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Chronobiology International
The Journal of Biological and Medical Rhythm Research
Volume 40, 2023 - Issue 1
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Review Article

Circadian rhythms in cardiac metabolic flexibility

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Pages 13-26 | Received 30 Mar 2021, Accepted 01 Jun 2021, Published online: 23 Jun 2021

References

  • Abdurrachim D, Luiken JJ, Nicolay K, Glatz JF, Prompers JJ, Nabben M. 2015. Good and bad consequences of altered fatty acid metabolism in heart failure: evidence from mouse models. Cardiovasc Res. 106:194–205. doi:10.1093/cvr/cvv105
  • Aerni-Flessner L, Abi-Jaoude M, Koenig A, Payne M, Hruz PW. 2012. GLUT4, GLUT1, and GLUT8 are the dominant GLUT transcripts expressed in the murine left ventricle. Cardiovasc Diabetol. 11:63. doi:10.1186/1475-2840-11-63
  • Ando H, Ushijima K, Shimba S, Fujimura A. 2016. Daily fasting blood glucose rhythm in male Mice: a role of the circadian clock in the liver. Endocrinology. 157:463–469. doi:10.1210/en.2015-1376
  • Antle MC, Silver R. 2005. Orchestrating time: arrangements of the brain circadian clock. Trends Neurosci. 28:145–151. doi:10.1016/j.tins.2005.01.003
  • Arble DM, Bass J, Laposky AD, Vitaterna MH, Turek FW. 2009. Circadian timing of food intake contributes to weight gain. Obesity (Silver Spring). 17:2100–2102. doi:10.1038/oby.2009.264
  • Balsalobre A, Damiola F, Schibler U. 1998. A serum shock induces circadian gene expression in mammalian tissue culture cells. Cell. 93:929–937. doi:10.1016/S0092-8674(00)81199-X
  • Barclay JL, Husse J, Bode B, Naujokat N, Meyer-Kovac J, Schmid SM, Lehnert H, Oster H, Mistlberger RE. 2012. Circadian desynchrony promotes metabolic disruption in a mouse model of shiftwork. PLoS One. 7:e37150. doi:10.1371/journal.pone.0037150
  • Benavides A, Siches M, Llobera M. 1998. Circadian rhythms of lipoprotein lipase and hepatic lipase activities in intermediate metabolism of adult rat. Am J Physiol. 275:R811–817. doi:10.1152/ajpregu.1998.275.3.R811
  • Berryman CE, Lieberman HR, Fulgoni VL 3rd, Pasiakos SM. 2021. Greater protein intake at breakfast or as snacks and less at dinner is associated with cardiometabolic health in adults. Clinical nutrition. doi:10.1016/J.clnu.2021.01.018
  • Bolli GB, De Feo P, De Cosmo S, Perriello G, Ventura MM, Calcinaro F, Lolli C, Campbell P, Brunetti P, Gerich JE. 1984. Demonstration of a dawn phenomenon in normal human volunteers. Diabetes. 33:1150–1153. doi:10.2337/diab.33.12.1150
  • Bolli GB, Gerich JE. 1984. The “dawn phenomenon”--a common occurrence in both non-insulin-dependent and insulin-dependent diabetes mellitus. N Engl J Med. 310:746–750. doi:10.1056/NEJM198403223101203
  • Bonney S, Kominsky D, Brodsky K, Eltzschig H, Walker L, Eckle T, Rosenberger P. 2013. Cardiac Per2 functions as novel link between fatty acid metabolism and myocardial inflammation during ischemia and reperfusion injury of the heart. PLoS One. 8:e71493. doi:10.1371/journal.pone.0071493
