References
- Alaraby Salem, M., & Brown, A. (2015). Two-photon absorption of fluorescent protein chromophores incorporating non-canonical amino acids: TD-DFT screening and classical dynamics. Physical Chemistry Chemical Physics: PCCP, 17(38), 25563–25571. https://doi.org/https://doi.org/10.1039/c5cp03875h
- Anand, K., Ziebuhr, J., Wadhwani, P., Mesters, J. R., & Hilgenfeld, R. (2003). Coronavirus main proteinase (3CLpro) structure: Basis for design of anti-SARS drugs. Science (New York, N.Y.), 300(5626), 1763–1767. https://doi.org/https://doi.org/10.1126/science.1085658
- Ancy, I., Sivanandam, M., & Kumaradhas, P. (2020). Possibility of HIV-1 protease inhibitors-clinical trial drugs as repurposed drugs for SARS-CoV-2 main protease: A molecular docking, molecular dynamics and binding free energy simulation study. Journal of Biomolecular Structure and Dynamics, 1–8. https://doi.org/https://doi.org/10.1080/07391102.2020.1786459
- Anighoro, A., & Bajorath, J. (2016a). Binding mode similarity measures for ranking of docking poses: A case study on the adenosine A2A receptor. Journal of Computer-Aided Molecular Design, 30(6), 447–456. https://doi.org/https://doi.org/10.1007/s10822-016-9918-z
- Anighoro, A., & Bajorath, J. (2016b). Three-dimensional similarity in molecular docking: Prioritizing ligand poses on the basis of experimental binding modes. Journal of Chemical Information and Modeling, 56(3), 580–587. https://doi.org/https://doi.org/10.1021/acs.jcim.5b00745
- Aouidate, A., Ghaleb, A., Chtita, S., Aarjane, M., Ousaa, A., Maghat, H., Sbai, A., Choukrad, M. b., Bouachrine, M., & Lakhlifi, T. (2020). Identification of a novel dual-target scaffold for 3CLpro and RdRp proteins of SARS-CoV-2 using 3D-similarity search, molecular docking, molecular dynamics and ADMET evaluation. Journal of Biomolecular Structure and Dynamics, 1–14. https://doi.org/https://doi.org/10.1080/07391102.2020.1779130
- Arun, K. G., Sharanya, C. S., Abhithaj, J., Francis, D., & Sadasivan, C. (2020). Drug repurposing against SARS-CoV-2 using E-pharmacophore based virtual screening, molecular docking and molecular dynamics with main protease as the target. Journal of Biomolecular Structure and Dynamics, 1–12. https://doi.org/https://doi.org/10.1080/07391102.2020.1779819
- Bacha, U., Barrila, J., Velazquez-Campoy, A., Leavitt, S. A., & Freire, E. (2004). Identification of novel inhibitors of the SARS coronavirus main protease 3CLpro. Biochemistry, 43(17), 4906–4912. https://doi.org/https://doi.org/10.1021/bi0361766
- Bailey, O. T., Pappenheimer, A. M., Cheever, F. S., & Daniels, J. B. (1949). A murine virus (Jhm) causing disseminated encephalomyelitis with extensive destruction of myelin: II. Pathology. The Journal of Experimental Medicine, 90(3), 195–212. https://doi.org/https://doi.org/10.1084/jem.90.3.195
- Barretto, N., Jukneliene, D., Ratia, K., Chen, Z., Mesecar, A. D., & Baker, S. C. (2005). The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity. Journal of Virology, 79(24), 15189–15198.https://doi.org/https://doi.org/10.1128/JVI.79.24.15189-15198.2005
- Bartlam, M., Xu, Y., & Rao, Z. (2007). Structural proteomics of the SARS coronavirus: A model response to emerging infectious diseases. Journal of Structural and Functional Genomics, 8(2–3), 85–97. https://doi.org/https://doi.org/10.1007/s10969-007-9024-5
