Publication Cover
Chronobiology International
The Journal of Biological and Medical Rhythm Research
Volume 38, 2021 - Issue 5
418
Views
0
CrossRef citations to date
0
Altmetric
Original Articles

Different expressions of clock genes in fatty liver induced by high-sucrose and high-fat diets

, , & ORCID Icon
Pages 762-778 | Received 02 Sep 2020, Accepted 08 Feb 2021, Published online: 22 Feb 2021

References

  • Andre E, Gawlas K, Becker-Andre M. 1998. A novel isoform of the orphan nuclear receptor RORbeta is specifically expressed in pineal gland and retina. Gene. 216:277–283. doi:10.1016/s0378-1119(98)00348-5
  • Angelin B, Backman L, Einarsson K, Eriksson L, Ewerth S. 1982. Hepatic cholesterol metabolism in obesity: activity of microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase. J Lipid Res. 23:770–773 doi:10.1016/S0022-2275(20)38111-6
  • Balsalobre A, Marcacci L, Schibler U. 2000. Multiple signaling pathways elicit circadian gene expression in cultured Rat-1 fibroblasts. Curr Biol. 10:1291–1294. doi:10.1016/s0960-9822(00)00758-2
  • Barnea M, Madar Z, Froy O. 2009. High-fat diet delays and fasting advances the circadian expression of adiponectin signaling components in mouse liver. Endocrinology. 150:161–168. doi:10.1210/en.2008-0944
  • Brewer M, Lange D, Baler R, Anzulovich A. 2005. SREBP-1 as a transcriptional integrator of circadian and nutritional cues in the liver. J Biol Rhythms. 20:195–205. doi:10.1177/0748730405275952
  • Bugge A, Feng D, Everett LJ, Briggs ER, Mullican SE, Wang F, Jager J, Lazar MA. 2012. Rev-erbalpha and Rev-erbbeta coordinately protect the circadian clock and normal metabolic function. Genes Dev. 26:657–667. doi:10.1101/gad.186858.112
  • Chen L, Yang G. 2014. PPARs integrate the mammalian clock and energy metabolism. PPAR Res. 2014:653017. doi:10.1155/2014/653017
  • Cho H, Mu J, Kim JK, Thorvaldsen JL, Chu Q, Crenshaw EB 3rd, Kaestner KH, Bartolomei MS, Shulman GI, Birnbaum MJ. 2001. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science. 292:1728–1731. doi:10.1126/science.292.5522.1728
  • Cho H, Zhao X, Hatori M, Yu RT, Barish GD, Lam MT, Chong LW, DiTacchio L, Atkins AR, Glass CK, et al. 2012. Regulation of circadian behaviour and metabolism by REV-ERB-alpha and REV-ERB-beta. Nature. 485:123–127. doi:10.1038/nature11048
  • Dang F, Sun X, Ma X, Wu R, Zhang D, Chen Y, Xu Q, Wu Y, Liu Y. 2016. Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock. Nat Commun. 7:12696. doi:10.1038/ncomms12696
  • De Bacquer D, Van Risseghem M, Clays E, Kittel F, De Backer G, Braeckman L. 2009. Rotating shift work and the metabolic syndrome: a prospective study. Int J Epidemiol. 38:848–854. doi:10.1093/ije/dyn360
  • DeBruyne JP, Weaver DR, Reppert SM. 2007. CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock. Nat Neurosci. 10:543–545. doi:10.1038/nn1884
  • Eckel-Mahan KL, Patel VR, De Mateo S, Orozco-Solis R, Ceglia NJ, Sahar S, Dilag-Penilla SA, Dyar KA, Baldi P, Sassone-Corsi P. 2013. Reprogramming of the circadian clock by nutritional challenge. Cell. 155:1464–1478. doi:10.1016/j.cell.2013.11.034
  • Fernandes-Lima F, Monte TL, Nascimento FA, Gregorio BM. 2015. Short exposure to a high-sucrose diet and the first ‘hit’ of nonalcoholic fatty liver disease in mice. Cells Tissues Organs. 201:464–472. doi:10.1159/000446514
