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Original Articles

DNA-Bending on Ligand Binding; Change of DNA Persistence Length

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Pages 315-329 | Received 24 Apr 1991, Published online: 21 May 2012

References and Footnotes

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  • Reinert , K. E. 1991 . J. Biomolec. Struct. & Dynam. , 9 : 331 – 352 .
  • Diekmann , St. 1987 . Nucleic Acids and Molecular Biology Vol. 1 , 138 – 156 . Berlin : Springer .
  • Reinert , K. E. 1981 . Biophysical Chem. , 13 : 1 – 14 .
  • Schütz , H. , Reinert , K. E. and Brathuhn , H. 1984 . studio biophysica , 104 : 309 – 312 .
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  • Schellman , J. A. 1980 . Biophysical Chem. , 11 : 329 – 337 .
  • An illustration for these three molecule models is given in Figure A-2 of (4)
  • Birshtein , T. M. 1966 . Vysokomolek. Soedin. , 8 : 168 – 175 .
  • Kratky , O. and Porod , G. 1949 . Rec. Trav. Chim. , 68 : 1106 – 1122 .
  • cf. Figure 5 in (4)
  • Reinert , K. E. 1983 . Nucleic Acids Res. , 11 : 3411 – 3430 .
  • For α> 1, the first bound ligand molecule will cover α adjacent base pairs. On saturation-minus- one-bound molecules, however, the α uncovered base pairs will randomly be distributed over the DNA molecule. Thus the symmetry is lost
  • Berg , H. , Fritzsche , H. , Ihn , W. , Mühlig , P. , Pohle , W. , Reinert , K. E. , Schütz , H. , Stutter , E. , Tresselt , D. , Tricbel , H. , Walter , A. and Weller , K. Sitzungsberichte d. Sachs. Akad. d. Wissensch. Leipzig, Vol. 120 (1) Kanzerostatische Anthrazykline, Physikochemische Eigenschaften and Wirkungsmechanismen 1 – 125 .
  • Experimentally, this minimum would be rather difficult to be observed since it appears at high r values. We also scarely know anti-cooperative systems
  • Remember the proportionality of l/â with the second power of γ
  • Zhurkin , V. B. , Lysov , Y. P. and Ivanov , V. I. 1979 . Nucleic Acids Res. , 6 : 1081 – 1096 .
  • Trifonov , E. N. 1985 . CRC Crit. Rev. Biochem. , 19 : 89 – 106 .
  • Evidently, with α= 10 the singular behaviour has its absolute extremum at saturation, αr= 1
  • Schütz , H. , Gollmick , F. A. and Stutter , E. 1979 . studio biophysica , 75 : 147 – 159 .
  • Stutter , E. , Gollmick , F. A. and Schütz , H. 1982 . studio biophysica , 88 : 131 – 138 .
  • Walter , A. , Schütz , H. and Stutter , E. 1983 . Int. J. Biol. Macromol. , 5 : 351 – 355 .
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  • Lifson , S. 1964 . J. Chem. Phys. , 40 : 3705 – 3710 .
  • Waring , M. J. 1981 . Ann. Rev. Biochem. , 50 : 159 – 192 .
  • As a helix-geometric property, for DNA interaction with bisintercalators the resulting bending angle γ is smaller than the sum of the two single bending angles, γ1, +γ3. Hence, the variation of δΨ implicates a variation of γ
  • The reader may ask for a copy of the computer program

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