Curcumin and vitamin E improve hot flashes, lipid profile, and fasting blood glucose without any detrimental effect on the liver and renal function in postmenopausal women: A triple-blind placebo-controlled clinical trial

References

• Ahmed, S. B., Culleton, B. F., Tonelli, M., Klarenbach, S. W., MacRae, J. M., Zhang, J., & Hemmelgarn, B. R. (2008). Oral estrogen therapy in postmenopausal women is associated with loss of kidney function. Kidney International, 74(3), 370–376. https://doi.org/10.1038/ki.2008.205
   PubMed Web of Science ®Google Scholar
• AK, T., & İlhami, G. (2008). Antioxidant and radical scavenging properties of curcumin. Chemico-Biological Interactions, 174(1), 27–37. https://doi.org/10.1016/j.cbi.2008.05.003
   PubMed Web of Science ®Google Scholar
• Ali, B. H., Al-Salam, S., Al Suleimani, Y., Al Kalbani, J., Al Bahlani, S., Ashique, M., Manoj, P., Al Dhahli, B., Al Abri, N., Naser, H. T., Yasin, J., Nemmar, A., Al Za’abi, M., Hartmann, C., & Schupp, N. (2018). Curcumin ameliorates kidney function and oxidative stress in experimental chronic kidney disease. Basic & Clinical Pharmacology & Toxicology, 122(1), 65–73. https://doi.org/10.1111/bcpt.12817
   PubMed Web of Science ®Google Scholar
• Alves Luzia, L., Mendes Aldrighi, J., Teixeira Damasceno, N. R., Rodrigues Sampaio, G., Aparecida Manólio Soares, R., Tande Silva, I., De Queiroz Mello, A. P., Ferreira Carioca, A. A., & Ferraz da Silva Torres, E. A. (2015). Fish oil and vitamin e change lipid profiles and anti-ldl-antibodies in two different ethnic groups of women transitioning through menopause. Nutricion Hospitalaria, 32(1), 165–174. https://doi.org/10.3305/nh.2015.32.1.9079[PMC][26262712
   PubMed Web of Science ®Google Scholar
• Amanullah, I., Khan, Y. H., Anwar, I., Gulzar, A., Mallhi, T. H., & Raja, A. A. (2019). Effect of vitamin E in non-alcoholic fatty liver disease: A systematic review and meta-analysis of randomised controlled trials. Postgraduate Medical Journal, 95(1129), 601–611. https://doi.org/10.1136/postgradmedj-2018-136364
   PubMed Web of Science ®Google Scholar
• Arnlöv, J., Zethelius, B., Risérus, U., Basu, S., Berne, C., Vessby, B., Alfthan, G., & Helmersson, J. (2009). Serum and dietary β-carotene and α-tocopherol and incidence of type 2 diabetes mellitus in a community-based study of Swedish men: Report from the Uppsala Longitudinal Study of Adult Men (ULSAM) study. Diabetologia, 52(1), 97–105. https://doi.org/10.1007/s00125-008-1189-3
   PubMed Web of Science ®Google Scholar
• Ataei-Almanghadim, K., Farshbaf-Khalili, A., Ostadrahimi, A. R., Shaseb, E., & Mirghafourvand, M. (2020). The effect of oral capsule of curcumin and vitamin E on the hot flashes and anxiety in postmenopausal women: A triple blind randomised controlled trial. Complementary Therapies in Medicine, 48, 102267. https://doi.org/10.1016/j.ctim.2019.102267
   PubMed Web of Science ®Google Scholar
• Balbi, M. E., Tonin, F. S., Mendes, A. M., Borba, H. H., Wiens, A., Fernandez-Llimos, F., & Pontarolo, R. (2018). Antioxidant effects of vitamins in type 2 diabetes: A meta-analysis of randomized controlled trials. Diabetology & Metabolic Syndrome, 10, 18. https://doi.org/10.1186/s13098-018-0318-5[PMC][29568330
   PubMed Web of Science ®Google Scholar
• Barton, D. L., Loprinzi, C., Quella, S. K., Sloan, J. A., Veeder, M. H., Egner, J. R., Fidler, P., Stella, P. J., Swan, D.,K., Vaught, N. L., & Novotny, P. (1998). Prospective evaluation of vitamin E for hot flashes in breast cancer survivors. Journal of Clinical Oncology, 16(2), 495–500. https://doi.org/10.1200/JCO.1998.16.2.495
   PubMed Web of Science ®Google Scholar