  • Bray M, Shaw C, Moore M, Garcia R, Zanquetta M, Durgan D, Jeong W, Tsai J, Bugger H, Zhang D, et al. 2008. Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function; metabolism; and gene expression. Am J Physiol Heart Circ Physiol. 294:H1036–H1047. doi:10.1152/ajpheart.01291.2007
  • Bray MS, Ratcliffe WF, Grenett MH, Brewer RA, Gamble KL, Young ME. 2013. Quantitative analysis of light-phase restricted feeding reveals metabolic dyssynchrony in mice. Int J Obes (Lond). 37:843–852. doi:10.1038/ijo.2012.137
  • Bray MS, Tsai JY, Villegas-Montoya C, Boland BB, Blasier Z, Egbejimi O, Kueht M, Young ME. 2010. Time-of-day-dependent dietary fat consumption influences multiple cardiometabolic syndrome parameters in mice. Int J Obes (Lond). 34:1589–1598. doi:10.1038/ijo.2010.63
  • Brewer RA, Collins HE, Berry RD, Brahma MK, Tirado BA, Peliciari-Garcia RA, Stanley HL, Wende AR, Taegtmeyer H, Rajasekaran NS, et al. 2018. Temporal partitioning of adaptive responses of the murine heart to fasting. Life Sci. 197:30–39. doi:10.1016/j.lfs.2018.01.031
  • Bush NC, Resuehr HE, Goree LL, Locher JL, Bray MS, Soleymani T, Gower BA. 2018. A high-fat compared with a high-carbohydrate breakfast enhances 24-hour fat oxidation in older adults. J Nutr. 148:220–226. doi:10.1093/jn/nxx040
  • Chang J, Garva R, Pickard A, C-y CY, Mallikarjun V, Swift J, Holmes DF, Calverley B, Lu Y, Adamson A, et al. 2019. Circadian control of the secretory pathway is a central mechanism in tissue homeostasis. Nature Cell Biology. 22:74–86. doi:10.1038/s41556-019-0441-z
  • Chua EC, Shui G, Lee IT, Lau P, Tan LC, Yeo SC, Lam BD, Bulchand S, Summers SA, Puvanendran K, et al. 2013. Extensive diversity in circadian regulation of plasma lipids and evidence for different circadian metabolic phenotypes in humans. Proc Natl Acad Sci U S A. 110:14468–14473. doi:10.1073/pnas.1222647110
  • Chung H, Chou W, Sears DD, Patterson RE, Webster NJ, Ellies LG. 2016. Time-restricted feeding improves insulin resistance and hepatic steatosis in a mouse model of postmenopausal obesity. Metabolism. 65:1743–1754. doi:10.1016/j.metabol.2016.09.006
  • Collins HE, Rodrigo GC. 2010. Inotropic response of cardiac ventricular myocytes to beta-adrenergic stimulation with isoproterenol exhibits diurnal variation: involvement of nitric oxide. Circ Res. 106:1244–1252. doi:10.1161/CIRCRESAHA.109.213942
  • Dallmann R, Viola AU, Tarokh L, Cajochen C, Brown SA. 2012. The human circadian metabolome. Proc Natl Acad Sci U S A. 109:2625–2629. doi:10.1073/pnas.1114410109
  • Durgan D, Moore M, Ha N, Egbejimi O, Fields A, Mbawuike U, Egbejimi A, Shaw C, Bray M, Nannegari V, et al. 2007. Circadian rhythms in myocardial metabolism and contractile function: influence of workload and oleate. Am J Physiol Heart Circ Physiol. 293:H2385–H2393. doi:10.1152/ajpheart.01361.2006
  • Durgan DJ, Hotze MA, Tomlin TM, Egbejimi O, Graveleau C, Abel ED, Shaw CA, Bray MS, Hardin PE, Young ME. 2005. The intrinsic circadian clock within the cardiomyocyte. Am J Physiol Heart Circ Physiol. 289:H1530–1541. doi:10.1152/ajpheart.00406.2005