  • Foretz M, Pacot C, Dugail I, Lemarchand P, Guichard C, Le Liepvre X, Berthelier-Lubrano C, Spiegelman B, Kim JB, Ferre P, et al. 1999. ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose. Mol Cell Biol. 19:3760–3768. doi:10.1128/mcb.19.5.3760
  • Gallego M, Virshup DM. 2007. Post-translational modifications regulate the ticking of the circadian clock. Nat Rev Mol Cell Biol. 8:139–148. doi:10.1038/nrm2106
  • Gekakis N, Staknis D, Nguyen HB, Davis FC, Wilsbacher LD, King DP, Takahashi JS, Weitz CJ. 1998. Role of the CLOCK protein in the mammalian circadian mechanism. Science. 280:1564–1569. doi:10.1126/science.280.5369.1564
  • Gnerre C, Schuster GU, Roth A, Handschin C, Johansson L, Looser R, Parini P, Podvinec M, Robertsson K, Gustafsson JA, et al. 2005. LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver. J Lipid Res. 46:1633–1642. doi:10.1194/jlr.M400453-JLR200
  • Grimaldi B, Bellet MM, Katada S, Astarita G, Hirayama J, Amin RH, Granneman JG, Piomelli D, Leff T, Sassone-Corsi P. 2010. PER2 controls lipid metabolism by direct regulation of PPARγ. Cell Metab. 12:509–520. doi:10.1016/j.cmet.2010.10.005
  • Hermida MA, Dinesh Kumar J, Leslie NR. 2017. GSK3 and its interactions with the PI3K/AKT/mTOR signalling network. Adv Biol Regul. 65:5–15. doi:10.1016/j.jbior.2017.06.003
  • Hirota T, Okano T, Kokame K, Shirotani-Ikejima H, Miyata T, Fukada Y. 2002. Glucose down-regulates Per1 and Per2 mRNA levels and induces circadian gene expression in cultured Rat-1 fibroblasts. J Biol Chem. 277:44244–44251. doi:10.1074/jbc.M206233200
  • Hogenesch JB, Gu YZ, Jain S, Bradfield CA. 1998. The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proc Natl Acad Sci USA. 95:5474–5479. doi:10.1073/pnas.95.10.5474
  • Honma K, Hikosaka M, Mochizuki K, Goda T. 2016. Loss of circadian rhythm of circulating insulin concentration induced by high-fat diet intake is associated with disrupted rhythmic expression of circadian clock genes in the liver. Metabolism. 65:482–491. doi:10.1016/j.metabol.2015.12.003
  • Hsieh MC, Yang SC, Tseng HL, Hwang LL, Chen CT, Shieh KR. 2010. Abnormal expressions of circadian-clock and circadian clock-controlled genes in the livers and kidneys of long-term, high-fat-diet-treated mice. Int J Obes (Lond). 34:227–239. doi:10.1038/ijo.2009.228
  • Kersten S, Seydoux J, Peters JM, Gonzalez FJ, Desvergne B, Wahli W. 1999. Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J Clin Invest. 103:1489–1498. doi:10.1172/jci6223
  • Kim K, Boo K, Yu YS, Oh SK, Kim H, Jeon Y, Bhin J, Hwang D, Kim KI, Lee JS, et al. 2017. RORalpha controls hepatic lipid homeostasis via negative regulation of PPARgamma transcriptional network. Nat Commun. 8:162. doi:10.1038/s41467-017-00215-1
  • King DP, Zhao Y, Sangoram AM, Wilsbacher LD, Tanaka M, Antoch MP, Steeves TD, Vitaterna MH, Kornhauser JM, Lowrey PL, et al. 1997. Positional cloning of the mouse circadian clock gene. Cell. 89:641–653. doi:10.1016/s0092-8674(00)80245-7
  • Kohsaka A, Laposky AD, Ramsey KM, Estrada C, Joshu C, Kobayashi Y, Turek FW, Bass J. 2007. High-fat diet disrupts behavioral and molecular circadian rhythms in mice. Cell Metab. 6:414–421. doi:10.1016/j.cmet.2007.09.006