• Bije, N., Jamali, F. S., Ghalandarabadi, M., & Rezayi, R. (2020). Effects of eight weeks of aerobic exercise in water with and without the use of wild mountain cumin on renal function factors and blood mineral levels in obese postmenopausal women. Quarterly of the Horizon of Medical Sciences, 26(3), 228–243. https://doi.org/10.32598/hms.26.3.3080.1
   Google Scholar
• Brady, C. W. (2015). Liver disease in menopause. World Journal of Gastroenterology, 21(25), 7613–7620. https://doi.org/10.3748/wjg.v21.i25.7613
   PubMed Web of Science ®Google Scholar
• Buyuklu, M., Kandemir, F., Ozkaraca, M., Set, T. U., Bakirci, E. M., & Topal, E. (2014). Protective effect of curcumin against contrast induced nephropathy in rat kidney: What is happening to oxidative stress, inflammation, autophagy and apoptosis? European Review for Medical and Pharmacological Sciences. 18(4), 461–470.
   PubMed Web of Science ®Google Scholar
• Crowe, B. M., Van Puymbroeck, M., Linder, S. M., Mcguire, F. A., & Watt, P. J. (2015). The effects of yoga participation on women’s quality of life and symptom management during the menopausal transition: A pilot study. Health Care for Women International, 36(10), 1124–1142. https://doi.org/10.1080/07399332.2015.1066789.
   PubMed Web of Science ®Google Scholar
• Delavar, M. A., & Hajiahmadi, M. (2011). Factors Affecting the Age in Normal Menopause and frequency of Menopausal Symptoms in Northern Iran. Iranian Red Crescent Medical Journal, 13(3), 192–198.
   PubMed Web of Science ®Google Scholar
• DiSilvestro, R. A., Joseph, E., Zhao, S., & Bomser, J. (2012). Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people. Nutrition Journal, 11, 79. https://doi.org/10.1186/1475-2891-11-79[PMC][23013352
   PubMed Web of Science ®Google Scholar
• Doshi, S. B., & Agarwal, A. (2013). The role of oxidative stress in menopause. Journal of Mid-Life Health, 4(3), 140–146. https://doi.org/10.4103/0976-7800.118990
   Google Scholar
• Ezhilarasan, D. (2020). Critical role of estrogen in the progression of chronic liver diseases. Hepatobiliary & Pancreatic Diseases International: HBPD INT, 19(5), 429–434. https://doi.org/10.1016/j.hbpd.2020.03.011
   PubMed Web of Science ®Google Scholar
• Ferguson, J. J. A., Stojanovski, E., MacDonald-Wicks, L., & Garg, M. L. (2018). Curcumin potentiates cholesterol-lowering effects of phytosterols in hypercholesterolaemic individuals. A randomised controlled trial. Metabolism, 82, 22–35. https://doi.org/10.1016/j.metabol.2017.12.009
   PubMed Web of Science ®Google Scholar
• Fong, H. (2002). Integration of herbal medicine into modern medical practices: Issues and prospects. Integrative Cancer Therapies, 1(3), 287–293; discussion 293. https://doi.org/10.1177/153473540200100313
   PubMedGoogle Scholar
• Ghosh, S. S., Krieg, R., Massey, H. D., Sica, D. A., Fakhry, I., Ghosh, S., & Gehr, T. W. (2012). Curcumin and enalapril ameliorate renal failure by antagonizing inflammation in ⅚ nephrectomized rats: Role of phospholipase and cyclooxygenase. American Journal of Physiology. Renal Physiology, 302(4), F439–454. https://doi.org/10.1152/ajprenal.00356.2010
   PubMed Web of Science ®Google Scholar
• Ghosh, S. S., Massey, H. D., Krieg, R., Fazelbhoy, Z. A., Ghosh, S., Sica, D. A., Fakhry, I., & Gehr, T. W. (2009). Curcumin ameliorates renal failure in 5/6 nephrectomized rats: Role of inflammation. American Journal of Physiology. Renal Physiology, 296(5), F1146–1157. https://doi.org/10.1152/ajprenal.90732.2008
   PubMed Web of Science ®Google Scholar
• Gluhovschi, G., Gluhovschi, A., Anastasiu, D., Petrica, L., Gluhovschi, C., & Velciov, S. (2012). Chronic kidney disease and the involvement of estrogen hormones in its pathogenesis and progression. Romanian Journal of Internal Medicine = Revue Roumaine de Medecine Interne, 50(2), 135–144.
