Unravelling hub genes as potential therapeutic targets in lung cancer using integrated transcriptomic meta-analysis and in silico approach

References

• An, L., Zhang, J., Feng, D., Zhao, Y., Ouyang, W., Shi, R., Zhou, X., Yu, Z., Wei, S., Min, J., & Wang, H. (2021). KIF2C is a novel prognostic biomarker and correlated with immune infiltration in endometrial cancer. Stem Cells International, 2021, 1434856. https://doi.org/10.1155/2021/1434856
   PubMed Web of Science ®Google Scholar
• Bayliss, R., Sardon, T., Vernos, I., & Conti, E. (2003). Structural basis of aurora-a activation by TPX2 at the mitotic spindle. Molecular Cell, 12(4), 851–862. https://doi.org/10.1016/S1097-2765(03)00392-7
   PubMed Web of Science ®Google Scholar
• Borah, N. A., & Reddy, M. M. (2021). Aurora kinase b inhibition: a potential therapeutic strategy for cancer. Molecules, 26(7), 1981. https://doi.org/10.3390/molecules26071981
   PubMed Web of Science ®Google Scholar
• Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 68(6), 394-424. https://doi.org/10.3322/caac.21492
   Google Scholar
• Bu, H., Li, Y., Jin, C., Yu, H., Wang, X., Chen, J., Wang, Y., Ma, Y., Zhang, Y., & Kong, B. (2020). Overexpression of PRC1 indicates a poor prognosis in ovarian cancer. International Journal of Oncology, 56(3), 685–696. https://doi.org/10.3892/ijo.2020.4959
   PubMed Web of Science ®Google Scholar
• Cerami, E., Gao, J., Dogrusoz, U., Gross, B. E., Sumer, S. O., Aksoy, B. A., Jacobsen, A., Byrne, C. J., Heuer, M. L., Larsson, E., Antipin, Y., Reva, B., Goldberg, A. P., Sander, C., & Schultz, N. (2012). The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data. Cancer Discovery, 2(5), 401–404. https://doi.org/10.1158/2159-8290.CD-12-0095
   PubMed Web of Science ®Google Scholar
• Chen, E. Y., Tan, C. M., Kou, Y., Duan, Q., Wang, Z., Meirelles, G. V., Clark, N. R., & Ma’ayan, A. (2013). Enrichr: Interactive and collaborative HTML5 gene list enrichment analysis tool. BMC Bioinformatics, 14(1), 128. https://doi.org/10.1186/1471-2105-14-128
   PubMed Web of Science ®Google Scholar
• Dong, S., Men, W., Yang, S., & Xu, S. (2020). Identification of lung adenocarcinoma biomarkers based on bioinformatic analysis and human samples. Oncology Reports, 43(5), 1437-1450. https://doi.org/10.3892/or.2020.7526
   Google Scholar
• Du, R., Huang, C., Liu, K., Li, X., & Dong, Z. (2021). Targeting AURKA in cancer: Molecular mechanisms and opportunities for cancer therapy. Molecular Cancer, 20(1), 15. https://doi.org/10.1186/s12943-020-01305-3
   PubMed Web of Science ®Google Scholar
• Ettinger, D. S., Akerley, W., Bepler, G., Blum, M. G., Chang, A., Cheney, R. T., Chirieac, L. R., D'Amico, T. A., Demmy, T. L., Ganti, A. K. P., Govindan, R., Grannis, F. W., Jahan, T., Jahanzeb, M., Johnson, D. H., Kessinger, A., Komaki, R., Kong, F.-M., Kris, M. G., … NCCN Non-Small Cell Lung Cancer Panel Members (2010). Non–Small cell lung cancer. Journal of the National Comprehensive Cancer Network : JNCCN, 8(7), 740–801. https://doi.org/10.6004/jnccn.2010.0056
   PubMed Web of Science ®Google Scholar
