177
Views
4
CrossRef citations to date
0
Altmetric
Research Articles

Role of N-glycan in the structural changes of myelin oligodendrocyte glycoprotein and its complex with an antibody

ORCID Icon
Pages 1649-1658 | Received 20 Feb 2019, Accepted 28 Apr 2019, Published online: 13 May 2019

References

  • Androutsou, M.-E., Tapeinou, A., Vlamis-Gardikas, A., & Tselios, T. (2018). Myelin oligodendrocyte glycoprotein and multiple sclerosis. Medicinal Chemistry, 14, 120–128.
  • Axisa, P. P., & Hafler, D. A. (2016). Multiple sclerosis: Genetics, biomarkers, treatments. Current Opinion in Neurology, 29(3), 345–353. doi: 10.1097/WCO.0000000000000319
  • Berendsen, H. J. C., Postma, J. P. M., van Gunsteren, W. F., DiNola, A., & Haak, J. R. (1984). Molecular dynamics with coupling to an external bath. Journal of Chemical Physics., 81(8), 3684–3690. doi: 10.1063/1.448118
  • Breithaupt, C., Schubart, A., Zander, H., Skerra, A., Huber, R., Linington, C., & Jacob, U. (2003). Structural insights into the antigenicity of myelin oligodendrocyte glycoprotein. Proceedings of the National Academy of Sciences of the United States of America, 100(16), 9446–9451. doi: 10.1073/pnas.1133443100
  • Case, D. A., Betz, R. M., Cerutti, D. S., Cheatham, T. E. III, Darden, T. A., Duke, R. E., … Kollman, P. A. (2016). AMBER 2016. San Francisco, CA: University of California.
  • Clements, C. S., Reid, H. H., Beddoe, T., Tynan, F. E., Perugini, M. A., Johns, T. G., … Rossjohn, J. (2003). The crystal structure of myelin oligodendrocyte glycoprotein, a key autoantigen in multiple sclerosis. Proceedings of the National Academy of Sciences ofthe United States of America, 100(19), 11059–11064. doi: 10.1073/pnas.1833158100
  • Iglesias, A., Bauer, J., Litzenburger, T., Schubart, A., & Linington, C. (2001). T- and B-cell responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis and multiple sclerosis. Glia, 36(2), 220–234. doi: 10.1002/glia.1111
  • Jorgensen, W. L., Chandrasekhar, J., Madura, J. D., Impey, R. W., & Klein, M. L. (1983). Comparison of simple potential functions for simulating liquid water. Journal of Chemical Physics, 79(2), 926–935. doi: 10.1063/1.445869
  • Jung, J., Dudek, E., & Michalak, M. (2015). The role of N-glycan in folding, trafficking and pathogenicity of myelin oligodendrocyte glycoprotein (MOG). Biochimica et Biophysica Acta, 1853(9), 2115–2121. doi: 10.1016/j.bbamcr.2014.12.023
  • Kirschner, K. N., Yongye, A. B., Tschampel, S. M., González-Outeiriño, J., Daniels, C. R., Foley, B. L., & Woods, R. J. (2008). Glycam06: a generalizable biomolecular force field. Carbohydrates. Journal of Computational Chemistry, 29(4), 622–655. doi: 10.1002/jcc.20820
  • Lee, D., & Linker, R. A. (2012). The role of myelin oligodendrocyte glycoprotein in autoimmune demyelination: A target for multiple sclerosis therapy. Expert Opinion on Therapeutic Targets, 16(5), 451–462. doi: 10.1517/14728222.2012.677438
  • Levy, Y., & Becker, O. M. (2001). Energy landscapes of conformationally constrained peptides. The Journal of Chemical Physics, 114(2), 993–1009. doi: 10.1063/1.1329646
  • Maier, J. A., Martinez, C., Kasavajhala, K., Wickstrom, L., Hauser, K. E., & Simmerling, C. (2015). ff14SB: Improving the accuracy of protein side chain and backbone parameters from ff99sb. Journal of Chemical Theory and Computation, 11(8), 3696–3713. doi: 10.1021/acs.jctc.5b00255
  • Mony, J. T., Khorooshi, R., & Owens, T. (2014). MOG extracellular domain (p1-125) triggers elevated frequency of CXCR3+ CD4+ Th1 cells in the CNS of mice and induces greater incidence of severe EAE. Multiple Sclerosis Journal, 20(10), 1312–1321. doi: 10.1177/1352458514524086
  • Pacini, G., Ieronymaki, M., Nuti, F., Sabatino, G., Larregola, M., Aharoni, R., … Rovero, P. (2016). Epitope mapping of anti-myelin oligodendrocyte glycoprotein (MOG) antibodies in a mouse model of multiple sclerosis: Microwave-assisted synthesis of the peptide antigens and ELISA screening. Journal of Peptide Science, 22(1), 52–58. doi: 10.1002/psc.2839
  • Podbielska, M., Banik, N. L., Kurowska, E., & Hogan, E. L. (2013). Myelin recovery in multiple sclerosis: The challenge of remyelination. Brain Sciences, 3(3), 1282–1324. doi: 10.3390/brainsci3031282
  • Quarles, R. H., Macklin, W. B., & Morell, P. (2006). Myelin formation, structure and biochemistry. In G. J. Siegel, R. W. Albers, S. T. Brady, & D. L. Price (Eds.), Basic neurochemistry: Molecular, cellular, and medical aspects (7th ed., pp. 51–144). Cambridge, MA: Elsevier Academic Press.
  • Roe, D. R., & Cheatham, T. E. III. (2013). PTRAJ and CPPTRAJ: Software for processing and analysis of molecular dynamics trajectory data. Journal of Chemical Theory and Computation, 9(7), 3084–3095. doi: 10.1021/ct400341p
  • Sedzik, J., Jastrzebski, J. P., & Grandis, M. (2015). Glycans of myelin proteins. Journal of Neuroscience Research, 93(1), 1–18. doi: 10.1002/jnr.23462
  • Sospedra, M., & Martin, R. (2005). Immunology of multiple sclerosis. Annual Review of Immunology, 23, 683–747. doi: 10.1146/annurev.immunol.23.021704.115707
  • Yannakakis, M. P., Tzoupis, H., Michailidou, E., Mantzourani, E., Simal, C., & Tselios, T. (2016). Molecular dynamics at the receptor level of immunodominant myelin oligodendrocyte glycoprotein 35–55 epitope implicated in multiple sclerosis. Journal of Molecular Graphics and Modelling, 68, 78–86. doi: 10.1016/j.jmgm.2016.06.005

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.