- Bégué, J.-P., & Bonnet-Delpon, D. (1991). Preparation of trifluoromethyl ketones and related fluorinated ketones. Tetrahedron, 47(20–21), 3207–3258. https://doi.org/https://doi.org/10.1016/S0040-4020(01)86391-2
- Chatterjee, S., Maity, A., Chowdhury, S., Islam, M. A., Muttinini, R. K., & Sen, D. (2020). In silico analysis and identification of promising hits against 2019 novel coronavirus 3C-like main protease enzyme. Journal of Biomolecular Structure and Dynamics, 1–14. https://doi.org/https://doi.org/10.1080/07391102.2020.1787228
- Chen, L., Li, J., Luo, C., Liu, H., Xu, W., Chen, G., Liew, O. W., Zhu, W., Puah, C. M., Shen, X., & Jiang, H. (2006). Binding interaction of quercetin-3-beta-galactoside and its synthetic derivatives with SARS-CoV 3CL(pro): Structure-activity relationship studies reveal salient pharmacophore features. Bioorganic & Medicinal Chemistry, 14(24), 8295–8306. https://doi.org/https://doi.org/10.1016/j.bmc.2006.09.014
- Chen, Z. M., Fu, J. F., Shu, Q., Chen, Y. H., Hua, C. Z., Li, F. B., Lin, R., Tang, L. F., Wang, T. L., Wang, W., Wang, Y. S., Xu, W. Z., Yang, Z. H., Ye, S., Yuan, T. M., Zhang, C. M., & Zhang, Y. Y. (2020). Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus. World Journal of Pediatrics: WJP, 16(3), 240–246. https://doi.org/https://doi.org/10.1007/s12519-020-00345-5
- Case, D. A., Belfon, K., Ben-Shalom, I. Y., Brozell, S. R., Cerutti, D. S., Cheatham, T. E., Cruzeiro III, V. W. D., Darden, T. A., Duke, R. E., Giambasu, G., Gilson, M. K., Gohlke, H., Goetz, A. W., Harris, R., Izadi, S., Izmailov, S. A., Kasavajhala, K., Kovalenko, A., Krasny, R., … Kollman, P. A. (2020). Amber 12, University of California.
- Da, C., & Kireev, D. (2014). Structural protein-ligand interaction fingerprints (SPLIF) for structure-based virtual screening: Method and benchmark study. Journal of Chemical Information and Modeling, 54(9), 2555–2561. https://doi.org/https://doi.org/10.1021/ci500319f
- Darden, T., York, D., & Pedersen, L. (1993). Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems. The Journal of Chemical Physics, 98(12), 10089–10092. https://doi.org/https://doi.org/10.1063/1.464397
- Drosten, C., Gunther, S., Preiser, W., van der Werf, S., Brodt, H. R., Becker, S., Rabenau, H., Panning, M., Kolesnikova, L., Fouchier, R. A., Berger, A., Burguiere, A. M., Cinatl, J., Eickmann, M., Escriou, N., Grywna, K., Kramme, S., Manuguerra, J. C., Muller, S., … Doerr, H. W. (2003). Identification of a novel coronavirus in patients with severe acute respiratory syndrome. The New England Journal of Medicine, 348(20), 1967–1976. https://doi.org/https://doi.org/10.1056/NEJMoa030747
- Elmezayen, A. D., Al-Obaidi, A., Şahin, A. T., & Yelekçi, K. (2020). Drug repurposing for coronavirus (COVID-19): In silico screening of known drugs against coronavirus 3CL hydrolase and protease enzymes. Journal of Biomolecular Structure and Dynamics, 1–13. https://doi.org/https://doi.org/10.1080/07391102.2020.1758791
- Food and Drug Administration (FDA). (2020). Retrieved May 3, 2020, from https://www.fda.gov/media/137564/download
- Gelb, M. H., Svaren, J. P., & Abeles, R. H. (1985). Fluoro ketone inhibitors of hydrolytic enzymes. Biochemistry, 24(8), 1813–1817. https://doi.org/https://doi.org/10.1021/bi00329a001
