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Research Articles

Developing human olfactory network and exploring olfactory receptor-odorant interaction

, & ORCID Icon
Pages 8941-8960 | Received 26 Jul 2022, Accepted 17 Oct 2022, Published online: 30 Oct 2022

References

  • Abraham, M. J., Murtola, T., Schulz, R., Páll, S., Smith, J. C., Hess, B., & Lindahl, E. (2015). GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers. SoftwareX, 1–2, 19–25. https://doi.org/10.1016/j.softx.2015.06.001
  • Addinsoft. 2021. XLSTAT Statistical and Data Analysis Solution. Paris, France. [(accessed on 2 March 2021)]; Available online: https://www.xlstat.com.
  • Altschul, S. F., Madden, T. L., Schäffer, A. A., Zhang, J., Zhang, Z., Miller, W., & Lipman, D. J. (1997). Gapped BLAST and PSI-BLAST: A new generation of protein database search programs. Nucleic Acids Research, 25(17), 3389–3402. https://doi.org/10.1093/nar/25.17.3389
  • Araneda, R. C., Peterlin, Z., Zhang, X., Chesler, A., & Firestein, S. (2004). A pharmacological profile of the aldehyde receptor repertoire in rat olfactory epithelium. The Journal of Physiology, 555(Pt 3), 743–756. https://doi.org/10.1113/jphysiol.2003.058040
  • Berman, H. M., Westbrook, J., Feng, Z., Gilliland, G., Bhat, T. N., Weissig, H., Shindyalov, IN., & Bourne, P. E. (2000). The protein data bank. Nucleic Acids Research, 28(1), 235–242. https://doi.org/10.1093/nar/28.1.235
  • Block, E. (2018). Molecular basis of mammalian odor discrimination: A status report. Journal of Agricultural and Food Chemistry, 66(51), 13346–13366. https://doi.org/10.1021/acs.jafc.8b04471
  • Bozza, T., Feinstein, P., Zheng, C., & Mombaerts, O. (2002). Odorant receptor expression defines functional units in the mouse olfactory system. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 22(8), 3033–3043. https://doi.org/10.1523/JNEUROSCI.22-08-03033.2002
  • Braun, T., Voland, P., Kunz, L., Prinz, C., & Gratzl, M. (2007). Enterochromaffin cells of the human gut: Sensors for spices and odorants. Gastroenterology, 132(5), 1890–1901. https://doi.org/10.1053/j.gastro.2007.02.036
  • Cao, W., Li, F., Yao, J., & Yu, J. (2015). Prostate specific G protein coupled receptor is associated with prostate cancer prognosis and affects cancer cell proliferation and invasion. BMC Cancer, 15, 915. https://doi.org/10.1186/s12885-015-1921-6
  • Castro, J. B., Ramanathan, A., & Chennubhotla, C. S. (2013). Categorical dimensions of human odor descriptor space revealed by non-negative matrix factorization. PLoS One, 8(9), e73289. https://doi.org/10.1371/journal.pone.0073289
  • Chen, P., Wang, W., Liu, R., Lyu, J., Zhang, L., Li, B., Qiu, B., Tian, A., Jiang, W., Ying, H., Jing, R., Wang, Q., Zhu, K., Bai, R., Zeng, L., Duan, S., & Liu, C. (2022). Olfactory sensory experience regulates gliomagenesis via neuronal IGF1. Nature, 606(7914), 550–556. https://doi.org/10.1038/s41586-022-04719-9
  • Chin, C. H., Chen, S. H., Wu, H. H., Ho, C. W., Ko, M. T., & Lin, C. Y. (2014). cytoHubba: Identifying hub objects and sub-networks from complex interactome. BMC Systems Biology, 8 Suppl 4, S11. https://doi.org/10.1186/1752-0509-8-S4-S11
  • Croft, D., O'Kelly, G., Wu, G., Haw, R., Gillespie, M., Matthews, L., Caudy, M., Garapati, P., Gopinath, G., Jassal, B., Jupe, S., Kalatskaya, I., Mahajan, S., May, B., Ndegwa, N., Schmidt, E., Shamovsky, V., Yung, C., Birney, E., … Stein, L. (2011). Reactome: A database of reactions, pathways and biological processes. Nucleic Acids Research, 39(Database issue), D691–D697. https://doi.org/10.1093/nar/gkq1018
