69
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Evaluation of anticancer activity of Gmelina asiatica leaves, in-vitro and in-silico studies

, , , &
Received 25 Jul 2023, Accepted 21 Sep 2023, Published online: 03 Oct 2023

References

  • Balijepalli, M. K., Tandra, S., & Pichika, M. R. (2010). Antiproliferative activity and induction of apoptosis in estrogen receptor-positive and negative human breast carcinoma cell lines by Gmelina asiatica roots. Pharmacognosy Research, 2(2), 113–119. https://doi.org/10.4103/0974-8490.62949
  • Bhanukiran, K., Singh, S. K., Singh, R., Kumar, A., & Hemalatha, S. (2023a). Discovery of Multitarget-Directed Ligands from Piperidine Alkaloid Piperine as a Cap Group for the Management of Alzheimer’s Disease. ACS Chemical Neuroscience, 14(15), 2743–2760. https://doi.org/10.1021/acschemneuro.3c00269
  • Bhanukiran, K., T.a, G., Krishnamurthy, S., Singh, S. K., & Hemalatha, S. (2023b). Discovery of multi-target directed 3-OH pyrrolidine derivatives through a semisynthetic approach from alkaloid vasicine for the treatment of Alzheimer’s disease. European Journal of Medicinal Chemistry, 249, 115145. https://doi.org/10.1016/j.ejmech.2023.115145
  • Daina, A., Michielin, O., & Zoete, V. (2017). SwissADME: A free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Scientific Reports, 7(1), 42717. https://doi.org/10.1038/SREP42717
  • Das, B., Baidya, A. T., Devi, B., Rom, T., Paul, A. K., Thakur, B., Darreh-Shori, T., & Kumar, R. (2023). Synthesis, single crystal X-ray, DFT, spectroscopic, molecular docking studies and in vitro biological evaluation of compound N-benzyl-4-(4-chlorophenyl)-2-oxobutanamide. Journal of Molecular Structure, 1276, 134782. https://doi.org/10.1016/j.molstruc.2022.134782
  • De Cicco, P., Panza, E., Armogida, C., Ercolano, G., Cirino, G., & Ianaro, A. (2018). Current practices and awareness of anticancer plants in the traditional healthcare system. In M. S. Akhtar & M. K. Swamy (Eds.), Anticancer plants: Properties and Application (vol. 1, pp. 1–36). Springer.
  • Duenas-Gonzalez, A., Serrano-Olvera, A., Cetina, L., & Coronel, J. (2014). New molecular targets against cervical cancer. International Journal of Women’s Health, 6, 1023–1031. https://doi.org/10.2147/IJWH.S49471
  • El Fadili, M., Er-Rajy, M., Ali Eltayb, W., Kara, M., Imtara, H., Zarougui, S., Al-Hoshani, N., Hamadi, A., & Elhallaoui, M. (2023). An in-silico investigation based on molecular simulations of novel and potential brain-penetrant GluN2B NMDA receptor antagonists as anti-stroke therapeutic agents. Journal of Biomolecular Structure & Dynamics, 1–15. https://doi.org/10.1080/07391102.2023.2232024
  • Florence, A. R., & Balasingh, G. S. R. (2016). In vitro antibacterial activities of crude leaf extracts of Gmelina asiatica L. World Journal of Pharmaceutical Research, 5(12), 536–549.
  • Florence, A., & Jeeva, S. (2016). In vitro anticancer activity of gmelina asiatica l. leaf against human breast cancer cell line (MCF-7). International Journal of Pharmaceutical Sciences and Research, 7(5), 2116.
  • Florence, A., & Regini Balasingh, G. (2016). Phytochemical analysis of Gmelina asiatica L. leaves. Int. J. Chem. Stud, 4(6), 78–82.