  • Durgan DJ, Pat BM, Laczy B, Bradley JA, Tsai JY, Grenett MH, Ratcliffe WF, Brewer RA, Nagendran J, Villegas-Montoya C, et al. 2011. O-GlcNAcylation, novel post-translational modification linking myocardial metabolism and cardiomyocyte circadian clock. J Biol Chem. 286:44606–44619. doi:10.1074/jbc.M111.278903
  • Feigin RD, Klainer AS, Beisel WR. 1968. Factors affecting circadian periodicity of blood amino acids in man. Metabolism. 17:764–775. doi:10.1016/0026-0495(68)90026-7
  • Fukushima A, Lopaschuk GD. 2016. Acetylation control of cardiac fatty acid beta-oxidation and energy metabolism in obesity, diabetes, and heart failure. Biochim Biophys Acta. 1862:2211–2220. doi:10.1016/j.bbadis.2016.07.020
  • Gamble KL, Berry R, Frank SJ, Young ME. 2014. Circadian clock control of endocrine factors. Nat Rev Endocrinol. 10:466–475. doi:10.1038/nrendo.2014.78
  • Gan Y, Yang C, Tong X, Sun H, Cong Y, Yin X, Li L, Cao S, Dong X, Gong Y, et al. 2015. Shift work and diabetes mellitus: a meta-analysis of observational studies. Occup Environ Med. 72:72–78. doi:10.1136/oemed-2014-102150
  • Garaulet M, Gomez-Abellan P, Alburquerque-Bejar JJ, Lee YC, Ordovas JM, Scheer FA. 2013. Timing of food intake predicts weight loss effectiveness. Int J Obes (Lond). 37:604–611. doi:10.1038/ijo.2012.229
  • Gekakis N, Staknis D, Nguyen HB, Davis FC, Wilsbacher LD, King DP, Takahashi JS, Weitz CJ. 1998. Role of the CLOCK protein in the mammalian circadian mechanism. Science. 280:1564–1569. doi:10.1126/science.280.5369.1564
  • Gill S, Le HD, Melkani GC, Panda S. 2015. Time-restricted feeding attenuates age-related cardiac decline in Drosophila. Science. 347:1265–1269. doi:10.1126/science.1256682
  • Gimble JM, Floyd ZE. 2009. Fat circadian biology. J Appl Physiol. 107:1629–1637. doi:10.1152/japplphysiol.00090.2009
  • Glatz JFC, Nabben M, Young ME, Schulze PC, Taegtmeyer H, Luiken J. 2020. Re-balancing cellular energy substrate metabolism to mend the failing heart. Biochim Biophys Acta Mol Basis Dis. 1866:165579. doi:10.1016/j.bbadis.2019.165579
  • Goodwin G, Taylor C, Taegtmeyer H. 1998. Regulation of energy metabolism of the heart during acute increase in heart work. J Biol Chem. 273:29530–29539. doi:10.1074/jbc.273.45.29530
  • Hampton SM, Morgan LM, Lawrence N, Anastasiadou T, Norris F, Deacon S, Ribeiro D, Arendt J. 1996. Postprandial hormone and metabolic responses in simulated shift work. J Endocrinol. 151:259–267. doi:10.1677/joe.0.1510259
  • Harfmann BD, Schroder EA, Kachman MT, Hodge BA, Zhang X, Esser KA. 2016. Muscle-specific loss of Bmal1 leads to disrupted tissue glucose metabolism and systemic glucose homeostasis. Skelet Muscle. 6:12. doi:10.1186/s13395-016-0082-x
  • Hatori M, Vollmers C, Zarrinpar A, Ditacchio L, Bushong EA, Gill S, Leblanc M, Chaix A, Joens M, Fitzpatrick JA, et al. 2012. Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet. Cell Metab. 15:848–860. doi:10.1016/j.cmet.2012.04.019
  • He L, Hamm JA, Reddy A, Sams D, Peliciari-Garcia RA, McGinnis GR, Bailey SM, Chow CW, Rowe GC, Chatham JC, et al. 2016. Biotinylation: a novel posttranslational modification linking cell autonomous circadian clocks with metabolism. Am J Physiol Heart Circ Physiol. 310:H1520–1532. doi:10.1152/ajpheart.00959.2015