   PubMedGoogle Scholar
• Greendale, G., Lee, N., & Arriola, E. (1999). The menopause. The Lancet, 353(9152), 571–580. https://doi.org/10.1016/S0140-6736(98)05352-5
   PubMed Web of Science ®Google Scholar
• Iglia, N., Sgandurra, P., Peano, E., Marenco, D., Moggio, G., Bounous, V., Tomasi Cont, N., Ponzone, R., & Sismondi, P. (2009). Non-hormonal treatment of hot flushes in breast cancer survivors: Gabapentin vs. vitamin E. Climacteric, 12(4), 310–318. https://doi.org/10.1080/13697130902736921
   PubMed Web of Science ®Google Scholar
• Kaur, G., Tirkey, N., Bharrhan, S., Chanana, V., Rishi, P., & Chopra, K. (2006). Inhibition of oxidative stress and cytokine activity by curcumin in amelioration of endotoxin-induced experimental hepatoxicity in rodents. Clinical and Experimental Immunology, 145(2), 313–321. https://doi.org/10.1111/j.1365-2249.2006.03108.x
   PubMed Web of Science ®Google Scholar
• khosrojerdi, A., Mashayekhi, K., & Zare Marzouni, H. (2016). Curcumin (Extracted from Tumeric) and its Therapeutic Effects [Review Article]. Jorjani Biomedicine Journal, 4(2), 1–20.
   Google Scholar
• Kim, C. (2012). Does menopause increase diabetes risk? Strategies for diabetes prevention in midlife women. Women’s Health (London, England), 8(2), 155–167. https://doi.org/10.2217/whe.11.95
   PubMedGoogle Scholar
• Kim, S. W., Ha, K. C., Choi, E. K., Jung, S. Y., Kim, M. G., Kwon, D. Y., Yang, H. J., Kim, M. J., Kang, H. J., Back, H. I., Kim, S. Y., Park, S. H., Baek, H. Y., Kim, Y. J., Lee, J. Y., & Chae, S. W. (2013). The effectiveness of fermented turmeric powder in subjects with elevated alanine transaminase levels: A randomised controlled study. BMC Complementary and Alternative Medicine, 13, 58. https://doi.org/10.1186/1472-6882-13-58[PMC][23497020
   PubMed Web of Science ®Google Scholar
• Ko, S. H., & Kim, H. S. (2020). Menopause-associated lipid metabolic disorders and foods beneficial for postmenopausal women. Nutrients, 12(1), 202. https://doi.org/10.3390/nu12010202
   PubMed Web of Science ®Google Scholar
• Koay, Y. Y., Tan, G. C. J., Phang, S. C. W., Ho, J. I., Chuar, P. F., Ho, L. S., Ahmad, B., & Abdul Kadir, K. (2021). A phase IIb randomized controlled trial investigating the effects of tocotrienol-rich vitamin E on diabetic kidney disease. Nutrients, 13(1), 258. https://doi.org/10.3390/nu13010258
   PubMed Web of Science ®Google Scholar
• Kravitz, H. M., Avery, E., Sowers, M., Bromberger, J. T., Owens, J. F., Matthews, K. A., Hall, M., Zheng, H., Gold, E. B., & Buysse, D. J. (2011). Relationships between menopausal and mood symptoms and EEG sleep measures in a multi-ethnic sample of middle-aged women: The SWAN sleep study. Sleep, 34(9), 1221–1232. https://doi.org/10.5665/SLEEP.1244
   PubMed Web of Science ®Google Scholar
• Kuhad, A., Pilkhwal, S., Sharma, S., Tirkey, N., & Chopra, K. (2007). Effect of curcumin on inflammation and oxidative stress in cisplatin-induced experimental nephrotoxicity. Journal of Agricultural and Food Chemistry, 55(25), 10150–10155. https://doi.org/10.1021/jf0723965
