Network pharmacology integrated molecular docking of fucoidan against oral cancer and in vitro evaluation- A study using GEO datasets

References

• Ahmed, S. R., Al-Sanea, M. M., Mostafa, E. M., Qasim, S., Abelyan, N., & Mokhtar, F. A. (2022). A network pharmacology analysis of cytotoxic triterpenes isolated from Euphorbia abyssinica latex supported by drug-likeness and ADMET studies. ACS Omega, 7(21), 17713–17722. https://doi.org/10.1021/acsomega.2c00750
   PubMed Web of Science ®Google Scholar
• Ain-Ali, Q., Mushtaq, N., Amir, R., Gul, A., Tahir, M., & Munir, F. (2021). Genome-wide promoter analysis, homology modeling and protein interaction network of Dehydration Responsive Element Binding (DREB) gene family in Solanum tuberosum. PloS One, 16(12), e0261215. https://doi.org/10.1371/journal.pone.0261215
   PubMed Web of Science ®Google Scholar
• Alwarsamy, M., Gooneratne, R., & Ravichandran, R. (2016). Effect of fucoidan from Turbinaria conoides on human lung adenocarcinoma epithelial (A549) cells. Carbohydrate Polymers, 152, 207–213. https://doi.org/10.1016/j.carbpol.2016.06.112
   PubMed Web of Science ®Google Scholar
• Ambatipudi, S., Gerstung, M., Pandey, M., Samant, T., Patil, A., Kane, S., Desai, R. S., Schäffer, A. A., Beerenwinkel, N., & Mahimkar, M. B. (2012). Genome-wide expression and copy number analysis identifies driver genes in gingivobuccal cancers. Genes, Chromosomes & Cancer, 51(2), 161–173. https://doi.org/10.1002/gcc.20940
   PubMed Web of Science ®Google Scholar
• Atashrazm, F., Lowenthal, R. M., Woods, G. M., Holloway, A. F., & Dickinson, J. L. (2015). Fucoidan and cancer: A multifunctional molecule with anti-tumor potential. Marine Drugs, 13(4), 2327–2346. https://doi.org/10.3390/md13042327
   PubMed Web of Science ®Google Scholar
• Atyeo, N., Rodriguez, M. D., Papp, B., & Toth, Z. (2021). Clinical manifestations and epigenetic regulation of oral herpesvirus infections. Viruses, 13(4), 681. https://doi.org/10.3390/v13040681
   PubMed Web of Science ®Google Scholar
• Babiuch, K., Kuśnierz-Cabala, B., Kęsek, B., Okoń, K., Darczuk, D., & Chomyszyn-Gajewska, M. (2020). Evaluation of proinflammatory, NF-kappaB dependent cytokines: IL-1α, IL-6, IL-8, and TNF-α in tissue specimens and saliva of patients with oral squamous cell carcinoma and oral potentially malignant disorders. Journal of Clinical Medicine, 9(3), 867. https://doi.org/10.3390/jcm9030867
   PubMed Web of Science ®Google Scholar
• Bai, X., Zhang, E., Hu, B., Liang, H., Song, S., & Ji, A. (2020). Study on absorption mechanism and tissue distribution of fucoidan. Molecules (Basel, Switzerland), 25(5), 1087. https://doi.org/10.3390/molecules25051087
   PubMed Web of Science ®Google Scholar
• Bhandare, R. R., Sigalapalli, D. K., Shaik, A. B., Canney, D. J., & Blass, B. E. (2022). Selectivity profile comparison for certain γ-butyrolactone and oxazolidinone-based ligands on a sigma 2 receptor over sigma 1: A molecular docking approach. RSC Advances, 12(31), 20096–20109. https://doi.org/10.1039/D2RA03497B
   PubMed Web of Science ®Google Scholar
