References
- Tata JR. A hormone for all seasons. Perspect Biol Med. 2007;50:89–103.
- Brent GA. Mechanisms of thyroid hormone action. J Clin Invest. 2012;122:3035–3043.
- Cheng SY, Leonard JL, Davis PJ. Molecular aspects of thyroid hormone actions. Endocr Rev. 2010;31:139–170.
- Puzianowska-Kuznicka M, Pawlik-Pachucka E, Owczarz M, Budzinska M, Polosak J. Small-molecule hormones: molecular mechanisms of action. Int J Endocrinol. 2013;2013:601246.
- Gnocchi D, Steffensen KR, Bruscalupi G, Parini P. Emerging role of thyroid hormone metabolites. Acta Physiol (Oxf). 2016;217:184–216.
- Casas F, Rochard P, Rodier A, et al. A variant form of the nuclear triiodothyronine receptor c-ErbAα1 plays a direct role in regulation of mitochondrial RNA synthesis. Mol Cell Biol. 1999;19:7913–7924.
- Hollowell JG, Staehling NW, Flanders WD, et al. Serum TSH, T4, and thyroid antibodies in the United States population (1988 to 1994): national health and nutrition examination survey (NHANES III). J Clin Endocrinol Metab. 2002;87:489–499.
- Bremner AP, Feddema P, Leedman PJ, et al. Age-related changes in thyroid function: a longitudinal study of a community-based cohort. J Clin Endocrinol Metab. 2012;97:1554–1562.
- Jansen SW, Roelfsema F, van der Spoel E, et al. Familial longevity is associated with higher TSH secretion and strong TSH-fT3 relationship. J Clin Endocrinol Metab. 2015;100:3806–3813.
- Baranowska B, Wolinska-Witort E, Bik W, Baranowska-Bik A, Martynska L, Broczek K, Mossakowska M, Chmielowska M. Evaluation of neuroendocrine status in longevity. Neurobiol Aging. 2007;28:774–783.
- Atzmon G, Barzilai N, Hollowell JG, Surks MI, Gabriely I. Extreme longevity is associated with increased serum thyrotropin. J Clin Endocrinol Metab. 2009;94:1251–1254.
- Gussekloo J, van Exel E, de Craen AJ, Meinders AE, Frölich M, Westendorp RG. Thyroid status, disability and cognitive function, and survival in old age. Jama. 2004;292:2591–2599.
- van den Beld AW, Visser TJ, Feelders RA, Grobbee DE, Lamberts SW. Thyroid hormone concentrations, disease, physical function, and mortality in elderly men. J Clin Endocrinol Metab. 2005;90:6403–6409.
- Razvi S, Shakoor A, Vanderpump M, Weaver JU, Pearce SH. The influence of age on the relationship between subclinical hypothyroidism and ischemic heart disease: a metaanalysis. J Clin Endocrinol Metab. 2008;93:2998–3007.
- Gosden JR, Middleton PG, Rout D, De Angelis C. Chromosomal localization of the human oncogene ERBA2. Cytogenet Cell Genet. 1986;43:150–153.
- Drabkin H, Kao FT, Hartz J, et al. Localization of human ERBA2 to the 3p22-3p24.1 region of chromosome 3 and variable deletion in small cell lung cancer. Proc Natl Acad Sci USA. 1988;85:9258–9262.
- Deelen J, Beekman M, Capri M, Franceschi C, Slagboom PE. Identifying the genomic determinants of aging and longevity in human population studies: progress and challenges. Bioessays. 2013;35:386–396.
- Contreras-Jurado C, Alonso-Merino E, Saiz-Ladera C, et al. The thyroid hormone receptors inhibit hepatic interleukin-6 signaling during endotoxemia. Sci Rep. 2016;6:30990.
- Alamino VA, Mascanfroni ID, Montesinos MM, et al. Antitumor responses stimulated by dendritic cells are improved by triiodothyronine binding to the thyroid hormone receptor β. Cancer Res. 2015;75:1265–1274.
- Fulop T, Larbi A, Dupuis G, et al. Immunosenescence and inflamm-aging as two sides of the same coin: friends or foes? Front Immunol. 2018;8:1960.
- Dorshkind K, Horseman ND. The roles of prolactin, growth hormone, insulin-like growth factor-I, and thyroid hormones in lymphocyte development and function: insights from genetic models of hormone and hormone receptor deficiency. Endocr Rev. 2000;21:292–312.
- Casas F, Pessemesse L, Grandemange S, et al. Overexpression of the mitochondrial T3 receptor induces skeletal muscle atrophy during aging. PLoS One. 2009;4:e5631.
- Pal S, Tyler JK. Epigenetics and aging. Sci Adv. 2016;2:e1600584.
- Sen P, Shah PP, Nativio R, Berger SL. Epigenetic mechanisms of longevity and aging. Cell. 2016;166:822–839.
- Neitzel H. A routine method for the establishment of permanent growing lymphoblastoid cell lines. Hum Genet. 1986;73:320–326.
- Polosak J, Roszkowska-Gancarz M, Kurylowicz A, et al. Decreased expression and the Lys751Gln polymorphism of the XPD gene are associated with extreme longevity. Biogerontology. 2010;11:287–297.
- Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162:156–159.
- Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 1988;16:1215.
- Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell. 2009;136:215–233.