  • De la Cruz, O., Blekhman, R., Zhang, X., Nicolae, D., Firestein, S., & Gilad, Y. (2009). A signature of evolutionary constraint on a subset of ectopically expressed olfactory receptor genes. Molecular Biology and Evolution, 26(3), 491–494. https://doi.org/10.1093/molbev/msn294
  • Dixon, S. L., Smondyrev, A. M., & Rao, S. N. (2006). PHASE: A novel approach to pharmacophore modeling and 3D database searching. Chemical Biology & Drug Design, 67(5), 370–372. https://doi.org/10.1111/j.1747-0285.2006.00384.x
  • Escanilla, N. S., Hellerstein, L., Kleiman, R., Kuang, Z., Shull, J. D., & Page, D. (2018). Recursive feature elimination by sensitivity testing. Proceedings of the. International Conference on Machine Learning and Applications. International Conference on Machine Learning and Applications, 2018, 40–47. https://doi.org/10.1109/ICMLA.2018.00014
  • Feldmesser, E., Olender, T., Khen, M., Yanai, I., Ophir, R., & Lancet, D. (2006). Widespread ectopic expression of olfactory receptor genes. BMC Genomics, 7, 121. https://doi.org/10.1186/1471-2164-7-121
  • Filiz, G., Poupon, D., Banks, S., Fernandez, P., & Frasnelli, J. (2022). Olfactory bulb volume and cortical thickness evolve during sommelier training. Human Brain Mapping, 43(8), 2621–2633. https://doi.org/10.1002/hbm.25809
  • Flegel, C., Manteniotis, S., Osthold, S., Hatt, H., & Gisselmann, G. (2013). Expression profile of ectopic olfactory receptors determined by deep sequencing. PLoS One, 8(2), e55368. https://doi.org/10.1371/journal.pone.0055368
  • Flegel, C., Vogel, F., Hofreuter, A., Schreiner, B. S., Osthold, S., Veitinger, S., Becker, C., Brockmeyer, N. H., Muschol, M., Wennemuth, G., Altmüller, J., Hatt, H., & Gisselmann, G. (2015). Characterization of the olfactory receptors expressed in human spermatozoa. Frontiers in Molecular Biosciences, 2, 73. https://doi.org/10.3389/fmolb.2015.00073
  • Floriano, W. B., Vaidehi, N., Goddard, W. A., Singer, M. S., & Shepherd, G. M. (2000). Molecular mechanisms underlying differential odor responses of a mouse olfactory receptor. Proceedings of the National Academy of Sciences of the United States of America, 97(20), 10712–10716. https://doi.org/10.1073/pnas.97.20.10712
  • Foster, S. R., Roura, E., & Thomas, W. G. (2014). Extrasensory perception: Odorant and taste receptors beyond the nose and mouth. Pharmacology & Therapeutics, 142(1), 41–61. https://doi.org/10.1016/j.pharmthera.2013.11.004
  • Friesner, R. A., Murphy, R. B., Repasky, M. P., Frye, L. L., Greenwood, J. R., Halgren, T. A., Sanschagrin, P. C., & Mainz, D. T. (2006). Extra precision glide: Docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes. Journal of Medicinal Chemistry, 49(21), 6177–6196. https://doi.org/10.1021/jm051256o
  • Fukuda, N., Yomogida, K., Okabe, M., & Touhara, K. (2004). Functional characterization of a mouse testicular olfactory receptor and its role in chemosensing and in regulation of sperm motility. Journal of Cell Science, 117(Pt 24), 5835–5845. https://doi.org/10.1242/jcs.01507
  • Gaillard, I., Rouquier, S., Pin, J. P., Mollard, P., Richard, S., Barnabe, C., Demaille, J., & Giorgi, D. (2002). A single olfactory receptor specifically binds a set of odorant molecules. The European Journal of Neuroscience, 15(3), 409–418. https://doi.org/10.1046/j.0953-816x.2001.01871.x
