Sakuranetin ameliorates streptozotocin-induced diabetes in rodents by inhibiting caspase-3 activity, modulating hematological parameters, and suppressing inflammatory cytokines: a molecular docking and dynamics study

References

• Aatif, M., Muteeb, G., Alsultan, A., Alshoaibi, A., & Khelif, B. Y. (2021). Dieckol and its derivatives as potential inhibitors of sars-cov-2 spike protein (uk strain: Vui 202012/01): A computational study. Marine Drugs, 19(5), 242. https://doi.org/10.3390/md19050242
   PubMed Web of Science ®Google Scholar
• Abdullah, A., Biswas, P., Sahabuddin, M., Mubasharah, A., Khan, D. A., Hossain, A., Roy, T., Rafi, N. M. R., Dey, D., Hasan, M. N., Bibi, S., Moustafa, M., Shati, A., Hassan, H., & Garg, R. (2023). Molecular dynamics simulation and pharmacoinformatic integrated analysis of bioactive phytochemicals from azadirachta indica (neem) to treat diabetes mellitus. Journal of Chemistry, 2023, 1–19. https://doi.org/10.1155/2023/4170703
   Web of Science ®Google Scholar
• Alam, S., Sarker, M. M. R., Sultana, T. N., Chowdhury, M. N. R., Rashid, M. A., Chaity, N. I., Zhao, C., Xiao, J., Hafez, E. E., Khan, S. A., & Mohamed, I. N. (2022). Antidiabetic phytochemicals from medicinal plants: Prospective candidates for new drug discovery and development. Frontiers in Endocrinology, 13, 800714. https://doi.org/10.3389/fendo.2022.800714
   PubMed Web of Science ®Google Scholar
• Asgary, S., Naderi, G., & Askari, N. (2006). Protective effect of flavonoids, against red blood cell hemolysis. Iranian Journal of Medicinal and Aromatic Plants Research, 21(4), 505–515.
   Google Scholar
• Bhatti, J. S., Sehrawat, A., Mishra, J., Sidhu, I. S., Navik, U., Khullar, N., Kumar, S., Bhatti, G. K., & Reddy, P. H. (2022). Oxidative stress in the pathophysiology of type 2 diabetes and related complications: Current therapeutics strategies and future perspectives. Free Radical Biology & Medicine, 184, 114–134. https://doi.org/10.1016/j.freeradbiomed.2022.03.019
   PubMed Web of Science ®Google Scholar
• Bittencourt-Mernak, M. I., Pinheiro, N. M., Santana, F. P. R., Guerreiro, M. P., Saraiva-Romanholo, B. M., Grecco, S. S., Caperuto, L. C., Felizardo, R. J. F., Câmara, N. O. S., Tibério, I. F. L. C., Martins, M. A., Lago, J. H. G., & Prado, C. M. (2017). Prophylactic and therapeutic treatment with the flavonone sakuranetin ameliorates lps-induced acute lung injury. American Journal of Physiology. Lung Cellular and Molecular Physiology, 312(2), L217–L230. https://doi.org/10.1152/ajplung.00444.2015
   PubMed Web of Science ®Google Scholar
• Chow, E., Rendleman, C. A., Bowers, K. J., Dror, R. O., Hughes, D. H., Gullingsrud, J., Sacerdoti, F. D., & Shaw, D. E. (2008). Desmond performance on a cluster of multicore processors. DE Shaw Research Technical Report DESRES/TR–2008-01.
   Google Scholar
• Demirtas, L., Degirmenci, H., Akbas, E. M., Ozcicek, A., Timuroglu, A., Gurel, A., & Ozcicek, F. (2015). Association of hematological indicies with diabetes, impaired glucose regulation and microvascular complications of diabetes. International Journal of Clinical and Experimental Medicine, 8(7), 11420.
