Inhibition of protein–protein interaction of HER2–EGFR and HER2–HER3 by a rationally designed peptidomimetic

References

• Ahn , E.R. and Vogel , C.L. 2011 . Dual HER2-targeted approaches in HER2-positive breast cancer . Breast Cancer Research and Treatment , 131 : 371 – 383 .
   PubMedGoogle Scholar
• Allen , S. , Garrett , J.T. , Rawale , S.V. , Jones , A.L. , Philips , G. , Forni , G. , … and Kaumaya , T.P. 2007 . Peptide vaccines of the HER-2/neu dimerization loop are effective in inhibiting mammary tumor growth in vivo . Journal of Immunology , 179 : 472 – 482 .
   PubMed Web of Science ®Google Scholar
• Arcangeli , C. , Cantale , C. , Galeffi , P. , Gianese , G. , Paparcone , R. and Rosato , V. 2008 . Understanding structural/functional properties of immunoconjugates for cancer therapy by computational approaches . Journal of Biomolecular Structure and Dynamics , 26 : 35 – 48 .
   PubMed Web of Science ®Google Scholar
• Arnold , K. , Bordoli , L. , Kopp , J. and Schwede , T. 2010 . The SWISS-MODEL workspace: A web-based environment for protein structure homology modeling . Bioinformatics , 22 : 195 – 201 .
   Google Scholar
• Arpino , G. , Gutierrez , C. , Weiss , H. , Rimawi , M. , Massarweh , S. , Bharwani , L. , … and Schiff , R. 2007 . Treatment of human epidermal growth factor receptor 2-overexpressing breast cancer xenografts with multiagent HER-targeted therapy . Journal of the National Cancer Institute , 99 : 694 – 705 .
   PubMed Web of Science ®Google Scholar
• Bahadur , R.P. , Chakrabarti , P. , Rodier , F. and Janin , J. 2004 . A dissection of specific and non-specific protein–protein interfaces . Journal of Molecular Biology , 336 : 943 – 955 .
   PubMed Web of Science ®Google Scholar
• Banappagari , S. , Ronald , S. and Satyanarayanajois , S.D. 2011 . Structure–activity relationship of conformationally constrained peptidomimetics for antiproliferative activity in HER2-overexpressing breast cancer cell lines . MedChemComm , 2 : 752 – 759 .
   PubMedGoogle Scholar
• Banappagari , S. , Satyanarayanajois , S.D. and Ronald , S. 2010 . A conformationally constrained peptidomimetic binds to extracellular region of HER2 protein . Journal of Biomolecular Structure and Dynamics , 28 : 289 – 308 .
   PubMed Web of Science ®Google Scholar
• Baselga , J. and Swain , S. 2009 . Novel anticancer targets: Revisiting ERBB2 and discovering ERBB3 . Nature Reviews. Cancer , 9 : 463 – 475 .
   PubMed Web of Science ®Google Scholar
• Berezov , A. , Chen , J. , Liu , Q. , Zhang , H.T. , Greene , M.I. and Murali , R. 2002 . Disabling receptor ensembles with rationally designed interface peptidomimetics . Journal of Biological Chemistry , 277 : 28330 – 28339 .
   PubMed Web of Science ®Google Scholar
• Berezov , A. , Zhang , H.T. , Greene , M.I. and Murali , R. 2001 . Disabling ErbB receptors with rationally designed exocyclic mimetics of antibodies: Structure–function analysis . Journal of Medicinal Chemistry , 44 : 2565 – 2574 .
   PubMed Web of Science ®Google Scholar
• Burgess , A.W. , Cho , H.S. , Eigenbrot , C. , Ferguson , K.M. , Garrett , T.P. , Leahy , D.J. , … and Yokoyama , S. 2003 . An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors . Molecular Cell , 12 : 541 – 552 .
   PubMed Web of Science ®Google Scholar
• Chang , J.C. 2007 . HER2 inhibition: From discovery to clinical practice . Clinical Cancer Research , 13 : 1 – 3 .