  • Kroenke CH, Spiegelman D, Manson J, Schernhammer ES, Colditz GA, Kawachi I. 2007. Work characteristics and incidence of type 2 diabetes in women. Am J Epidemiol. 165:175–183. doi:10.1093/aje/kwj355
  • Kume K, Zylka MJ, Sriram S, Shearman LP, Weaver DR, Jin X, Maywood ES, Hastings MH, Reppert SM. 1999. mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell. 98:193–205. doi:10.1016/s0092-8674(00)81014-4
  • Lau P, Fitzsimmons RL, Raichur S, Wang SC, Lechtken A, Muscat GE. 2008. The orphan nuclear receptor, RORalpha, regulates gene expression that controls lipid metabolism: staggerer (SG/SG) mice are resistant to diet-induced obesity. J Biol Chem. 283:18411–18421. doi:10.1074/jbc.M710526200
  • Lavery DJ, Schibler U. 1993. Circadian transcription of the cholesterol 7 alpha hydroxylase gene may involve the liver-enriched bZIP protein DBP. Genes Dev. 7:1871–1884. doi:10.1101/gad.7.10.1871
  • Li D, Ikaga R, Yamazaki T. 2018. Soya protein beta-conglycinin ameliorates fatty liver and obesity in diet-induced obese mice through the down-regulation of PPARgamma. Br J Nutr. 119:1220–1232. doi:10.1017/s0007114518000739
  • Lin Y, Wang S, Zhou Z, Guo L, Yu F, Wu B. 2019a. Bmal1 regulates circadian expression of cytochrome P450 3a11 and drug metabolism in mice. Commun Biol. 2:378. doi:10.1038/s42003-019-0607-z.
  • Lin Y, Zhou Z, Yang Z, Gao L, Wang S, Yu P, Wu B. 2019b. Circadian Cyp3a11 metabolism contributes to chronotoxicity of hypaconitine in mice. Chem Biol Interact. 308:288–293. doi:10.1016/j.cbi.2019.05.049
  • Longo VD, Panda S. 2016. Fasting, circadian rhythms, and time-restricted feeding in healthy lifespan. Cell Metab. 23:1048–1059. doi:10.1016/j.cmet.2016.06.001
  • Ma X, Zhou Z, Chen Y, Wu Y, Liu Y. 2016. RBP4 functions as a hepatokine in the regulation of glucose metabolism by the circadian clock in mice. Diabetologia. 59:354–362. doi:10.1007/s00125-015-3807-1
  • Malik VS, Schulze MB, Hu FB. 2006. Intake of sugar-sweetened beverages and weight gain: a systematic review. Am J Clin Nutr. 84:274–288. doi:10.1093/ajcn/84.1.274
  • Mayer D. 1976. The circadian rhythm of synthesis and catabolism of cholesterol. Arch Toxicol. 36:267–276. doi:10.1007/BF00340534
  • Minnich A, Tian N, Byan L, Bilder G. 2001. A potent PPARalpha agonist stimulates mitochondrial fatty acid beta-oxidation in liver and skeletal muscle. Am J Physiol Endocrinol Metab. 280:E270–279. doi:10.1152/ajpendo.2001.280.2.E270
  • Mitsui S, Yamaguchi S, Matsuo T, Ishida Y, Okamura H. 2001. Antagonistic role of E4BP4 and PAR proteins in the circadian oscillatory mechanism. Genes Dev. 15:995–1006. doi:10.1101/gad.873501
  • Mukherji A, Bailey SM, Staels B, Baumert TF. 2019. The circadian clock and liver function in health and disease. J Hepatol. 71:200–211. doi:10.1016/j.jhep.2019.03.020
  • Mukherji A, Dachraoui M, Baumert TF. 2020. Perturbation of the circadian clock and pathogenesis of NAFLD. Metabolism. 111S:154337. doi:10.1016/j.metabol.2020.154337
  • Myant NB, Mitropoulos KA. 1977. Cholesterol 7 alpha-hydroxylase. J Lipid Res. 18:135–153. doi:10.1016/S0022-2275(20)41693-1