  • Gelis, L., Jovancevic, N., Bechara, F. G., Neuhaus, E. M., & Hatt, H. (2017). Functional expression of olfactory receptors in human primary melanoma and melanoma metastasis. Experimental Dermatology, 26(7), 569–576. https://doi.org/10.1111/exd.13316
  • Gelis, L., Jovancevic, N., Veitinger, S., Mandal, B., Arndt, H. D., Neuhaus, E. M., & Hatt, H. (2016). Functional characterization of the odorant receptor 51E2 in human melanocytes. The Journal of Biological Chemistry, 291(34), 17772–17786. https://doi.org/10.1074/jbc.M116.734517
  • Genva, M., Kenne, K. T., Deleu, M., Lins, L., & Fauconnier, M. L. (2019). Is it possible to predict the odor of a molecule on the basis of its structure? International Journal of Molecular Sciences, 20(12), 3018. https://doi.org/10.3390/ijms20123018
  • Gonzalez-Kristeller, D. C., do Nascimento, J. B. P., Galante, P. A. F., & Malnic, B. (2015). Identification of agonists for a group of human odorant receptors. Frontiers in Pharmacology, 6, 35. https://doi.org/10.3389/fphar.2015.00035
  • Greenwood, J. R., Calkins, D., Sullivan, A. P., & Shelley, J. C. (2010). Towards the comprehensive, rapid, and accurate prediction of the favorable tautomeric states of drug-like molecules in aqueous solution. Journal of Computer-Aided Molecular Design, 24(6-7), 591–604. https://doi.org/10.1007/s10822-010-9349-1
  • Griffin, C. A., Kafadar, K. A., & Pavlath, G. K. (2009). MOR23 promotes muscle regeneration and regulates cell adhesion and migration. Developmental Cell, 17(5), 649–661. https://doi.org/10.1016/j.devcel.2009.09.004
  • Hall, L. H., Kier, L. B. (2001). Issues in representation of molecular structure the development of molecular connectivity. Journal of Chemical Information and Modeling, 20(1), 4–18. https://doi.org/10.1016/s1093-3263(01)00097-3.
  • Harini, K., & Sowdhamini, R. (2015). Computational approaches for decoding select odorant-olfactory receptor interactions using mini-virtual screening. PLoS One, 10(7), e0131077. https://doi.org/10.1371/journal.pone.0131077
  • Hofmann, K., & Stoffel, W. (1993). TMBASE - A database of membrane spanning protein segments. Biological Chemistry. 374, 166.
  • Jensen, L. J., Kuhn, M., Stark, M., Chaffron, S., Creevey, C., Muller, J., Doerks, T., Julien, P., Roth, A., Simonovic, M., Bork, P., & von Mering, C. (2009). STRING 8–a global view on proteins and their functional interactions in 630 organisms. Nucleic Acids Research. 37(Database), D412–D416. https://doi.org/10.1093/nar/gkn760
  • Kalbe, B., Knobloch, J., Schulz, V. M., Wecker, C., Schlimm, M., Scholz, P., Jansen, F., Stoelben, E., Philippou, S., Hecker, E., Lübbert, H., Koch, A., Hatt, H., & Osterloh, S. (2016). Olfactory receptors modulate physiological processes in human airway smooth muscle cells. Frontiers in Physiology, 7, 339. https://doi.org/10.3389/fphys.2016.00339
  • Kalbe, B., Schlimm, M., Mohrhardt, J., Scholz, P., Jansen, F., Hatt, H., & Osterloh, S. (2016). Helional induces Ca2+ decrease and serotonin secretion of QGP-1 cells via a PKG-mediated pathway. Journal of Molecular Endocrinology, 57(3), 201–210. https://doi.org/10.1530/JME-16-0063
  • Kang, N., & Koo, J. (2012). Olfactory receptors in non-chemosensory tissues. BMB Reports, 45(11), 612–622. https://doi.org/10.5483/bmbrep.2012.45.11.232
