A reverse docking approach to explore the anticancer potency of natural compounds by interfering metastasis and angiogenesis

References

• Agwupuye, J. A., Louis, H., Gber, T. E., Ahmad, I., Agwamba, E. C., Samuel, A. B., Ejiako, E. J., Patel, H., Ita, I. T., & Bassey, V. M. (2022). Molecular modeling and DFT studies of diazenylphenyl derivatives as a potential HBV and HCV antiviral agents. Chemical Physics Impact, 5, 100122. https://doi.org/10.1016/j.chphi.2022.100122
   Google Scholar
• Aljuhani, A., Ahmed, H. E. A., Ihmaid, S. K., Omar, A. M., Althagfan, S. S., Alahmadi, Y. M., Ahmad, I., Patel, H., Ahmed, S., Almikhlafi, M. A., El-Agrody, A. M., Zayed, M. F., Turkistani, S. A., Abulkhair, S. H., Almaghrabi, M., Salama, S. A., Al-Karmalawy, A. A., & Abulkhair, H. S. (2022). In vitro and computational investigations of novel synthetic carboxamide-linked pyridopyrrolopyrimidines with potent activity as SARS-CoV-2-M Pro inhibitors. RSC Advances, 12(41), 26895–26907. https://doi.org/10.1039/d2ra04015h
   PubMed Web of Science ®Google Scholar
• Alok, A., Singh, I. D., Singh, S., Kishore, M., & Jha, P. C. (2015). Curcumin – Pharmacological actions and its role in oral submucous fibrosis: A review. Journal of Clinical and Diagnostic Research, 9(10), Ze01-3.
   PubMedGoogle Scholar
• Ansari, M. J., Bokov, D., Markov, A., Jalil, A. T., Shalaby, M. N., Suksatan, W., Chupradit, S., Al-Ghamdi, H. S., Shomali, N., Zamani, A., Mohammadi, A., & Dadashpour, M. (2022). Cancer combination therapies by angiogenesis inhibitors; a comprehensive review. Cell Communication and Signaling: CCS, 20(1), 49. https://doi.org/10.1186/s12964-022-00838-y
   PubMed Web of Science ®Google Scholar
• Ayipo, Y. O., Ahmad, I., Alananzeh, W., Lawal, A., Patel, H., & Mordi, M. N. (2022). Computational modelling of potential Zn-sensitive non-β-lactam inhibitors of imipenemase-1 (IMP-1). Journal of Biomolecular Structure & Dynamics, 1–21. https://doi.org/10.1080/07391102.2022.2153168
   Google Scholar
• Bappy, M. N. I., Robin, T. B., Prome, A. A., Patil, R. B., Moin, A. T., Akter, R., Laskar, F. S., Roy, A., Akter, H., & Zinnah, K. M. A. (2023). Subtractive proteomics analysis to uncover the potent drug targets for distinctive drug design of Candida auris. Heliyon, 9(6), e17026. https://doi.org/10.1016/j.heliyon.2023.e17026
   PubMedGoogle Scholar
• Benet, L. Z., Hosey, C. M., Ursu, O., & Oprea, T. I. (2016). BDDCS, the rule of 5 and drugability. Advanced Drug Delivery Reviews, 101, 89–98. https://doi.org/10.1016/j.addr.2016.05.007
   PubMed Web of Science ®Google Scholar
• Berman, H. M., Westbrook, J., Feng, Z., Gilliland, G., Bhat, T. N., Weissig, H., Shindyalov, I. N., & Bourne, P. E. (2000). The protein data bank. Nucleic Acids Research, 28(1), 235–242. https://doi.org/10.1093/nar/28.1.235
   PubMed Web of Science ®Google Scholar
• Cabral-Pacheco, G. A., Garza-Veloz, I., Castruita-De La Rosa, C., Ramirez-Acuña, J. M., Perez-Romero, B. A., Guerrero-Rodriguez, J. F., Martinez-Avila, N., & Martinez-Fierro, M. L. (2020). The roles of matrix metalloproteinases and their inhibitors in human diseases. International Journal of Molecular Science, 21(24), 9739.
