143
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Phytochemical composition, anti-microbial, anti-oxidant and anti-diabetic effects of Solanum elaeagnifolium Cav. leaves: in vitro and in silico assessments

, , , , , , , , , & show all
Received 09 Jun 2023, Accepted 20 Dec 2023, Published online: 05 Jan 2024

References

  • Adams, R. (2017). Identification of essential oil components by gas chromatography/mass spectrometry. Carol Stream: Allured Publishing Corporation. 456, 544–545.
  • Alajmi, M. F., Alam, P., Rehman, M. T., Husain, F. M., Khan, A. A., Siddiqui, N. A., Hussain, A., Kalam, M. A., & Parvez, M. K. (2018). Interspecies anticancer and antimicrobial activities of genus Solanum and estimation of rutin by validated UPLC-PDA method. Evidence-Based Complementary and Alternative Medicine: ECAM, 2018, e6040815. https://doi.org/10.1155/2018/6040815
  • Amalraj, S., Krupa, J., Sriramavaratharajan, V., Mariyammal, V., Murugan, R., & Ayyanar, M. (2021a). Chemical characterization, antioxidant, antibacterial and enzyme inhibitory properties of Canthium coromandelicum, a valuable source for bioactive compounds. Journal of Pharmaceutical and Biomedical Analysis, 192, 113620. https://doi.org/10.1016/j.jpba.2020.113620
  • Amalraj, S., Mariyammal, V., Murugan, R., Gurav, S. S., Krupa, J., & Ayyanar, M. (2021b). Comparative evaluation on chemical composition, in vitro antioxidant, antidiabetic and antibacterial activities of various solvent extracts of Dregea volubilis leaves. South African Journal of Botany, 138, 115–123. https://doi.org/10.1016/j.sajb.2020.12.013
  • Badawy, A., Zayed, R., Ahmed, S., & Hassanean, H. (2013). Phytochemical and pharmacological studies of Solanum elaeagnifolium growing in Egypt. Journal of Natural Products. 6, 156–167.
  • Balah, M. A., & AbdelRazek, G. M. (2020). Pesticidal activity of Solanum elaeagnifolium Cav. leaves against nematodes and perennial weeds. Acta Ecologica Sinica, 40(5), 373–379. https://doi.org/10.1016/j.chnaes.2019.07.001
  • Basnet, S., Marahatha, R., Shrestha, A., Bhattarai, S., Katuwal, S., Sharma, K. R., Marasini, B. P., Dahal, S. R., Basnyat, R. C., Patching, S. G., & Parajuli, N. (2022). In vitro and in silico studies for the identification of potent metabolites of some high-altitude medicinal plants from Nepal inhibiting SARS-CoV-2 spike protein. Molecules (Basel, Switzerland), 27(24), 8957. https://doi.org/10.3390/molecules27248957
  • Benayad, O., Bouhrim, M., Tiji, S., Kharchoufa, L., Addi, M., Drouet, S., Hano, C., Lorenzo, J. M., Bendaha, H., Bnouham, M., & Mimouni, M. (2021). Phytochemical profile, α-glucosidase, and α-amylase inhibition potential and toxicity evaluation of extracts from Citrus aurantium (L) peel, a valuable by-product from Northeastern Morocco. Biomolecules, 11(11), 1555. https://doi.org/10.3390/biom11111555
  • Bouslamti, M., El Barnossi, A., Kara, M., Alotaibi, B. S., Al Kamaly, O., Assouguem, A., Lyoussi, B., & Benjelloun, A. S. (2022). Total polyphenols content, antioxidant and antimicrobial activities of leaves of Solanum elaeagnifolium Cav. from Morocco. Molecules (Basel, Switzerland), 27(13), 4322. https://doi.org/10.3390/molecules27134322
  • Bouslamti, M., Loukili, E. H., Elrherabi, A., El Moussaoui, A., Chebaibi, M., Bencheikh, N., Nafidi, H. A., Bin Jardan, Y. A., Bourhia, M., Bnouham, M., Lyoussi, B., & Benjelloun, A. S. (2023). Phenolic profile, inhibition of α-amylase and α-glucosidase enzymes, and antioxidant properties of Solanum elaeagnifolium Cav. (Solanaceae): In vitro and in silico investigations. Processes, 11(5), 1384. https://doi.org/10.3390/pr11051384