  • Funaoka, K., Shindoh, M., Yamashita, T., Fujinaga, K., Amemiya, A., & Totsuka, Y. (1996). High-risk HPV-positive human cancer cell lines show different sensitivity to cisplatin-induced apoptosis correlated with the p21Waf1/Cip1 level. Cancer Letters, 108(1), 15–23. https://doi.org/10.1016/S0304-3835(96)04362-5
  • George, I. A., Chauhan, R., Dhawale, R., Iyer, R., Limaye, S., Sankaranarayanan, R., Venkataramanan, R., & Kumar, P. (2022). Insights into therapy resistance in cervical cancer. Advances in Cancer Biology - Metastasis, 6, 100074. https://doi.org/10.1016/j.adcanc.2022.100074
  • Girija, S., & Ravindhran, R. (2011). Identification of antioxidant potential of Gmelina asiatica. Biosciences Biotechnology Research Asia, 8(2), 845–848. https://doi.org/10.13005/bbra/948
  • Gomes, D., Silvestre, S., Duarte, A. P., Venuti, A., Soares, C. P., Passarinha, L., & Sousa, Â. (2021). In silico approaches: A way to unveil novel therapeutic drugs for cervical cancer management. Pharmaceuticals (Basel, Switzerland), 14(8), 741. https://doi.org/10.3390/ph14080741
  • Greenwell, M., & Rahman, P. (2015). Medicinal plants: Their use in anticancer treatment. International Journal of Pharmaceutical Sciences and Research, 6(10), 4103–4112. https://doi.org/10.13040/IJPSR.0975-8232.6(10).4103-12
  • Huang, M., Lu, J.-J., & Ding, J. (2021). Natural products in cancer therapy: Past, present and future. Natural Products and Bioprospecting, 11(1), 5–13. https://doi.org/10.1007/s13659-020-00293-7
  • Itte, P., Amshumali, M., & Pasha, M. (2017). Molecular modeling, geometry optimization and characterization of bimetallic complexes derived from s-indacene. Universal Journal of Chemistry, 5(3), 48–57. https://doi.org/10.13189/ujc.2017.050302
  • Kannan, R., Prasant, K., & Babu, U. (2012). Botanical pharmacognosy of stem of Gmelina asiatica Linn. Ancient Science of Life, 31(4), 190–193. https://doi.org/10.4103/0257-7941.107347
  • Khare, C. P. (2007). Gmelina asiatica Linn. In C. P. Khare (Ed.), Indian medicinal plants: An illustrated dictionary (pp. 1–1). Springer.
  • Kiruba, K. (2014). In vitro studies on nephroprotective efficacy of cynodon dactylon and Gmelina asiatica. Asian Journal of Pharmaceutical and Clinical Research, 7(4), 111–120.
  • Kumar, A., Rathi, E., & Kini, S. G. (2020). Drug repurposing approach for the identification and designing of potential E6 inhibitors against cervical cancer: An in silico investigation. Structural Chemistry, 31(1), 141–153. https://doi.org/10.1007/s11224-019-01378-x
  • Liu, L., Wang, M., Li, X., Yin, S., & Wang, B. (2021). An overview of novel agents for cervical cancer treatment by inducing apoptosis: Emerging drugs ongoing clinical trials and preclinical studies. Frontiers in Medicine, 8, 682366. https://doi.org/10.3389/fmed.2021.682366
  • Malecka, K. A., Fera, D., Schultz, D. C., Hodawadekar, S., Reichman, M., Donover, P. S., Murphy, M. E., & Marmorstein, R. (2014). Identification and characterization of small molecule human papillomavirus E6 inhibitors. ACS Chemical Biology, 9(7), 1603–1612. https://doi.org/10.1021/cb500229d
  • Mbemi, A., Khanna, S., Njiki, S., Yedjou, C. G., & Tchounwou, P. B. (2020). Impact of gene–environment interactions on cancer development. International Journal of Environmental Research and Public Health, 17(21), 8089. https://doi.org/10.3390/ijerph17218089
  • Merlin, N., & Parthasarathy, V. (2010). Potential antitumour activity of Gmelina asiatica aerial parts against Dalton Ascites Lymphoma in mice. Asian Journal of Chemistry, 22(4), 3193–3199.
  • Merlin, N., Parthasarathy, V., & Santhoshkumar, T. (2010). Induction of apoptosis in human breast cancer cell line MCF-7 by phytochemicals from Gmelina asiatica. African Journal of Biotechnology, 9(28), 4451–4456.