   PubMed Web of Science ®Google Scholar
• Carmeliet, P. (2005). VEGF as a key mediator of angiogenesis in cancer. Oncology, 69(Suppl. 3), 4–10. https://doi.org/10.1159/000088478
   PubMed Web of Science ®Google Scholar
• Chao, Y., Li, C.-P., Chau, G.-Y., Chen, C.-P., King, K.-L., Lui, W.-Y., Yen, S.-H., Chang, F.-Y., Chan, W.-K., & Lee, S.-D. (2003). Prognostic significance of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin in patients with resectable hepatocellular carcinoma after surgery. Annals of Surgical Oncology, 10(4), 355–362. (https://doi.org/10.1245/aso.2003.10.002
   PubMed Web of Science ®Google Scholar
• Chen, C.-H., Liao, C.-H., Chang, Y.-L., Guh, J.-H., Pan, S.-L., & Teng, C.-M. (2012). Protopine, a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines. Cancer Letters, 315(1), 1–11. https://doi.org/10.1016/j.canlet.2011.09.042
   PubMed Web of Science ®Google Scholar
• Daina, A., & Zoete, V. (2016). A boiled‐egg to predict gastrointestinal absorption and brain penetration of small molecules. ChemMedChem, 11(11), 1117–1121. https://doi.org/10.1002/cmdc.201600182
   PubMed Web of Science ®Google Scholar
• Daina, A., Michielin, O., & Zoete, V. (2017). SwissADME: A free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Scientific Reports, 7(1), 42717. https://doi.org/10.1038/srep42717
   PubMed Web of Science ®Google Scholar
• Desai, N. C., Jadeja, D. J., Jethawa, A. M., Ahmad, I., Patel, H., & Dave, B. (2023). Design and synthesis of some novel hybrid molecules based on 4-thiazolidinone bearing pyridine-pyrazole scaffolds: Molecular docking and molecular dynamics simulations of its major constituent onto DNA gyrase inhibition. Molecular Diversity, 1–17. https://doi.org/10.1007/s11030-023-10612-y
   Web of Science ®Google Scholar
• Duesberg, P., Stindl, R., & Hehlmann, R. (2000). Explaining the high mutation rates of cancer cells to drug and multidrug resistance by chromosome reassortments that are catalyzed by aneuploidy. Proceedings of the National Academy of Sciences of the United States of America, 97(26), 14295–14300. https://doi.org/10.1073/pnas.97.26.14295
   PubMed Web of Science ®Google Scholar
• Everett, J. A. (2013). The 12 item social and economic conservatism scale (SECS). PloS One, 8(12), e82131. https://doi.org/10.1371/journal.pone.0082131
   PubMed Web of Science ®Google Scholar
• Ferrè, F., & Clote, P. (2005). DiANNA: A web server for disulfide connectivity prediction. Nucleic Acids Research, 33, W230–W2. https://doi.org/10.1093/nar/gki412
   PubMed Web of Science ®Google Scholar
• Freyssin, A., Rioux Bilan, A., Fauconneau, B., Galineau, L., Serrière, S., Tauber, C., Perrin, F., Guillard, J., Chalon, S., & Page, G. (2022). Trans ε-viniferin decreases amyloid deposits with greater efficiency than resveratrol in an Alzheimer’s mouse model. Frontiers in Neuroscience, 15, 803927. https://doi.org/10.3389/fnins.2021.803927
   PubMed Web of Science ®Google Scholar
• Fuloria, S., Sekar, M., Khattulanuar, F. S., Gan, S. H., Rani, N. N. I. M., Ravi, S., Subramaniyan, V., Jeyabalan, S., Begum, M. Y., Chidambaram, K., Sathasivam, K. V., Safi, S. Z., Wu, Y. S., Nordin, R., Maziz, M. N. H., Kumarasamy, V., Lum, P. T., & Fuloria, N. K. (2022). Chemistry, biosynthesis and pharmacology of viniferin: Potential resveratrol-derived molecules for new drug discovery, development and therapy. Molecules (Basel, Switzerland), 27(16), 5072. https://doi.org/10.3390/molecules27165072
   PubMed Web of Science ®Google Scholar
• Guo, S., Bai, X., Shi, S., Deng, Y., Kang, X., & An, H. (2021). TMEM16A, a homoharringtonine receptor, as a potential endogenic target for lung cancer treatment. International Journal of Molecular Sciences, 22(20), 10930. https://doi.org/10.3390/ijms222010930
   PubMed Web of Science ®Google Scholar
• Halder, S. K., Ahmad, I., Shathi, J. F., Mim, M. M., Hassan, M. R., Jewel, M. J. I., Dey, P., Islam, M. S., Patel, H., Morshed, M. R., Shakil, M. S., & Hossen, M. S. (2022). A comprehensive study to unleash the putative inhibitors of serotype2 of dengue virus: Insights from an in silico structure-based drug discovery. Molecular Biotechnology, 1–14. https://doi.org/10.1007/s12033-022-00582-1