• Bhardwaj, V. K., Singh, R., Sharma, J., Rajendran, V., Purohit, R., & Kumar, S. (2020). Identification of bioactive molecules from tea plant as SARS-CoV-2 main protease inhibitors. Journal of Biomolecular Structure & Dynamics, 39(10), 3449–3458. https://doi.org/10.1080/07391102.2020.1766572
   PubMed Web of Science ®Google Scholar
• Borse, V., Konwar, A. N., & Buragohain, P. (2020). Oral cancer diagnosis and perspectives in India. Sensors International, 1, 100046. https://doi.org/10.1016/j.sintl.2020.100046
   PubMedGoogle Scholar
• Chantree, P., Surarak, T., Sangpairoj, K., Aguilar, P., & Hitakomate, E. (2020). Antitumor effects of fucoidan via apoptotic and autophagic induction on HSC-3 oral squamous cellcarcinoma. Asian Pacific Journal of Cancer Prevention, 21(8), 2469–2477. https://doi.org/10.31557/APJCP.2020.21.8.2469
   PubMedGoogle Scholar
• Chen, J., Wang, J., Lai, F., Wang, W., Pang, L., & Zhu, W. (2018). Dynamics revelation of conformational changes and binding modes of heat shock protein 90 induced by inhibitor associations. RSC Advances, 8(45), 25456–25467. https://doi.org/10.1039/C8RA05042B
   PubMed Web of Science ®Google Scholar
• Chen, J. Y.-F., Hung, C.-C., Huang, K.-L., Chen, Y.-T., Liu, S.-Y., Chiang, W.-F., Chen, H.-R., Yen, C.-Y., Wu, Y.-J., Ko, J.-Y., & Jou, Y.-S. (2008). Src family kinases mediate betel quid-induced oral cancer cell motility and could be a biomarker for early invasion in oral squamous cell carcinoma. Neoplasia (New York, N.Y.), 10(12), 1393–1401. https://doi.org/10.1593/neo.08854
   PubMed Web of Science ®Google Scholar
• Chin, C.-H., Chen, S.-H., Wu, H.-H., Ho, C.-W., Ko, M.-T., & Lin, C.-Y. (2014). cytoHubba: Identifying hub objects and sub-networks from complex interactome. BMC Systems Biology, 8(Suppl. 4), S11. https://doi.org/10.1186/1752-0509-8-S4-S11
   PubMed Web of Science ®Google Scholar
• Cunha, L., & Grenha, A. (2016). Sulfated seaweed polysaccharides as multifunctional materials in drug delivery applications. Marine Drugs, 14(3), 42. https://doi.org/10.3390/md14030042
   PubMed Web of Science ®Google Scholar
• Das, T., Andrieux, G., Ahmed, M., & Chakraborty, S. (2020). Integration of online omics-data resources for cancer research. Frontiers in Genetics, 11, 578345. https://doi.org/10.3389/fgene.2020.578345
   PubMed Web of Science ®Google Scholar
• Fan, G., Tu, Y., Wu, N., & Xiao, H. (2020). The expression profiles and prognostic values of HSPs family members in head and neck cancer. Cancer Cell International, 20(1), 220. https://doi.org/10.1186/s12935-020-01296-7
   PubMed Web of Science ®Google Scholar
• Friesner, R. A., Banks, J. L., Murphy, R. B., Halgren, T. A., Klicic, J. J., Mainz, D. T., Repasky, M. P., Knoll, E. H., Shelley, M., Perry, J. K., Shaw, D. E., Francis, P., & Shenkin, P. S. (2004). Glide: A new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy. Journal of Medicinal Chemistry, 47(7), 1739–1749. https://doi.org/10.1021/jm0306430
   PubMed Web of Science ®Google Scholar
• Ganapathy, S., Asmy, S., Natarajan, J., Selvaraj, U., & Thirugnanasambandan, S. (2020). Invitro and insilico analysis of the marine seaweed-derived compound fucoidan against EMT markers. International Journal of Scientific & Technology Research, 9(4), 1–4.