   PubMed Web of Science ®Google Scholar
• Erukainure, O. L., Ebuehi, O. A., Adeboyejo, F. O., Aliyu, M., & Elemo, G. N. (2013). Hematological and biochemical changes in diabetic rats fed with fiber-enriched cake. Journal of Acute Medicine, 3(2), 39–44. https://doi.org/10.1016/j.jacme.2013.03.001
   Google Scholar
• Essiet, G. A., Eko, O. W., Udoh, E. S., Umoren, A. I., Anwankwo, M. U., & Okwesileze, C. N. (2020). Hematological indices of diabetic rats treated with crude extract and fractions of lasianthera africana leaf. African Journal of Health Sciences, 33(6), 53–64.
   Google Scholar
• Fischer, W., Currais, A., Liang, Z., Pinto, A., & Maher, P. (2019). Old age-associated phenotypic screening for alzheimer’s disease drug candidates identifies sterubin as a potent neuroprotective compound from yerba santa. Redox Biology, 21, 101089. https://doi.org/10.1016/j.redox.2018.101089
   PubMed Web of Science ®Google Scholar
• Goedeke, L., Perry, R. J., & Shulman, G. I. (2019). Emerging pharmacological targets for the treatment of nonalcoholic fatty liver disease, insulin resistance, and type 2 diabetes. Annual Review of Pharmacology and Toxicology, 59(1), 65–87. https://doi.org/10.1146/annurev-pharmtox-010716-104727
   PubMedGoogle Scholar
• Graf, B. A., Milbury, P. E., & Blumberg, J. B. (2005). Flavonols, flavones, flavanones, and human health: Epidemiological evidence. Journal of Medicinal Food, 8(3), 281–290. https://doi.org/10.1089/jmf.2005.8.281
   PubMed Web of Science ®Google Scholar
• Grecco, S., Ferreira, M. J., Romoff, P., Favero, O. A., & Lago, J. H. G. (2012). Phenolic derivatives from baccharis retusa dc.(asteraceae). Biochemical Systematics and Ecology. 42, 21–24. https://doi.org/10.1016/j.bse.2011.12.014
   Web of Science ®Google Scholar
• Grecco, S., Reimão, J. Q., Tempone, A. G., Sartorelli, P., Cunha, R. L., Romoff, P., Ferreira, M. J., Fávero, O. A., & Lago, J. H. G. (2012). In vitro antileishmanial and antitrypanosomal activities of flavanones from baccharis retusa dc.(asteraceae). Experimental Parasitology, 130(2), 141–145. https://doi.org/10.1016/j.exppara.2011.11.002
   PubMed Web of Science ®Google Scholar
• He, Y., Wang, S., Sun, H., Li, Y., & Feng, J. (2022). Naringenin ameliorates myocardial injury in stz-induced diabetic mice by reducing oxidative stress, inflammation and apoptosis via regulating the nrf2 and nf-κb signaling pathways. Frontiers in Cardiovascular Medicine, 9, 946766. https://doi.org/10.3389/fcvm.2022.946766
   PubMed Web of Science ®Google Scholar
• Hetta, M., El-Alfy, T., Yassin, N., Abdel-Rahman, R., & Kadry, E. (2013). Phytochemical and antihyperglycemic studies on citrus medica l. Leaves (Etrog) Growing in Egypt. Int J Pharmacogn Phytochem Res, 5, 271–277.
