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Research Article

Chinese herb couple against diabetes: integrating network pharmacology and mechanism study

, , , , &
Received 25 Aug 2023, Accepted 30 Jan 2024, Published online: 12 Feb 2024

References

  • Abdel-Moneim, A., Bakery, H. H., & Allam, G. (2018). The potential pathogenic role of IL-17/Th17 cells in both type 1 and type 2 diabetes mellitus. Biomedicine & Pharmacotherapy, 101, 287–292. https://doi.org/10.1016/j.biopha.2018.02.103
  • Akbari, M., & Hassan-Zadeh, V. (2018). IL-6 signalling pathways and the development of type 2 diabetes. Inflammopharmacology, 26(3), 685–698. https://doi.org/10.1007/s10787-018-0458-0
  • Albury-Warren, T. M., Pandey, V., Spinel, L. P., Masternak, M. M., & Altomare, D. A. (2016). Prediabetes linked to excess glucagon in transgenic mice with pancreatic active AKT1. Journal of Endocrinology, 228(1), 49–59. https://doi.org/10.1530/JOE-15-0288
  • Archundia Herrera, M. C., Subhan, F. B., & Chan, C. B. (2017). Dietary patterns and cardiovascular disease risk in people with type 2 diabetes. Current Obesity Reports, 6(4), 405–413. https://doi.org/10.1007/s13679-017-0284-5
  • Cai, Y., Liu, L., Xia, M., Tian, C., Wu, W., Dong, B., & Chu, X. (2022). SEDDS facilitate cinnamaldehyde crossing the mucus barrier: The perspective of mucus and Caco-2/HT29 co-culture models. International Journal of Pharmaceutics, 614, 121461. https://doi.org/10.1016/j.ijpharm.2022.121461
  • Chandramohan, R., & Pari, L. (2021). Antihyperlipidemic effect of tyrosol, a phenolic compound in streptozotocin-induced diabetic rats. Toxicology Mechanisms and Methods, 31(7), 507–516. https://doi.org/10.1080/15376516.2021.1926030
  • Chen, Q., & Lv, M. (2020). Clinical study of modified Huangqi Guizhi Wuwu decoction combined with western medicine in the treatment of diabetic peripheral neuropathy. China Journal of Pharmaceutical Economics, 15(03), 63–66.
  • Chen, G. M., Zhong, X. Y., Zhao, J. L., Huang, Y., Lin, H. R., Liang, M. Z., Liu, Y. Y., Yu, J. W., Huang, R. L., & Liu, M. (2018). Prediction of targets and mechanism of Astragalus and Gui Zhi Wu Wu Wu Tang for the treatment of diabetic peripheral neuropathy. Chinese Journal of Experimental Formulas, 24(08), 214–222.
  • Dandawate, S., Williams, L., Joshee, N., Rimando, A. M., Mittal, S., Thakur, A., Lum, L. G., & Parajuli, P. (2012). Scutellaria extract and wogonin inhibit tumor-mediated induction of T(reg) cells via inhibition of TGF-beta1 activity. Cancer Immunology, Immunotherapy: CII, 61(5), 701–711. https://doi.org/10.1007/s00262-011-1130-3
  • Dong, B., Chen, J., Cai, Y., Wu, W., & Chu, X. (2022). In vitro and in vivo evaluation of cinnamaldehyde Microemulsion-Mucus interaction. Journal of Food Biochemistry, 46(10), e14307.
