scholar
• Huang M, Zhao Y, Li R, et al. Improvement of L-arginine production by in silico genome-scale metabolic network model guided genetic engineering. 3 Biotech. 2020;10(3):1–10.
   PubMedGoogle Scholar
• Xu M, Tang M, Chen J, et al. PII signal transduction protein GlnK alleviates the feedback inhibition of N-acetyl-l-glutamate kinase by L-arginine in Corynebacterium glutamicum. Appl Environ Microbiol. 2020;86(8):e00039.
   PubMed Web of Science ®Google Scholar
• Zhang B, Fang W, Qiu YL, et al. Increased L-arginine production by site-directed mutagenesis of N-acetyl-l-glutamate kinase and proB gene deletion in Corynebacterium crenatum. Biomed Environ Sci. 2015;28(12):864–874.
   PubMed Web of Science ®Google Scholar
• Xu M, Qin J, Rao Z, et al. Effect of Polyhydroxybutyrate (PHB) storage on L-arginine production in recombinant Corynebacterium crenatum using coenzyme regulation. Microb Cell Fact. 2016;15:15.
   PubMed Web of Science ®Google Scholar
• Zhao Q, Luo Y, Dou W, et al. Controlling the transcription levels of argGH redistributed L-arginine metabolic flux in N-acetylglutamate kinase and ArgR-deregulated Corynebacterium crenatum. J Ind Microbiol Biotechnol. 2016;43(1):55–66.
   PubMed Web of Science ®Google Scholar
• Cheng G, Xu J, Xia X, et al. Breeding L-arginine-producing strains by a novel mutagenesis method: atmospheric and room temperature plasma (ARTP). Prep Biochem Biotechnol. 2016;46(5):509–516.
   PubMed Web of Science ®Google Scholar
• Chen M, Chen X, Wan F, et al. Effect of Tween 40 and DtsR1 on L-arginine overproduction in Corynebacterium crenatum. Microb Cell Fact. 2015;14:119.
   PubMed Web of Science ®Google Scholar
• Xu M, Rao Z, Dou W, et al. Site-directed mutagenesis and feedback-resistant N-acetyl-L-glutamate kinase (NAGK) increase Corynebacterium crenatum L-arginine production. Amino Acids. 2012;43(1):255–266.
   PubMed Web of Science ®Google Scholar
• Dou W, Xu M, Cai D, et al. Improvement of L-arginine production by overexpression of a bifunctional ornithine acetyltransferase in Corynebacterium crenatum. Appl Biochem Biotechnol. 2011;165(3–4):845–855.
   PubMed Web of Science ®Google Scholar
• Shin JH, Lee SY. Metabolic engineering of microorganisms for the production of L-arginine and its derivatives. Microb Cell Fact. 2014;13:166.
   PubMed Web of Science ®Google Scholar
• Lee SY, Park J-M, Lee JH, et al. Interaction of transcriptional repressor ArgR with transcriptional regulator FarR at the argB promoter region in Corynebacterium glutamicum. Appl Environ Microbiol. 2011;77(3):711–718.
   PubMed Web of Science ®Google Scholar
• Yim SH, Jung S, Lee SK, et al. Purification and characterization of an arginine regulatory protein, ArgR, in Corynebacterium glutamicum. J Ind Microbiol Biotechnol. 2011;38(12):1911–1920.
   PubMed Web of Science ®Google Scholar
• Morizono H, Cabrera-Luque J, Shi D, et al. Acetylornithine transcarbamylase: a novel enzyme in arginine biosynthesis. J Bacteriol. 2006;188(8):2974–2982.
   PubMed Web of Science ®Google Scholar
• Wu XY, Guo XY, Zhang B, et al. Recent advances of L-ornithine biosynthesis in metabolically engineered Corynebacterium glutamicum. Front Bioeng Biotechnol. 2019;7:440.
   PubMed Web of Science ®Google Scholar
• Lee SY, Kim HU. Systems strategies for developing industrial microbial strains. Nat Biotechnol. 2015;33(10):1061–1072.
   PubMed Web of Science ®Google Scholar
• Chen XL, Zhang B, Li T, et al. Expression and characterization of ArgR, an arginine regulatory protein in Corynebacterium crenatum. Biomed Environ Sci. 2014;27:436–443.