   PubMed Web of Science ®Google Scholar
• Liguori, I., Russo, G., Curcio, F., Bulli, G., Aran, L., Della-Morte, D., Gargiulo, G., Testa, G., Cacciatore, F., Bonaduce, D., & Abete, P. (2018). Oxidative stress, aging, and diseases. Clinical Interventions in Aging, 13, 757–772. https://doi.org/10.2147/CIA.S158513
   PubMed Web of Science ®Google Scholar
• Maithili Karpaga Selvi, N., Sridhar, M. G., Swaminathan, R. P., & Sripradha, R. (2015). Efficacy of turmeric as adjuvant therapy in type 2 diabetic patients. Indian Journal of Clinical Biochemistry, 30(2), 180–186. https://doi.org/10.1007/s12291-014-0436-2
   PubMedGoogle Scholar
• Makara-Studzińśka, M. T., Kryś-Noszczyk, K. M., & Jakiel, G. (2014). Epidemiology of the symptoms of menopause - an intercontinental review. Przeglad Menopauzalny = Menopause Review, 13(3), 203–211. https://doi.org/10.5114/pm.2014.43827
   PubMedGoogle Scholar
• Manjunatha, H., & Srinivasan, K. (2006). Protective effect of dietary curcumin and capsaicin on induced oxidation of low-density lipoprotein, iron-induced hepatotoxicity and carrageenan-induced inflammation in experimental rats. The FEBS Journal, 273(19), 4528–4537. https://doi.org/10.1111/j.1742-4658.2006.05458.x
   PubMed Web of Science ®Google Scholar
• Mercantepe, T., Unal, D., Selli, J., Mercantepe, F., Unal, B., & Karabiyik, T. N. (2016). Protective effects of estrogen and bortezomib in kidney tissue of post-menopausal rats: An ultrastructural study. Renal Failure, 38(7), 1129–1135. https://doi.org/10.1080/0886022X.2016.1184958
   PubMed Web of Science ®Google Scholar
• Mesh. (2016, July 1). Vitamin E. Retrieved March 29, from https://www.ncbi.nlm.nih.gov/mesh/68014810
   Google Scholar
• Mesh. (2017, July 2). alpha-Tocopherol. Retrieved March 29, from https://meshb.nlm.nih.gov/record/ui?ui=D024502
   Google Scholar
• Mohamed, H. A., Lamadah, S. M., & Zamil, L. G. (2014). Quality of life among menopausal women. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 3(3), 552–561. https://doi.org/10.5455/2320-1770.ijrcog20140906
   Google Scholar
• Naziroğlu, M., Simşek, M., Simşek, H., Aydilek, N., Ozcan, Z., & Atilgan, R. (2004). The effects of hormone replacement therapy combined with vitamins C and E on antioxidants levels and lipid profiles in postmenopausal women with Type 2 diabetes. Clinica Chimica Acta; International Journal of Clinical Chemistry, 344(1–2), 63–71. https://doi.org/10.1016/j.cccn.2004.01.031
   PubMed Web of Science ®Google Scholar
• Nelson, H. D., Humphrey, L. L., Nygren, P., Teutsch, S. M., & Allan, J. D. (2002). Postmenopausal hormone replacement therapy: Scientific review. JAMA, 288(7), 872–881. https://doi.org/10.1001/jama.288.7.872
   PubMed Web of Science ®Google Scholar
• Norouzpour, M., Marandi, M., Ghanbarzadeh, M., & ZareMaivan, A. (2020). The effect of aerobic-resistance exercise on serum level of retinol-bonded protein 4, abdominal obesity, and metabolic markers in postmenopausal women with non-alcoholic fatty liver. Journal of Applied Exercise Physiology, 16(32), 13–14. https://doi.org/10.22080/jaep.2020.19884.1981