  • Ellingsgaard, H., Ehses, J. A., Hammar, E. B., Van Lommel, L., Quintens, R., Martens, G., Kerr-Conte, J., Pattou, F., Berney, T., Pipeleers, D., Halban, P. A., Schuit, F. C., & Donath, M. Y. (2008). Interleukin-6 regulates pancreatic alpha-cell mass expansion. Proceedings of the National Academy of Sciences of the USA, 105(35), 13163–13168. https://doi.org/10.1073/pnas.0801059105
  • GBD 2021 Diabetes Collaborators. (2023). Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: A systematic analysis for the Global Burden of Disease Study 2021 [published correction appears in Lancet. Lancet (London, England), 402(10397), 203–234. https://doi.org/10.1016/S0140-6736(23)01301-6
  • Goodsell, D. S., Zardecki, C., Di Costanzo, L., Duarte, J. M., Hudson, B. P., Persikova, I., Segura, J., Shao, C., Voigt, M., Westbrook, J. D., Young, J. Y., & Burley, S. K. (2020). RCSB Protein Data Bank: Enabling biomedical research and drug discovery. Protein Science, 29(1), 52–65. https://doi.org/10.1002/pro.3730
  • Guo, W., Huang, J., Wang, N., Tan, H. Y., Cheung, F., Chen, F., & Feng, Y. (2019). Integrating network pharmacology and pharmacological evaluation for deciphering the action mechanism of herbal formula Zuojin Pill in suppressing hepatocellular carcinoma. Frontiers in Pharmacology, 10, 1185. https://doi.org/10.3389/fphar.2019.01185
  • Hamilton, K. E., Rekman, J. F., Gunnink, L. K., Busscher, B. M., Scott, J. L., Tidball, A. M., Stehouwer, N. R., Johnecheck, G. N., Looyenga, B. D., & Louters, L. L. (2018). Quercetin inhibits glucose transport by binding to an exofacial site on GLUT1. Biochimie, 151, 107–114. https://doi.org/10.1016/j.biochi.2018.05.012
  • Hu, Y., Wang, J., Zhou, Y., Xie, H., Yan, X., Chu, X., Chen, W., Liu, Y., Wang, X., Wang, J., Zhang, A., & Han, S. (2019). Peptidomics analysis of umbilical cord blood reveals potential preclinical biomarkers for neonatal respiratory distress syndrome. Life Sciences, 236, 116737. https://doi.org/10.1016/j.lfs.2019.116737
  • Huang, C. Y., Wu, C. L., Yang, Y. C., Chang, J. W., Kuo, Y. C., Cheng, Y. Y., Wu, J. S., Lee, C. C., & Guo, H. R. (2015). Association between dioxin and diabetes mellitus in an endemic area of exposure in Taiwan: A population-based study. Medicine, 94(42), e1730. https://doi.org/10.1097/MD.0000000000001730
  • Javeed, N., & Matveyenko, A. V. (2018). Circadian etiology of type 2 diabetes mellitus. Physiology (Bethesda, Md.), 33(2), 138–150. https://doi.org/10.1152/physiol.00003.2018
  • Jia, W., Weng, J., & Zhu, D. (2019). Standards of medical care for type 2 diabetes in China 2019. Diabetes Metabolism Research and Reviews, 35(6), e3158.
  • Khan, M. A. B., Hashim, M. J., King, J. K., Govender, R. D., Mustafa, H., & Al Kaabi, J. (2020). Epidemiology of type 2 diabetes - global burden of disease and forecasted trends. Journal of Epidemiology and Global Health, 10(1), 107–111. https://doi.org/10.2991/jegh.k.191028.001
  • Leach, M. J., & Kumar, S. (2012). Cinnamon for diabetes mellitus. Cochrane Database of Systematic Reviews, 2012(9), CD007170.