   PubMed Web of Science ®Google Scholar
• Xu M, Rao Z, Dou W, et al. The role of ArgR repressor regulation on L-arginine production in Corynebacterium crenatum. Appl Biochem Biotechnol. 2013;170(3):587–597.
   PubMed Web of Science ®Google Scholar
• Xu M, Rao Z, Yang J, et al. Heterologous and homologous expression of the arginine biosynthetic argC ∼ H cluster from Corynebacterium crenatum for improvement of (L) -arginine production. J Ind Microbiol Biotechnol. 2012;39(3):495–502.
   PubMed Web of Science ®Google Scholar
• Huang Y, Li C, Zhang H, et al. Monomeric Corynebacterium glutamicum N-acetyl glutamate kinase maintains sensitivity to L-arginine but has a lower intrinsic catalytic activity. Appl Microbiol Biotechnol. 2016;100(4):1789–1798.
   PubMed Web of Science ®Google Scholar
• Ikeda M, Mitsuhashi S, Tanaka K, et al. Reengineering of a Corynebacterium glutamicum L-arginine and L-citrulline producer. Appl Environ Microbiol. 2009;75(6):1635–1641.
   PubMed Web of Science ®Google Scholar
• Xu M, Rao Z, Dou W, et al. Site-directed mutagenesis studies on the L-arginine-binding sites of feedback inhibition in N-acetyl-L-glutamate kinase (NAGK) from Corynebacterium glutamicum. Curr Microbiol. 2012;64(2):164–172.
   PubMed Web of Science ®Google Scholar
• Jensen JV, Eberhardt D, Wendisch VF. Modular pathway engineering of Corynebacterium glutamicum for production of the glutamate-derived compounds ornithine, proline, putrescine, citrulline, and arginine. J Biotechnol. 2015;214:85–94.
   PubMed Web of Science ®Google Scholar
• Schendzielorz G, Dippong M, Grünberger A, et al. Taking control over control: use of product sensing in single cells to remove flux control at key enzymes in biosynthesis pathways. ACS Synth Biol. 2014;3(1):21–29.
   PubMed Web of Science ®Google Scholar
• Huang Y, Zhang H, Tian H, et al. Mutational analysis to identify the residues essential for the inhibition of N-acetyl glutamate kinase of Corynebacterium glutamicum. Appl Microbiol Biotechnol. 2015;99(18):7527–7537.
   PubMed Web of Science ®Google Scholar
• Lee SY, Cho JY, Lee HJ, et al. Enhancement of ornithine production in proline-supplemented Corynebacterium glutamicum by ornithine cyclodeaminase. J Microbiol Biotechnol. 2010;20(1):127–131.
   PubMed Web of Science ®Google Scholar
• Wendisch VF, Jorge JM, Pérez-García F, et al. Updates on industrial production of amino acids using Corynebacterium glutamicum. World J Microbiol Biotechnol. 2016;32(6):105
   PubMed Web of Science ®Google Scholar
• Zhang B, Ren LQ, Yu M, et al. Enhanced L-ornithine production by systematic manipulation of L-ornithine metabolism in engineered Corynebacterium glutamicum S9114. Bioresour Technol. 2018;250:60–68.
   PubMed Web of Science ®Google Scholar
• Park SH, Kim HU, Kim TY, et al. Metabolic engineering of Corynebacterium glutamicum for L-arginine production. Nat Commun. 2014;5:4618.
   PubMed Web of Science ®Google Scholar
• Zhang X, Lai L, Xu G, et al. Rewiring the central metabolic pathway for high‐yield L‐serine production in Corynebacterium glutamicum by using glucose. Biotechnol J. 2019;14(6):1800497.
   Web of Science ®Google Scholar
• Tenhaef N, Brüsseler C, Radek A, et al. Production of d-xylonic acid using a non-recombinant Corynebacterium glutamicum strain. Bioresour Technol. 2018;268:332–339.
   PubMed Web of Science ®Google Scholar
• Shin W-S, Lee D, Lee SJ, et al. Characterization of a non-phosphotransferase system for cis,cis-muconic acid production in Corynebacterium glutamicum . Biochem Biophys Res Commun. 2018;499(2):279–284.