   Google Scholar
• Gangadharappa, B. S., Sharath, R., Revanasiddappa, P. D., Chandramohan, V., Balasubramaniam, M., & Vardhineni, T. P. (2020). Structural insights of metallo-beta-lactamase revealed an effective way of inhibition of enzyme by natural inhibitors. Journal of Biomolecular Structure & Dynamics, 38(13), 3757–3771. https://doi.org/10.1080/07391102.2019.1667265
   PubMed Web of Science ®Google Scholar
• Hassanpour, S. H., & Dehghani, M. (2017). Review of cancer from perspective of molecular. Journal of Cancer Research and Practice, 4(4), 127–129. https://doi.org/10.1016/j.jcrpr.2017.07.001
   Google Scholar
• He, S., Zhang, W., Li, X., Wang, J., Chen, X., Chen, Y., & Lai, R. (2021). Oral squamous cell carcinoma (OSCC)-derived exosomal MiR-221 targets and regulates phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1) to promote human umbilical vein endothelial cells migration and tube formation. Bioengineered, 12(1), 2164–2174. https://doi.org/10.1080/21655979.2021.1932222
   PubMed Web of Science ®Google Scholar
• Hopkins, A. L. (2008). Network pharmacology: The next paradigm in drug discovery. Nature Chemical Biology, 4(11), 682–690. https://doi.org/10.1038/nchembio.118
   PubMed Web of Science ®Google Scholar
• Hsu, H. Y., Chiu, S. L., Wen, M. H., Chen, K. Y., & Hua, K. F. (2001). Ligands of macrophage scavenger receptor induce cytokine expression via differential modulation of protein kinase signaling pathways. The Journal of Biological Chemistry, 276(31), 28719–28730. https://doi.org/10.1074/jbc.M011117200
   PubMed Web of Science ®Google Scholar
• Iannuccelli, M., Micarelli, E., Surdo, P. L., Palma, A., Perfetto, L., Rozzo, I., Castagnoli, L., Licata, L., & Cesareni, G. (2020). CancerGeneNet: Linking driver genes to cancer hallmarks. Nucleic Acids Research, 48(D1), D416–D421. https://doi.org/10.1093/nar/gkz871
   PubMed Web of Science ®Google Scholar
• Irby, R. B., & Yeatman, T. J. (2000). Role of Src expression and activation in human cancer. Oncogene, 19(49), 5636–5642. https://doi.org/10.1038/sj.onc.1203912
   PubMed Web of Science ®Google Scholar
• Jacobsen, K., Bertran-Alamillo, J., Molina, M. A., Teixidó, C., Karachaliou, N., Pedersen, M. H., Castellví, J., Garzón, M., Codony-Servat, C., Codony-Servat, J., Giménez-Capitán, A., Drozdowskyj, A., Viteri, S., Larsen, M. R., Lassen, U., Felip, E., Bivona, T. G., Ditzel, H. J., & Rosell, R. (2017). Convergent Akt activation drives acquired EGFR inhibitor resistance in lung cancer. Nature Communications, 8(1), 410. https://doi.org/10.1038/s41467-017-00450-6
   PubMedGoogle Scholar
• Jin, J.-O., Chauhan, P. S., Arukha, A. P., Chavda, V., Dubey, A., & Yadav, D. (2021). The therapeutic potential of the anticancer activity of fucoidan: Current advances and hurdles. Marine Drugs, 19(5), 265. https://doi.org/10.3390/md19050265
   PubMed Web of Science ®Google Scholar
• Johnson, N. W., Warnakulasuriya, S., Gupta, P. C., Dimba, E., Chindia, M., Otoh, E. C., Sankaranarayanan, R., Califano, J., & Kowalski, L. (2011). Global oral health inequalities in incidence and outcomes for oral cancer: Causes and solutions. Advances in Dental Research, 23(2), 237–246. https://doi.org/10.1177/0022034511402082
   PubMedGoogle Scholar
• Kakarala, K. K., & Jamil, K. (2022). Identification of novel allosteric binding sites and multi-targeted allosteric inhibitors of receptor and non-receptor tyrosine kinases using a computational approach. Journal of Biomolecular Structure & Dynamics, 40(15), 6889–6909. https://doi.org/10.1080/07391102.2021.1891140