  • Pagliassotti MJ, Kang J, Thresher JS, Sung CK, Bizeau ME. 2002. Elevated basal PI 3-kinase activity and reduced insulin signaling in sucrose-induced hepatic insulin resistance. Am J Physiol Endocrinol Metab. 282:E170–176. doi:10.1152/ajpendo.2002.282.1.E170
  • Pan A, Schernhammer ES, Sun Q, Hu FB. 2011. Rotating night shift work and risk of type 2 diabetes: two prospective cohort studies in women. PLoS Med. 8:e1001141. doi:10.1371/journal.pmed.1001141
  • Panda S, Antoch MP, Miller BH, Su AI, Schook AB, Straume M, Schultz PG, Kay SA, Takahashi JS, Hogenesch JB. 2002. Coordinated transcription of key pathways in the mouse by the circadian clock. Cell. 109:307–320. doi:10.1016/s0092-8674(02)00722-5
  • Peplonska B, Bukowska A, Sobala W. 2015. Association of rotating night shift work with BMI and abdominal obesity among nurses and midwives. PLoS ONE. 10:e0133761. doi:10.1371/journal.pone.0133761
  • Polonsky KS, Given BD, Hirsch LJ, Tillil H, Shapiro ET, Beebe C, Frank BH, Galloway JA, Van Cauter E. 1988. Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus. N Engl J Med. 318:1231–1239. doi:10.1056/nejm198805123181903
  • Portaluppi F, Smolensky MH, Touitou Y. 2010. Ethics and methods for biological rhythm research on animals and human beings. Chronobiol Int. 27:1911–1929. doi:10.3109/07420528.2010.516381
  • Ralph MR, Foster RG, Davis FC, Menaker M. 1990. Transplanted suprachiasmatic nucleus determines circadian period. Science. 247:975–978. doi:10.1126/science.2305266
  • Refinetti R, Lissen GC, Halberg F. 2007. Procedures for numerical analysis of circadian rhythms. Biol Rhythm Res. 38:275–325. doi:10.1080/09291010600903692
  • Rey G, Cesbron F, Rougemont J, Reinke H, Brunner M, Naef F. 2011. Genome-wide and phase-specific DNA-binding rhythms of BMAL1 control circadian output functions in mouse liver. PLoS Biol. 9(2):e1000595. doi:10.1371/journal.pbio.1000595
  • Ripperger JA, Shearman LP, Reppert SM, Schibler U. 2000. CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBP. Genes Dev. 14:679–689. doi:10.1101/gad.14.6.679
  • Rosen ED, Sarraf P, Troy AE, Bradwin G, Moore K, Milstone DS, Spiegelman BM, Mortensen RM. 1999. PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol Cell. 4:611–617. doi:10.1016/s1097-2765(00)80211-7
  • Russell DW, Setchell KD. 1992. Bile acid biosynthesis. Biochemistry. 31:4737–4749. doi:10.1021/bi00135a001
  • Sato TK, Panda S, Miraglia LJ, Reyes TM, Rudic RD, McNamara P, Naik KA, FitzGerald GA, Kay SA, Hogenesch JB. 2004. A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. Neuron. 43:527–537. doi:10.1016/j.neuron.2004.07.018
  • Shearman LP, Sriram S, Weaver DR, Maywood ES, Chaves I, Zheng B, Kume K, Lee CC, Van Der Horst GT, Hastings MH, et al. 2000. Interacting molecular loops in the mammalian circadian clock. Science. 288:1013–1019. doi:10.1126/science.288.5468.1013
  • Stoeckman AK, Towle HC. 2002. The role of SREBP-1c in nutritional regulation of lipogenic enzyme gene expression. J Biol Chem. 277:27029–27035. doi:10.1074/jbc.M202638200
  • Sun S, Hanzawa F, Kim D, Umeki M, Nakajima S, Sakai K, Ikeda S, Mochizuki S, Oda H. 2019. Circadian rhythm-dependent induction of hepatic lipogenic gene expression in rats fed a high-sucrose diet. J Biol Chem. 294:15206–15217. doi:10.1074/jbc.RA119.010328