  • Kaupp, U. B., Niidome, T., Tanabe, T., Terada, S., Bönigk, W., Stühmer, W., Cook, N. J., Kangawa, K., Matsuo, H., & Hirose, T. (1989). Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel. Nature, 342(6251), 762–766. https://doi.org/10.1038/342762a0
  • Kidd, M., Modlin, I. M., Gustafsson, B. I., Drozdov, I., Hauso, O., & Pfragner, R. (2008). Luminal regulation of normal and neoplastic human EC cell serotonin release is mediated by bile salts, amines, tastants, and olfactants. American Journal of Physiology. Gastrointestinal and Liver Physiology, 295(2), G260–G272. https://doi.org/10.1152/ajpgi.00056.2008
  • Kim, S. H., Yoon, Y. C., Lee, A. S., Kang, N., Koo, J., Rhyu, M. R., & Park, J. H. (2015). Expression of human olfactory receptor 10J5 in heart aorta, coronary artery, and endothelial cells and its functional role in angiogenesis. Biochemical and Biophysical Research Communications, 460(2), 404–408. https://doi.org/10.1016/j.bbrc.2015.03.046
  • Lu, M., Echeverri, F., & Moyer, B. D. (2003). Endoplasmic reticulum retention, degradation, and aggregation of olfactory G-protein coupled receptors. Traffic (Copenhagen, Denmark), 4(6), 416–433. https://doi.org/10.1034/j.1600-0854.2003.00097.x
  • Mainland, J. D., Li, Y. R., Zhou, T., Liu, W. L. L., & Matsunami, H. (2015). Human olfactory receptor responses to odorants. Scientific Data, 2, 150002. https://doi.org/10.1038/sdata.2015.2
  • Manteniotis, S., Wojcik, S., Brauhoff, P., Möllmann, M., Petersen, L., Göthert, J. R., Schmiegel, W., Dührsen, U., Gisselmann, G., & Hatt, H. (2016). Functional characterization of the ectopically expressed olfactory receptor 2AT4 in human myelogenous leukemia. Cell Death Discovery, 2, 15070. https://doi.org/10.1038/cddiscovery.2015.70
  • Martin, A. L., Anadon, C. M., Biswas, S., Mine, J. A., Handley, K. F., Payne, K. K., Mandal, G., Chaurio, R. A., Powers, J. J., Sprenger, K. B., Rigolizzo, K. E., Innamarato, P., Harro, C. M., Mehta, S., Perez, B. A., Wenham, R. M., & Conejo-Garcia, J. R. (2022). Olfactory receptor OR2H1 is an effective target for CAR T cells in human epithelial tumors. Molecular Cancer Therapeutics, 21(7), 1184–1194. https://doi.org/10.1158/1535-7163.MCT-21-0872
  • Maßberg, D., & Hatt, H. (2018). Human olfactory receptors: Novel Cellular functions outside of the nose. Physiological Reviews, 98(3), 1739–1763. https://doi.org/10.1152/physrev.00013.2017
  • Maßberg, D., Jovancevic, N., Offermann, A., Simon, A., Baniahmad, A., Perner, S., Pungsrinont, T., Luko, K., Philippou, S., Ubrig, B., Heiland, M., Weber, L., Altmüller, J., Becker, C., Gisselmann, G., Gelis, L., & Hatt, H. (2016). The activation of OR51E1 causes growth suppression of human prostate cancer cells. Oncotarget, 7(30), 48231–48249. https://doi.org/10.18632/oncotarget.10197
  • Maßberg, D., Simon, A., Häussinger, D., Keitel, V., Gisselmann, G., Conrad, H., & Hatt, H. (2015). Monoterpene (-)-citronellal affects hepatocarcinoma cell signaling via an olfactory receptor. Archives of Biochemistry and Biophysics, 566, 100–109. https://doi.org/10.1016/j.abb.2014.12.004
  • Matarazzo, V., Clot-Faybesse, O., Marcet, B., Guiraudie-Capraz, G., Atanasova, B., Devauchelle, G., Cerutti, M., ETievant, P., & Ronin, C. (2005). Functional characterization of two human olfactory receptors expressed in the baculovirus Sf9 insect cell system. Chemical Senses, 30(3), 195–207. https://doi.org/10.1093/chemse/bji015