   PubMed Web of Science ®Google Scholar
• Kase, Y., Uzawa, K., Wagai, S., Yoshimura, S., Yamamoto, J. I., Toeda, Y., Okubo, M., Eizuka, K., Ando, T., Nobuchi, T., Kawasaki, K., Saito, T., Iyoda, M., Nakashima, D., Kasamatsu, A., & Tanzawa, H. (2021). Engineered exosomes delivering specific tumor-suppressive RNAi attenuate oral cancer progression. Scientific Reports, 11(1), 5897. https://doi.org/10.1038/s41598-021-85242-1
   PubMed Web of Science ®Google Scholar
• Kazybay, B., Sun, Q., Dukenbayev, K., Nurkesh, A. A., Xu, N., Kutzhanova, A., Razbekova, M., Kabylda, A., Yang, Q., Wang, Q., Ma, C., & Xie, Y. (2022). Network pharmacology with experimental investigation of the mechanisms of rhizoma polygonati against prostate cancer with additional herbzymatic activity. ACS Omega, 7(17), 14465–14477. https://doi.org/10.1021/acsomega.1c03018
   PubMed Web of Science ®Google Scholar
• Ketabat, F., Pundir, M., Mohabatpour, F., Lobanova, L., Koutsopoulos, S., Hadjiiski, L., Chen, X., Papagerakis, P., & Papagerakis, S. (2019). Controlled drug delivery systems for oral cancer treatment-current status and future perspectives. Pharmaceutics, 11(7), 302. https://doi.org/10.3390/pharmaceutics11070302
   PubMed Web of Science ®Google Scholar
• Kumar, V., Kumar, A., Kumar, M., Lone, M. R., Mishra, D., & Chauhan, S. S. (2022). NFκB (RelA) mediates transactivation of hnRNPD in oral cancer cells. Scientific Reports, 12(1), 5944. https://doi.org/10.1038/s41598-022-09963-7
   PubMed Web of Science ®Google Scholar
• Kumari, R., Kumar, R., & Lynn, A, Open Source Drug Discovery Consortium. (2014). g_mmpbsa—A GROMACS tool for high-throughput MM-PBSA calculations. Journal of Chemical Information and Modeling, 54(7), 1951–1962. https://doi.org/10.1021/ci500020m
   PubMed Web of Science ®Google Scholar
• Lakshmana Senthil, S., Raghu, C., Arjun, H. A., & Anantharaman, P. (2019). In vitro and in silico inhibition properties of fucoidan against α-amylase and α-D-glucosidase with relevance to type 2 diabetes mellitus. Carbohydrate Polymers, 209, 350–355. https://doi.org/10.1016/j.carbpol.2019.01.039
   PubMed Web of Science ®Google Scholar
• Lánczky, A., & Győrffy, B. (2021). Web-based survival analysis tool tailored for medical research (KMplot): Development and Implementation. Journal of Medical Internet Research, 23(7), e27633. https://doi.org/10.2196/27633
   PubMed Web of Science ®Google Scholar
• Lee, N. Y., Ermakova, S. P., Zvyagintseva, T. N., Kang, K. W., Dong, Z., & Choi, H. S. (2008). Inhibitory effects of fucoidan on activation of epidermal growth factor receptor and cell transformation in JB6 Cl41 cells. Food and Chemical Toxicology, 46(5), 1793–1800. https://doi.org/10.1016/j.fct.2008.01.025
   PubMed Web of Science ®Google Scholar
• Legeay, M., Doncheva, N. T., Morris, J. H., & Jensen, L. J. (2020). Visualize omics data on networks with Omics Visualizer, a Cytoscape app. F1000Research, 9, 157. https://doi.org/10.12688/f1000research.22280.2
   PubMedGoogle Scholar
• Li, B., Lu, F., Wei, X., & Zhao, R. (2008). Fucoidan: Structure and Bioactivity. Molecules (Basel, Switzerland), 13(8), 1671–1695. https://doi.org/10.3390/molecules13081671
   PubMed Web of Science ®Google Scholar
• Li, X., Lin, B., Lin, Z., Ma, Y., Wang, Q., Zheng, Y., Cui, L., Luo, H., & Luo, L. (2021). Exploration in the mechanism of fucosterol for the treatment of non-small cell lung cancer based on network pharmacology and molecular docking. Scientific Reports, 11(1), 4901. https://doi.org/10.1038/s41598-021-84380-w
   PubMed Web of Science ®Google Scholar
