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Letter to the Editor

Searching new targets to counter drug resistance – GTPase-Obg mRNA expression analysis in Mycobacterium under stress and in silico docking with GTPase inhibitors

, , , &
Pages 1804-1812 | Received 29 Mar 2016, Accepted 24 May 2016, Published online: 12 Aug 2016

References

  • Bharat, A., Blanchard, J. E., & Brown, E. C. (2013). A high-throughput screen of the GTPase activity of Escherichia coli EngA to find an inhibitor of bacterial ribosome biogenesis. Journal of Biomolecular Screening, 18, 830–836. doi:10.1177/1087057113486001
  • Chetty, S., Bhakat, S., Martin, A. J., & Soliman, M. E. (2016). Multi-drug resistance profile of PR20 HIV-1 protease is attributed to distorted conformational and drug binding landscape: molecular dynamics insights. Journal of Biomolecular Structure and Dynamics, 34, 135–151. doi:10.1080/07391102.2015.1018326
  • Feng, B., Mandava, C. S., Guo, Q., Wang, J., Cao, W., Li, N., … Gao, N. (2014). Structural and functional insights into the mode of action of a universally conserved Obg GTPase, PLoS Biology, 12, e1001866. doi: 10.1371/journal.pbio.1001866
  • Geiman, D. E., Raghunand, T. R., Agarwal, N., & Bishai, W. R. (2006). Differential gene expression in response to exposure to antimycobacterial agents and other stress conditions among seven Mycobacterium tuberculosis whiB-like genes. Antimicrobial Agents Chemotherapy, 50, 2836–2841. doi:10.1128/AAC.00295-06
  • Jones, P., & Inouye, M. (1994). The cold shock response – A hot topic. Molecular Microbiology, 11, 811–818. doi:10.1111/j.1365-2958.1994.tb00359.x
  • Kesherwani, M., Michael, G. M., Fukui, K., & Velmurugan, D. (2016). Identification of novel natural inhibitor for NorM – A multidrug and toxic compound extrusion transporter – An insilico molecular modeling and simulation studies. Journal of Biomolecular Structure and Dynamics, 20, 1–20. doi:10.1080/07391102.2015.1132391
  • Läppchen, T., Hartog, A. F., Pinas, V. A., Koomen, G. J., & den Blaauwen, T. (2005). GTP analogue inhibits polymerization and GTPase activity of the bacterial protein FtsZ without affecting its eukaryotic homologue tubulin. Biochemistry, 44, 7879–7884. doi:10.1021/bi047297o
  • Lin, Y., Li, Y., Zhu, N., Han, Y., Jiang, W., Wang, Y., Si, S., & Jianga, J. (2014). The antituberculosis antibiotic capreomycin Inhibits protein synthesis by disrupting interaction between ribosomal proteins L12 and L10. Antimicrobial Agents and Chemotherapy, 58, 2038–2044. doi:10.1128/AAC.02394-13
  • Lin, Y., Zhu, N., Han, Y., Jiang, J., & Si, S. (2014). Identification of anti-tuberculosis agents that target the cell-division protein FtsZ. Journal of Antibiotics, 67, 671–676. doi:10.1038/ja.2014.89
  • Michel, B. (2005). Obg/CtgA, a signaling protein that controls replication, translation, and morphological development? Developmental Cell, 8, 300–301. doi:10.1016/j.devcel.2005.02.002
  • Rouvière-Yaniv, J., Yaniv, M., & Germond, J. E. (1979). E. coli DNA binding protein HU forms nucleosome like structure with circular double-stranded DNA. Cell, 17, 265–274. doi:10.1016/0092-8674(79)90152-1
  • Sasindran, S. J., Saikolappan, S., Scofield, V. L., & Dhandayuthapani, S. (2011). Biochemical and physiological characterization of the GTP-binding protein Obg of Mycobacterium tuberculosis. BMC Microbiology, 11, 43. doi:10.1186/1471-2180-11-43
  • Sengupta, S., Roy, D., & Bandyopadhyay, S. (2015). Structural insight into Mycobacterium tuberculosis maltosyl transferase inhibitors: Pharmacophore-based virtual screening, docking, and molecular dynamics simulations. Journal of Biomolecular Structure and Dynamics, 33, 2655–2666. doi:10.1080/07391102.2014.1003602
  • Shires, K., & Steyn, L. (2001). The cold-shock stress response in Mycobacterium smegmatis induces the expression of a histone-like protein. Molecular Microbiology, 39, 994–1009. doi:10.1046/j.1365-2958.2001.02291.x
  • Skariyachan, S., Acharya, A. B., Subramaniyan, S., Babu, S., Kulkarni, S., & Narayanappa, R. (2015). Secondary metabolites extracted from marine sponge associated Comamonas testosteroni and Citrobacter freundii as potential antimicrobials against MDR pathogens and hypothetical leads for VP40 matrix protein of Ebola virus: an in vitro and in silico investigation. Journal of Biomolecular Structure and Dynamics, 18, 1–19. doi:10.1080/07391102.2015.1094412
  • Sun, S., Chan, F., Lu, Y., Neves, M. A. C., Lui, H. K., Wang, Y., … Wong, K. Y. (2014). Rational design of berberine-based FtsZ inhibitors with broad-spectrum antibacterial activity, PLoS ONE, 9, e97514. doi: 10.1371/journal.pone.0097514
  • Verstraeten, N., Fauvart, M., Versées, W., & Michiels, J. (2011). The universally conserved prokaryotic GTPases. Microbiology and Molecular Biology Reviews, 75, 507–542. doi:10.1128/MMBR.00009-11
  • Zielke, R. A., Wierzbicki, I. H., Baarda, B. I., & Sikora, A. E. (2015). The Neisseria gonorrhoeae Obg protein is an essential ribosome-associated GTPase and a potential drug target. BMC Microbiology, 15, 129. doi:10.1186/s12866-015-0453-1

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