  • Matsueda, S., Wang, M., Weng, J., Li, Y., Yin, B., Zou, J., Li, Q., Zhao, W., Peng, W., Legras, X., Loo, C., Wang, R. F., & Wang, H. Y. (2012). Identification of prostate-specific G-protein coupled receptor as a tumor antigen recognized by CD8(+) T cells for cancer immunotherapy. PLoS One, 7(9), e45756. https://doi.org/10.1371/journal.pone.0045756
  • McClintock, T. S., Khan, N., Alimova, Y., Aulisio, M., Han, D. Y., & Breheny, P. (2020). Encoding the odor of cigarette smoke. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 40(37), 7043–7053. https://doi.org/10.1523/JNEUROSCI.1144-20.2020
  • Muelbert, M., Bloomfield, F. H., Pundir, S., Harding, J. E., & Pook, C. (2020). Olfactory cues in infant feeds: Volatile profiles of different milks fed to preterm infants. Frontiers in Nutrition, 7, 603090. https://doi.org/10.3389/fnut.2020.603090
  • Neuhaus, E. M., Mashukova, A., Barbour, J., Wolters, D., & Hatt, H. (2006). Novel function of beta-arrestin2 in the nucleus of mature spermatozoa. Journal of Cell Science, 119(Pt 15), 3047–3056. https://doi.org/10.1242/jcs.03046
  • Neuhaus, E. M., Mashukova, A., Zhang, W., Barbour, J., & Hatt, H. (2006). A specific heat shock protein enhances the expression of mammalian olfactory receptor proteins. Chemical Senses, 31(5), 445–452. https://doi.org/10.1093/chemse/bjj049
  • Neuhaus, E. M., Zhang, W., Gelis, L., Deng, Y., Noldus, J., & Hatt, H. (2009). Activation of an olfactory receptor inhibits proliferation of prostate cancer cells. The Journal of Biological Chemistry, 284(24), 16218–16225. https://doi.org/10.1074/jbc.M109.012096
  • Oka, Y., Omura, M., Kataoka, H., & Touhara, K. (2004). Olfactory receptor antagonism between odorants. The EMBO Journal, 23(1), 120–126. https://doi.org/10.1038/sj.emboj.7600032
  • Parmentier, M., Libert, F., Schurmans, S., Schiffmann, S., Lefort, A., Eggerickx, D., Ledent, C., Mollereau, C., Gérard, C., & Perret, J. (1992). Expression of members of the putative olfactory receptor gene family in mammalian germ cells. Nature, 355(6359), 453–455. https://doi.org/10.1038/355453a0
  • Pletscher-Frankild, S., Pallejà, A., Tsafou, K., Binder, J. X., & Jensen, L. J. (2015). Diseases: Text mining and data integration of disease-gene associations. Methods (San Diego, Calif.), 74, 83–89. https://doi.org/10.1016/j.ymeth.2014.11.020
  • Pluznick, J. L. (2016). Gut microbiota in renal physiology: Focus on short-chain fatty acids and their receptors. Kidney International, 90(6), 1191–1198. https://doi.org/10.1016/j.kint.2016.06.033
  • Repicky, S. E., & Luetje, C. W. (2009). Molecular receptive range variation among mouse odorant receptors for aliphatic carboxylic acids. Journal of Neurochemistry, 109(1), 193–202. https://doi.org/10.1111/j.1471-4159.2009.05925.x
  • Roberts, R. E., Biswas, T., Yuvaraj, J. K., Grosse-Wilde, E., Powell, D., Hansson, B. S., Löfstedt, C., & Andersson, M. N. (2022). Odorant receptor orthologues in conifer-feeding beetles display conserved responses to ecologically relevant odours. Molecular Ecology, 31(13), 3693–3707. https://doi.org/10.1111/mec.16494
  • Rodriguez, M., Luo, W., Weng, J., Zeng, L., Yi, Z., Siwko, S., & Liu, M. (2014). PSGR promotes prostatic intraepithelial neoplasia and prostate cancer xenograft growth through NF-κB. Oncogenesis, 3(8), e114. https://doi.org/10.1038/oncsis.2014.29
  • Saito, H., Chi, Q., Zhuang, H., Matsunami, H., & Mainland, J. D. (2009). Odor coding by a mammalian receptor repertoire. Science Signaling, 2, 1–14.