• Lin, Y., Qi, X., Liu, H., Xue, K., Xu, S., & Tian, Z. (2020). The anti-cancer effects of fucoidan: A review of both in vivo and in vitro investigations. Cancer Cell International, 20(1), 154. https://doi.org/10.1186/s12935-020-01233-8
   PubMed Web of Science ®Google Scholar
• Lingamgunta, L. K., Aloor, B. P., Dasari, S., Ramakrishnan, R., Botlagunta, M., Madikonda, A. K., Gopal, S., & Sade, A. (2023). Identification of prognostic hub genes and therapeutic targets for selenium deficiency in chicks model through transcriptome profiling. Scientific Reports, 13(1), 8695. https://doi.org/10.1038/s41598-023-34955-6
   PubMed Web of Science ®Google Scholar
• Liu, X., Ouyang, S., Yu, B., Liu, Y., Huang, K., Gong, J., Zheng, S., Li, Z., Li, H., & Jiang, H. (2010). PharmMapper server: A web server for potential drug target identification using pharmacophore mapping approach. Nucleic Acids Research, 38(Web Server issue), W609–14. https://doi.org/10.1093/nar/gkq300
   PubMed Web of Science ®Google Scholar
• Lokhande, K. B., Ghosh, P., Nagar, S., & Venkateswara Swamy, K. (2022). Novel B, C-ring truncated deguelin derivatives reveals as potential inhibitors of cyclin D1 and cyclin E using molecular docking and molecular dynamic simulation. Molecular Diversity, 26(4), 2295–2309. https://doi.org/10.1007/s11030-021-10334-z
   PubMed Web of Science ®Google Scholar
• Mohamed, N., Litlekalsøy, J., Ahmed, I. A., Martinsen, E. M. H., Furriol, J., Javier-Lopez, R., Elsheikh, M., Gaafar, N. M., Morgado, L., Mundra, S., Johannessen, A. C., Osman, T. A.-H., Nginamau, E. S., Suleiman, A., & Costea, D. E. (2021). Analysis of salivary mycobiome in a cohort of oral squamous cell carcinoma patients from Sudan identifies higher salivary carriage of Malassezia as an independent and favorable predictor of overall survival. Frontiers in Cellular and Infection Microbiology, 11, 673465. https://doi.org/10.3389/fcimb.2021.673465
   PubMed Web of Science ®Google Scholar
• Mosmann, T. (1983). Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. Journal of Immunological Methods, 65(1–2), 55–63. https://doi.org/10.1016/0022-1759(83)90303-4
   PubMed Web of Science ®Google Scholar
• Mourad, A. A. E., Farouk, N. A., El-Sayed, E.-S H., & Mahdy, A. R. E. (2021). EGFR/VEGFR-2 dual inhibitor and apoptotic inducer: Design, synthesis, anticancer activity and docking study of new 2-thioxoimidazolidin-4one derivatives. Life Sciences, 277, 119531. https://doi.org/10.1016/j.lfs.2021.119531
   PubMed Web of Science ®Google Scholar
• Nagao, Y., Sata, M., Tanikawa, K., Itoh, K., & Kameyama, T. (1995). High prevalence of hepatitis C virus antibody and RNA in patients with oral cancer. Journal of Oral Pathology & Medicine, 24(8), 354–360. https://doi.org/10.1111/j.1600-0714.1995.tb01199.x
   PubMed Web of Science ®Google Scholar
• Nagy, Á., Munkácsy, G., & Győrffy, B. (2021). Pancancer survival analysis of cancer hallmark genes. Scientific Reports, 11(1), 6047. https://doi.org/10.1038/s41598-021-84787-5
   PubMed Web of Science ®Google Scholar
• Nakano, Y., Kobayashi, W., Sugai, S., Kimura, H., & Yagihashi, S. (1999). Expression of tumor necrosis factor-α and interleukin-6 in oral squamous cell carcinoma. Japanese Journal of Cancer Research: Gann, 90(8), 858–866. https://doi.org/10.1111/j.1349-7006.1999.tb00827.x
   PubMedGoogle Scholar
• Nicora, G., Vitali, F., Dagliati, A., Geifman, N., & Bellazzi, R. (2020). Integrated multi-omics analyses in oncology: A review of machine learning methods and tools. Frontiers in Oncology, 10, 1030. https://doi.org/10.3389/fonc.2020.01030