   PubMed Web of Science ®Google Scholar
• Hossain, F. M. A., Bappy, M. N. I., Robin, T. B., Ahmad, I., Patel, H., Jahan, N., Rabbi, M. G. R., Roy, A., Chowdhury, W., Ahmed, N., Prome, A. A., Rani, N. A., Khan, P., & Zinnah, K. M. A. (2023). A review on computational studies and bioinformatics analysis of potential drugs against monkeypox virus. Journal of Biomolecular Structure & Dynamics, 1–17. https://doi.org/10.1080/07391102.2023.2231542
   Google Scholar
• Huang, W., Kong, L., Cao, Y., & Yan, L. (2022). Identification and quantification, metabolism and pharmacokinetics, pharmacological activities, and botanical preparations of protopine: A review. Molecules (Basel, Switzerland), 27(1), 215. https://doi.org/10.3390/molecules27010215
   Web of Science ®Google Scholar
• Jiang, H., & Li, H. (2021). Prognostic values of tumoral MMP2 and MMP9 overexpression in breast cancer: A systematic review and meta-analysis. BMC Cancer, 21(1), 149. https://doi.org/10.1186/s12885-021-07860-2
   PubMed Web of Science ®Google Scholar
• Kikiowo, B., Ahmad, I., Alade, A. A., Ijatuyi, T., Iwaloye, O., & Patel, H. M. (2022). Molecular dynamics simulation and pharmacokinetics studies of ombuin and quercetin against human pancreatic α-amylase. Journal of Biomolecular Structure & Dynamics, 1–8. https://doi.org/10.1080/07391102.2022.2155699
   Web of Science ®Google Scholar
• Kumar, G., & Patnaik, R. (2018). Inhibition of gelatinases (MMP-2 and MMP-9) by Withania somnifera phytochemicals confers neuroprotection in stroke: An in silico analysis. Interdisciplinary Sciences, Computational Life Sciences, 10(4), 722–733. https://doi.org/10.1007/s12539-017-0231-x
   PubMed Web of Science ®Google Scholar
• Kumar, S., Oh, J. M., Abdelgawad, M. A., Abourehab, M. A., Tengli, A. K., Singh, A. K., Ahmad, I., Patel, H., Mathew, B., & Kim, H. (2023). Development of isopropyl-tailed chalcones as a new class of selective MAO-B inhibitors for the treatment of Parkinson’s disorder. ACS Omega, 8(7), 6908–6917. https://doi.org/10.1021/acsomega.2c07694
   PubMed Web of Science ®Google Scholar
• Li, H., Qiu, Z., Li, F., & Wang, C. (2017). The relationship between MMP-2 and MMP-9 expression levels with breast cancer incidence and prognosis. Oncology Letters, 14(5), 5865–5870. https://doi.org/10.3892/ol.2017.6924
   PubMed Web of Science ®Google Scholar
• Liao, C.,Sitzmann, M.,Pugliese, A., &Nicklaus, M. C. (2011). Software and resources for computational medicinal chemistry. Future Medicinal Chemistry, 3(8), 1057–1085. https://doi.org/10.4155/fmc.11.63 21707404
   PubMed Web of Science ®Google Scholar
• Liu, M., & Xing, L. Q. (2017). Basic fibroblast growth factor as a potential biomarker for diagnosing malignant tumor metastasis in women. Oncology Letters, 14(2), 1561–1567. https://doi.org/10.3892/ol.2017.6335
   PubMed Web of Science ®Google Scholar
• Liu, Y., Grimm, M., Dai, W.-T., Hou, M.-C., Xiao, Z.-X., & Cao, Y. (2020). CB-dock: A web server for cavity detection-guided protein–ligand blind docking. Acta Pharmacologica Sinica, 41(1), 138–144. https://doi.org/10.1038/s41401-019-0228-6
   PubMed Web of Science ®Google Scholar
• Lü, S., & Wang, J. (2014). Homoharringtonine and omacetaxine for myeloid hematological malignancies. Journal of Hematology & Oncology, 7, 2. https://doi.org/10.1186/1756-8722-7-2
   PubMed Web of Science ®Google Scholar
• Martin, Y. (2005). A bioavailability score. Journal of Medicinal Chemistry, 48(9), 3164–3170. (https://doi.org/10.1021/jm0492002
   PubMed Web of Science ®Google Scholar
• Mathew, B., Parambi, D. G. T., Singh, M., Hendawy, O. M., Al-Sanea, M. M., & Bakr, R. B. (2021). Chapter 3.1.12 – Protopine. In Belwal, T., Nabavi, S. M., Nabavi, S. F., Dehpour, A. R., & Shirooie, S. (Eds). Naturally occurring chemicals against Alzheimer’s disease (pp. 167–174). Academic Press.