  • Sanz, G., Leray, I., Dewaele, A., Sobilo, J., Lerondel, S., Bouet, S., Grébert, D., Monnerie, R., Pajot-Augy, E., & Mir, L. M. (2014). Promotion of cancer cell invasiveness and metastasis emergence caused by olfactory receptor stimulation. PLoS One, 9(1), e85110. https://doi.org/10.1371/journal.pone.0085110
  • Sarafoleanu, C., Mella, C., Georgescu, M., & Perederco, C. (2009). The importance of the olfactory sense in the human behavior and evolution. Journal of Medicine and Life, 2(2), 196–198.
  • Schiffman, S. S. (1974). Contributions to the physicochemical dimensions of odor: A psychophysical approach. Annals of the New York Academy of Sciences, 237(0), 164–183. https://doi.org/10.1111/j.1749-6632.1974.tb49852.x
  • Schmiedeberg, K., Shirokova, E., Weber, H. P., Schilling, B., Meyerhof, W., & Krautwurst, D. (2007). Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2. Journal of Structural Biology, 159(3), 400–412. https://doi.org/10.1016/j.jsb.2007.04.013
  • Schüttelkopf, A. W., & van Aalten, D. M. (2004). PRODRG: A tool for high-throughput crystallography of protein-ligand complexes. Acta Crystallographica. Section D, Biological Crystallography, 60(Pt 8), 1355–1363. https://doi.org/10.1107/S0907444904011679
  • Seo, J., Choi, S., Kim, H., Park, S. H., & Lee, J. (2022). Association between olfactory receptors and skin physiology. Annals of Dermatology, 34(2), 87–94. https://doi.org/10.5021/ad.2022.34.2.87
  • Shannon, P., Markiel, A., Ozier, O., Baliga, N. S., Wang, J. T., Ramage, D., Amin, N., Schwikowski, B., & Ideker, T. (2003). Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Research, 13(11), 2498–2504. https://doi.org/10.1101/gr.1239303
  • Sharma, A., Kumar, R., Aier, I., Semwal, R., Tyagi, P., & Varadwaj, P. (2019). Sense of smell: Structural, functional, mechanistic advancements and challenges in human olfactory research. Current Neuropharmacology, 17(9), 891–911. https://doi.org/10.2174/1570159X17666181206095626
  • Sharma, A., Kumar, R., Ranjta, S., & Varadwaj, P. K. (2021). SMILES to smell: Decoding the structure-odor relationship of chemical compounds using the deep neural network approach. Journal of Chemical Information and Modeling, 61(2), 676–688. https://doi.org/10.1021/acs.jcim.0c01288
  • Sharma, A., Kumar, R., Semwal, R., Aier, I., Tyagi, P., & Varadwaj, P. (2022). DeepOlf: Deep neural network-based architecture for predicting odorants and their interacting Olfactory Receptors. IEEE/ACM Transactions on Computational Biology and Bioinformatics, 19(1), 418–428. https://doi.org/10.1109/TCBB.2020.3002154
  • Sharma, A., Saha, B. K., Kumar, R., & Varadwaj, P. K. (2022). OlfactionBase: A repository to explore odors, odorants, olfactory receptors and odorant-receptor interactions. Nucleic Acids Research, 50(D1), D678–D686. https://doi.org/10.1093/nar/gkab763
  • Spehr, J., Gelis, L., Osterloh, M., Oberland, S., Hatt, H., Spehr, M., & Neuhaus, E. M. (2011). G protein-coupled receptor signaling via Src kinase induces endogenous human transient receptor potential vanilloid type 6 (TRPV6) channel activation. The Journal of Biological Chemistry, 286(15), 13184–13192. https://doi.org/10.1074/jbc.M110.183525
  • Spehr, M., Gisselmann, G., Poplawski, A., Riffell, J. A., Wetzel, C. H., Zimmer, R. K., & Hatt, H. (2003). Identification of a testicular odorant receptor mediating human sperm chemotaxis. Science (New York, N.Y.), 299(5615), 2054–2058. https://doi.org/10.1126/science.1080376
  • Spehr, M., Schwane, K., Riffell, J. A., Barbour, J., Zimmer, R. K., Neuhaus, E. M., & Hatt, H. (2004). Particulate adenylate cyclase plays a key role in human sperm olfactory receptor-mediated chemotaxis. Journal of Biological Chemistry. 279(38), 40194–40203. https://doi.org/10.1074/jbc.M403913200
  • Stelzer, G., Rosen, N., Plaschkes, I., Zimmerman, S., Twik, M., Fishilevich, S., Stein, T. I., Nudel, R., Lieder, I., Mazor, Y., Kaplan, S., Dahary, D., Warshawsky, D., Guan-Golan, Y., Kohn, A., Rappaport, N., Safran, M., & Lancet, D. (2016). The GeneCards suite: From gene data mining to disease genome sequence analyses. Curr Protoc Bioinformatics, 54, 1.30.1–1.30.33.