  • Hirota T, Fukada Y. 2004. Resetting mechanism of central and peripheral circadian clocks in mammals. Zoological Sci. 21:359–368. doi:10.2108/zsj.21.359
  • Hogenesch JB, Gu YZ, Jain S, Bradfield CA. 1998. The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proc Natl Acad Sci U S A. 95:5474–5479. doi:10.1073/pnas.95.10.5474
  • Ichihara K, Neely JR, Siehl DL, Morgan HE. 1980. Utilization of leucine by working rat heart. Am J Physiol. 239:E430–436. doi:10.1152/ajpendo.1980.239.6.E430
  • Jeyaraj D, Scheer FA, Ripperger JA, Haldar SM, Lu Y, Prosdocimo DA, Eapen SJ, Eapen BL, Cui Y, Mahabeleshwar GH, et al. 2012. Klf15 orchestrates circadian nitrogen homeostasis. Cell Metab. 15:311–323. doi:10.1016/j.cmet.2012.01.020
  • Kolbe I, Leinweber B, Brandenburger M, Oster H. 2019. Circadian clock network desynchrony promotes weight gain and alters glucose homeostasis in mice. Mol Metab. 30:140–151. doi:10.1016/j.molmet.2019.09.012
  • Kume K, Zylka MJ, Sriram S, Shearman LP, Weaver DR, Jin X, Maywood ES, Hastings MH, Reppert SM. 1999. mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell. 98:193–205. doi:10.1016/S0092-8674(00)81014-4
  • la Fleur SE, Kalsbeek A, Wortel J, Fekkes ML, Buijs RM. 2001. A daily rhythm in glucose tolerance: a role for the suprachiasmatic nucleus. Diabetes. 50:1237–1243. doi:10.2337/diabetes.50.6.1237
  • Labbé SM, Grenier-Larouche T, Croteau E, Normand-Lauzière F, Frisch F, Ouellet R, Guérin B, Turcotte EE, Carpentier AC. 2011. Organ-specific dietary fatty acid uptake in humans using positron emission tomography coupled to computed tomography. Am J Physiol Endocrinol Metab. 300:E445–453. doi:10.1152/ajpendo.00579.2010
  • Lamia KA, Storch KF, Weitz CJ. 2008. Physiological significance of a peripheral tissue circadian clock. Proc Natl Acad Sci U S A. 105:15172–15177. doi:10.1073/pnas.0806717105
  • Latimer MN, Sonkar R, Mia S, Robillard Frayne I, Carter KJ, Johnson CA, Rana S, Xie M, Rowe GC, Wende AR, et al. 2021. Branched chain amino acids selectively promote cardiac growth at the end of the awake period. JMCC. 157:31–44. doi:10.16/j.yjmcc.2021.04.005
  • Lavu S, Boss O, Elliott PJ, Lambert PD. 2008. Sirtuins--novel therapeutic targets to treat age-associated diseases. Nat Rev Drug Discov. 7:841–853. doi:10.1038/nrd2665
  • Lee J, Kim MS, Li R, Liu VY, Fu L, Moore DD, Ma K, Yechoor VK. 2011. Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in beta-cells. Islets. 3:381–388. doi:10.4161/isl.3.6.18157
  • Lee J, Moulik M, Fang Z, Saha P, Zou F, Xu Y, Nelson DL, Ma K, Moore DD, Yechoor VK. 2013. Bmal1 and beta-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced beta-cell failure in mice. Mol Cell Biol. 33:2327–2338. doi:10.1128/MCB.01421-12
  • Lloyd S, Brocks C, Chatham JC. 2003. Differential modulation of glucose, lactate, and pyruvate oxidation by insulin and dichloroacetate in the rat heart. Am J Physiol Heart Circ Physiol. 285:H163–172. doi:10.1152/ajpheart.01117.2002
