Not all AMLETs are made equal: complexes of cow and camel α-lactalbumin with oleic acid show different structure and stability

References

• Acharya, K. R., Ren, J. S., Stuart, D. I., Phillips, D. C., & Fenna, R. E. (1991). Crystal structure of human alpha-lactalbumin at 1.7 A resolution. Journal of Molecular Biology, 221(2), 571–581.10.1016/0022-2836(91)80073-4
   PubMed Web of Science ®Google Scholar
• Barbana, C., Perez, M. D., Pocovi, C., Sanchez, L., & Wehbi, Z. (2008). Interaction of human alpha-lactalbumin with fatty acids: Determination of binding parameters. Biochemistry, 73(6), 711–716.10.1134/S0006297908060126
   PubMed Web of Science ®Google Scholar
• Barbana, C., Sanchez, L., & Perez, M. D. (2011). Bioactivity of alpha-lactalbumin related to its interaction with fatty acids: A review. Critical Reviews in Food Science and Nutrition, 51(8), 783–794. doi:10.1080/10408398.2010.481368
   PubMed Web of Science ®Google Scholar
• Cawthern, K. M., Narayan, M., Chaudhuri, D., Permyakov, E. A., & Berliner, L. J. (1997). Interactions of alpha-lactalbumin with fatty acids and spin label analogs. Journal of Biological Chemistry, 272(49), 30812–30816.10.1074/jbc.272.49.30812
   PubMed Web of Science ®Google Scholar
• Delavari, B., Saboury, A. A., Atri, M. S., Ghasemi, A., Bigdeli, B., Khammari, A., & Goliaei, B. (2014). Alpha-lactalbumin: A new carrier for vitamin D3 food enrichment. Food Hydrocolloids, 45, 124–131. doi:10.1016/j.foodhyd.2014.10.017
   Web of Science ®Google Scholar
• Farah, Z. (1993). Composition and characteristics of camel milk. Journal of Dairy Research, 60(4), 603–626.10.1017/S0022029900027953
   PubMed Web of Science ®Google Scholar
• Hakansson, A., Zhivotovsky, B., Orrenius, S., Sabharwal, H., & Svanborg, C. (1995). Apoptosis induced by a human milk protein. Proceedings of the National Academy of Sciences USA, 92(17), 8064–8068. doi:10.1073/pnas.92.17.8064
   PubMed Web of Science ®Google Scholar
• Kaspersen, J. D., Pedersen, J. N., Hansted, J. G., Nielsen, S. B., Sakthivel, S., Wilhelm, K., & Pedersen, J. S. (2014). Generic structures of cytotoxic liprotides: Nano-sized complexes with oleic acid cores and shells of disordered proteins. ChemBioChem, 15(18), 2693–2702. doi:10.1002/cbic.201402407
   PubMed Web of Science ®Google Scholar
• Knyazeva, E. L., Grishchenko, V. M., Fadeev, R. S., Akatov, V. S., Permyakov, S. E., & Permyakov, E. A. (2008). Who is Mr. HAMLET? Interaction of human alpha-lactalbumin with monomeric oleic acid. Biochemistry, 47(49), 13127–13137. doi:10.1021/bi801423s
   PubMed Web of Science ®Google Scholar
• Kuwajima, K. (1996). The molten globule state of alpha-lactalbumin. FASEB Journal, 10(1), 102–109.