  • Chen, C. (2016). Sinapic Acid and its derivatives as medicine in oxidative stress-induced diseases and aging. Oxidative Medicine and Cellular Longevity, 2016, 3571614. https://doi.org/10.1155/2016/3571614
  • Chen, C., Song, X., Wei, W., Zhong, H., Dai, J., Lan, Z., Li, F., Yu, X., Feng, Q., Wang, Z., Xie, H., Chen, X., Zeng, C., Wen, B., Zeng, L., Du, H., Tang, H., Xu, C., Xia, Y., … Jia, H. (2017). The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases. Nature Communications, 8(1), 1-11. https://doi.org/10.1038/s41467-017-00901-0
  • Cordero, C. S., Meve, U., & Alejandro, G. J. D. (2023). Ethnobotany and diversity of medicinal plants used among rural communities in Mina, Iloilo, Philippines: A quantitative study. Journal of Asia-Pacific Biodiversity, 16(1), 96–117. https://doi.org/10.1016/j.japb.2022.12.003
  • Dej-Adisai, S., Sakulkeo, O., Wattanapiromsakul, C., & Pitakbut, T. (2022). Flavonoid constituents and alpha-glucosidase inhibition of Solanum stramonifolium Jacq. inflorescence with in vitro and in silico studies. Molecules (Basel, Switzerland), 27(23), 8189. https://doi.org/10.3390/molecules27238189
  • Devaraji, V., Sivaraman, J., & Prabhu, S. (2023). Large-scale computational screening of Indian medicinal plants reveals Cassia angustifolia to be a potentially anti-diabetic. Journal of Biomolecular Structure & Dynamics, 41, 1–17. https://doi.org/10.1080/07391102.2023.2192886
  • Dwivedi, P. S. R., Patil, R., Khanal, P., Gurav, N. S., Murade, V. D., Hase, D. P., Kalaskar, M. G., Ayyanar, M., Chikhale, R. V., & Gurav, S. S. (2021). Exploring the therapeutic mechanisms of Cassia glauca in diabetes mellitus through network pharmacology, molecular docking and molecular dynamics. RSC Advances, 11(62), 39362–39375. https://doi.org/10.1039/d1ra07661b
  • El Ghouizi, A., Ousaaid, D., Laaroussi, H., Bakour, M., Aboulghazi, A., Soutien, R. S., Hano, C., & Lyoussi, B. (2023). Ficus carica (Linn.) leaf and bud extracts and their combination attenuates type-1 diabetes and its complications via the inhibition of oxidative stress. Foods (Basel, Switzerland), 12(4), 759. https://doi.org/10.3390/foods12040759
  • Feki, H., Koubaa, I., & Damak, M. (2014). Secondary metabolites and antioxidant activity of seed extracts from Solanum elaeagnifolium Cav. Mediterranean Journal of Chemistry, 2(5), 639–647. https://doi.org/10.13171/mjc.2.5.2014.05.01.22
  • Francis Xavier, T., Sabitha, R., & Balavivekananthan, S. (2022). In vitro pharmacological investigations of Oxystelma esculentum R.Br. and in silico molecular docking analysis of its leaf constituents on diabetic related target. South African Journal of Botany, 149, 320–338. https://doi.org/10.1016/j.sajb.2022.06.021
  • Hbika, A., Daoudi, N. E., Bouyanzer, A., Bouhrim, M., Mohti, H., Loukili, E. H., Mechchate, H., Al-Salahi, R., Nasr, F. A., Bnouham, M., & Zaid, A. (2022). Artemisia absinthium L. aqueous and ethyl acetate extracts: antioxidant effect and potential activity in vitro and in vivo against pancreatic α-amylase and intestinal α-glucosidase. Pharmaceutics, 14(3), 481. https://doi.org/10.3390/pharmaceutics14030481
  • Houda, M., Derbré, S., Jedy, A., Tlili, N., Legault, J., Richomme, P., Limam, F., & Saidani-Tounsi, M. (2014). Combined anti-ages and antioxidant activities of different solvent extracts of Solanum elaeagnifolium Cav (Solanacea) fruits during ripening and related to their phytochemical compositions. EXCLI Journal, 13, 1029–1042.