  • Lopaschuk GD, Ussher JR, Folmes CD, Jaswal JS, Stanley WC. 2010. Myocardial Fatty Acid metabolism in health and disease. Physiol Rev. 90:207–258. doi:10.1152/physrev.00015.2009
  • Lyons MM, Squibb RL, Siegal H. 1967. Nucleotide rhythms in the mature rat heart. Nature. 216:1113–1114. doi:10.1038/2161113a0
  • Maouyo D, Sarfati P, Guan D, Morisset J, Adelson JW. 1993. Circadian rhythm of exocrine pancreatic secretion in rats: major and minor cycles. Am J Physiol. 264:G792–800. doi:10.1152/ajpgi.1993.264.4.G792
  • Marcheva B, Ramsey KM, Buhr ED, Kobayashi Y, Su H, Ko CH, Ivanova G, Omura C, Mo S, Vitaterna MH, et al. 2010. Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature. 466:627–631. doi:10.1038/nature09253
  • Marsin AS, Bertrand L, Rider MH, Deprez J, Beauloye C, Vincent MF, Van den Berghe G, Carling D, Hue L. 2000. Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia. Curr Biol. 10:1247–1255. doi:10.1016/S0960-9822(00)00742-9
  • McGinnis GR, Tang Y, Brewer RA, Brahma MK, Stanley HL, Shanmugam G, Rajasekaran NS, Rowe GC, Frank SJ, Wende AR, et al. 2017. Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heart. J Mol Cell Cardiol. 110:80–95. doi:10.1016/j.yjmcc.2017.07.005
  • McHill AW, Melanson EL, Higgins J, Connick E, Moehlman TM, Stothard ER, Wright KP Jr. 2014. Impact of circadian misalignment on energy metabolism during simulated nightshift work. Proc Natl Acad Sci U S A. 111:17302–17307. doi:10.1073/pnas.1412021111
  • McNamara P, Seo SB, Rudic RD, Sehgal A, Chakravarti D, FitzGerald GA. 2001. Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock. Cell. 105:877–889. doi:10.1016/S0092-8674(01)00401-9
  • Mia S, Kane MS, Latimer MN, Reitz CJ, Sonkar R, Benavides GA, Smith SR, Frank SJ, Martino TA, Zhang J, et al. 2020. Differential effects of REV-ERBalpha/beta agonism on cardiac gene expression, metabolism, and contractile function in a mouse model of circadian disruption. Am J Physiol Heart Circ Physiol. 318:H1487–H1508. doi:10.1152/ajpheart.00709.2019
  • Mia S, Sonkar R, Williams L, Latimer MN, Frayne Robillard I, Diwan A, Frank SJ, Des Rosiers C, Young ME. 2021. Impact of obesity on day-night differences in cardiac metabolism. FASEB J. 35:e21298. doi:10.1096/fj.202001706RR
  • Minami Y, Kasukawa T, Kakazu Y, Iigo M, Sugimoto M, Ikeda S, Yasui A, Van Der Horst GT, Soga T, Ueda HR. 2009. Measurement of internal body time by blood metabolomics. Proc Natl Acad Sci U S A. 106:9890–9895. doi:10.1073/pnas.0900617106
  • Morgan L, Arendt J, Owens D, Folkard S, Hampton S, Deacon S, English J, Ribeiro D, Taylor K. 1998. Effects of the endogenous clock and sleep time on melatonin, insulin, glucose and lipid metabolism. J Endocrinol. 157:443–451. doi:10.1677/joe.0.1570443
  • Noh HL, Okajima K, Molkentin JD, Homma S, Goldberg IJ. 2006. Acute lipoprotein lipase deletion in adult mice leads to dyslipidemia and cardiac dysfunction. Am J Physiol Endocrinol Metab. 291:E755–760. doi:10.1152/ajpendo.00111.2006
  • Olsen MK, Choi MH, Kulseng B, Zhao CM, Chen D. 2017. Time-restricted feeding on weekdays restricts weight gain: a study using rat models of high-fat diet-induced obesity. Physiol Behav. 173:298–304. doi:10.1016/j.physbeh.2017.02.032