  • Surwit RS, Feinglos MN, Rodin J, Sutherland A, Petro AE, Opara EC, Kuhn CM, Rebuffe-Scrive M. 1995. Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice. Metabolism. 44:645–651. doi:10.1016/0026-0495(95)90123-x
  • Suzuki C, Ushijima K, Ando H, Kitamura H, Horiguchi M, Akita T, Yamashita C, Fujimura A. 2019. Induction of Dbp by a histone deacetylase inhibitor is involved in amelioration of insulin sensitivity via adipocyte differentiation in ob/ob mice. Chronobiol Int. 36:955–968. doi:10.1080/07420528.2019.1602841
  • Takeda Y, Jothi R, Birault V, Jetten AM. 2012. RORgamma directly regulates the circadian expression of clock genes and downstream targets in vivo. Nucleic Acids Res. 40:8519–8535. doi:10.1093/nar/gks630
  • Takeda Y, Kang HS, Freudenberg J, DeGraff LM, Jothi R, Jetten AM. 2014a. Retinoic acid-related orphan receptor gamma (RORgamma): a novel participant in the diurnal regulation of hepatic gluconeogenesis and insulin sensitivity. PLoS Genet. 10:e1004331. doi:10.1371/journal.pgen.1004331
  • Takeda Y, Kang HS, Lih FB, Jiang H, Blaner WS, Jetten AM. 2014b. Retinoid acid-related orphan receptor gamma, RORgamma, participates in diurnal transcriptional regulation of lipid metabolic genes. Nucleic Acids Res. 42:10448–10459. doi:10.1093/nar/gku766
  • Te Morenga L, Mallard S, Mann J. 2012. Dietary sugars and body weight: systematic review and meta-analyses of randomised controlled trials and cohort studies. BMJ. 346:e7492. doi:10.1136/bmj.e7492
  • Tong X, Li P, Zhang D, VanDommelen K, Gupta N, Rui L, Omary MB, Yin L. 2016. E4BP4 is an insulin-induced stabilizer of nuclear SREBP-1c and promotes SREBP-1c-mediated lipogenesis. J Lipid Res. 57:1219–1230. doi:10.1194/jlr.M067181
  • Toshihiro M, Saito K, Takikawa S, Takebe N, Onoda T, Satoh J. 2008. Psychosocial factors are independent risk factors for the development of Type 2 diabetes in Japanese workers with impaired fasting glucose and/or impaired glucose tolerance. Diabet Med. 25:1211–1217. doi:10.1111/j.1464-5491.2008.02566.x
  • Van Der Horst GT, Muijtjens M, Kobayashi K, Takano R, Kanno S, Takao M, De Wit J, Verkerk A, Eker AP, Van Leenen D, et al. 1999. Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms. Nature. 398:627–630. doi:10.1038/19323
  • Wada T, Kang HS, Angers M, Gong H, Bhatia S, Khadem S, Ren S, Ellis E, Strom SC, Jetten AM, et al. 2008. Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3). Mol Pharmacol. 73:891–899. doi:10.1124/mol.107.040741
  • Whiteman EL, Cho H, Birnbaum MJ. 2002. Role of Akt/protein kinase B in metabolism. Trends Endocrinol Metab. 13:444–451. doi:10.1016/s1043-2760(02)00662-8
  • Yamajuku D, Shibata Y, Kitazawa M, Katakura T, Urata H, Kojima T, Takayasu S, Nakata O, Hashimoto S. 2011. Cellular DBP and E4BP4 proteins are critical for determining the period length of the circadian oscillator. FEBS Lett. 585:2217–2222. doi:10.1016/j.febslet.2011.05.038
  • Yamazaki S, Numano R, Abe M, Hida A, Takahashi R, Ueda M, Block GD, Sakaki Y, Menaker M, Tei H. 2000. Resetting central and peripheral circadian oscillators in transgenic rats. Science. 288:682–685. doi:10.1126/science.288.5466.682
  • Yamazaki T, Kishimoto K, Ezaki O. 2012a. The ddY mouse: a model of postprandial hypertriglyceridemia in response to dietary fat. J Lipid Res. 53:2024–2037. doi:10.1194/jlr.M023713.