  • http://www.chemspider.com
  • http://www.rcsb.com
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464466/
  • Kalaimathi, K., Maria-Jancy-Rani, J., Manogar, P., Vijayakumar, S., Prakash, N., Karthikeyan, K., Thiyagarajan, G., Bhavani, K., & Prabhu, S. (2022a). In vitro and in silico strategies for the assessment of fungicidal compounds from the bark of Bauhinia racemosa against dermatitis: Clinical isolates. Integrative Medicine Reports, 1(1), 76–85. https://doi.org/10.1089/imr.2021.0022
  • Kalaimathi, K., Rani, J. M. J., Vijayakumar, S., Prakash, N., Karthikeyan, K., Thiyagarajan, G., Bhavani, K., Prabhu, S., & Varatharaju, G. (2022b). Anti-dengue potential of mangiferin: Intricate network of dengue to human genes. Revista Brasileira de Farmacognosia: Orgao Oficial da Sociedade Brasileira de Farmacognosia, 32(3), 410–420. https://doi.org/10.1007/s43450-022-00258-6
  • Kalaimathi, K., Thiyagarajan, G., Vijayakumar, S., Bhavani, K., Karthikeyan, K., Maria-Jancy-Rani, J., Dass, K., Sureshkumar, S., & Prabhu, S. (2021). Molecular docking and network pharmacology-based approaches to explore the potential of terpenoids for Mycobacterium tuberculosis. Pharmacological Research - Modern Chinese Medicine, 1, 100002. https://doi.org/10.1016/j.prmcm.2021.100002
  • Kandimalla, R., Kalita, S., Choudhury, B., & Kotoky, J. (2015). A review on anti-diabetic potential of genus Solanum (solanaceae). Journal of Drug Delivery and Therapeutics, 5(1), 24-27. https://doi.org/10.22270/jddt.v5i1.1026
  • Khatoon, U., Sharma, L., & Dubey, R. K. (2018). Assessment of bioactive compounds, antioxidative activity and quantification of phenols through HPLC in Solanum species. Ethno Med, 12(2), 87–95. https://doi.org/10.31901/24566772.2018/12.02.559
  • Khatoon, U., Sharma, L., & Dubey, R. K. (2018). Assessment of bioactive compounds, antioxidative activity and quantification of phenols through HPLC in Solanum species. Krishi.icar.gov.in. https://krishi.icar.gov.in/jspui/handle/123456789/21686
  • Krigas, N., Tsoktouridis, G., Anestis, I., Khabbach, A., Libiad, M., Megdiche-Ksouri, W., Ghrabi-Gammar, Z., Lamchouri, F., Tsiripidis, I., Tsiafouli, M. A., El Haissoufi, M., & Bourgou, S. (2021). Exploring the potential of neglected local endemic plants of three Mediterranean regions in the ornamental sector: Value chain feasibility and readiness timescale for their sustainable exploitation. Sustainability, 13(5), 2539. https://doi.org/10.3390/su13052539
  • Krupa, J., Murugan, R., Gangapriya, P., Amalraj, S., Gurav, S., Sam Arulraj, M., & Ayyanar, M. (2022). Moringa concanensis Nimmo. seed extracts as a potential source of bioactive molecules, antioxidants and enzyme inhibitors. Journal of Food Measurement and Characterization, 16(5), 3699–3711. https://doi.org/10.1007/s11694-022-01463-6
  • Kumar, R. S., Karthick Raja, N., Vijay, M., & Siva, C. (2016). Anti-oxidant, anti-diabetic, antimicrobial and hemolytic activity of Solanum torvum and Solanum trilobatum. Article in Journal of Pharmaceutical Sciences and Research, 8(8), 725–728.