  • Oparija-Rogenmozere L, Rajendran A, Poncet N, Camargo SMR, Verrey F, Albrecht U. 2020. Phosphorylation of mouse intestinal basolateral amino acid uniporter LAT4 is controlled by food-entrained diurnal rhythm and dietary proteins. PLoS One. 15:e0233863. doi:10.1371/journal.pone.0233863
  • Pan X, Bradfield CA, Hussain MM. 2016. Global and hepatocyte-specific ablation of Bmal1 induces hyperlipidaemia and enhances atherosclerosis. Nat Commun. 7:13011. doi:10.1038/ncomms13011
  • Pan X, Terada T, Okuda M, Inui K. 2004. The diurnal rhythm of the intestinal transporters SGLT1 and PEPT1 is regulated by the feeding conditions in rats. J Nutr. 134:2211–2215. doi:10.1093/jn/134.9.2211
  • Pan X, Zhang Y, Wang L, Hussain MM. 2010. Diurnal regulation of MTP and plasma triglyceride by CLOCK is mediated by SHP. Cell Metab. 12:174–186. doi:10.1016/j.cmet.2010.05.014
  • Park TS, Yamashita H, Blaner WS, Goldberg IJ. 2007. Lipids in the heart: a source of fuel and a source of toxins. Curr Opin Lipidol. 18:277–282. doi:10.1097/MOL.0b013e32814a57db
  • Pearce KL, Noakes M, Keogh J, Clifton PM. 2008. Effect of carbohydrate distribution on postprandial glucose peaks with the use of continuous glucose monitoring in type 2 diabetes. Am J Clin Nutr. 87:638–644. doi:10.1093/ajcn/87.3.638
  • Peliciari-Garcia RA, Goel M, Aristorenas JA, Shah K, He L, Yang Q, Shalev A, Bailey SM, Prabhu SD, Chatham JC, et al. 2016. Altered myocardial metabolic adaptation to increased fatty acid availability in cardiomyocyte-specific CLOCK mutant mice. Biochim Biophys Acta. 1860:1579–1595. doi:10.1016/j.bbalip.2015.12.012
  • Powanda MC, Wannemacher RW Jr. 1970. Evidence for a linear correlation between the level of dietary tryptophan and hepatic NAD concentration and for a systematic variation in tissue NAD concentration in the mouse and the rat. J Nutr. 100:1471–1478. doi:10.1093/jn/100.12.1471
  • Preitner N, Damiola F, Lopez-Molina L, Zakany J, Duboule D, Albrecht U, Schibler U. 2002. The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell. 110:251–260. doi:10.1016/S0092-8674(02)00825-5
  • Rana S, Prabhu SD, Young ME. 2020. chronobiological influence over cardiovascular function: the good, the bad, and the ugly. Circ Res. 126:258–279. doi:10.1161/CIRCRESAHA.119.313349
  • Riera CE, Dillin A. 2015. Tipping the metabolic scales towards increased longevity in mammals. Nat Cell Biol. 17:196–203. doi:10.1038/ncb3107
  • Sachan N, Dey A, Rotter D, Grinsfelder DB, Battiprolu PK, Sikder D, Copeland V, Oh M, Bush E, Shelton JM, et al. 2011. Sustained hemodynamic stress disrupts normal circadian rhythms in calcineurin-dependent signaling and protein phosphorylation in the heart. Circ Res. 108:437–445. doi:10.1161/CIRCRESAHA.110.235309
  • Scheer FA, Hilton MF, Mantzoros CS, Shea SA. 2009. Adverse metabolic and cardiovascular consequences of circadian misalignment. Proc Natl Acad Sci U S A. 106:4453–4458. doi:10.1073/pnas.0808180106