   Google Scholar
• Meng, X. Y., Zhang, H. X., Mezei, M., & Cui, M. (2011). Molecular docking: A powerful approach for structure-based drug discovery. Current Computer-Aided Drug Design, 7(2), 146–157. https://doi.org/10.2174/157340911795677602
   PubMed Web of Science ®Google Scholar
• Nagase, H., Visse, R., & Murphy, G. (2006). Structure and function of matrix metalloproteinases and TIMPs. Cardiovascular Research, 69(3), 562–573. https://doi.org/10.1016/j.cardiores.2005.12.002
   PubMed Web of Science ®Google Scholar
• Nemunaitis, J., Mita, A., Stephenson, J., Mita, M. M., Sarantopoulos, J., Padmanabhan-Iyer, S., Nanda, N., Gleich, L., Benichou, A. C., & Craig, A. (2013). Pharmacokinetic study of omacetaxine mepesuccinate administered subcutaneously to patients with advanced solid and hematologic tumors. Cancer Chemotherapy and Pharmacology, 71(1), 35–41. https://doi.org/10.1007/s00280-012-1963-2
   PubMed Web of Science ®Google Scholar
• Nishida, N., Yano, H., Nishida, T., Kamura, T., & Kojiro, M. (2006). Angiogenesis in cancer. Vascular Health and Risk Management, 2(3), 213–219. https://doi.org/10.2147/vhrm.2006.2.3.213
   PubMedGoogle Scholar
• Niu, G., & Chen, X. (2010). Vascular endothelial growth factor as an anti-angiogenic target for cancer therapy. Current Drug Targets, 11(8), 1000–1017. https://doi.org/10.2174/138945010791591395
   PubMed Web of Science ®Google Scholar
• Norma, F.-H., Juan, F., & Daniel, G.-M. (2019). Chemical reactivity properties and bioactivity scores of the angiotensin II vasoconstrictor octapeptide. In Amalia, S., Azhar, R., & Ghulam, H. (Eds). Cheminformatics and its applications. IntechOpen.
   Google Scholar
• O'boyle, N. M., Banck, M., James, C. A., Morley, C., Vandermeersch, T., & Hutchison, G. R. (2011). Open Babel: An open chemical toolbox. Journal of Cheminformatics, 3(1), 33. https://doi.org/10.1186/1758-2946-3-33
   PubMed Web of Science ®Google Scholar
• Odot, J., Albert, P., Carlier, A., Tarpin, M., Devy, J., & Madoulet, C. (2004). In vitro and in vivo anti-tumoral effect of curcumin against melanoma cells. International Journal of Cancer, 111(3), 381–387. https://doi.org/10.1002/ijc.20160
   PubMed Web of Science ®Google Scholar
• Osmaniye, D., Ahmad, I., Sağlık, B. N., Levent, S., Patel, H. M., Ozkay, Y., & Kaplancıklı, Z. A. (2022). Design, synthesis and molecular docking and ADME studies of novel hydrazone derivatives for AChE inhibitory, BBB permeability and antioxidant effects. Journal of Biomolecular Structure & Dynamics, 1–17. https://doi.org/10.1080/07391102.2022.2139762
   Google Scholar
• Oun, R., Moussa, Y. E., & Wheate, N. J. (2018). The side effects of platinum-based chemotherapy drugs: A review for chemists. Dalton Transactions (Cambridge, England: 2003), 47(19), 6645–6653. https://doi.org/10.1039/c8dt00838h
   PubMed Web of Science ®Google Scholar
• Özdemir, F., Akalın, G., Şen, M., Önder, N. I., Işcan, A., Kutlu, H. M., & Incesu, Z. (2014). Towards novel anti-tumor strategies for hepatic cancer: ɛ-viniferin in combination with vincristine displays pharmacodynamic synergy at lower doses in HepG2 cells. Omics: A Journal of Integrative Biology, 18(5), 324–334. https://doi.org/10.1089/omi.2013.0045
   PubMed Web of Science ®Google Scholar
• Pettersen, E. F., Goddard, T. D., Huang, C. C., Couch, G. S., Greenblatt, D. M., Meng, E. C., & Ferrin, T. E. (2004). UCSF chimera—A visualization system for exploratory research and analysis. Journal of Computational Chemistry, 25(13), 1605–1612. https://doi.org/10.1002/jcc.20084