- Genheden, S., & Ryde, U. (2015). The MM/PBSA and MM/GBSA methods to estimate ligand-binding affinities. Expert Opinion on Drug Discovery, 10(5), 449–461. https://doi.org/https://doi.org/10.1517/17460441.2015.1032936
- Hilgenfeld, R. (2014). From SARS to MERS: Crystallographic studies on coronaviral proteases enable antiviral drug design. The FEBS Journal, 281(18), 4085–4096. https://doi.org/https://doi.org/10.1111/febs.12936
- Homeyer, N., & Gohlke, H. (2012). Free energy calculations by the molecular mechanics poisson-boltzmann surface area method. Molecular Informatics, 31(2), 114–122. https://doi.org/https://doi.org/10.1002/minf.201100135
- Humphrey, W., Dalke, A., & Schulten, K. (1996). VMD: Visual molecular dynamics. Journal of Molecular Graphics, 14(1), 33–38, 27-38. https://doi.org/https://doi.org/10.1016/0263-7855(96)00018-5
- Jacobs, J., Grum-Tokars, V., Zhou, Y., Turlington, M., Saldanha, S. A., Chase, P., Eggler, A., Dawson, E. S., Baez-Santos, Y. M., Tomar, S., Mielech, A. M., Baker, S. C., Lindsley, C. W., Hodder, P., Mesecar, A., & Stauffer, S. R. (2013). Discovery, synthesis, and structure-based optimization of a series of N-(tert-butyl)-2-(N-arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease. Journal of Medicinal Chemistry, 56(2), 534–546. https://doi.org/https://doi.org/10.1021/jm301580n
- Jain, R. P., Pettersson, H. I., Zhang, J., Aull, K. D., Fortin, P. D., Huitema, C., Eltis, L. D., Parrish, J. C., James, M. N., Wishart, D. S., & Vederas, J. C. (2004). Synthesis and evaluation of keto-glutamine analogues as potent inhibitors of severe acute respiratory syndrome 3CLpro. Journal of Medicinal Chemistry, 47(25), 6113–6116. https://doi.org/https://doi.org/10.1021/jm0494873
- Jenwitheesuk, E., & Samudrala, R. (2003). Identifying inhibitors of the SARS coronavirus proteinase. Bioorganic & Medicinal Chemistry Letters, 13(22), 3989–3992. https://doi.org/https://doi.org/10.1016/j.bmcl.2003.08.066
- Jin, Z., Du, X., Xu, Y., Deng, Y., Liu, M., Zhao, Y., Zhang, B., Li, X., Zhang, L., Peng, C., Duan, Y., Yu, J., Wang, L., Yang, K., Liu, F., Jiang, R., Yang, X., You, T., Liu, X., … Yang, H. (2020). Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors. Nature, 582(7811), 289–293. https://doi.org/https://doi.org/10.1038/s41586-020-2223-y
- Jones, G., Willett, P., & Glen, R. C. (1995). Molecular recognition of receptor sites using a genetic algorithm with a description of desolvation. Journal of Molecular Biology, 245(1), 43–53. https://doi.org/https://doi.org/10.1016/S0022-2836(95)80037-9
- Jones, G., Willett, P., Glen, R. C., Leach, A. R., & Taylor, R. (1997). Development and validation of a genetic algorithm for flexible docking. Journal of Molecular Biology, 267(3), 727–748. https://doi.org/https://doi.org/10.1006/jmbi.1996.0897
- Khan, R. J., Jha, R. K., Amera, G. M., Jain, M., Singh, E., Pathak, A., Singh, R. P., Muthukumaran, J., & Singh, A. K. (2020). Targeting SARS-CoV-2: A systematic drug repurposing approach to identify promising inhibitors against 3C-like proteinase and 2′-O-ribose methyltransferase. Journal of Biomolecular Structure and Dynamics, 1–14. https://doi.org/https://doi.org/10.1080/07391102.2020.1753577