• Gan, H., Lin, L., Hu, N., Yang, Y., Gao, Y., Pei, Y., Chen, K., & Sun, B. (2019). KIF2C exerts an oncogenic role in nonsmall cell lung cancer and is negatively regulated by miR‐325‐3p. Cell Biochemistry and Function, 37(6), 424–431. https://doi.org/10.1002/cbf.3420
   PubMed Web of Science ®Google Scholar
• Hao, X., & Qu, T. (2019). Expression of CENPE and its prognostic role in non-small cell lung cancer. Open Medicine (Warsaw, Poland), 14(1), 497–502. https://doi.org/10.1515/med-2019-0053
   PubMedGoogle Scholar
• Janeček, M., Rossmann, M., Sharma, P., Emery, A., Huggins, D. J., Stockwell, S. R., Stokes, J. E., Tan, Y. S., Almeida, E. G., Hardwick, B., Narvaez, A. J., Hyvönen, M., Spring, D. R., McKenzie, G. J., & Venkitaraman, A. R. (2016). Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2. Scientific Reports, 6(1), 28528. https://doi.org/10.1038/srep28528
   PubMedGoogle Scholar
• Janerich, D. T., Thompson, W. D., Varela, L. R., Greenwald, P., Chorost, S., Tucci, C., Zaman, M. B., Melamed, M. R., Kiely, M., & McKneally, M. F. (1990). Lung cancer and exposure to tobacco smoke in the household. The New England Journal of Medicine, 323(10), 632–636. https://doi.org/10.1056/NEJM199009063231003
   PubMed Web of Science ®Google Scholar
• Li, J., Dallmayer, M., Kirchner, T., Musa, J., & Grünewald, T. G. P. (2018). PRC1: Linking cytokinesis, chromosomal instability, and cancer evolution. Trends in Cancer, 4(1), 59–73. https://doi.org/10.1016/j.trecan.2017.11.002
   PubMed Web of Science ®Google Scholar
• Li, M., Gao, K., Chu, L., Zheng, J., & Yang, J. (2018). The role of Aurora-A in cancer stem cells. The International Journal of Biochemistry & Cell Biology, 98, 89–92. https://doi.org/10.1016/j.biocel.2018.03.007
   PubMed Web of Science ®Google Scholar
• Li, X.-L., Ji, Y.-M., Song, R., Li, X.-N., & Guo, L.-S. (2019). KIF23 promotes gastric cancer by stimulating cell proliferation. Disease Markers, 2019, 9751923–9751929. https://doi.org/10.1155/2019/9751923
   PubMed Web of Science ®Google Scholar
• Liu, X., Gong, H., & Huang, K. (2013). Oncogenic role of kinesin proteins and targeting kinesin therapy. Cancer Science, 104(6), 651–656. https://doi.org/10.1111/cas.12138
   PubMed Web of Science ®Google Scholar
• Liu, N., Wang, Y. A., Sun, Y., Ecsedy, J., Sun, J., Li, X., & Wang, P. (2019). Inhibition of Aurora A enhances radiosensitivity in selected lung cancer cell lines. Respiratory Research, 20(1), 230. https://doi.org/10.1186/s12931-019-1194-8
   PubMed Web of Science ®Google Scholar
• Li, Z., Yang, H.-Y., Zhang, X.-L., Zhang, X., Huang, Y.-Z., Dai, X.-Y., Shi, L., Zhou, G.-R., Wei, J.-F., & Ding, Q. (2022). Kinesin family member 23, regulated by FOXM1, promotes triple negative breast cancer progression via activating Wnt/β-catenin pathway. Journal of Experimental & Clinical Cancer Research : CR, 41(1), 168. https://doi.org/10.1186/s13046-022-02373-7
   PubMed Web of Science ®Google Scholar
• Loiselle, J. J., Roy, J. G., & Sutherland, L. C. (2016). RBM5 reduces small cell lung cancer growth, increases cisplatin sensitivity and regulates key transformation-associated pathways. Heliyon, 2(11), e00204. https://doi.org/10.1016/j.heliyon.2016.e00204
   PubMed Web of Science ®Google Scholar
• Malumbres, M., & Barbacid, M. (2009). Cell cycle, CDKs and cancer: A changing paradigm. Nature Reviews. Cancer, 9(3), 153–166. https://doi.org/10.1038/nrc2602