  • Schlierf G, Dorow E. 1973. Diurnal patterns of triglycerides, free fatty acids, blood sugar, and insulin during carbohydrate-induction in man and their modification by nocturnal suppression of lipolysis. J Clin Invest. 52:732–740. doi:10.1172/JCI107235
  • Shao D, Tian R. 2015. Glucose transporters in cardiac metabolism and hypertrophy. Compr Physiol. 6:331–351. doi:10.1002/cphy.c150016
  • Shearman LP, Sriram S, Weaver DR, Maywood ES, Chaves I, Zheng B, Kume K, Lee CC, Van Der Horst GT, Hastings MH, et al. 2000. Interacting molecular loops in the mammalian circadian clock. Science. 288:1013–1019. doi:10.1126/science.288.5468.1013
  • Snook JT, Meyer JH. 1964. Response of digestive enzymes to dietary protein. J Nutr. 82:409–414. doi:10.1093/jn/82.4.409
  • Stavinoha M, RaySpellicy J, Hart-Sailors M, Mersmann H, Bray M, Young M. 2004. Diurnal variations in the responsiveness of cardiac and skeletal muscle to fatty acids. Am J Physiol. 287:E878–E887. doi:10.1152/ajpendo.00189.2004
  • Stephan FK. 2002. The “other” circadian system: food as a Zeitgeber. J Biol Rhythms. 17:284–292. doi:10.1177/074873002129002591
  • St-Onge MP, Ard J, Baskin ML, Chiuve SE, Johnson HM, Kris-Etherton P, Varady K. 2017. Meal Timing and Frequency: implications for Cardiovascular Disease Prevention: a Scientific Statement From the American Heart Association. Circulation. 135:e96–e121. doi:10.1161/CIR.0000000000000476. American Heart Association Obesity Committee of the Council on L, Cardiometabolic H, Council on Cardiovascular Disease in the Y, Council on Clinical C, Stroke C.
  • Taegtmeyer H, Golfman L, Sharma S, Razeghi P, van Arsdall M. 2004. Linking gene expression to function: metabolic flexibility in the normal and diseased heart. Ann N Y Acad Sci. 1015:202–213. doi:10.1196/annals.1302.017
  • Takahashi JS, Hong HK, Ko CH, McDearmon EL. 2008. The genetics of mammalian circadian order and disorder: implications for physiology and disease. Nat Rev Genet. 9:764–775. doi:10.1038/nrg2430
  • Takeda N, Maemura K, Horie S, Oishi K, Imai Y, Harada T, Saito T, Shiga T, Amiya E, Manabe I, et al. 2007. Thrombomodulin is a clock-controlled gene in vascular endothelial cells. J Biol Chem. 282:32561–32567. doi:10.1074/jbc.M705692200
  • Tsai JY, Kienesberger PC, Pulinilkunnil T, Sailors MH, Durgan DJ, Villegas-Montoya C, Jahoor A, Gonzalez R, Garvey ME, Boland B, et al. 2010. Direct regulation of myocardial triglyceride metabolism by the cardiomyocyte circadian clock. J Biol Chem. 285:2918–2929. doi:10.1074/jbc.M109.077800
  • Tsai JY, Villegas-Montoya C, Boland BB, Blasier Z, Egbejimi O, Gonzalez R, Kueht M, McElfresh TA, Brewer RA, Chandler MP, et al. 2013. Influence of dark phase restricted high fat feeding on myocardial adaptation in mice. J Mol Cell Cardiol. 55:147–155. doi:10.1016/j.yjmcc.2012.09.010
  • Van Cauter E, Desir D, Decoster C, Fery F, Balasse EO. 1989. Nocturnal decrease in glucose tolerance during constant glucose infusion. J Clin Endocrinol Metab. 69:604–611. doi:10.1210/jcem-69-3-604