- Kumar, D., Kumari, K., Vishvakarma, V. K., Jayaraj, A., Kumar, D., Ramappa, V. K., Patel, R., Kumar, V., Dass, S. K., Chandra, R., & Singh, P. (2020). Promising inhibitors of main protease of novel corona virus to prevent the spread of COVID-19 using docking and molecular dynamics simulation. Journal of Biomolecular Structure and Dynamics, 1–15. https://doi.org/https://doi.org/10.1080/07391102.2020.1779131
- Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Ren, R., Leung, K. S. M., Lau, E. H. Y., Wong, J. Y., Xing, X., Xiang, N., Wu, Y., Li, C., Chen, Q., Li, D., Liu, T., Zhao, J., Liu, M., … Feng, Z. (2020). Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. The New England Journal of Medicine, 382(13), 1199–1207. https://doi.org/https://doi.org/10.1056/NEJMoa2001316
- Loncharich, R. J., Brooks, B. R., & Pastor, R. W. (1992). Langevin dynamics of peptides: The frictional dependence of isomerization rates of N-acetylalanyl-N'-methylamide. Biopolymers, 32(5), 523–535. https://doi.org/https://doi.org/10.1002/bip.360320508
- Ma, C., Sacco, M. D., Hurst, B., Townsend, J. A., Hu, Y., Szeto, T., Zhang, X., Tarbet, B., Marty, M. T., Chen, Y., & Wang, J. (2020). Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease. Cell Research, 30(8), 678–692. https://doi.org/https://doi.org/10.1038/s41422-020-0356-z
- Mesecar, A. D. (2020). A taxonomically-driven approach to development of potent, broad-spectrum inhibitors of coronavirus main protease including SARS-CoV-2 (COVID-19). https://doi.org/https://doi.org/10.2210/pdb6W63/pdb
- Miller, B. R., 3rd, McGee, T. D., Jr., Swails, J. M., Homeyer, N., Gohlke, H., & Roitberg, A. E. (2012). MMPBSA.py: An efficient program for end-state free energy calculations. Journal of Chemical Theory and Computation, 8(9), 3314–3321. https://doi.org/https://doi.org/10.1021/ct300418h
- Molecular Operating Environment (MOE). (2019). 2019.01, Chemical Computing Group ULC, 1010 Sherbrooke St. West, Suite #910, Montreal, QC, Canada, H3A 2R7.
- Mysinger, M. M., Carchia, M., Irwin, J. J., & Shoichet, B. K. (2012). Directory of useful decoys, enhanced (DUD-E): Better ligands and decoys for better benchmarking. Journal of Medicinal Chemistry, 55(14), 6582–6594. https://doi.org/https://doi.org/10.1021/jm300687e
- Neudert, G., & Klebe, G. (2011). DSX: A knowledge-based scoring function for the assessment of protein-ligand complexes. Journal of Chemical Information and Modeling, 51(10), 2731–2745. https://doi.org/https://doi.org/10.1021/ci200274q
- Payne, S. (2017). Chapter 17- Family coronaviridae. In S. Payne (Ed.), Viruses (pp.149–158). Academic Press. https://doi.org/https://doi.org/10.1016/B978-0-12-803109-4.00017-9
- Roe, D. R., & Cheatham, T. E. 3rd. (2013). PTRAJ and CPPTRAJ: Software for processing and analysis of molecular dynamics trajectory data. Journal of Chemical Theory and Computation, 9(7), 3084–3095. https://doi.org/https://doi.org/10.1021/ct400341p
- Rota, P. A., Oberste, M. S., Monroe, S. S., Nix, W. A., Campagnoli, R., Icenogle, J. P., Penaranda, S., Bankamp, B., Maher, K., Chen, M. H., Tong, S., Tamin, A., Lowe, L., Frace, M., DeRisi, J. L., Chen, Q., Wang, D., Erdman, D. D., Peret, T. C., … Bellini, W. J. (2003). Characterization of a novel coronavirus associated with severe acute respiratory syndrome. Science (New York, N.Y.), 300(5624), 1394–1399. https://doi.org/https://doi.org/10.1126/science.1085952
- Schrodinger, LLC. (2015). The PyMOL Molecular Graphics System, Version 1.8.