   PubMed Web of Science ®Google Scholar
• Zhang B, Gao G, Chu XH, et al. Metabolic engineering of Corynebacterium glutamicum S9114 to enhance the production of L-ornithine driven by glucose and xylose. Bioresour Technol. 2019; 284:204–213.
   PubMed Web of Science ®Google Scholar
• Xu JZ, Yang HK, Zhang WG. NADPH metabolism: a survey of its theoretical characteristics and manipulation strategies in amino acid biosynthesis. Crit Rev Biotechnol. 2018;38(7):1061–1076.
   PubMed Web of Science ®Google Scholar
• Wu W, Zhang Y, Liu D, et al. Efficient mining of natural NADH-utilizing dehydrogenases enables systematic cofactor engineering of lysine synthesis pathway of Corynebacterium glutamicum. Metab Eng. 2019;52:77–86.
   PubMed Web of Science ®Google Scholar
• Hwang GH, Cho JY. Implication of gluconate kinase activity in L-ornithine biosynthesis in Corynebacterium glutamicum. J Ind Microbiol Biotechnol. 2012;39(12):1869–1874.
   PubMed Web of Science ®Google Scholar
• Li Y, Cong H, Liu B, et al. Metabolic engineering of Corynebacterium glutamicum for methionine production by removing feedback inhibition and increasing NADPH level. Antonie Van Leeuwenhoek. 2016;109(9):1185–1197.
   PubMed Web of Science ®Google Scholar
• Zhang H, Li Y, Wang C, et al. Understanding the high L-valine production in Corynebacterium glutamicum VWB-1 using transcriptomics and proteomics. Sci Rep. 2018;8(1):3632.
   PubMedGoogle Scholar
• Ma W, Wang J, Li Y, et al. Enhancing pentose phosphate pathway in Corynebacterium glutamicum to improve L‐isoleucine production. Biotechnol Appl Biochem. 2016;63(6):877–885.
   PubMed Web of Science ®Google Scholar
• Siedler S, Lindner SN, Bringer S, et al. Reductive whole-cell biotransformation with Corynebacterium glutamicum: improvement of NADPH generation from glucose by a cyclized pentose phosphate pathway using pfkA and gapA deletion mutants. Appl Microbiol Biotechnol. 2013;97(1):143–152.
   PubMed Web of Science ®Google Scholar
• Takeno S, Hori K, Ohtani S, et al. L-Lysine production independent of the oxidative pentose phosphate pathway by Corynebacterium glutamicum with the Streptococcus mutans gapN gene. Metab Eng. 2016;37:1–10.
   PubMed Web of Science ®Google Scholar
• Hoffmann SL, Jungmann L, Schiefelbein S, et al. Lysine production from the sugar alcohol mannitol: design of the cell factory Corynebacterium glutamicum SEA-3 through integrated analysis and engineering of metabolic pathway fluxes. Metab Eng. 2018;47:475–487.
   PubMed Web of Science ®Google Scholar
• Takeno S, Murata R, Kobayashi R, et al. Engineering of Corynebacterium glutamicum with an NADPH-generating glycolytic pathway for L-lysine production. Appl Environ Microbiol. 2010;76(21):7154–7160.
   PubMed Web of Science ®Google Scholar
• Lindner SN, Niederholtmeyer H, Schmitz K, et al. Polyphosphate/ATP-dependent NAD kinase of Corynebacterium glutamicum: biochemical properties and impact of ppnK overexpression on lysine production. Appl Microbiol Biotechnol. 2010;87(2):583–593.
   PubMed Web of Science ®Google Scholar
• Xu M, Rao Z, Xu H, et al. Enhanced production of L-arginine by expression of Vitreoscilla hemoglobin using a novel expression system in Corynebacterium crenatum. Appl Biochem Biotechnol. 2011;163(6):707–719.
   PubMed Web of Science ®Google Scholar
• Nakayama Y, Yoshimura K, Iida H. A gain-of-function mutation in gating of Corynebacterium glutamicum NCgl1221 causes constitutive glutamate secretion. Appl Environ Microbiol. 2012;78(15):5432–5434.