   PubMed Web of Science ®Google Scholar
• Molina, J. R., Yang, P., Cassivi, S. D., Schild, S. E., & Adjei, A. A. (2008). Non-Small cell lung cancer: Epidemiology, risk factors, treatment, and survivorship. Mayo Clinic Proceedings, 83(5), 584–594. https://doi.org/10.4065/83.5.584
   PubMed Web of Science ®Google Scholar
• Mou, P. K., Yang, E. J., Shi, C., Ren, G., Tao, S., & Shim, J. S. (2021). Aurora kinase A, a synthetic lethal target for precision cancer medicine. Experimental & Molecular Medicine, 53(5), 835–847. https://doi.org/10.1038/s12276-021-00635-6
   PubMed Web of Science ®Google Scholar
• Omenn, G. S., Merchant, J., Boatman, E., Dement, J. M., Kuschner, M., Nicholson, W., Peto, J., & Rosenstock, L. (1986). Contribution of environmental fibers to respiratory cancer. Environmental Health Perspectives, 70, 51–56. https://doi.org/10.1289/ehp.867051
   PubMed Web of Science ®Google Scholar
• Pan, H.-W., Su, H.-H., Hsu, C.-W., Huang, G.-J., Wu,., & T., T.-L. (2017). Targeted TPX2 increases chromosome missegregation and suppresses tumor cell growth in human prostate cancer. OncoTargets and Therapy, 10, 3531–3543. volumehttps://doi.org/10.2147/OTT.S136491
   PubMed Web of Science ®Google Scholar
• Ren, K., Zhou, D., Wang, M., Li, E., Hou, C., Su, Y., Zou, Q., Zhou, P., & Liu, X. (2021). RACGAP1 modulates ECT2-Dependent mitochondrial quality control to drive breast cancer metastasis. Experimental Cell Research, 400(1), 112493. https://doi.org/10.1016/j.yexcr.2021.112493
   PubMed Web of Science ®Google Scholar
• Ruan, X., & Jiang, J. (2022). RACGAP1 promotes proliferation and cell cycle progression by regulating CDC25C in cervical cancer cells. Tissue & Cell, 76, 101804. https://doi.org/10.1016/j.tice.2022.101804
   PubMed Web of Science ®Google Scholar
• Schüttelkopf, A. W., & van Aalten, D. M. F. (2004). PRODRG: A tool for high-throughput crystallography of protein-ligand complexes. Acta Crystallographica. Section D, Biological Crystallography, 60(Pt 8), 1355–1363. https://doi.org/10.1107/S0907444904011679
   PubMedGoogle Scholar
• Shannon, P., Markiel, A., Ozier, O., Baliga, N. S., Wang, J. T., Ramage, D., Amin, N., Schwikowski, B., & Ideker, T. (2003). Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Research, 13(11), 2498–2504. https://doi.org/10.1101/gr.1239303
   PubMed Web of Science ®Google Scholar
• Shen, T., Yang, L., Zhang, Z., Yu, J., Dai, L., Gao, M., Shang, Z., & Niu, Y. (2019). KIF20A Affects the Prognosis of Bladder Cancer by Promoting the Proliferation and Metastasis of Bladder Cancer Cells. Disease Markers, 2019, 1–9. https://doi.org/10.1155/2019/4863182
   Google Scholar
• Shriwash, N., Singh, P., Arora, S., Ali, S. M., Ali, S., & Dohare, R. (2019). Identification of differentially expressed genes in small and non-small cell lung cancer based on meta-analysis of mRNA. Heliyon, 5(6), e01707. https://doi.org/10.1016/j.heliyon.2019.e01707
   PubMed Web of Science ®Google Scholar
• Taylor, N. J., Bensen, J. T., Poole, C., Troester, M. A., Gammon, M. D., Luo, J., Millikan, R. C., & Olshan, A. F. (2015). Genetic variation in cell cycle regulatory gene AURKA and association with intrinsic breast cancer subtype. Molecular Carcinogenesis, 54(12), 1668–1677. https://doi.org/10.1002/mc.22238