  • Li, M., Han, B., Zhao, H., Xu, C., Xu, D., Sieniawska, E., Lin, X., & Kai, G. (2022). Biological active ingredients of Astragali radix and its mechanisms in treating cardiovascular and cerebrovascular diseases. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology, 98, 153918. https://doi.org/10.1016/j.phymed.2021.153918
  • Lind, P. M., & Lind, L. (2018). Endocrine-disrupting chemicals and risk of diabetes: An evidence-based review. Diabetologia, 61(7), 1495–1502. https://doi.org/10.1007/s00125-018-4621-3
  • Li, X. Y., Shen, L., & Ji, H. F. (2019). Astragalus alters gut-microbiota composition in type 2 diabetes mice: Clues to its pharmacology. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 12, 771–778. https://doi.org/10.2147/DMSO.S203239
  • Liu, L., Cao, W., Xia, M., Tian, C., Wu, W., Cai, Y., & Chu, X. (2022). Self-emulsifying drug delivery system enhances tissue distribution of cinnamaldehyde by altering the properties of the mucus layer. AAPS PharmSciTech, 23(7), 261. https://doi.org/10.1208/s12249-022-02416-4
  • Liu, L., Chu, X., Tian, C., Xia, M., Zhang, L., Jiang, J., & Gui, S. (2021). Chemo proling and simultaneous analysis of different combinations of sinomenii caulis and ramulus cinnamomi using UHPLC-Q-TOF-MS, GC-MS and HPLC methods. Journal of Chromatographic Science, 59(7), 606–617. https://doi.org/10.1093/chromsci/bmab048
  • Liu, Y., Deng, J., & Fan, D. (2019). Ginsenoside Rk3 ameliorates high-fat-diet/streptozocin induced type 2 diabetes mellitus in mice via the AMPK/Akt signaling pathway. Food & Function, 10(5), 2538–2551. https://doi.org/10.1039/c9fo00095j
  • Liu, K., Yang, Y., Zhou, F., Xiao, Y., & Shi, L. (2020). Inhibition of PI3K/AKT/mTOR signaling pathway promotes autophagy and relieves hyperalgesia in diabetic rats. Neuroreport, 31(9), 644–649. https://doi.org/10.1097/WNR.0000000000001461
  • Li, C., Zhang, K., Liu, L., Shen, J., Wang, Y., Tan, Y., Feng, X., Liu, W., Zhang, H., & Sun, J. (2023). Study of the mechanism of astragali radix in treating type 2 diabetes mellitus and its renal protection based on enzyme activity, network pharmacology, and experimental verification. Molecules (Basel, Switzerland), 28(24), 8030. https://doi.org/10.3390/molecules28248030
  • Matsuda, S., Nakanishi, A., Wada, Y., & Kitagishi, Y. (2013). Roles of PI3K/AKT/PTEN pathway as a target for pharmaceutical therapy. The Open Medicinal Chemistry Journal, 7(1), 23–29. https://doi.org/10.2174/1874104501307010023
  • Melmer, A., & Laimer, M. (2016). Treatment goals in diabetes. Endocrine Development, 31, 1–27. https://doi.org/10.1159/000439364
  • Miossec, P., & Kolls, J. K. (2012). Targeting IL-17 and TH17 cells in chronic inflammation. Nature Reviews. Drug Discovery, 11(10), 763–776. https://doi.org/10.1038/nrd3794
  • Naz, S., Shafique, N., Sharif, S., Manzoor, F., Saifi, S. Z., Firasat, S., & Kaul, H. (2020). Association of interleukin 10 (IL-10) gene with type 2 diabetes mellitus by single nucleotide polymorphism of its promotor region G/A 1082. Critical Reviews in Eukaryotic Gene Expression, 30(4), 285–289. https://doi.org/10.1615/CritRevEukaryotGeneExpr.2020030714
  • Nogales, C., Mamdouh, Z. M., List, M., Kiel, C., Casas, A. I., & Schmidt, H. (2022). Network pharmacology: Curing causal mechanisms instead of treating symptoms. Trends in Pharmacological Sciences, 43(2), 136–150. https://doi.org/10.1016/j.tips.2021.11.004
  • Ojo, O. (2019). Dietary intake and type 2 diabetes. Nutrients, 11(9), 2177. https://doi.org/10.3390/nu11092177
  • Oza, M. J., & Kulkarni, Y. A. (2018). Formononetin treatment in type 2 diabetic rats reduces insulin resistance and hyperglycemia. Frontiers in Pharmacology, 9, 739. https://doi.org/10.3389/fphar.2018.00739
  • Oza, M. J., & Kulkarni, Y. A. (2019). Formononetin attenuates kidney damage in type 2 diabetic rats. Life Sciences, 219, 109–121. https://doi.org/10.1016/j.lfs.2019.01.013
  • Papadopoulou, S. K., Papandreou, D., Tassoulas, E., Biskanaki, F., Kalogiannis, S., & Hassapidou, M. N. (2020). Gender and exercise in relation to obesity in greek elderly population. International Journal of Environmental Research and Public Health, 17(18), 6575.