- Shao, Y. M., Yang, W. B., Kuo, T. H., Tsai, K. C., Lin, C. H., Yang, A. S., Liang, P. H., & Wong, C. H. (2008). Design, synthesis, and evaluation of trifluoromethyl ketones as inhibitors of SARS-CoV 3CL protease. Bioorganic & Medicinal Chemistry, 16(8), 4652–4660. https://doi.org/https://doi.org/10.1016/j.bmc.2008.02.040
- Shie, J. J., Fang, J. M., Kuo, C. J., Kuo, T. H., Liang, P. H., Huang, H. J., Yang, W. B., Lin, C. H., Chen, J. L., Wu, Y. T., & Wong, C. H. (2005). Discovery of potent anilide inhibitors against the severe acute respiratory syndrome 3CL protease. Journal of Medicinal Chemistry, 48(13), 4469–4473. https://doi.org/https://doi.org/10.1021/jm050184y
- Shimamoto, Y., Hattori, Y., Kobayashi, K., Teruya, K., Sanjoh, A., Nakagawa, A., Yamashita, E., & Akaji, K. (2015). Fused-ring structure of decahydroisoquinolin as a novel scaffold for SARS 3CL protease inhibitors. Bioorganic & Medicinal Chemistry, 23(4), 876–890. https://doi.org/https://doi.org/10.1016/j.bmc.2014.12.028
- Thanigaimalai, P., Konno, S., Yamamoto, T., Koiwai, Y., Taguchi, A., Takayama, K., Yakushiji, F., Akaji, K., Chen, S. E., Naser-Tavakolian, A., Schon, A., Freire, E., & Hayashi, Y. (2013). Development of potent dipeptide-type SARS-CoV 3CL protease inhibitors with novel P3 scaffolds: Design, synthesis, biological evaluation, and docking studies. European Journal of Medicinal Chemistry, 68, 372–384. https://doi.org/https://doi.org/10.1016/j.ejmech.2013.07.037
- Thanigaimalai, P., Konno, S., Yamamoto, T., Koiwai, Y., Taguchi, A., Takayama, K., Yakushiji, F., Akaji, K., Kiso, Y., Kawasaki, Y., Chen, S. E., Naser-Tavakolian, A., Schon, A., Freire, E., & Hayashi, Y. (2013). Design, synthesis, and biological evaluation of novel dipeptide-type SARS-CoV 3CL protease inhibitors: Structure-activity relationship study. European Journal of Medicinal Chemistry, 65, 436–447. https://doi.org/https://doi.org/10.1016/j.ejmech.2013.05.005
- Tomlinson, S. M., & Watowich, S. J. (2011). Anthracene-based inhibitors of dengue virus NS2B-NS3 protease. Antiviral Research, 89(2), 127–135. https://doi.org/https://doi.org/10.1016/j.antiviral.2010.12.006
- Turlington, M., Chun, A., Tomar, S., Eggler, A., Grum-Tokars, V., Jacobs, J., Daniels, J. S., Dawson, E., Saldanha, A., Chase, P., Baez-Santos, Y. M., Lindsley, C. W., Hodder, P., Mesecar, A. D., & Stauffer, S. R. (2013). Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding. Bioorganic & Medicinal Chemistry Letters, 23(22), 6172–6177. https://doi.org/https://doi.org/10.1016/j.bmcl.2013.08.112
- Turner, P. J. (2005). XMGRACE (Version 5.1.19). Beaverton, OR: Center for Coastal and Land-Margin Research, Oregon Graduate Institute of Science and Technology.