   PubMed Web of Science ®Google Scholar
• Chen , C.Y.C. 2009 . Weighted equation and rules–a novel concept for evaluating protein–ligand interaction . Journal of Biomolecular Structure and Dynamics , 3 : 271 – 282 .
   Google Scholar
• Chen , V.B. , Arendall , W.B. III , Headd , J.J. , Keedy , D.A. , Immormino , R.M. , Kapral , G.J. , … and Richardson , D.C. 2010 . MolProbity: All-atom structure validation for macromolecular crystallography . Acta Crystallographica , D66 : 12 – 21 .
   Web of Science ®Google Scholar
• Chene , P. 2006 . Drugs targeting protein–protein interactions . ChemMedChem , 1 : 400 – 411 .
   PubMed Web of Science ®Google Scholar
• Cho , H.S. and Leahy , D.J. 2002 . Structure of the extracellular region of HER3 reveals an interdomain tether . Science , 297 : 1330 – 1333 .
   PubMed Web of Science ®Google Scholar
• Cho , H.S. , Mason , K. , Ramyar , K.X. , Stanley , A.M. , Gabelll , S.B. , Denney , D.W. and Leahy , D.J. 2003 . Structure of the extracellular region of HER2 alone and in complex with herceptin Fab . Nature , 421 : 756 – 760 .
   PubMed Web of Science ®Google Scholar
• Dakappagari , N.K. , Lunte , K.D. , Rawale , S. , Steele , J.T. , Allen , S.D. , Phillips , G. , … and Kaumaya , T.P. 2005 . Conformational HER-2/neu B-cell epitope peptide vaccine designed to incorporate two native disulfide bonds enhances tumor cell binding and antitumor activities . Journal of Biological Chemistry , 280 : 54 – 63 .
   PubMed Web of Science ®Google Scholar
• Dawson , J.P. , Berger , M.B. , Lin , C.C. , Schlessinger , J. , Lemmon , M.A. and Ferguson , K.M. 2005 . Epidermal growth factor receptor dimerization and activation require ligand-induced conformational changes in the dimer interface . Molecular and Cellular Biology , 25 : 7734 – 7742 .
   PubMed Web of Science ®Google Scholar
• Drozdov-Tikhomirov , L.N. , Linde , D.M. , Poroikov , V.V. , Alexandrov , A.A. and Skurida , G.I. 2001 . Molecular mechanisms of protein–protein recognition: Whether the surface placed charged residues determine the recognition process? . Journal of Biomolecular Structure and Dynamics , 19 : 279 – 284 .
   PubMed Web of Science ®Google Scholar
• Ferguson , K.M. 2008 . Structure-based view of epidermal growth factor receptor regulation . Annual Review of Biophysics , 37 : 353 – 373 .
   PubMed Web of Science ®Google Scholar
• Fisher , R.D. , Ultsch , M. , Lingel , A. , Schaefer , G. , Shao , L. , Birtalan , S. , … and Eigenbrot , C. 2010 . Structure of the complex between HER2 and an antibody paratope formed by side chains from tryptophan and serine . Journal of Molecular Biology , 402 : 217 – 229 .
   PubMedGoogle Scholar
• Franklin , M.C. , Carey , K.D. , Vajdos , F.F. , Leahy , D.J. , De Vos , A.M. and Sliwkowski , M.X. 2004 . Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex . Cancer Cell , 5 : 317 – 328 .
   PubMed Web of Science ®Google Scholar
• Fuller , J.C. , Burgoyne , N.J. and Jackson , R.M. 2009 . Predicting druggable binding sites at the protein–protein interface . Drug Discovery Today , 14 : 155 – 161 .
   PubMed Web of Science ®Google Scholar
• Gijsen , M. , King , P. , Perera , T. , Parker , P.J. , Harris , A.L. , Larijani , B. and Kong , A. 2010 . HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer . PLoS Biology , 8 : e1000563
   PubMed Web of Science ®Google Scholar
• Huang , H.J. , Lee , K.J. , Yu , H.W. , Chen , C.Y. , Hsu , C.H. , Chen , H.Y. , … and Chen , C.Y.C. 2010 . Structure-based and ligand-based drug design for HER 2 receptor . Journal of Biomolecular Structure and Dynamics , 28 : 23 – 37 .