   Google Scholar
• Ilyas, U., Nazir, B., Altaf, R., Muhammad, S. A., Zafar, H., Paiva-Santos, A. C., Abbas, M., & Duan, Y. (2022). Investigation of anti-diabetic potential and molecular simulation studies of dihydropyrimidinone derivatives. Frontiers in Endocrinology, 13, 1022623. https://doi.org/10.3389/fendo.2022.1022623
   PubMed Web of Science ®Google Scholar
• Jorgensen, W. L., Chandrasekhar, J., Madura, J. D., Impey, R. W., & Klein, M. L. (1983). Comparison of simple potential functions for simulating liquid water. The Journal of Chemical Physics, 79(2), 926–935. https://doi.org/10.1063/1.445869
   Web of Science ®Google Scholar
• Junejo, J. A., Zaman, K., Ali, M., & Rudrapal, M. (2020). New flavonoid with antidiabetic and antioxidant potential from tetrastigma angustifolia (roxb.) deb leaves. Brazilian Journal of Pharmaceutical Sciences, 56, e18806. https://doi.org/10.1590/s2175-97902019000418806
   Web of Science ®Google Scholar
• Kazmi, I., Al-Abbasi, F. A., AlGhamdi, S. A., Alghamdi, A. M., Zeyadi, M., Sheikh, R. A., Gupta, G., & Sayyed, N. (2023). Influence of rosiridin on streptozotocin-induced diabetes in rodents through endogenous antioxidants-inflammatory cytokines pathway and molecular docking study. Journal of Biomolecular Structure & Dynamics, 20, 1–16. https://doi.org/10.1080/07391102.2023.2282738
   Google Scholar
• Khan, M. A. B., Hashim, M. J., King, J. K., Govender, R. D., Mustafa, H., & Al Kaabi, J. (2020). Epidemiology of type 2 diabetes - global burden of disease and forecasted trends. Journal of Epidemiology and Global Health, 10(1), 107–111. https://doi.org/10.2991/jegh.k.191028.001
   PubMed Web of Science ®Google Scholar
• Kodama, O., Miyakawa, J., Akatsuka, T., & Kiyosawa, S. (1992). Sakuranetin, a flavanone phytoalexin from ultraviolet-irradiated rice leaves. Phytochemistry, 31(11), 3807–3809. https://doi.org/10.1016/S0031-9422(00)97532-0
   Web of Science ®Google Scholar
• Li, S., Zhang, Y., Sun, Y., Zhang, G., Bai, J., Guo, J., Su, X., Du, H., Cao, X., Yang, J., & Wang, T. (2019). Naringenin improves insulin sensitivity in gestational diabetes mellitus mice through ampk. Nutrition & Diabetes, 9(1), 28. https://doi.org/10.1038/s41387-019-0095-8
   PubMedGoogle Scholar
• Maqbool, M., Dar, M. A., Gani, I., & Mir, S. A. (2019). Animal models in diabetes mellitus: An overview. Journal of Drug Delivery and Therapeutics, 9(1-s), 472–475. https://doi.org/10.22270/jddt.v9i1-s.2351
   Google Scholar
• Martyna, G. J., Klein, M. L., & Tuckerman, M. (1992). Nosé–hoover chains: The canonical ensemble via continuous dynamics. The Journal of Chemical Physics, 97(4), 2635–2643. https://doi.org/10.1063/1.463940
   Web of Science ®Google Scholar
• Martyna, G. J., Tobias, D. J., & Klein, M. L. (1994). Constant pressure molecular dynamics algorithms. The Journal of Chemical Physics, 101(5), 4177–4189. https://doi.org/10.1063/1.467468
   Web of Science ®Google Scholar
• Mata, R., Contreras, J. L., Crisanto, D., Pereda-Miranda, R., Castañeda, P., & Del Rio, F. (1991). Chemical studies on Mexican plants used in traditional medicine, xviii. New secondary metabolites from Dodonaea viscosa. Journal of Natural Products, 54(3), 913–917. https://doi.org/10.1021/np50075a033
   Web of Science ®Google Scholar
• Miyazawa, M., Kinoshita, H., & Okuno, Y. (2003). Antimutagenic activity of sakuranetin from prunus jamasakura. Journal of Food Science, 68(1), 52–56. https://doi.org/10.1111/j.1365-2621.2003.tb14113.x
   Web of Science ®Google Scholar
• Moulishankar, A., & Lakshmanan, K. (2020). Data on molecular docking of naturally occurring flavonoids with biologically important targets. Data in Brief, 29, 105243. https://doi.org/10.1016/j.dib.2020.105243
   PubMed Web of Science ®Google Scholar
