Analysis of MTNR1B gene polymorphisms in relationship with IRS2 gene variants, epicardial fat thickness, glucose homeostasis and cognitive performance in the elderly

References

• Albrecht U. (2012). Timing to perfection: The biology of central and peripheral circadian clocks. Neuron. 74:246–60.
   PubMed Web of Science ®Google Scholar
• Berg AH, Scherer PE. (2005). Adipose tissue, inflammation, and cardiovascular disease. Circ Res. 96:939–49.
   PubMed Web of Science ®Google Scholar
• Chambers JC, Zhang W, Zabaneh D, et al. (2009). Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians. Diabetes. 58:2703–08.
   PubMed Web of Science ®Google Scholar
• D’Alfonso R, Marini MA, Frittitta L, et al. (2003). Polymorphisms of the insulin receptor substrate-2 in patients with type 2 diabetes. J Clin Endocrinol Metab. 88:317–22.
   PubMed Web of Science ®Google Scholar
• Hastings MH, Reddy AB, Maywood ES. (2003). A clockwork web: Circadian timing in brain and periphery, in health and disease. Nat Rev Neurosci. 4:649–61.
   PubMed Web of Science ®Google Scholar
• Holzapfel C, Siegrist M, Rank M, et al. (2011). Association of a MTNR1B gene variant with fasting glucose and HOMA-B in children and adolescents with high BMI-SDS. Eur J Endocrinol. 164:205–12.
   PubMed Web of Science ®Google Scholar
• Hu C, Zhang R, Wang C, et al. (2010). Effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretion. Plos One. 5:e11761.
   PubMed Web of Science ®Google Scholar
• Iacobellis G. (2015). Local and systemic effects of the multifaceted epicardial adipose tissue depot. Nat Rev Endocrinol. 11:363–71.
   PubMed Web of Science ®Google Scholar
• Iacobellis G, Leonetti F. (2005). Epicardial adipose tissue and insulin resistance in obese subjects. J Clin Endocrinol Metab. 90:6300–02.
   PubMed Web of Science ®Google Scholar
• Kan MY, Zhou DZ, Zhang D, et al. (2010). Two susceptible diabetogenic variants near/in MTNR1B are associated with fasting plasma glucose in a Han Chinese cohort. Diabet Med. 27:598–602.
   PubMed Web of Science ®Google Scholar
• Lane JM, Chang AM, Bjonnes AC, et al. (2016). Impact of common diabetes risk variant in MTNR1B on sleep, circadian, and melatonin physiology. Diabetes. 65:1741–51.
   PubMed Web of Science ®Google Scholar
• Langenberg C, Pascoe L, Mari A, et al. (2009). Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response. Diabetologia. 52:1537–42.
   PubMed Web of Science ®Google Scholar
• Lavin DP, White MF, Brazil DP. (2016). IRS proteins and diabetic complications. Diabetologia. 59:2280–91.
   PubMed Web of Science ®Google Scholar
• Liu C, Wu Y, Li H, et al. (2010). MTNR1B rs10830963 is associated with fasting plasma glucose, HbA1C and impaired beta-cell function in Chinese Hans from Shanghai. BMC Med Genet. 11:59.
   PubMed Web of Science ®Google Scholar
• Liu J, Clough SJ, Hutchinson AJ, et al. (2016). MT1 and MT2 melatonin receptors: A therapeutic perspective. Annu Rev Pharmacol Toxicol. 56:361–83.
   PubMed Web of Science ®Google Scholar
• Lyssenko V, Nagorny CL, Erdos MR, et al. (2009). Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet. 41:82–88.
   PubMed Web of Science ®Google Scholar
• Matthews DR, Hosker JP, Rudenski AS, et al. (1985). Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 28:412–19.
   PubMed Web of Science ®Google Scholar
• Mazzoccoli G, Dagostino MP, Fontana A, et al. (2012a). Influence of the Gly1057Asp variant of the insulin receptor substrate 2 (IRS2) on insulin resistance and relationship with epicardial fat thickness in the elderly. Exp Gerontol. 47:988–93.a.
   PubMed Web of Science ®Google Scholar
• Mazzoccoli G, Dagostino MP, Vinciguerra M, et al. (2014). An association study between epicardial fat thickness and cognitive impairment in the elderly. Am J Physiol Heart Circ Physiol. 307:H1269–76.
   PubMed Web of Science ®Google Scholar
• Mazzoccoli G, Pazienza V, Vinciguerra M. (2012b). Clock genes and clock-controlled genes in the regulation of metabolic rhythms. Chronobiol Int. 29:227–51.b.
   PubMed Web of Science ®Google Scholar
• Mazzoccoli G, Rubino R, Tiberio C, et al. (2016). Clock gene expression in human and mouse hepatic models shows similar periodicity but different dynamics of variation. Chronobiol Int. 33:181–90.
   PubMed Web of Science ®Google Scholar
• Miller SA, Dykes DD, Polesky HF. (1988). A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 16:1215.
   PubMed Web of Science ®Google Scholar
• Müssig K, Staiger H, Machicao F, et al. (2010). Genetic variants in MTNR1B affecting insulin secretion. Ann Med. 42:387–93.
   PubMed Web of Science ®Google Scholar
• Nagorny CL, Sathanoori R, Voss U, et al. (2011). Distribution of melatonin receptors in murine pancreatic islets. J Pineal Res. 50:412–17.
   PubMed Web of Science ®Google Scholar
• Persaud SJ, Jones PM. (2016). A wake-up call for type 2 diabetes? N Engl J Med. 375:1090–92.
   PubMed Web of Science ®Google Scholar
• Peschke E, Mühlbauer E. (2010). New evidence for a role of melatonin in glucose regulation. Best Pract Res Clin Endocrinol Metab. 24:829–41.
   PubMed Web of Science ®Google Scholar
• Prokopenko I, Langenberg C, Florez JC, et al. (2009). Variants in MTNR1B influence fasting glucose levels. Nat Genet. 41:77–81.
   PubMed Web of Science ®Google Scholar
• Reinehr T, Scherag A, Wang HJ, et al. (2011). Relationship between MTNR1B (melatonin receptor 1B gene) polymorphism rs10830963 and glucose levels in overweight children and adolescents. Pediatr Diabetes. 12:435–41.
   PubMed Web of Science ®Google Scholar
• Rönn T, Wen J, Yang Z, et al. (2009). A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals. Diabetologia. 52:830–33.
   PubMed Web of Science ®Google Scholar
• Sparsø T, Bonnefond A, Andersson E, et al. (2009). G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: Studies involving 19,605 Europeans. Diabetes. 58:1450–56.
   PubMed Web of Science ®Google Scholar
• Staiger H, Machicao F, Schäfer SA, et al. (2008). Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function. Plos One. 3:e3962.
   PubMed Web of Science ®Google Scholar
• Stefan N, Kovacs P, Stumvoll M, et al. (2003). Metabolic effects of the Gly1057Asp polymorphism in IRS-2 and interactions with obesity. Diabetes. 52:1544–50.
   PubMed Web of Science ®Google Scholar
• Tam CH, Ho JS, Wang Y, et al. (2010). Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects. Plos One. 5:e11428.
   PubMed Web of Science ®Google Scholar
• Tombaugh TN, McIntyre NJ. (1992). The mini-mental state examination: A comprehensive review. J Am Geriatr Soc. 40:922–35.
   PubMed Web of Science ®Google Scholar
• Tuomi T, Nagorny CL, Singh P, et al. (2016). Increased melatonin signaling is a risk factor for type 2 diabetes. Cell Metab. 23:1067–77.
   PubMed Web of Science ®Google Scholar