  • Peng, P., Zhang, B., Huang, J., Xing, C., Liu, W., Sun, C., Guo, W., Yao, S., Ruan, W., Ning, G., Kong, X., & Feng, S. (2020). Identification of a circRNA-miRNA-mRNA network to explore the effects of circRNAs on pathogenesis and treatment of spinal cord injury. Life Sciences, 257, 118039. https://doi.org/10.1016/j.lfs.2020.118039
  • Plotnikov, M. B., & Plotnikova, T. M. (2021). Tyrosol as a neuroprotector: strong effects of a “weak” antioxidant. Current Neuropharmacology, 19(4), 434–448. https://doi.org/10.2174/1570159X18666200507082311
  • Ranasinghe, P., Galappaththy, P., Constantine, G. R., Jayawardena, R., Weeratunga, H. D., Premakumara, S., & Katulanda, P. (2017). Cinnamomum zeylanicum (Ceylon cinnamon) as a potential pharmaceutical agent for type-2 diabetes mellitus: Study protocol for a randomized controlled trial. Trials, 18(1), 446. https://doi.org/10.1186/s13063-017-2192-0
  • Ranasinghe, P., Jayawardana, R., Galappaththy, P., Constantine, G. R., de Vas Gunawardana, N., & Katulanda, P. (2012). Efficacy and safety of 'true’ cinnamon (Cinnamomum zeylanicum) as a pharmaceutical agent in diabetes: A systematic review and meta-analysis. Diabetic Medicine, 29(12), 1480–1492. https://doi.org/10.1111/j.1464-5491.2012.03718.x
  • Ru, J., Li, P., Wang, J., Zhou, W., Li, B., Huang, C., Li, P., Guo, Z., Tao, W., Yang, Y., Xu, X., Li, Y., Wang, Y., & Yang, L. (2014). TCMSP: A database of systems pharmacology for drug discovery from herbal medicines. Journal of Cheminformatics, 6(1), 13. https://doi.org/10.1186/1758-2946-6-13
  • Saxton, R. A., Tsutsumi, N., Su, L. L., Abhiraman, G. C., Mohan, K., Henneberg, L. T., Aduri, N. G., Gati, C., & Garcia, K. C. (2021). Structure-based decoupling of the pro- and anti-inflammatory functions of interleukin-10. Science (New York, N.Y.), 371(6535), eabc8433. https://doi.org/10.1126/science.abc8433
  • Schmidt, A. M. (2019). Diabetes mellitus and cardiovascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 39(4), 558–568. https://doi.org/10.1161/ATVBAHA.119.310961
  • Short, W. D., Steen, E., Kaul, A., Wang, X., Olutoye, O. O., 2nd, Vangapandu, H. V., Templeman, N., Blum, A. J., Moles, C. M., Narmoneva, D. A., Crombleholme, T. M., Butte, M. J., Bollyky, P. L., Keswani, S. G., & Balaji, S. (2022). IL-10 promotes endothelial progenitor cell infiltration and wound healing via STAT3. Faseb Journal, 36(7), e22298.
  • Sidhu, H., & Capalash, N. (2021). Synergistic anti-cancer action of salicylic acid and cisplatin on HeLa cells elucidated by network pharmacology and in vitro analysis. Life Sciences, 282, 119802. https://doi.org/10.1016/j.lfs.2021.119802
  • Wang, X., & Zhao, L. (2016). Calycosin ameliorates diabetes-induced cognitive impairments in rats by reducing oxidative stress via the PI3K/Akt/GSK-3beta signaling pathway. Biochemical and Biophysical Research Communications, 473(2), 428–434. https://doi.org/10.1016/j.bbrc.2016.03.024
  • Wu, Y., Ding, Y., Tanaka, Y., & Zhang, W. (2014). Risk factors contributing to type 2 diabetes and recent advances in the treatment and prevention. International Journal of Medical Sciences, 11(11), 1185–1200. https://doi.org/10.7150/ijms.10001
  • Wu, L., Meng, Y., Xu, Y., & Chu, X. (2022). Improved uptake and bioavailability of cinnamaldehyde via solid lipid nanoparticles for oral delivery. Pharmaceutical Development and Technology, 27(10), 1038–1048. https://doi.org/10.1080/10837450.2022.2147542
  • Xia, Q. D., Xun, Y., Lu, J. L., Lu, Y. C., Yang, Y. Y., Zhou, P., Hu, J., Li, C., & Wang, S. G. (2020). Network pharmacology and molecular docking analyses on Lianhua Qingwen capsule indicate Akt1 is a potential target to treat and prevent COVID-19. Cell Proliferation, 53(12), e12949.