   PubMed Web of Science ®Google Scholar
• Hynes , E.N. and Lane , H.A. 2005 . ERBB receptors and cancer: The complexity of targeted inhibitors . Nature Reviews, Cancer , 5 : 341 – 354 .
   PubMed Web of Science ®Google Scholar
• Khan , S.H. , Ahmad , F. , Ahmad , N. , Flynn , D.C. and Kumar , R. 2011 . Protein–Protein interactions: Principles, techniques, and their potential role in new drug development . Journal of Biomolecular Structure and Dynamics , 28 : 929 – 938 .
   PubMed Web of Science ®Google Scholar
• Komolov , K.E. and Koch , K.W. 2010 . “ Application of surface plasmon resonance spectroscopy to study G-protein coupled receptor signaling in surface plasmon resonance ” . In Methods in molecular biology , Edited by: Moi , N.J. and Fischer , M.J.E. 627 New York , NY : Springer Science . Chapter 17
   Google Scholar
• Kumagai , T. , Katsumata , M. , Hasegawa , A. , Furuuchi , K. , Funakoshi , T. , Kawase , I. and Greene , M.I. 2003 . Role of extracellular subdomains of p185c-neu and epidermal growth factor receptor in ligand-independent association and transactivation . Proceedings of the National Academy of Sciences USA , 100 : 9220 – 9225 .
   PubMed Web of Science ®Google Scholar
• Landgraf , R. 2007 . HER2(ERBB2):functional diversity from structurally conserved building blocks . Breast Cancer Research , 9 : 202 – 209 .
   PubMed Web of Science ®Google Scholar
• Lee-Hoeflich , S.T. , Crocker , L. , Yao , E. , Pham , T. , Munroe , X. , Heoflich , K.P. , … and Stern , H. 2008 . A central role of HER3 in HER2 amplified breast cancer: Implications for targeting therapy . Cancer Research , 68 : 5878 – 5887 .
   PubMed Web of Science ®Google Scholar
• Levitzki , A. and Gazit , A. 1995 . Tyrosine kinase inhibition: An approach to drug development . Science , 267 : 1782 – 1788 .
   PubMed Web of Science ®Google Scholar
• Liang , S. , Li , W. , Xiao , L. , Wang , J. and Lai , L. 2000 . Grafting of protein–protein interaction epitope . Journal of Biomolecular Structure and Dynamics , 17 : 821 – 828 .
   PubMed Web of Science ®Google Scholar
• Lombardi , A. , Gianese , G. , Arcangeli , C. , Galeffi , P. and Sperandei , M. 2011 . Bacterial cytoplasm production of an EGFP-labeled single-chain Fv antibody specific for the HER2 human receptor . Journal of Biomolecular Structure and Dynamics , 29 : 425 – 439 .
   PubMed Web of Science ®Google Scholar
• Lu , C. , Mi , L.Z. , Grey , M.J. , Zhu , J. , Graef , E. , Yokoyama , S. and Springer , T.A. 2010 . Structural evidence for loose linkage between ligand binding and kinase activation in the epidermal growth factor receptor . Molecular and Cellular Biology , 30 : 5432 – 5443 .
   PubMedGoogle Scholar
• Molina , M.A. , Codony-Servat , J. , Albancell , J. , Rojo , F. , Arribas , J. and Baselga , J. 2001 . Trastuzumab (herceptin), a humanized anti-HER2 receptor monoclonal antibody, inhibits basal and activated HER2 ectodomain cleavage in breast cancer cells . Cancer Research , 61 : 4744 – 4749 .
   PubMed Web of Science ®Google Scholar
• Moreira , I.S. , Fernandes , P.A. and Ramos , M.J. 2007 . Hot spots – a review of the protein–protein interface determinant amino acid residues . Proteins , 68 : 803 – 812 .
   PubMed Web of Science ®Google Scholar
• Myszka , D.G. 2000 . Kinetic, equilibrium, and thermodynamic analysis of macromolecular interactions with BIACORE . Methods in Enzymology , 323 : 325 – 340 .