  • Morris, G. M., Huey, R., Lindstrom, W., Sanner, M. F., Belew, R. K., Goodsell, D. S., & Olson, A. J. (2009). AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. Journal of Computational Chemistry, 30(16), 2785–2791. https://doi.org/10.1002/jcc.21256
  • Mukherjee, S., Abdalla, M., Yadav, M., Madhavi, M., Bhrdwaj, A., Khandelwal, R., Prajapati, L., Panicker, A., Chaudhary, A., Albrakati, A., Hussain, T., Nayarisseri, A., & Singh, S. K. (2022). Structure-based virtual screening, molecular docking, and molecular dynamics simulation of VEGF inhibitors for the clinical treatment of Ovarian Cancer. Journal of Molecular Modeling, 28(4), 100. https://doi.org/10.1007/s00894-022-05081-3
  • Nabati, F., Moradi, M., & Mohabatkar, H. (2020). In silico analyzing the molecular interactions of plant-derived inhibitors against E6AP, p53, and c-Myc binding sites of HPV type 16 E6 oncoprotein. Molecular Biology Research Communications, 9(2), 71–82. https://doi.org/10.22099/MBRC.2020.36522.1483
  • Nasir, N. M., Alsalim, T. A., El-Arabey, A. A., & Abdalla, M. (2023). Anticancer, antioxidant activities and molecular docking study of thiazolidine-4-one and thiadiazol derivatives. Journal of Biomolecular Structure & Dynamics, 41(9), 3976–3992. https://doi.org/10.1080/07391102.2022.2060306
  • O'boyle, N. M., Tenderholt, A. L., & Langner, K. M. (2008). Cclib: A library for package‐independent computational chemistry algorithms. Journal of Computational Chemistry, 29(5), 839–845. https://doi.org/10.1002/JCC.20823
  • Rani, N., Rawat, K., Saini, M., Yadav, S., Syeda, S., Saini, K., & Shrivastava, A. (2023). Comparative In vitro anticancer study of cisplatin drug with green synthesized ZnO nanoparticles on cervical squamous carcinoma (SiHa) cell lines. ACS Omega, 8(16), 14509–14519. https://doi.org/10.1021/acsomega.2c08302
  • Ricci-López, J., Vidal-Limon, A., Zunñiga, M., Jimènez, V. A., Alderete, J. B., Brizuela, C. A., & Aguila, S. (2019). Molecular modeling simulation studies reveal new potential inhibitors against HPV E6 protein. PloS One, 14(3), e0213028. https://doi.org/10.1371/journal.pone.0213028
  • Seul, S. C. (2004). Bioinformatics and molecular design research center. PreADMET program. http://preadmet.bmdrc.org
  • Shiri Aghbash, P., Hemmat, N., Baradaran, B., & Bannazadeh Baghi, H. (2023). siRNA-E6 sensitizes HPV-16-related cervical cancer through Oxaliplatin: An in vitro study on anti-cancer combination therapy. European Journal of Medical Research, 28(1), 42. https://doi.org/10.1186/s40001-023-01014-9
  • Shivaji, K., Mani, S., Ponmurugan, P., De Castro, C. S., Lloyd Davies, M., Balasubramanian, M. G., & Pitchaimuthu, S. (2018). Green-synthesis-derived CdS quantum dots using tea leaf extract: Antimicrobial, bioimaging, and therapeutic applications in lung cancer cells. ACS Applied Nano Materials, 1(4), 1683–1693. https://doi.org/10.1021/acsanm.8b00147
  • Siegel, R. L., Miller, K. D., Fuchs, H. E., & Jemal, A. (2022). Cancer statistics, 2022. A Cancer Journal for Clinicians, 72(1), 7–33. https://doi.org/10.3322/caac.21708
  • Silvia, N., & Satyanaraya, T. (2014). Phytochemical and antioxidant studies on methanolic extract of Gmelina asiatica Linn stem. International Journal of Pharmacognosy and Phytochemical Research, 6(2), 276–281.
  • Soumia, M., Hajji, H., El Mzibri, M., Younes, F. Z., Mohammed, B., Mohamed, B., & Benaissa, M. (2022). In-silico molecular modeling studies to identify novel potential inhibitors of HPV E6 protein. Vaccines, 10(9), 1452. https://doi.org/10.3390/vaccines10091452
  • Sudhakar, M., Rao, C. V., Rao, P., & Raju, D. (2006). Evaluation of antimicrobial activity of Cleome viscosa and Gmelina asiatica. Fitoterapia, 77(1), 47–49. https://doi.org/10.1016/j.fitote.2005.08.003
  • Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. A Cancer Journal for Clinicians, 71(3), 209–249. https://doi.org/10.3322/caac.21660
  • Waghray, D., & Zhang, Q. (2018). Inhibit or evade multidrug resistance P-glycoprotein in cancer treatment. Journal of Medicinal Chemistry, 61(12), 5108–5121. https://doi.org/10.1021/acs.jmedchem.7b01457
  • Zhang, I. Y., Wu, J., & Xu, X. (2010). Extending the reliability and applicability of B3LYP. Chemical Communications (Cambridge, England), 46(18), 3057–3070. https://doi.org/10.1039/c000677g
  • Zhang, S., Xu, H., Zhang, L., & Qiao, Y. (2020). Cervical cancer: Epidemiology, risk factors and screening. Chinese Journal of Cancer Research = Chung-Kuo Yen Cheng Yen Chiu, 32(6), 720–728. https://doi.org/10.21147/j.issn.1000-9604.2020.06.05

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.