   PubMed Web of Science ®Google Scholar
• Niu, M., Zhang, B., Li, L., Su, Z., Pu, W., Zhao, C., Wei, L., Lian, P., Lu, R., Wang, R., Wazir, J., Gao, Q., Song, S., & Wang, H. (2021). Targeting HSP90 inhibits proliferation and induces apoptosis through AKT1/ERK pathway in lung cancer. Frontiers in Pharmacology, 12, 724192. https://doi.org/10.3389/fphar.2021.724192
   PubMed Web of Science ®Google Scholar
• Omer, S. E., Ibrahim, T. M., Krar, O. A., Ali, A. M., Makki, A. A., Ibraheem, W., & Alzain, A. A. (2022). Drug repurposing for SARS-CoV-2 main protease: Molecular docking and molecular dynamics investigations. Biochemistry and Biophysics Reports, 29, 101225. https://doi.org/10.1016/j.bbrep.2022.101225
   PubMedGoogle Scholar
• Oo, M. W., Kawai, H., Takabatake, K., Shan, Q., Eain, H. S., Sukegawa, S., Nakano, K., & Nagatsuka, H. (2022). Cancer-associated stromal cells promote the contribution of MMP2-positive bone marrow-derived cells to oral squamous cell carcinoma invasion. Cancers, 14(1). https://doi.org/10.3390/cancers14010137
   Web of Science ®Google Scholar
• Palanisamy, S., Vinosha, M., Marudhupandi, T., Rajasekar, P., & Prabhu, N. M. (2017). In vitro antioxidant and antibacterial activity of sulfated polysaccharides isolated from Spatoglossum asperum. Carbohydrate Polymers, 170, 296–304. https://doi.org/10.1016/j.carbpol.2017.04.085
   PubMed Web of Science ®Google Scholar
• Pan, T.-J., Li, L.-X., Zhang, J.-W., Yang, Z.-S., Shi, D.-M., Yang, Y.-K., & Wu, W.-Z. (2019). Antimetastatic effect of Fucoidan-Sargassum against liver cancer cell invadopodia formation via targeting integrin αVβ3 and mediating αVβ3/Src/E2F1 signaling. Journal of Cancer, 10(20), 4777–4792. https://doi.org/10.7150/jca.26740
   PubMed Web of Science ®Google Scholar
• Peng, C.-H., Liao, C.-T., Peng, S.-C., Chen, Y.-J., Cheng, A.-J., Juang, J.-L., Tsai, C.-Y., Chen, T.-C., Chuang, Y.-J., Tang, C.-Y., Hsieh, W.-P., & Yen, T.-C. (2011). A novel molecular signature identified by systems genetics approach predicts prognosis in oral squamous cell carcinoma. PloS One, 6(8), e23452. https://doi.org/10.1371/journal.pone.0023452
   PubMed Web of Science ®Google Scholar
• Ribeiro, F. A. P., Noguti, J., Oshima, C. T. F., & Ribeiro, D. A. (2014). Effective targeting of the epidermal growth factor receptor (EGFR) for treating oral cancer: A promising approach. Anticancer Research, 34(4), 1547–1552.
   PubMed Web of Science ®Google Scholar
• Sachit, H. G., Almahbobi, T. F., Ali, Z. M. M., Ali, S. H. M., & Mohammed Al-Alwany, S. H. (2019). A molecular implicatory propositioning roles for human cytomegalovirus and p16 gene expression in oral squamous cellular carcinogenesis. Journal of Pure and Applied Microbiology, 13(4), 2333–2342. https://doi.org/10.22207/JPAM.13.4.49
   Web of Science ®Google Scholar
• Salvo, E., Tu, N. H., Scheff, N. N., Dubeykovskaya, Z. A., Chavan, S. A., Aouizerat, B. E., & Ye, Y. (2021). TNFα promotes oral cancer growth, pain, and Schwann cell activation. Scientific Reports, 11(1), 1840. https://doi.org/10.1038/s41598-021-81500-4
   PubMed Web of Science ®Google Scholar
• Sharif Siam, M. K., Sarker, A., & Sayeem, M. M. S. (2021). In silico drug design and molecular docking studies targeting Akt1 (RAC-alpha serine/threonine-protein kinase) and Akt2 (RAC-beta serine/threonine-protein kinase) proteins and investigation of CYP (cytochrome P450) inhibitors against MAOB (monoamine oxida oxidase B) for OSCC (oral squamous cell carcinoma) treatment). Journal of Biomolecular Structure & Dynamics, 39(17), 6467–6479. https://doi.org/10.1080/07391102.2020.1802335