- Gentilini D, Mari D, Castaldi D, et al. Role of epigenetics in human aging and longevity: genome-wide DNA methylation profile in centenarians and centenarians’ offspring. Age (Dordr). 2013;35:1961–1973.
- Milman S, Barzilai N. Dissecting the mechanisms underlying unusually successful human health span and life span. Cold Spring Harb Perspect Med. 2015;6:a025098.
- Sakurai A, Miyamoto T, DeGroot LJ. Cloning and characterization of the human thyroid hormone receptor β1 gene promoter. Biochem Biophys Res Commun. 1992;185:78–84.
- Jazdzewski K, Boguslawska J, Jendrzejewski J, et al. Thyroid hormone receptor β (THRB) is a major target gene for microRNAs deregulated in papillary thyroid carcinoma (PTC). J Clin Endocrinol Metab. 2011;96:E546–53.
- Best BP. Nuclear DNA damage as a direct cause of aging. Rejuvenation Res. 2009;12:199–208.
- Soares JP, Cortinhas A, Bento T, et al. Aging and DNA damage in humans: a meta‐analysis study. Aging (Albany NY). 2014;6:432–439.
- Kirkwood TBL, Kowald A. The free-radical theory of ageing – older, wiser and still alive: modeling positional effects of the primary targets of ROS reveals new support. Bioessays. 2012;34:692–700.
- Yu Y, Cui Y, Niedernhofer LJ, Wang Y. Occurrence, biological consequences, and human health relevance of oxidative stress-induced DNA damage. Chem Res Toxicol. 2016;29:2008–2039.
- Chandrasekaran A, Idelchik MD, Melendez JA. Redox control of senescence and age-related disease. Redox Biol. 2016;11:91–102.
- Fernández V, Tapia G, Varela P, Romanque P, Cartier-Ugarte D, Videla LA. Thyroid hormone-induced oxidative stress in rodents and humans: a comparative view and relation to redox regulation of gene expression. Comp Biochem Physiol C Toxicol Pharmacol. 2006;142:231–239.
- Harper ME, Seifert EL. Thyroid hormone effects on mitochondrial energetics. Thyroid. 2008;18:145–156.
- Saelim N, John LM, Wu J, et al. Nontranscriptional modulation of intracellular Ca2+ signaling by ligand stimulated thyroid hormone receptor. J Cell Biol. 2004;167:915–924.
- Venditti P, Chiellini G, Di Stefano L, et al. The TRβ-selective agonist, GC-1, stimulates mitochondrial oxidative processes to a lesser extent than triiodothyronine. J Endocrinol. 2010;205:279–289.
- Zambrano A, García-Carpizo V, Gallardo ME, et al. The thyroid hormone receptor β induces DNA damage and premature senescence. J Cell Biol. 2014;204:129–146.
- Li R, Luciakova K, Zaid A, Betina S, Fridell E, Nelson BD. Thyroid hormone activates transcription from the promoter regions of some human nuclear-encoded genes of the oxidative phosphorylation system. Mol Cell Endocrinol. 1997;128:69–75.
- Feart C, Pallet V, Boucheron C, et al. Aging affects the retinoic acid and the triiodothyronine nuclear receptor mRNA expression in human peripheral blood mononuclear cells. Eur J Endocrinol. 2005;152:449–458.
- Hodkinson CF, Simpson EEA, Beattie JH, et al. Preliminary evidence of immune function modulation by thyroid hormones in healthy men and women aged 55-70 years. J Endocrinol. 2009;202:55–63.
- De Vito P, Incerpi S, Pedersen JZ, Luly P, Davis FB, Davis PJ. Thyroid hormones as modulators of immune activities at the cellular level. Thyroid. 2011;21:879–890.
- De Vito P, Balducci V, Leone S, et al. Nongenomic effects of thyroid hormones on the immune system cells: new targets, old players. Steroids. 2012;77:988–995.
- Rozing MP, Westendorp RG, Maier AB, et al. Serum triiodothyronine levels and inflammatory cytokine production capacity. Age (Dordr). 2012;34:195–201.
- Arpin C, Pihlgren M, Fraichard A, et al. Effects of T3Rα1 and T3Rα2 gene deletion on T and B lymphocyte development. J Immunol. 2000;164:152–160.
- Contreras-Jurado C, García-Serrano L, Gómez-Ferrería M, Costa C, Paramio JM, Aranda A. The thyroid hormone receptors as modulators of skin proliferation and inflammation. J Biol Chem. 2011;286:24079–24088.
- Mascanfroni I, Montesinos M del M, Susperreguy S, et al. Control of dendritic cell maturation and function by triiodothyronine. Faseb J. 2008;22:1032–1042.
- Mascanfroni ID, Montesinos M del M, Va A, et al. Nuclear factor (NF)-κB-dependent thyroid hormone receptor β1 expression controls dendritic cell function via Akt signaling. J Biol Chem. 2010;285:9569–9582.
- Barkoff MS, Kocherginsky M, Anselmo J, Weiss RE, Refetoff S. Autoimmunity in patients with resistance to thyroid hormone. J Clin Endocrinol Metab. 2010;95:3189–3193.
- Ponnappan S, Ponnappan U. Aging and immune function: molecular mechanisms to interventions. Antioxid Redox Signal. 2011;14:1551–1585.
- Montecino-Rodriguez E, Berent-Maoz B, Dorshkind K. Causes, consequences, and reversal of immune system aging. J Clin Invest. 2013;123:958–965.