   PubMed Web of Science ®Google Scholar
• Pires, D. E. V., Blundell, T. L., & Ascher, D. B. (2015). pkCSM: Predicting small-molecule pharmacokinetic and toxicity properties using graph-based signatures. Journal of Medicinal Chemistry, 58(9), 4066–4072. https://doi.org/10.1021/acs.jmedchem.5b00104
   PubMed Web of Science ®Google Scholar
• Rajabi, M., & Mousa, S. A. (2017). The role of angiogenesis in cancer treatment. Biomedicines, 5(2), 34. https://doi.org/10.3390/biomedicines5020034
   PubMed Web of Science ®Google Scholar
• Rempe, R. G., Hartz, A. M. S., & Bauer, B. (2016). Matrix metalloproteinases in the brain and blood-brain barrier: Versatile breakers and makers. Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism, 36(9), 1481–1507. https://doi.org/10.1177/0271678X16655551
   PubMed Web of Science ®Google Scholar
• Riva, A., Ronchi, M., Petrangolini, G., Bosisio, S., & Allegrini, P. (2019). Improved oral absorption of quercetin from quercetin Phytosome®, a new delivery system based on food grade lecithin. European Journal of Drug Metabolism and Pharmacokinetics, 44(2), 169–177. https://doi.org/10.1007/s13318-018-0517-3
   PubMed Web of Science ®Google Scholar
• Robin, T. B., Rani, N. A., Ahmed, N., Prome, A. A., Bappy, N. I., & Ahmed, F. (2023). Identification of novel drug targets and screening potential drugs against Cryptococcus gattii: An in silico approach. Informatics in Medicine Unlocked, 38, 101222. https://doi.org/10.1016/j.imu.2023.101222
   Google Scholar
• Ruocco, M. R., Avagliano, A., Granato, G., Vigliar, E., Masone, S., Montagnani, S., & Arcucci, A. (2019). Metabolic flexibility in melanoma: A potential therapeutic target. Seminars in Cancer Biology, 59, 187–207. https://doi.org/10.1016/j.semcancer.2019.07.016
   PubMed Web of Science ®Google Scholar
• Seca, A. M., & Pinto, D. C. (2018). Plant secondary metabolites as anticancer agents: Successes in clinical trials and therapeutic application. International Journal of Molecular Sciences, 19(1), 263. https://doi.org/10.3390/ijms19010263
   PubMed Web of Science ®Google Scholar
• Seyfried, T. N., & Huysentruyt, L. C. (2013). On the origin of cancer metastasis. Critical Reviews™ in Oncogenesis, 18(1–2), 43–73. https://doi.org/10.1615/CritRevOncog.v18.i1-2.40
   PubMedGoogle Scholar
• Sharma, A., Sharma, L., Nandy, S. K., Payal, N., Yadav, S., Vargas-De-La-Cruz, C., Anwer, M. K., Khan, H., Behl, T., & Bungau, S. G. (2023). Molecular aspects and therapeutic implications of herbal compounds targeting different types of cancer. Molecules (Basel, Switzerland), 28(2), 750. https://doi.org/10.3390/molecules28020750
   PubMed Web of Science ®Google Scholar
• Shiomi, T., Lemaître, V., D'armiento, J., & Okada, Y. (2010). Matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs in non-neoplastic diseases. Pathology International, 60(7), 477–496. https://doi.org/10.1111/j.1440-1827.2010.02547.x
   PubMed Web of Science ®Google Scholar
• Song, Z., Wang, J., Su, Q., Luan, M., Chen, X., & Xu, X. (2021). The role of MMP-2 and MMP-9 in the metastasis and development of hypopharyngeal carcinoma. Brazilian Journal of Otorhinolaryngology, 87(5), 521–528. (https://doi.org/10.1016/j.bjorl.2019.10.009
   PubMed Web of Science ®Google Scholar
• Stacker, S. A., Caesar, C., Baldwin, M. E., Thornton, G. E., Williams, R. A., Prevo, R., Jackson, D. G., Nishikawa, S., Kubo, H., & Achen, M. G. (2001). VEGF-D promotes the metastatic spread of tumor cells via the lymphatics. Nature Medicine, 7(2), 186–191. https://doi.org/10.1038/84635