  • Laaraj, N., Bouhrim, M., Kharchoufa, L., Tiji, S., Bendaha, H., Addi, M., Drouet, S., Hano, C., Lorenzo, J. M., Bnouham, M., & Mimouni, M. (2022). Phytochemical analysis, α-glucosidase and α-amylase inhibitory activities and acute toxicity studies of extracts from pomegranate (Punica granatum) bark, a valuable agro-industrial by-product. Foods (Basel, Switzerland), 11(9), 1353. https://doi.org/10.3390/foods11091353
  • Loukili, E. H., Bouchal, B., Bouhrim, M., Abrigach, F., Genva, M., Zidi, K., Bnouham, M., Bellaoui, M., Hammouti, B., Addi, M., Ramdani, M., & Fauconnier, M.-L. (2022). Chemical composition, antibacterial, antifungal and antidiabetic activities of ethanolic extracts of Opuntia dillenii fruits collected from Morocco. Journal of Food Quality, 2022, 1–15. https://doi.org/10.1155/2022/9471239
  • Mandal, S., Kumar, G., Das, S., Sahu, R., Venkidesh, R., & Dewanjee, S. (2008). Hepatoprotective and antioxidant activities of smilax chinensis l. root. Pharmacology, 2, 529–553.
  • Miao, M., & Xiang, L. (2020). Chapter three – Pharmacological action and potential targets of chlorogenic acid. Edited by G. Du. Academic Press. https://www.sciencedirect.com/science/article/abs/pii/S1054358919300729
  • Mohyuddin, A., Kurniawan, T. A., Khan, Z-U-D., Nadeem, S., Javed, M., Dera, A. A., Iqbal, S., Awwad, N. S., Ibrahium, H. A., Abourehab, M. A. S., Rabea, S., Elkaeed, E. B., Asghar, M. N., & Saeed, S. (2022). Comparative insights into the antimicrobial, antioxidant, and nutritional potential of the Solanum nigrum complex. Processes, 10(8), 1455. https://doi.org/10.3390/pr10081455
  • Mueed, A., Shibli, S., Al-Quwaie, D. A., Ashkan, M. F., Alharbi, M., Alanazi, H., Binothman, N., Aljadani, M., Majrashi, K. A., Huwaikem, M., Abourehab, M. A. S., Korma, S. A., & El-Saadony, M. T. (2023). Extraction, characterization of polyphenols from certain medicinal plants and evaluation of their antioxidant, antitumor, antidiabetic, antimicrobial properties, and potential use in human nutrition. Frontiers in Nutrition, 10, 1125106. https://doi.org/10.3389/fnut.2023.1125106
  • Muruhan, S., Selvaraj, S., & Viswanathan, P. K. (2013). In vitro antioxidant activities of Solanum surattense leaf extract. Asian Pacific Journal of Tropical Biomedicine, 3(1), 28–34. https://doi.org/10.1016/s2221-1691(13)60019-2
  • Oikonomakos, N. G. (2002). Glycogen phosphorylase as a molecular target for type 2 diabetes therapy. Current Protein & Peptide Science, 3(6), 561–586. https://doi.org/10.2174/1389203023380422
  • Parthiban, R., Vijayakumar, S., Prabhu, S., & Morvin Yabesh, J. G. E. (2016). Quantitative traditional knowledge of medicinal plants used to treat livestock diseases from Kudavasal taluk of Thiruvarur district, Tamil Nadu, India. Revista Brasileira de Farmacognosia, 26(1), 109–121. https://doi.org/10.1016/j.bjp.2015.07.016
  • Pirolli, D., Righino, B., Camponeschi, C., Ria, F., Di-Sante, G., & De-Rosa, M. C. (2023). Virtual screening and molecular dynamics simulations provide insight into repurposing drugs against SARS-CoV-2 variants spike protein/ACE2 interface. Scientific Reports, 13(1), 1494. https://doi.org/10.1038/s41598-023-28716-8
  • Prabhu, S., Vijayakumar, S., & Praseetha, P. (2022). Cyanobacterial metabolites as novel drug candidates in corona viral therapies: A review. Chronic Diseases and Translational Medicine, 8(3), 172–183. https://doi.org/10.1002/cdt3.11
  • Prabhu, S., Vijayakumar, S., Kothandaraman, S., & Manogar, P. (2018). Anti-diabetic activity of quercetin extracted from Phyllanthus emblica L. fruit: In silico and in vivo approaches. Journal of Pharmaceutical Analysis, 8(2), 109–118. https://doi.org/10.1016/j.jpha.2017.10.005