   Google Scholar
• Palmisano, B. T., Zhu, L., & Stafford, J. M. (2017). Estrogens in the regulation of liver lipid metabolism. Advances in Experimental Medicine and Biology, 1043, 227–256. https://doi.org/10.1007/978-3-319-70178-3_12
   PubMed Web of Science ®Google Scholar
• Panahi, Y., Khalili, N., Sahebi, E., Namazi, S., Simental-Mendía, L. E., Majeed, M., & Sahebkar, A. (2018). Effects of curcuminoids plus piperine on glycemic, hepatic and inflammatory biomarkers in patients with type 2 diabetes mellitus: A randomized double-blind placebo-controlled trial. Drug Research, 68(07), 403–409. https://doi.org/10.1055/s-0044-101752
   Google Scholar
• Pazdro, R., & Burgess, J. R. (2010). The role of vitamin E and oxidative stress in diabetes complications. Mechanisms of Ageing and Development, 131(4), 276–286. https://doi.org/10.1016/j.mad.2010.03.005
   PubMed Web of Science ®Google Scholar
• Rader, D. J. (2007). Effect of insulin resistance, dyslipidemia, and intra-abdominal adiposity on the development of cardiovascular disease and diabetes mellitus. The American Journal of Medicine, 120(3), S12–S18. https://doi.org/10.1016/j.amjmed.2007.01.003
   PubMed Web of Science ®Google Scholar
• Rahimi, H. R., Mohammadpour, A. H., Dastani, M., Jaafari, M. R., Abnous, K., Ghayour Mobarhan, M., & Kazemi Oskuee, R. (2016). The effect of nano-curcumin on HbA1c, fasting blood glucose, and lipid profile in diabetic subjects: A randomized clinical trial. Avicenna Journal of Phytomedicine, 6(5), 567–577.
   PubMedGoogle Scholar
• Rahmani, S., Asgary, S., Askari, G., Keshvari, M., Hatamipour, M., Feizi, A., & Sahebkar, A. (2016). Treatment of non-alcoholic fatty liver disease with curcumin: A randomized placebo-controlled trial. Phytotherapy Research: PTR, 30(9), 1540–1548. https://doi.org/10.1002/ptr.5659
   PubMed Web of Science ®Google Scholar
• Rezasoltani, P., Elliyoun, N., Ziaie, T., Sobhani, A., Kazemnezhjad Leyli, E., & Kazemi Aski, S. (2021). Double-blind controlled trial of vitamin E effects on serum lipid profile in menopausal women. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 14, 1053–1060. https://doi.org/10.2147/DMSO.S233138
   PubMed Web of Science ®Google Scholar
• Slopien, R., Wender-Ozegowska, E., Rogowicz-Frontczak, A., Meczekalski, B., Zozulinska-Ziolkiewicz, D., Jaremek, J. D., Cano, A., Chedraui, P., Goulis, D. G., Lopes, P., Mishra, G., Mueck, A., Rees, M., Senturk, L. M., Simoncini, T., Stevenson, J. C., Stute, P., Tuomikoski, P., Paschou, S. A., Anagnostis, P., & Lambrinoudaki, I. (2018). Menopause and diabetes: EMAS clinical guide. Maturitas, 117, 6–10. https://doi.org/10.1016/j.maturitas.2018.08.009
   PubMed Web of Science ®Google Scholar
• Soetikno, V., Sari, F. R., Lakshmanan, A. P., Arumugam, S., Harima, M., Suzuki, K., Kawachi, H., & Watanabe, K. (2013). Curcumin alleviates oxidative stress, inflammation, and renal fibrosis in remnant kidney through the Nrf2-keap1 pathway. Molecular Nutrition & Food Research, 57(9), 1649–1659. https://doi.org/10.1002/mnfr.201200540