  • Tong, T., Wang, Y., Kang, S. G., & Huang, K. (2021). Ectopic odorant receptor responding to flavor compounds: Versatile roles in health and disease. Pharmaceutics, 13(8), 1314. https://doi.org/10.3390/pharmaceutics13081314
  • Tosadori, G., Bestvina, I., Spoto, F., Laudanna, C., & Scardoni, G. (2017). Creating, generating and comparing random network models with network randomizer. F1000Research, 5, 2524. https://doi.org/10.12688/f1000research.9203.2
  • Tromelin, A., Koensgen, F., Audouze, K., Guichard, E., & Thomas-Danguin, T. (2020). Exploring the characteristics of an aroma-blending mixture by investigating the network of shared odors and the molecular features of their related odorants. Molecules, 25(13), 3032. https://doi.org/10.3390/molecules25133032
  • Tsai, T., Veitinger, S., Peek, I., Busse, D., Eckardt, J., Vladimirova, D., Jovancevic, N., Wojcik, S., Gisselmann, G., Altmüller, J., Ständer, S., Luger, T., Paus, R., Cheret, J., & Hatt, H. (2017). Two olfactory receptors-OR2A4/7 and OR51B5-differentially affect epidermal proliferation and differentiation. Experimental Dermatology, 26(1), 58–65. https://doi.org/10.1111/exd.13132
  • Varnum, M. D., Black, K. D., & Zagotta, W. N. (1995). Molecular mechanism for ligand discrimination of cyclic nucleotide-gated channels. Neuron, 15(3), 619–625. https://doi.org/10.1016/0896-6273(95)90150-7
  • Veithen, A., Wilkin, F., & Philippeau, M. (2015). OR1D2 is a broadly tuned human olfactory receptor. Chemical Senses, 40(3), 262–263.
  • Veitinger, T., Riffell, J. R., Veitinger, S., Nascimento, J. M., Triller, A., Chandsawangbhuwana, C., Schwane, K., Geerts, A., Wunder, F., Berns, M. W., Neuhaus, E. M., Zimmer, R. K., Spehr, M., & Hatt, H. (2011). Chemosensory Ca2+ dynamics correlate with diverse behavioral phenotypes in human sperm. The Journal of Biological Chemistry, 286(19), 17311–17325. https://doi.org/10.1074/jbc.M110.211524
  • Watts, K. S., Dalal, P., Murphy, R. B., Sherman, W., Friesner, R. A., & Shelley, J. C. (2010). ConfGen: A conformational search method for efficient generation of bioactive conformers. Journal of Chemical Information and Modeling, 50(4), 534–546. https://doi.org/10.1021/ci100015j
  • Weber, L., Al-Refae, K., Ebbert, J., Jägers, P., Altmüller, J., Becker, C., Hahn, S., Gisselmann, G., & Hatt, H. (2017). Activation of odorant receptor in colorectal cancer cells leads to inhibition of cell proliferation and apoptosis. PLoS One, 12(3), e0172491. https://doi.org/10.1371/journal.pone.0172491
  • Weyand, I., Godde, M., Frings, S., Weiner, J., Müller, F., Altenhofen, W., Hatt, H., & Kaupp, U. B. (1994). Cloning and functional expression of a cyclic-nucleotide-gated channel from mammalian sperm. Nature, 368(6474), 859–863. https://doi.org/10.1038/368859a0
  • Wiese, H., Gelis, L., Wiese, S., Reichenbach, C., Jovancevic, N., Osterloh, M., Meyer, H. E., Neuhaus, E. M., Hatt, H. H., Radziwill, G., & Warscheid, B. (2015). Quantitative phosphoproteomics reveals the protein tyrosine kinase Pyk2 as a central effector of olfactory receptor signaling in prostate cancer cells. Biochimica et Biophysica Acta, 1854(6), 632–640. https://doi.org/10.1016/j.bbapap.2014.09.002