   PubMed Web of Science ®Google Scholar
• Mohammadi, F., & Moeeni, M. (2015a). Analysis of binding interaction of genistein and kaempferol with alpha-lactalbumin. Journal of Functional Foods, 12, 458–467. doi:10.1016/j.jff.2014.12.012
   Web of Science ®Google Scholar
• Mohammadi, F., & Moeeni, M. (2015). Study on the interactions of trans-resveratrol and curcumin with bovine alpha-lactalbumin by spectroscopic analysis and molecular docking. Materials Science and Engineering: C Materials for Biological Applications, 50, 358–366. doi:10.1016/j.msec.2015.02.007
   PubMed Web of Science ®Google Scholar
• Mossberg, A. K., Wullt, B., Gustafsson, L., Mansson, W., Ljunggren, E., & Svanborg, C. (2007). Bladder cancers respond to intravesical instillation of HAMLET (human alpha-lactalbumin made lethal to tumor cells). International Journal of Cancer, 121(6), 1352–1359. doi:10.1002/ijc.22810
   PubMed Web of Science ®Google Scholar
• Nakamura, T., Aizawa, T., Kariya, R., Okada, S., Demura, M., Kawano, K., & Kuwajima, K. (2013). Molecular mechanisms of the cytotoxicity of human alpha-lactalbumin made lethal to tumor cells (HAMLET) and other protein-oleic acid complexes. Journal of Biological Chemistry, 288(20), 14408–14416. doi:10.1074/jbc.M112.437889
   PubMed Web of Science ®Google Scholar
• Permyakov, S. E., Knyazeva, E. L., Khasanova, L. M., Fadeev, R. S., Zhadan, A. P., Roche-Hakansson, H., & Permyakov, E. A. (2012). Oleic acid is a key cytotoxic component of HAMLET-like complexes. Biological Chemistry, 393(1–2), 85–92. doi:10.1515/BC-2011-230
   PubMed Web of Science ®Google Scholar
• Redington, J. M., Breydo, L., Almehdar, H. A., Redwan, E. M., & Uversky, V. N. (2016). Alpha-lactalbumin: Of Camels and Cows. Protein & Peptide Letters, 23(12), 1072–1080.10.2174/0929866523666160517123738
   PubMed Web of Science ®Google Scholar
• Spolaore, B., Pinato, O., Canton, M., Zambonin, M., Polverino de Laureto, P., & Fontana, A. (2010). Alpha-lactalbumin forms with oleic acid a high molecular weight complex displaying cytotoxic activity. Biochemistry, 49(39), 8658–8667. doi:10.1021/bi1012832
   PubMed Web of Science ®Google Scholar
• Svensson, M., Hakansson, A., Mossberg, A. K., Linse, S., & Svanborg, C. (2000). Conversion of alpha-lactalbumin to a protein inducing apoptosis. Proceedings of the National Academy of Sciences USA, 97(8), 4221–4226.10.1073/pnas.97.8.4221
   PubMed Web of Science ®Google Scholar
• Tolin, S., De Franceschi, G., Spolaore, B., Frare, E., Canton, M., Polverino de Laureto, P., & Fontana, A. (2010). The oleic acid complexes of proteolytic fragments of alpha-lactalbumin display apoptotic activity. FEBS Journal, 277(1), 163–173. doi:10.1111/j.1742-4658.2009.07466.x
   PubMed Web of Science ®Google Scholar
• Uversky, V. N., El-Fakharany, E. M., Abu-Serie, M. M., Almehdar, H. A., & Redwan, E. M. (2017). Divergent anticancer activity of free and formulated camel milk alpha-lactalbumin. Cancer Investigation, 35(9), 610–623. doi:10.1080/07357907.2017.1373783
   PubMed Web of Science ®Google Scholar
• Yang, F., Jr, Zhang, M., Chen, J., & Liang, Y. (2006). Structural changes of alpha-lactalbumin induced by low pH and oleic acid. Biochimica et Biophysica Acta (BBA) – Proteins and Proteomics, 1764(8), 1389–1396. doi:10.1016/j.bbapap.2006.06.012
   PubMed Web of Science ®Google Scholar
• Zhang, M., Yang, F., Jr, Yang, F., Chen, J., Zheng, C. Y., & Liang, Y. (2009). Cytotoxic aggregates of alpha-lactalbumin induced by unsaturated fatty acid induce apoptosis in tumor cells. Chemico–Biological Interactions, 180(2), 131–142. doi:10.1016/j.cbi.2009.03.019
   PubMed Web of Science ®Google Scholar