   PubMed Web of Science ®Google Scholar
• Sundar Dhilip Kumar, S., Houreld, N. N., & Abrahamse, H. (2018). Therapeutic potential and recent advances of curcumin in the treatment of aging-associated diseases. Molecules, 23(4), 835. https://doi.org/10.3390/molecules23040835
   PubMed Web of Science ®Google Scholar
• Topatan, S., & Yıldız, H. (2012). Symptoms experienced by women who enter into natural and surgical menopause and their relation to sexual functions. Health Care for Women International, 33(6), 525–539. https://doi.org/10.1080/07399332.2011.646374
   PubMed Web of Science ®Google Scholar
• Traber, M. G., & Atkinson, J. (2007). Vitamin E, antioxidant and nothing more. Free Radical Biology & Medicine, 43(1), 4–15. https://doi.org/10.1016/j.freeradbiomed.2007.03.024
   PubMed Web of Science ®Google Scholar
• Ueki, M., Ueno, M., Morishita, J., & Maekawa, N. (2013). Curcumin ameliorates cisplatin-induced nephrotoxicity by inhibiting renal inflammation in mice. Journal of Bioscience and Bioengineering, 115(5), 547–551. https://doi.org/10.1016/j.jbiosc.2012.11.007
   PubMed Web of Science ®Google Scholar
• Vadarlis, A., Antza, C., Bakaloudi, D. R., Doundoulakis, I., Kalopitas, G., Samara, M., Dardavessis, T., Maris, T., & Chourdakis, M. (2021). Systematic review with meta-analysis: The effect of vitamin E supplementation in adult patients with non-alcoholic fatty liver disease. Journal of Gastroenterology and Hepatology, 36(2), 311–319. https://doi.org/10.1111/jgh.15221
   PubMed Web of Science ®Google Scholar
• Wang, Q., Sun, Y., Ma, A., Li, Y., Han, X., & Liang, H. (2010). Effects of vitamin E on plasma lipid status and oxidative stress in Chinese women with metabolic syndrome. International Journal for Vitamin and Nutrition Research, 80(3), 178–187. https://doi.org/10.1024/0300-9831/a000015
   PubMed Web of Science ®Google Scholar
• Weisberg, S. P., Leibel, R., & Tortoriello, D. V. (2008). Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity. Endocrinology, 149(7), 3549–3558. https://doi.org/10.1210/en.2008-0262
   PubMed Web of Science ®Google Scholar
• Yun, J. M., Jialal, I., & Devaraj, S. (2011). Epigenetic regulation of high glucose-induced proinflammatory cytokine production in monocytes by curcumin. The Journal of Nutritional Biochemistry, 22(5), 450–458. https://doi.org/10.1016/j.jnutbio.2010.03.014
   PubMed Web of Science ®Google Scholar
• Zhong, F., Chen, H., Han, L., Jin, Y., & Wang, W. (2011). Curcumin attenuates lipopolysaccharide-induced renal inflammation. Biological & Pharmaceutical Bulletin, 34(2), 226–232. https://doi.org/10.1248/bpb.34.226
   PubMed Web of Science ®Google Scholar
• Ziaei, S., Kazemnejad, A., & Zareai, M. (2007). The effect of vitamin E on hot flashes in menopausal women. Gynecologic and Obstetric Investigation, 64(4), 204–207. https://doi.org/10.1159/000106491
   PubMed Web of Science ®Google Scholar