- Wang, F., Chen, C., Tan, W., Yang, K., & Yang, H. (2016). Structure of main protease from human coronavirus NL63: Insights for wide spectrum anti-coronavirus drug design. Scientific Reports, 6, 22677 https://doi.org/https://doi.org/10.1038/srep22677
- Wang, J. (2020). Fast Identification of possible drug treatment of coronavirus disease-19 (COVID-19) through computational drug repurposing study. Journal of Chemical Information and Modeling, 60(6), 3277–3286. https://doi.org/https://doi.org/10.1021/acs.jcim.0c00179
- Wang, J., Ge, Y., & Xie, X. Q. (2019). Development and testing of druglike screening libraries. Journal of Chemical Information and Modeling, 59(1), 53–65. https://doi.org/https://doi.org/10.1021/acs.jcim.8b00537
- Wang, J., Wang, W., Kollman, P. A., & Case, D. A. (2006). Automatic atom type and bond type perception in molecular mechanical calculations. Journal of Molecular Graphics & Modelling, 25(2), 247–260. https://doi.org/https://doi.org/10.1016/j.jmgm.2005.12.005
- Wang, J., Wolf, R. M., Caldwell, J. W., Kollman, P. A., & Case, D. A. (2004). Development and testing of a general amber force field. Journal of Computational Chemistry, 25(9), 1157–1174. https://doi.org/https://doi.org/10.1002/jcc.20035
- World Health Organization (WHO). (2020). Timeline of WHO’s response to COVID-19. Retrieved July 24, 2020, from http://www.who.int/
- Word, J. M., Lovell, S. C., Richardson, J. S., & Richardson, D. C. (1999). Asparagine and glutamine: Using hydrogen atom contacts in the choice of side-chain amide orientation. Journal of Molecular Biology, 285(4), 1735–1747. https://doi.org/https://doi.org/10.1006/jmbi.1998.2401
- Xu, X., Chen, P., Wang, J., Feng, J., Zhou, H., Li, X., Zhong, W., & Hao, P. (2020). Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission. Science China. Life Sciences, 63(3), 457–460. https://doi.org/https://doi.org/10.1007/s11427-020-1637-5
- Xue, X., Yu, H., Yang, H., Xue, F., Wu, Z., Shen, W., Li, J., Zhou, Z., Ding, Y., Zhao, Q., Zhang, X. C., Liao, M., Bartlam, M., & Rao, Z. (2008). Structures of two coronavirus main proteases: implications for substrate binding and antiviral drug design. Journal of Virology, 82(5), 2515–2527. https://doi.org/https://doi.org/10.1128/JVI.02114-07
- Yang, H., Yang, M., Ding, Y., Liu, Y., Lou, Z., Zhou, Z., Sun, L., Mo, L., Ye, S., Pang, H., Gao, G. F., Anand, K., Bartlam, M., Hilgenfeld, R., & Rao, Z. (2003). The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor. Proceedings of the National Academy of Sciences of the United States of America, 100(23), 13190–13195. https://doi.org/https://doi.org/10.1073/pnas.1835675100
- Yi, L., Li, Z., Yuan, K., Qu, X., Chen, J., Wang, G., Zhang, H., Luo, H., Zhu, L., Jiang, P., Chen, L., Shen, Y., Luo, M., Zuo, G., Hu, J., Duan, D., Nie, Y., Shi, X., Wang, W., … Xu, X. (2004). Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cells. Journal of Virology, 78(20), 11334–11339. https://doi.org/https://doi.org/10.1128/JVI.78.20.11334-11339.2004
- Zhang, H. Z., Zhang, H., Kemnitzer, W., Tseng, B., Cinatl, J., Jr., Michaelis, M., Doerr, H. W., & Cai, S. X. (2006). Design and synthesis of dipeptidyl glutaminyl fluoromethyl ketones as potent severe acute respiratory syndrome coronovirus (SARS-CoV) inhibitors. Journal of Medicinal Chemistry, 49(3), 1198–1201. https://doi.org/https://doi.org/10.1021/jm0507678
- Zhang, L., Lin, D., Sun, X., Curth, U., Drosten, C., Sauerhering, L., Becker, S., Rox, K., & Hilgenfeld, R. (2020). Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved alpha-ketoamide inhibitors. Science, 368(6489), 409–412. https://doi.org/https://doi.org/10.1126/science.abb3405
- Zhang, Y. Z., & Holmes, E. C. (2020). A genomic perspective on the origin and emergence of SARS-CoV-2. Cell, 181(2), 223–227. https://doi.org/https://doi.org/10.1016/j.cell.2020.03.035
- Zhu, L., George, S., Schmidt, M. F., Al-Gharabli, S. I., Rademann, J., & Hilgenfeld, R. (2011). Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease. Antiviral Research, 92(2), 204–212. https://doi.org/https://doi.org/10.1016/j.antiviral.2011.08.001 [InsertedFromOnline[pubmedMismatch]]