  • Yamazaki T, Kishimoto K, Miura S, Ezaki O. 2012b. Dietary beta-conglycinin prevents fatty liver induced by a high-fat diet by a decrease in peroxisome proliferator-activated receptor gamma2 protein. J Nutr Biochem. 23:123–132. doi:10.1016/j.jnutbio.2010.11.006
  • Yamazaki T, Shiraishi S, Kishimoto K, Miura S, Ezaki O. 2011. An increase in liver PPARgamma2 is an initial event to induce fatty liver in response to a diet high in butter: pPARgamma2 knockdown improves fatty liver induced by high-saturated fat. J Nutr Biochem. 22:543–553. doi:10.1016/j.jnutbio.2010.04.009
  • Yanagihara H, Ando H, Hayashi Y, Obi Y, Fujimura A. 2006. High-fat feeding exerts minimal effects on rhythmic mRNA expression of clock genes in mouse peripheral tissues. Chronobiol Int. 23:905–914. doi:10.1080/07420520600827103
  • Yoo SH, Yamazaki S, Lowrey PL, Shimomura K, Ko CH, Buhr ED, Siepka SM, Hong HK, Oh WJ, Yoo OJ, et al. 2004. PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues. Proc Natl Acad Sci USA. 101:5339–5346. doi:10.1073/pnas.0308709101
  • Zhang D, Tong X, Arthurs B, Guha A, Rui L, Kamath A, Inoki K, Yin L. 2014a. Liver clock protein BMAL1 promotes de novo lipogenesis through insulin-mTORC2-AKT signaling. J Biol Chem. 289:25925–25935. doi:10.1074/jbc.M114.567628
  • Zhang R, Lahens NF, Ballance HI, Hughes ME, Hogenesch JB. 2014b. A circadian gene expression atlas in mammals: implications for biology and medicine. Proc Natl Acad Sci USA. 111:1621–1624. doi:10.1073/pnas.1408886111
  • Zhang T, Zhao M, Lu D, Wang S, Yu F, Guo L, Wen S, Wu B. 2018. REV-ERBα regulates CYP7A1 through repression of liver receptor homolog-1. Drug Metab Dispos. 46:248–258. doi:10.1124/dmd.117.078105
  • Zhang Y, Papazyan R, Damle M, Fang B, Jager J, Feng D, Peed LC, Guan D, Sun Z, Lazar MA. 2017. The hepatic circadian clock fine-tunes the lipogenic response to feeding through RORalpha/gamma. Genes Dev. 31:1202–1211. doi:10.1101/gad.302323.117
  • Zvonic S, Ptitsyn AA, Conrad SA, Scott LK, Floyd ZE, Kilroy G, Wu X, Goh BC, Mynatt RL, Gimble JM. 2006. Characterization of peripheral circadian clocks in adipose tissues. Diabetes. 55:962–970. doi:10.2337/diabetes.55.04.06.db05-0873

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.