• Onyango, E. M., & Onyango, B. M. (2018). The rise of noncommunicable diseases in kenya: An examination of the time trends and contribution of the changes in diet and physical inactivity. Journal of Epidemiology and Global Health, 8(1–2), 1–7. https://doi.org/10.2991/j.jegh.2017.11.004
   PubMed Web of Science ®Google Scholar
• Ramtahal, R., Khan, C., Maharaj-Khan, K., Nallamothu, S., Hinds, A., Dhanoo, A., Yeh, H. C., Hill-Briggs, F., & Lazo, M. (2015). Prevalence of self-reported sleep duration and sleep habits in type 2 diabetes patients in south trinidad. Journal of Epidemiology and Global Health, 5(4 Suppl 1), S35–S43. https://doi.org/10.1016/j.jegh.2015.05.003
   PubMedGoogle Scholar
• Saito, T., Abe, D., & Sekiya, K. (2008). Sakuranetin induces adipogenesis of 3t3-l1 cells through enhanced expression of pparγ2. Biochemical and Biophysical Research Communications, 372(4), 835–839. https://doi.org/10.1016/j.bbrc.2008.05.146
   PubMed Web of Science ®Google Scholar
• Shaw, D. E., Maragakis, P., Lindorff-Larsen, K., Piana, S., Dror, R. O., Eastwood, M. P., Bank, J. A., Jumper, J. M., Salmon, J. K., Shan, Y., & Wriggers, W. (2010). Atomic-level characterization of the structural dynamics of proteins. Science , 330(6002), 341–346. https://doi.org/10.1126/science.1187409
   PubMed Web of Science ®Google Scholar
• Shivakumar, D., Williams, J., Wu, Y., Damm, W., Shelley, J., & Sherman, W. (2010). Prediction of absolute solvation free energies using molecular dynamics free energy perturbation and the opls force field. Journal of Chemical Theory and Computation, 6(5), 1509–1519. https://doi.org/10.1021/ct900587b
   PubMed Web of Science ®Google Scholar
• Stravodimos, G., A., Chetter, B., Kyriakis, E., L., Kantsadi, A., S. M., Chatzileontiadou, D., T., Skamnaki, V., Kato, A., M., Hayes, J., D., & Leonidas, D. (2017). Phytogenic polyphenols as glycogen phosphorylase inhibitors: The potential of triterpenes and flavonoids for glycaemic control in type 2 diabetes. Current Medicinal Chemistry, 24(4), 384–403. https://doi.org/10.2174/0929867324666161118122534
   PubMed Web of Science ®Google Scholar
• Toledo, A. C., Sakoda, C. P. P., Perini, A., Pinheiro, N. M., Magalhães, R. M., Grecco, S., Tibério, I. F. L. C., Câmara, N. O., Martins, M. A., Lago, J. H. G., & Prado, C. M. (2013). Flavonone treatment reverses airway inflammation and remodelling in an asthma murine model. British Journal of Pharmacology, 168(7), 1736–1749. https://doi.org/10.1111/bph.12062
   PubMed Web of Science ®Google Scholar
• Toukmaji, A. Y., & Board Jr, J. A. (1996). Ewald summation techniques in perspective: A survey. Computer Physics Communications, 95(2-3), 73–92. https://doi.org/10.1016/0010-4655(96)00016-1
   Web of Science ®Google Scholar
• Vinayagam, R., & Xu, B. (2015). Antidiabetic properties of dietary flavonoids: A cellular mechanism review. Nutrition & Metabolism, 12(1), 60. https://doi.org/10.1186/s12986-015-0057-7
   PubMed Web of Science ®Google Scholar
• Wollenweber, E., & Egger, K. (1971). Flavonoid-aglykone im knospen-exkret von betula ermani. Zeitschrift Fur Pflanzenphysiologie, 65, 427–431.
   Google Scholar
• Zhang, L., Kong, Y., Wu, D., Zhang, H., Wu, J., Chen, J., Ding, J., Hu, L., Jiang, H., & Shen, X. (2008). Three flavonoids targeting the β‐hydroxyacyl‐acyl carrier protein dehydratase from helicobacter pylori: Crystal structure characterization with enzymatic inhibition assay. Protein Science: A Publication of the Protein Society, 17(11), 1971–1978. https://doi.org/10.1110/ps.036186.108
   PubMed Web of Science ®Google Scholar
• Zhang, X., Hung, T. M., Phuong, P. T., Ngoc, T. M., Min, B.-S., Song, K.-S., Seong, Y. H., & Bae, K. (2006). Anti-inflammatory activity of flavonoids from populus davidiana. Archives of Pharmacal Research, 29(12), 1102–1108. https://doi.org/10.1007/BF02969299
   PubMed Web of Science ®Google Scholar