   PubMed Web of Science ®Google Scholar
• Van Der Spoel, D., Lindahl, E., Hess, B., Groenhof, G., Mark, A. E., Berendsen, H., & J., C. (2005). GROMACS: Fast, flexible, and free. Journal of Computational Chemistry, 26(16), 1701–1718. https://doi.org/10.1002/jcc.20291
   PubMed Web of Science ®Google Scholar
• Wald, N. J., Nanchahal, K., Thompson, S. G., & Cuckle, H. S. (1986). Does breathing other people’s tobacco smoke cause lung cancer? British Medical Journal (Clinical Research ed.), 293(6556), 1217–1222. https://doi.org/10.1136/bmj.293.6556.1217
   PubMedGoogle Scholar
• Wei, P., Zhang, N., Xu, Y., Li, X., Shi, D., Wang, Y., Li, D., & Cai, S. (2013). TPX2 is a novel prognostic marker for the growth and metastasis of colon cancer. Journal of Translational Medicine, 11(1), 313. https://doi.org/10.1186/1479-5876-11-313
   PubMedGoogle Scholar
• Xiao, K., Liu, Q., Peng, G., Su, J., Qin, C.-Y., & Wang, X.-Y. (2020). Identification and validation of a three-gene signature as a candidate prognostic biomarker for lower grade glioma. PeerJ. 8, e8312. https://doi.org/10.7717/peerj.8312
   PubMed Web of Science ®Google Scholar
• Yang, K., Gao, J., & Luo, M. (2019). Identification of key pathways and hub genes in basal-like breast cancer using bioinformatics analysis. OncoTargets and Therapy, 12, 1319–1331. volumehttps://doi.org/10.2147/OTT.S158619
   PubMed Web of Science ®Google Scholar
• Yang, J., Wu, Z., Yang, L., Jeong, J.-H., Zhu, Y., Lu, J., Wang, B., Wang, N., Wang, Y., Shen, K., & Li, R. (2021). Characterization of kinesin family member 2C as a proto-oncogene in cervical cancer. Frontiers in Pharmacology, 12, 785981. https://doi.org/10.3389/fphar.2021.785981
   PubMed Web of Science ®Google Scholar
• Zhang, B., Shi, X., Xu, G., Kang, W., Zhang, W., Zhang, S., Cao, Y., Qian, L., Zhan, P., Yan, H., To, K. F., Wang, L., & Zou, X. (2017). Elevated PRC1 in gastric carcinoma exerts oncogenic function and is targeted by piperlongumine in a p53-dependent manner. Journal of Cellular and Molecular Medicine, 21(7), 1329–1341. https://doi.org/10.1111/jcmm.13063
   PubMed Web of Science ®Google Scholar
• Zhao, Z., Wang, Z., Bao, Z.-S., Gao, W.-Z., Zhang, Y.-D., Ruan, C.-J., Lv, T., Wang, Y., & Sun, L.-H. (2021). Mutation and copy number alterations analysis of KIF23 in Glioma. Frontiers in Genetics, 12, 646929. https://doi.org/10.3389/fgene.2021.646929
   PubMed Web of Science ®Google Scholar
• Zhao, X., Zhou, L., Li, X., Ni, J., Chen, P., Ma, R., Wu, J., & Feng, J. (2018). Overexpression of KIF20A confers malignant phenotype of lung adenocarcinoma by promoting cell proliferation and inhibiting apoptosis. Cancer Medicine, 7(9), 4678–4689. https://doi.org/10.1002/cam4.1710
   PubMed Web of Science ®Google Scholar
• Zhu, X., Luo, X., Feng, G., Huang, H., He, Y., Ma, W., Zhang, C., Zeng, M., & Liu, H. (2019). CENPE expression is associated with its DNA methylation status in esophageal adenocarcinoma and independently predicts unfavorable overall survival. PloS One, 14(2), e0207341. https://doi.org/10.1371/journal.pone.0207341
   PubMed Web of Science ®Google Scholar