  • Van Laake LW, Lüscher TF, Young ME. 2017. The circadian clock in cardiovascular regulation and disease: lessons from the Nobel Prize in physiology or medicine 2017. Eur Heart J. 39:2326–2329. doi:10.1093/eurheartj/ehx775
  • Wang Z, Tapa S, Francis Stuart SD, Wang L, Bossuyt J, Delisle BP, Ripplinger CM. 2020. Aging disrupts normal time-of-day variation in cardiac electrophysiology. Circ Arrhythm Electrophysiol. 13:e008093. doi:10.1161/CIRCEP.119.008093
  • Wolever TM, Bolognesi C. 1996. Source and amount of carbohydrate affect postprandial glucose and insulin in normal subjects. J Nutr. 126:2798–2806. doi:10.1093/jn/126.11.2798
  • Wright JN, Collins HE, Wende AR, Chatham JC. 2017. O-GlcNAcylation and cardiovascular disease. Biochem Soc Trans. 45:545–553. doi:10.1042/BST20160164
  • Yi-lin L, Ke Z, Dan W, Xi-hong Z, Zheng R, Xin W, Yu-long Y. 2018. Dynamic feeding low and high methionine diets affect the diurnal rhythm of amino acid transporters and clock related genes in jejunum of laying hens. Biol Rhythm Res. 49:671–679. doi:10.1080/09291016.2017.1395531
  • Young M. 2006. The circadian clock within the heart: potential influence on myocardial gene expression; metabolism; and function. Am J Physiol Heart Circ Physiol. 290:H1–H16. doi:10.1152/ajpheart.00582.2005
  • Young M, McNulty P, Taegtmeyer H. 2002. Adaptation and maladaptation of the heart in diabetes: part II: potential mechanisms. Circulation. 105:1861–1870. doi:10.1161/01.CIR.0000012467.61045.87
  • Young M, Razeghi P, Cedars A, Guthrie P, Taegtmeyer H. 2001. Intrinsic diurnal variations in cardiac metabolism and contractile function. Circ Res. 89:1199–1208. doi:10.1161/hh2401.100741
  • Young ME, Brewer RA, Peliciari-Garcia RA, Collins HE, He L, Birky TL, Peden BW, Thompson EG, Ammons BJ, Bray MS, et al. 2014. Cardiomyocyte-specific BMAL1 plays critical roles in metabolism, signaling, and maintenance of contractile function of the heart. J Biol Rhythms. 29:257–276. doi:10.1177/0748730414543141
  • Zhang EE, Liu Y, Dentin R, Pongsawakul PY, Liu AC, Hirota T, Nusinow DA, Sun X, Landais S, Kodama Y, et al. 2010. Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Nat Med. 16:1152–1156. doi:10.1038/nm.2214
  • Zhang L, Prosdocimo DA, Bai X, Fu C, Zhang R, Campbell F, Liao X, Coller J, Jain MK. 2015. KLF15 establishes the landscape of diurnal expression in the heart. Cell Rep. 13:2368–2375. doi:10.1016/j.celrep.2015.11.038
  • Zhang L, Zhang R, Tien CL, Chan RE, Sugi K, Fu C, Griffin AC, Shen Y, Burris TP, Liao X, et al. 2017a. REV-ERBalpha ameliorates heart failure through transcription repression. JCI Insight. 2(17):e95177. doi:10.1172/jci.insight.95177.
  • Zhang R, Lahens NF, Ballance HI, Hughes ME, Hogenesch JB. 2014. A circadian gene expression atlas in mammals: implications for biology and medicine. Proc Natl Acad Sci U S A. 111:16219–16224. doi:10.1073/pnas.1408886111
  • Zhang XY, Zhang NN, Wan XP, Li LL, Zou XT. 2017b. Gene expression of amino acid transporter in pigeon (Columbia livia) intestine during post-hatch development and its correlation with amino acid in pigeon milk. Poult Sci. 96:1120–1131. doi:10.3382/ps/pew320

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