   PubMed Web of Science ®Google Scholar
• Nakamura J, Hirano S, Ito H, et al. Mutations of the Corynebacterium glutamicum NCgl1221 gene, encoding a mechanosensitive channel homolog, induce L-glutamic acid production. Appl Environ Microbiol. 2007;73(14):4491–4498.
   PubMed Web of Science ®Google Scholar
• Wang Y, Cao G, Xu D, et al. A novel Corynebacterium glutamicum L-glutamate exporter. Appl Environ Microbiol. 2018;84(6):e02691.
   PubMed Web of Science ®Google Scholar
• Shang X, Zhang Y, Zhang G, et al. Characterization and molecular mechanism of AroP as an aromatic amino acid and histidine transporter in Corynebacterium glutamicum. J Bacteriol. 2013;195(23):5334–5342.
   PubMed Web of Science ®Google Scholar
• Vrljic M, Sahm H, Eggeling L. A new type of transporter with a new type of cellular function: L-lysine export from Corynebacterium glutamicum. Mol Microbiol. 1996;22(5):815–826.
   PubMed Web of Science ®Google Scholar
• Kind S, Kreye S, Wittmann C. Metabolic engineering of cellular transport for overproduction of the platform chemical 1,5-diaminopentane in Corynebacterium glutamicum. Metab Eng. 2011;13(5):617–627.
   PubMed Web of Science ®Google Scholar
• Kennerknecht N, Sahm H, Yen MR, et al. Export of L-isoleucine from Corynebacterium glutamicum: a two-gene-encoded member of a new translocator family. J Bacteriol. 2002;184(14):3947–3956.
   PubMed Web of Science ®Google Scholar
• Chen C, Li Y, Hu J, et al. Metabolic engineering of Corynebacterium glutamicum ATCC13869 for L-valine production. Metab Eng. 2015;29:66–75.
   PubMed Web of Science ®Google Scholar
• Bellmann A, Vrljic M, Patek M, et al. Expression control and specificity of the basic amino acid exporter LysE of Corynebacterium glutamicum. Microbiology (Reading). 2001;147(Pt 7):1765–1774.
   PubMedGoogle Scholar
• Marbaniang CN, Gowrishankar J. Transcriptional cross-regulation between Gram-negative and Gram-positive bacteria, demonstrated using ArgP-argO of Escherichia coli and LysG-lysE of Corynebacterium glutamicum. J Bacteriol. 2012;194(20):5657–5666.
   PubMed Web of Science ®Google Scholar
• Stella RG, Wiechert J, Noack S, et al. Evolutionary engineering of Corynebacterium glutamicum. Biotechnol J. 2019;14(9):e1800444.
   PubMed Web of Science ®Google Scholar
• Zeng W, Guo L, Xu S, et al. High-throughput screening technology in industrial biotechnology. Trends Biotechnol. 2020;38:888–906.
   PubMed Web of Science ®Google Scholar
• Nguyen NH, Kim J-R, Park S. Application of transcription factor-based 3-hydroxypropionic acid biosensor. Biotechnol Bioproc E. 2018;23(5):564–572.
   Web of Science ®Google Scholar
• Thompson MG, Costello Z, Hummel NF, et al. Robust characterization of two distinct glutarate sensing transcription factors of Pseudomonas putida L-lysine metabolism. ACS Synth Biol. 2019;8(10):2385–2396.
   PubMed Web of Science ®Google Scholar
• Hanko EK, Minton NP, Malys N. A transcription factor-based biosensor for detection of itaconic acid. ACS Synth Biol. 2018;7(5):1436–1446.
   PubMed Web of Science ®Google Scholar
• De Paepe B, Maertens J, Vanholme B, et al. Chimeric LysR-type transcriptional biosensors for customizing ligand specificity profiles toward flavonoids. ACS Synth Biol. 2019;8(2):318–331.
   PubMed Web of Science ®Google Scholar
• Trabelsi H, Koch M, Faulon JL. Building a minimal and generalizable model of transcription factor-based biosensors: SHowcasing flavonoids. Biotechnol Bioeng. 2018;115(9):2292–2304.
   PubMed Web of Science ®Google Scholar
• Zhang J, Barajas JF, Burdu M, et al. Development of a transcription factor-based lactam biosensor. ACS Synth Biol. 2017;6(3):439–445.