  • Xiao, F., Zhou, C., & Cao, M. (2022). Effect of Huangqi Guizhi Wuwutang on diabetic peripheral neuropathy in mkr mice via regulating endoplasmic reticulum stress. Chinese Journal of Experimental Traditional Medical Formulae, 228(16), 1–8.
  • Xu, J., Zhang, Z., Zhou, K., Li, Y., Wan, J., Mao, T., Ji, X., Liu, J., & Lin, Q. (2021). Integration of network pharmacology and molecular docking technology reveals the mechanism of the herbal pairing of Codonopsis Pilosula (Franch.) Nannf and Astragalus Membranaceus (Fisch.) Bge on chronic heart failure. Annals of Palliative Medicine, 10(7), 7942–7959. https://doi.org/10.21037/apm-21-1469
  • Yang, J. H., Shin, B. Y., Han, J. Y., Kim, M. G., Wi, J. E., Kim, Y. W., Cho, I. J., Kim, S. C., Shin, S. M., & Ki, S. H. (2014). Isorhamnetin protects against oxidative stress by activating Nrf2 and inducing the expression of its target genes. Toxicology and Applied Pharmacology, 274(2), 293–301. https://doi.org/10.1016/j.taap.2013.10.026
  • Ye, J., Li, L., & Hu, Z. (2021). Exploring the molecular mechanism of action of Yinchen Wuling powder for the treatment of hyperlipidemia, using network pharmacology, molecular docking, and molecular dynamics simulation. BioMed Research International, 2021, 9965906–9965914. https://doi.org/10.1155/2021/9965906
  • Yong, Z., Xingqi, W., Jie, H., Rongfeng, H., & Xiaoqin, C. (2020). Formulation, production, in vitro release and in vivo pharmacokinetics of cinnamaldehyde sub-micron emulsions. Pharmaceutical Development and Technology, 25(6), 676–685. https://doi.org/10.1080/10837450.2020.1729800
  • Zepp, J., Wu, L., & Li, X. (2011). IL-17 receptor signaling and T helper 17-mediated autoimmune demyelinating disease. Trends in Immunology, 32(5), 232–239. https://doi.org/10.1016/j.it.2011.02.007
  • Zhang, X. Q., & Li, L. (2021). Biological function and clinical value of VPS13A in Pan-Cancer based on bioinformatics analysis. International Journal of General Medicine, 14, 6825–6838. https://doi.org/10.2147/IJGM.S330256
  • Zhang, X., Ramírez, C. M., Aryal, B., Madrigal-Matute, J., Liu, X., Diaz, A., Torrecilla-Parra, M., Suárez, Y., Cuervo, A. M., Sessa, W. C., & Fernández-Hernando, C. (2020). Cav-1 (Caveolin-1) deficiency increases autophagy in the endothelium and attenuates vascular inflammation and atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 40(6), 1510–1522. https://doi.org/10.1161/ATVBAHA.120.314291
  • Zhao, Q., Zheng, B., Feng, P., & Li, X. (2021). A study to decipher the potential effects of butylphthalide against central nervous system diseases based on network pharmacology and molecular docking integration strategy. Evidence-Based Complementary and Alternative Medicine: ECAM, 2021, 6694698. https://doi.org/10.1155/2021/6694698
  • Zhou, X., Du, J., Liu, C., Zeng, H., Chen, Y., Liu, L., & Wu, D. (2021). A pan-cancer analysis of CD161, a potential new immune checkpoint. Frontiers in Immunology, 12, 688215. https://doi.org/10.3389/fimmu.2021.688215

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