  • Prabhu, S., Vijayakumar, S., Thilaka, G., Karthikeyan, K., Sureshkumar, J., & Manogar, P. (2022). A survey on medicinal plant knowledge among the indigenous communities (Tamilians) in the delta regions of Tamil Nadu, India. Journal of Herbs, Spices & Medicinal Plants, 28(1), 36–72. https://doi.org/10.1080/10496475.2021.1962474
  • Rajasulochana, P., Battineni, A., & Fahira Tasneem, S. (2021). Comparative analysis of in vitro antidiabetic activity of wild and micropropagated Solanum trilobatum L. Journal of Physics: Conference Series, 1979(1), 012013. https://doi.org/10.1088/1742-6596/1979/1/012013
  • Rani, A. C., Kalaimathi, K., Jayasree, S., Prabhu, S., Vijayakumar, S., Ramasubbu, R., & Priya, N. S. (2022). Exploring the drug potential of phytochemicals as a novel therapeutic drug candidate for herpesvirus: An in-silico evaluation. Chemistry Africa, 6(2), 805–818. https://doi.org/10.1007/s42250-022-00529-8
  • Renganathan, S., Manokaran, S., Vasanthakumar, P., Singaravelu, U., Kim, P. S., Kutzner, A., & Heese, K. (2021). Phytochemical profiling in conjunction with in vitro and in silico studies to identify human α-amylase inhibitors in Leucaena leucocephala (Lam.) De Wit for the treatment of diabetes mellitus. ACS Omega, 6(29), 19045–19057. https://doi.org/10.1021/acsomega.1c02350
  • Rifaioglu, A. S., Atas, H., Martin, M. J., Cetin-Atalay, R., Atalay, V., & Doğan, T. (2019). Recent applications of deep learning and machine intelligence on in silico drug discovery: Methods, tools and databases. Briefings in Bioinformatics, 20(5), 1878–1912. https://doi.org/10.1093/bib/bby061
  • Rizvi, S. A. A., Einstein, G. P., Tulp, O. L., Sainvil, F., & Branly, R. (2022). Introduction to traditional medicine and their role in prevention and treatment of emerging and re-emerging diseases. Biomolecules, 12(10), 1442. https://doi.org/10.3390/biom12101442
  • Robak, J., & Gryglewski, R. J. (1988). Flavonoids are scavengers of superoxide anions. Biochemical Pharmacology, 37(5), 837–841. https://doi.org/10.1016/0006-2952(88)90169-4
  • Roberts, J., & Florentine, S. (2022). Biology, distribution and management of the globally invasive weed Solanum elaeagnifolium Cav (silver leaf nightshade): A global review of current and future management challenges. Weed Research, 62(6), 393–403. https://doi.org/10.1111/wre.12556
  • Rondilla, N. A., Rocha, I. C. N., Roque, S. J., Lu, R. M., Apolinar, N. L. B., Solaiman-Balt, A. A., Abion, T. J., Banatin, P. B., & Javier, C. V. (2021). Folk medicine in the Philippines: A phenomenological study of health-seeking individuals. International Journal of Medical Students, 9(1), 25–32. https://doi.org/10.5195/ijms.2021.849
  • Sangeetha, M., Vijayakumar, S., Prabhu, S., & Manogar, P. (2018). In-silico and in-vitro studies on Lyngbya majuscula using against lung cancer cell line (A549). Pharmacogn J, 10(3), 421–428. https://doi.org/10.5530/pj.2018.3.69
  • Saraswathi, K., Bharkavi, R., Khusro, A., Sivaraj, C., Arumugam, P., Alghamdi, S., Dablool, A. S., Almehmadi, M., Bannunah, A. M., & Sahibzada, M. U. K. (2021). Assessment on in vitro medicinal properties and chemical composition analysis of Solanum virginianum dried fruits. Arabian Journal of Chemistry, 14(12), 103442. https://doi.org/10.1016/j.arabjc.2021.103442
  • Satyanarayana, N., Chinni, S. V., Gobinath, R., Sunitha, P., Uma Sankar, A., & Muthuvenkatachalam, B. S. (2022). Antidiabetic activity of Solanum torvum fruit extract in streptozotocin-induced diabetic rats. Frontiers in Nutrition, 9, 987552. https://doi.org/10.3389/fnut.2022.987552
  • Selvi, R., & Yogananth, N. (2016). In vitro evaluation of antidiabetic potential of leaf and stem extracts of Solanum xanthocarpum and Solanum nigrum. International Journal of Advanced Research in Biological Sciences, 3(12), 191–195.