   PubMed Web of Science ®Google Scholar
• Kortmann M, Mack C, Baumgart M, et al. Pyruvate carboxylase variants enabling improved lysine production from glucose identified by biosensor-based high-throughput fluorescence-activated cell sorting screening. ACS Synth Biol. 2019;8(2):274–281.
   PubMed Web of Science ®Google Scholar
• Han G, Xu N, Sun X, et al. Improvement of L-valine production by atmospheric and room temperature plasma mutagenesis and high-throughput screening in Corynebacterium glutamicum. ACS Omega. 2020;5(10):4751–4758.
   PubMed Web of Science ®Google Scholar
• Raghavan SS, Chee S, Li J, et al. Development and application of a transcriptional sensor for detection of heterologous acrylic acid production in E. coli. Microb Cell Fact. 2019;18(1):1–12.
   PubMed Web of Science ®Google Scholar
• Qian S, Li Y, Cirino PC. Biosensor-guided improvements in salicylate production by recombinant Escherichia coli. Microb Cell Fact. 2019;18(1):18.
   PubMedGoogle Scholar
• Kim SK, Kim SH, Subhadra B, et al. A genetically encoded biosensor for monitoring isoprene production in engineered Escherichia coli. ACS Synth Biol. 2018;7(10):2379–2390.
   PubMed Web of Science ®Google Scholar
• Liu C, Zhang B, Liu Y-M, et al. New intracellular shikimic acid biosensor for monitoring shikimate synthesis in Corynebacterium glutamicum. ACS Synth Biol. 2018;7(2):591–601.
   PubMed Web of Science ®Google Scholar
• Zheng B, Ma X, Wang N, et al. Utilization of rare codon-rich markers for screening amino acid overproducers. Nat Commun. 2018;9(1):11.
   PubMedGoogle Scholar
• Xu M, Liu P, Chen J, et al. Development of a novel biosensor-driven mutation and selection system via in situ growth of Corynebacterium crenatum for the production of L-arginine. Front Bioeng Biotechnol. 2020; 8:175.
   PubMed Web of Science ®Google Scholar
• Chen J, Wang Y, Guo X, et al. Efficient bioproduction of 5-aminolevulinic acid, a promising biostimulant and nutrient, from renewable bioresources by engineered Corynebacterium glutamicum. Biotechnol Biofuels. 2020;13(1):1–13.
   PubMed Web of Science ®Google Scholar
• Wendisch VF, De Brito LF, Lopez MG, et al. The flexible feedstock concept in industrial biotechnology: metabolic engineering of Escherichia coli, Corynebacterium glutamicum, Pseudomonas, Bacillus and yeast strains for access to alternative carbon sources. J Biotechnol. 2016;234:139–157.
   PubMed Web of Science ®Google Scholar
• Teusink B, Smid EJ. Modelling strategies for the industrial exploitation of lactic acid bacteria. Nat Rev Microbiol. 2006;4(1):46–56.
   PubMed Web of Science ®Google Scholar
• Kim S, Jeong H, Kim EY, et al. Genomic and transcriptomic landscape of Escherichia coli BL21(DE3). Nucleic Acids Res. 2017;45(9):5285–5293.
   PubMed Web of Science ®Google Scholar
• Varela C, Schmidt SA, Borneman AR, et al. Systems-based approaches enable identification of gene targets which improve the flavour profile of low-ethanol wine yeast strains. Metab Eng. 2018;49:178–191.
   PubMed Web of Science ®Google Scholar
• Shen HJ, Cheng BY, Zhang YM, et al. Dynamic control of the mevalonate pathway expression for improved zeaxanthin production in Escherichia coli and comparative proteome analysis. Metab Eng. 2016;38:180–190.
   PubMed Web of Science ®Google Scholar
• Wang B, Hu Q, Zhang Y, et al. A RecET-assisted CRISPR-Cas9 genome editing in Corynebacterium glutamicum. Microb Cell Fact. 2018;17(1):63.
   PubMedGoogle Scholar
• Cho JS, Choi KR, Prabowo CPS, et al. CRISPR/Cas9-coupled recombineering for metabolic engineering of Corynebacterium glutamicum. Metab Eng. 2017;42:157–167.
   PubMed Web of Science ®Google Scholar