   PubMed Web of Science ®Google Scholar
• Sharma, B., Bhattacherjee, D., Zyryanov, G. V., & Purohit, R. (2022). An insight from computational approach to explore novel, high-affinity phosphodiesterase 10A inhibitors for neurological disorders. Journal of Biomolecular Structure & Dynamics, 41(19), 9424–9436. https://doi.org/10.1080/07391102.2022.2141895
   PubMed Web of Science ®Google Scholar
• Sharma, S., Satyanarayana, L., Asthana, S., Shivalingesh, K. K., Goutham, B. S., & Ramachandra, S. (2018). Oral cancer statistics in India on the basis of first report of 29 population-based cancer registries. Journal of Oral and Maxillofacial Pathology: JOMFP, 22(1), 18–26. https://doi.org/10.4103/jomfp.JOMFP_113_17
   PubMedGoogle Scholar
• Shiau, J.-P., Chuang, Y.-T., Yang, K.-H., Chang, F.-R., Sheu, J.-H., Hou, M.-F., Jeng, J.-H., Tang, J.-Y., & Chang, H.-W. (2022). Brown algae-derived fucoidan exerts oxidative stress-dependent antiproliferation on oral cancer cells. Antioxidants (Basel, Switzerland), 11(5), 841. https://doi.org/10.3390/antiox11050841
   PubMedGoogle Scholar
• Subash, A., Bylapudi, B., Thakur, S., & Rao, V. U. S. (2022). Oral cancer in India, a growing problem: Is limiting the exposure to avoidable risk factors the only way to reduce the disease burden? Oral Oncology, 125, 105677. https://doi.org/10.1016/j.oraloncology.2021.105677
   PubMed Web of Science ®Google Scholar
• Suman, S., Das, T. P., Sirimulla, S., Alatassi, H., Ankem, M. K., & Damodaran, C. (2016). Withaferin-A suppress AKT induced tumor growth in colorectal cancer cells. Oncotarget, 7(12), 13854–13864. https://doi.org/10.18632/oncotarget.7351
   PubMedGoogle Scholar
• Tanveer, F., Anwar, M. F., Siraj, B., & Zarina, S. (2022). Evaluation of anti-EGFR potential of quinazoline derivatives using molecular docking: An in silico approach. Biotechnology and Applied Biochemistry, 69(3), 1226–1237. https://doi.org/10.1002/bab.2199
   PubMed Web of Science ®Google Scholar
• Tao, Q., Du, J., Li, X., Zeng, J., Tan, B., Xu, J., Lin, W., & Chen, X.-L. (2020). Network pharmacology and molecular docking analysis on molecular targets and mechanisms of Huashi Baidu formula in the treatment of COVID-19. Drug Development and Industrial Pharmacy, 46(8), 1345–1353. https://doi.org/10.1080/03639045.2020.1788070
   PubMed Web of Science ®Google Scholar
• Van Weelden, G., Bobiński, M., Okła, K., Van Weelden, W. J., Romano, A., & Pijnenborg, J. M. A. (2019). Fucoidan structure and activity in relation to anti-cancer mechanisms. Marine Drugs, 17(1), 32. https://doi.org/10.3390/md17010032
   PubMed Web of Science ®Google Scholar
• Veluthattil, A. C., Sudha, S. P., Kandasamy, S., & Chakkalakkoombil, S. V. (2019). Effect of hypofractionated, palliative radiotherapy on quality of life in late-stage oral cavity cancer: A prospective clinical trial. Indian Journal of Palliative Care, 25(3), 383–390. https://doi.org/10.4103/IJPC.IJPC_115_18
   PubMed Web of Science ®Google Scholar
• Wang, S., Tian, L., Wang, Y., He, J., Kang, Y., Shangguan, Y., Qian, W., Yang, P., & Huang, J. (2022). Identification of alkaloidal compounds from leaves and roots of Stephania succifera by HPLC-QTOF-MS and prediction of potential bioactivity with PharmMapper. Phytochemical Analysis, 33(2), 239–248. https://doi.org/10.1002/pca.3083
   PubMed Web of Science ®Google Scholar
• Wang, T., Cai, B., Ding, M., Su, Z., Liu, Y., & Shen, L. (2019). c-Myc overexpression promotes oral cancer cell proliferation and migration by enhancing glutaminase and glutamine synthetase activity. The American Journal of the Medical Sciences, 358(3), 235–242. https://doi.org/10.1016/j.amjms.2019.05.014