  • Wu, C., Jia, Y., Lee, J. H., Kim, Y., Sekharan, S., Batista, V. S., & Lee, S. J. (2015). Activation of OR1A1 suppresses PPAR-γ expression by inducing HES-1 in cultured hepatocytes. The International Journal of Biochemistry & Cell Biology, 64, 75–80. https://doi.org/10.1016/j.biocel.2015.03.008
  • Xia, J., Sun, L., Xu, S., Xiang, Q., Zhao, J., Xiong, W., Xu, Y., & Chu, S. (2020). A model using support vector machines recursive feature elimination (SVM-RFE) algorithm to classify whether copd patients have been continuously managed according to GOLD guidelines. International Journal of Chronic Obstructive Pulmonary Disease, 15, 2779–2786. https://doi.org/10.2147/COPD.S271237
  • Xu, R., Cong, X., Zheng, Q., Xu, L., Ni, M. J., de March, C. A., Matsunami, H., Golebiowski, J., Ma, M., & Yu, Y. (2022). Interactions among key residues regulate mammalian odorant receptor trafficking. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, 36(7), e22384. https://doi.org/10.1096/fj.202200116RR
  • Yap, C. W. (2011). PaDEL-Descriptor: An open-source software to calculate molecular descriptors and fingerprints. Journal of Computational Chemistry, 32(7), 1466–1474. https://doi.org/10.1002/jcc.21707
  • Younis, H., Anwar, M. W., Khan, M. U. G., Sikandar, A., & Bajwa, U. I. (2021). A new sequential forward feature selection (SFFS) algorithm for mining best topological and biological features to predict protein complexes from protein-protein interaction networks (PPINs). Interdisciplinary Sciences, Computational Life Sciences, 13(3), 371–388. https://doi.org/10.1007/s12539-021-00433-8
  • Yuan, T. T., Toy, P., McClary, J. A., Lin, R. J., Miyamoto, N. G., & Kretschmer, P. J. (2001). Cloning and genetic characterization of an evolutionarily conserved human olfactory receptor that is differentially expressed across species. Gene, 278(1-2), 41–51. https://doi.org/10.1016/s0378-1119(01)00709-0
  • Zarzo, M. (2007). The sense of smell: Molecular basis of odorant recognition. Biological Reviews of the Cambridge Philosophical Society, 82(3), 455–479. https://doi.org/10.1111/j.1469-185X.2007.00019.x
  • Zhang, J., Yang, J., Jang, R., & Zhang, Y. (2015). GPCR-I-TASSER: A hybrid approach to G protein-coupled receptor structure modeling and the application to the human genome. Structure (London, England: 1993), 23(8), 1538–1549. https://doi.org/10.1016/j.str.2015.06.007
  • Zhao, W., Ho, L., Varghese, M., Yemul, S., Dams-O'Connor, K., Gordon, W., Knable, L., Freire, D., Haroutunian, V., & Pasinetti, G. M. (2013). Decreased level of olfactory receptors in blood cells following traumatic brain injury and potential association with tauopathy. Journal of Alzheimer’s Disease: JAD, 34(2), 417–429. https://doi.org/10.3233/JAD-121894
  • Zhu, K. W., Burton, S. D., Nagai, M. H., Silverman, J. D., de March, C. A., Wachowiak, M., & Matsunami, H. (2022). Decoding the olfactory map through targeted transcriptomics links murine olfactory receptors to glomeruli. Nature Communications, 13(1), 5137. https://doi.org/10.1038/s41467-022-32267-3

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