   PubMed Web of Science ®Google Scholar
• Nahta , R. and Esteva , F.J. 2003 . HER2 targeted therapy: Lessions learned and future directions . Clinical Cancer Research , 9 : 5078 – 5084 .
   PubMed Web of Science ®Google Scholar
• Ogiso , H. , Ishitani , R. , Nureki , O. , Fukai , S. , Yamanaka , M. , Kim , J.H. , … and Yokoyama , S. 2002 . Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains . Cell , 110 : 775 – 787 .
   PubMed Web of Science ®Google Scholar
• Reichmann , D. , Rahat , O. , Cohen , M. , Neuvirth , H. and Schreiber , G. 2007 . The molecular architecture of protein–protein binding sites . Current Opinion in Structural Biology , 17 : 67 – 76 .
   PubMed Web of Science ®Google Scholar
• Ryan , D.P. and Mathews , J.M. 2005 . Protein–protein interactions in human disease . Current Opinion in Structural Biology , 15 : 441 – 446 .
   PubMed Web of Science ®Google Scholar
• Satyanarayanajois , S.D. , Villalba , S. , Jianchao , L. and Lin , G.M. 2009 . Design, synthesis, and docking studies of peptidomimetics based on HER2-herceptin binding site with potential antiproliferative activity against breast cancer cell lines . Chemical Biology and Drug Design , 74 : 246 – 257 .
   PubMed Web of Science ®Google Scholar
• Saxon , M.L. and Lee , D.C. 1999 . Mutagenesis reveals a role for epidermal growth factor receptor extracellular subdomain IV in ligand binding . Journal of Biological Chemistry , 274 : 28356 – 28362 .
   PubMed Web of Science ®Google Scholar
• Shankaran , H. , Wiley , H.S. and Resat , H. 2006 . Modeling the effects of HER/ErbB1–3 coexpression on receptor dimerization and biological response . Biophysical Journal , 90 : 3993 – 4009 .
   PubMedGoogle Scholar
• Sperandio , O. , Reynes , C.H. , Camproux , A.C. and Villoutriex , B.O. 2010 . Rationalizing the chemical space of protein–protein interaction inhibitors . Drug Discovery Today , 15 : 220 – 229 .
   PubMed Web of Science ®Google Scholar
• Tao , R.H. and Maruyama , I.N. 2008 . All EGFR (ErbB) receptors have preformed homo-and heterodimeric structures in living cells . Journal of Cell Science , 121 : 3207 – 3217 .
   PubMed Web of Science ®Google Scholar
• Venyaminov , S.U. and Yang , J.T. 1996 . “ Determination of protein secondary structure in circular dichroism and the conformational analysis of biomolecules ” . In Circular dichroism and the conformational analysis of biomolecules , Edited by: Fasman , G.D. 69 – 108 . New York , NY : Plenum Press .
   Google Scholar
• Wells , J.A. and McClendon , C.L. 2007 . Reaching for high-hanging fruit in drug discovery at protein–protein interfaces . Nature , 450 : 1001 – 1009 .
   PubMed Web of Science ®Google Scholar
• Yang , R.Y.C. , Yang , K.S. , Pike , L.J. , Garland , R. and Marshall , G.R. 2010 . Targeting the dimerization of epidermal growth factor receptors with small-molecule inhibitors . Chemical Biology and Drug Design , 76 : 1 – 9 .
   PubMedGoogle Scholar
• Yin , H. , Chu , A. , Li , W. , Wang , B. , Shelton , F. , Otero , F. , … and Chen , Y.A. 2009 . Lipid G protein-coupled receptor ligand identification using β-arrestin PathHunter™ assay . Journal of Biological Chemistry , 284 : 12328 – 12338 .
   PubMed Web of Science ®Google Scholar
• Yuzawa , S. , Opatowsky , Y. , Zhang , Z. , Mandiyan , V. , Lax , I. and Schlessinger , J. 2007 . Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor . Cell , 130 : 323 – 334 .
   PubMed Web of Science ®Google Scholar