  • Sivaraj, C., Yamini, S., Yahavi, A., Praveen Kumar, R., Arumugam, P., & Manimaaran, A. (2020). Antioxidant, antimicrobial activities and GCMS analysis of fruit extract of Solanum nigrum L. Journal of Pharmacognosy and Phytochemistry, 9(4), 1114–1121.
  • Sowndhararajan, K., & Kang, S. C. (2013). Free radical scavenging activity from different extracts of leaves of Bauhinia vahlii Wight & Arn. Saudi Journal of Biological Sciences, 20(4), 319–325. https://doi.org/10.1016/j.sjbs.2012.12.005
  • Sridevi, M., Kalaiarasi, P., & Pugalendi, K. V. (2011). Antihyperlipidemic activity of alcoholic leaf extract of Solanum surattense in streptozotocin-diabetic rats. Asian Pacific Journal of Tropical Biomedicine, 1(2), S276–S280. https://doi.org/10.1016/S2221-1691(11)60171-8
  • Sultana, B., Anwar, F., & Ashraf, M. (2009). Effect of extraction solvent/technique on the antioxidant activity of selected medicinal plant extracts. Molecules (Basel, Switzerland), 14(6), 2167–2180. https://doi.org/10.3390/molecules14062167
  • Sun, L., & Miao, M. (2020). Dietary polyphenols modulate starch digestion and glycaemic level: A review. Critical Reviews in Food Science and Nutrition, 60(4), 541–555. https://doi.org/10.1080/10408398.2018.1544883
  • Sureshkumar, J., Ayyanar, M., & Silambarasan, R. (2021). Ethnomedicinal uses, phytoconstituents and pharmacological importance of pteridophytes used by Malayalis in Kolli hills, India: A quantitative survey. Journal of Herbal Medicine, 25, 100418. https://doi.org/10.1016/j.hermed.2020.100418
  • Tajik, N., Tajik, M., Mack, I., & Enck, P. (2017). The potential effects of chlorogenic acid, the main phenolic components in coffee, on health: A comprehensive review of the literature. European Journal of Nutrition, 56(7), 2215–2244. https://doi.org/10.1007/s00394-017-1379-1
  • Thangaraj, P. (2016). Pharmacological Assays of Plant-Based Natural Products. Progress in Drug Research (vol. 71, pp. 49–55). Springer.
  • Torres-León, C., Ramírez, F. R., Aguirre-Joya, J. A., Ramírez-Moreno, A., Chávez-González, M. L., Aguillón-Gutierrez, D. R., Camacho-Guerra, L., Ramírez-Guzmán, N., Vélez, S. H., & Aguilar, C. N. (2023). Medicinal plants used by rural communities in the arid zone of Viesca and Parras Coahuila in northeast Mexico. Saudi Pharmaceutical Journal: SPJ: The Official Publication of the Saudi Pharmaceutical Society, 31(1), 21–28. https://doi.org/10.1016/j.jsps.2022.11.003
  • Yulia Putri, N. S. Y., Islami, D., Tresna, A. T., Hidayah, L. N., Mubarakati, N. J., & Jayanti, G. E. (2022). September. Molecular Docking Study of Takokak Plants (Solanum torvum) to α-glucosidase as Antidiabetic Type-2. In International Conference On Indigenous Knowledge For Sustainable Agriculture, 1–7. https://doi.org/10.35334/iciksa.v0i0.65

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.