   PubMed Web of Science ®Google Scholar
• Wang, Y., Gu, W., Kui, F., Gao, F., Niu, Y., Li, W., Zhang, Y., Guo, Z., & Du, G. (2021). The mechanism and active compounds of Semen Armeniacae amarum treating coronavirus disease 2019 based on network pharmacology and molecular docking. Food & Nutrition Research, 65. https://doi.org/10.29219/fnr.v65.5623
   Web of Science ®Google Scholar
• Warnakulasuriya, S. (2009). Causes of oral cancer – An appraisal of controversies. British Dental Journal, 207(10), 471–475. https://doi.org/10.1038/sj.bdj.2009.1009
   PubMed Web of Science ®Google Scholar
• Wu, Y., Gao, L.-J., Fan, Y.-S., Chen, Y., & Li, Q. (2021). Network pharmacology-based analysis on the action mechanism of oleanolic acid to alleviate osteoporosis. ACS Omega, 6(42), 28410–28420. https://doi.org/10.1021/acsomega.1c04825
   PubMed Web of Science ®Google Scholar
• Wu, Z., Pan, X., Deng, C., Cai, M., Yuan, K., Huang, P., & Shi, G. (2022). Mechanism of herb pairs Astragalus mongholicus and Curcuma phaeocaulis Valeton in treating gastric carcinoma: A network pharmacology combines with differential analysis and molecular docking. Evidence-Based Complementary and Alternative Medicine, 2022, 8361431. https://doi.org/10.1155/2022/8361431
   PubMed Web of Science ®Google Scholar
• Yang, L., Hu, Z., Zhu, J., Liang, Q., Zhou, H., Li, J., Fan, X., Zhao, Z., Pan, H., & Fei, B. (2020). Systematic elucidation of the mechanism of quercetin against gastric cancer via network pharmacology approach. BioMed Research International, 2020, 3860213–3860211. https://doi.org/10.1155/2020/3860213
   PubMed Web of Science ®Google Scholar
• Yu, Z., Wu, Y., Ma, Y., Cheng, Y., Song, G., & Zhang, F. (2022). Systematic analysis of the mechanism of aged citrus peel (Chenpi) in oral squamous cell carcinoma treatment via network pharmacology, molecular docking and experimental validation. Journal of Functional Foods, 91, 105012. https://doi.org/10.1016/j.jff.2022.105012
   Web of Science ®Google Scholar
• Zaki, H., Belhassan, A., Benlyas, M., Lakhlifi, T., & Bouachrine, M. (2021). New dehydroabietic acid (DHA) derivatives with anticancer activity against HepG2 cancer cell lines as a potential drug targeting EGFR kinase domain. CoMFA study and virtual ligand-based screening. Journal of Biomolecular Structure & Dynamics, 39(8), 2993–3003. https://doi.org/10.1080/07391102.2020.1759452
   PubMed Web of Science ®Google Scholar
• Zhang, M., Yuan, Y., Zhou, W., Qin, Y., Xu, K., Men, J., & Lin, M. (2020). Network pharmacology analysis of Chaihu Lizhong Tang treating non-alcoholic fatty liver disease. Computational Biology and Chemistry, 86, 107248. https://doi.org/10.1016/j.compbiolchem.2020.107248
   PubMed Web of Science ®Google Scholar
• Zhang, N., Gao, L., Ren, W., Li, S., Zhang, D., Song, X., Zhao, C., & Zhi, K. (2020). Fucoidan affects oral squamous cell carcinoma cell functions in vitro by regulating FLNA-derived circular RNA. Annals of the New York Academy of Sciences, 1462(1), 65–78. https://doi.org/10.1111/nyas.14190
   PubMed Web of Science ®Google Scholar
• Zhao, S., Jiang, Y., Zhao, J., Li, H., Yin, X., Wang, Y., Xie, Y., Chen, X., Lu, J., Dong, Z., & Liu, K. (2018). Quercetin-3-methyl ether inhibits esophageal carcinogenesis by targeting the AKT/mTOR/p70S6K and MAPK pathways. Molecular Carcinogenesis, 57(11), 1540–1552. https://doi.org/10.1002/mc.22876
   PubMed Web of Science ®Google Scholar