   PubMed Web of Science ®Google Scholar
• Sudevan, S. T., Oh, J. M., Abdelgawad, M. A., Abourehab, M. A., Rangarajan, T., Kumar, S., Ahmad, I., Patel, H., Kim, H., & Mathew, B. (2022). Introduction of benzyloxy pharmacophore into aryl/heteroaryl chalcone motifs as a new class of monoamine oxidase B inhibitors. Scientific Reports, 12(1), 22404. https://doi.org/10.1038/s41598-022-26929-x
   PubMed Web of Science ®Google Scholar
• Tai, W., He, L., Zhang, X., Pu, J., Voronin, D., Jiang, S., Zhou, Y., & Du, L. (2020). Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: Implication for development of RBD protein as a viral attachment inhibitor and vaccine. Cellular & Molecular Immunology, 17(6), 613–620. https://doi.org/10.1038/s41423-020-0400-4
   PubMed Web of Science ®Google Scholar
• Voron, T., Marcheteau, E., Pernot, S., Colussi, O., Tartour, E., Taieb, J., & Terme, M. (2014). Control of the immune response by pro-angiogenic factors. Frontiers in Oncology, 4, 70. https://doi.org/10.3389/fonc.2014.00070
   PubMedGoogle Scholar
• Vrba, J., Vrublova, E., Modriansky, M., & Ulrichova, J. (2011). Protopine and allocryptopine increase mRNA levels of cytochromes P450 1A in human hepatocytes and HepG2 cells independently of AhR. Toxicology Letters, 203(2), 135–141. https://doi.org/10.1016/j.toxlet.2011.03.015
   PubMed Web of Science ®Google Scholar
• Wu, F., Zhou, Y., Li, L., Shen, X., Chen, G., Wang, X., Liang, X., Tan, M., & Huang, Z. (2020). Computational approaches in preclinical studies on drug discovery and development. Frontiers in Chemistry, 8, 726. https://doi.org/10.3389/fchem.2020.00726
   PubMed Web of Science ®Google Scholar
• Yamamoto, Y., Matsui, J., Matsushima, T., Obaishi, H., Miyazaki, K., Nakamura, K., Tohyama, O., Semba, T., Yamaguchi, A., Hoshi, S. S., Mimura, F., Haneda, T., Fukuda, Y., Kamata, J. I., Takahashi, K., Matsukura, M., Wakabayashi, T., Asada, M., Nomoto, K. I., … Tsuruoka, A. (2014). Lenvatinib, an angiogenesis inhibitor targeting VEGFR/FGFR, shows broad antitumor activity in human tumor xenograft models associated with microvessel density and pericyte coverage. Vascular Cell, 6, 18. https://doi.org/10.1186/2045-824X-6-18
   PubMedGoogle Scholar
• Yuan, S., Chan, H. S., & Hu, Z. (2017). Using PyMOL as a platform for computational drug design. Wiley Interdisciplinary Reviews: Computational Molecular Science, 7(2), e1298.
   Web of Science ®Google Scholar
• Zala, A. R., Rajani, D. P., Ahmad, I., Patel, H., & Kumari, P. (2023). Synthesis, characterization, molecular dynamic simulation, and biological assessment of cinnamates linked to imidazole/benzimidazole as a CYP51 inhibitor. Journal of Biomolecular Structure & Dynamics, 1–17. https://doi.org/10.1080/07391102.2023.2170918
   Web of Science ®Google Scholar
• Zhao, Y., & Adjei, A. A. (2015). Targeting angiogenesis in cancer therapy: Moving beyond vascular endothelial growth factor. Oncologist, 20(6), 660–673. https://doi.org/10.1634/theoncologist.2014-0465
   PubMed Web of Science ®Google Scholar
• Zhou, D. C., Zittoun, R., & Marie, J. P. (1995). Homoharringtonine: An effective new natural product in cancer chemotherapy. Bulletin du Cancer, 82(12), 987–995.
   PubMed Web of Science ®Google Scholar
• Zittermann, S. I., & Issekutz, A. C. (2006). Endothelial growth factors VEGF and bFGF differentially enhance monocyte and neutrophil recruitment to inflammation. Journal of Leukocyte Biology, 80(2), 247–257. https://doi.org/10.1189/jlb.1205718
   PubMed Web of Science ®Google Scholar