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Research Article

Do Different TSH Suppression Levels Effect Heart Rate Variability and QT Dispersions in Patients with Differentiated Thyroid Cancer?

ORCID Icon, ORCID Icon & ORCID Icon
Received 06 Apr 2024, Accepted 18 Jul 2024, Published online: 25 Jul 2024

References

  • Boucai L, Zafereo M, Cabanillas ME. Thyroid cancer: A review. JAMA. 2024;331(5):425–435. doi:10.1001/jama.2023.26348. PMID: 38319329.
  • Ahmadi S, Landa I. The prognostic power of gene mutations in thyroid cancer. Endocr Connect. 2024;13(2):e230297. doi:10.1530/EC-23-0297.
  • McGriff NJ, Csako G, Gourgiotis L, Lori CG, Pucino F, Sarlis NJ. Effects of thyroid hormone suppression therapy on adverse clinical outcomes in thyroid cancer. Ann Med. 2002;34(7–8):554–664. doi:10.1080/078538902321117760.
  • Grani G, Ramundo V, Verrienti A, Sponziello M, Durante C. Thyroid hormone therapy in differentiated thyroid cancer. Endocrine. 2019;66(1):43–50. doi:10.1007/s12020-019-02051-3.
  • Praw SS, Brent GA. Approach to the patient with a suppressed TSH. J Clin Endocrinol Metab. 2023;108(2):472–482. doi:10.1210/clinem/dgac635.
  • Polikar R, Burger AG, Scherrer U, Nicod P. The thyroid and the heart. Circulation. 1993;87(5):1435–1441. doi:10.1161/01.cir.87.5.1435.
  • Stein PK, Bosner MS, Kleiger RE, Conger BM. Heart rate variability: a measure of cardiac autonomic tone. Am Heart J. 1994;127(5):1376–1381. doi:10.1016/0002-8703(94)90059-0.
  • Rezus C, Moga VD, Ouatu A, Floria M. QT interval variations and mortality risk: Is there any relationship? Anatol J Cardiol. 2015;15(3):255–258. doi:10.5152/akd.2015.5875.
  • Malik M, Batchvarov VN. Measurement, interpretation and clinical potential of QT dispersion. J Am Coll Cardiol. 2000;36(6):1749–1766. doi:10.1016/s0735-1097(00)00962-1.
  • Laborde S, Mosley E, Thayer JF. Heart rate variability and cardiac vagal tone in psychophysiological research - recommendations for experiment planning, data analysis, and data reporting. Front Psychol. 2017;8:213. doi:10.3389/fpsyg.2017.00213.
  • Haugen BR, Alexander EK, Bible KC, et al. 2015 American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American thyroid association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid. 2016;26(1):1–133. doi:10.1089/thy.2015.0020.
  • Bazett HC. An analysis of the time-relations of electrocardiograms. Heart. 1920;7:353–370.
  • Surawicz B, Childers R, Deal BJ, Gettes LS, Bailey JJ, Gorgels A. American heart association electrocardiography and arrhythmias committee, council on clinical cardiology; American college of cardiology foundation, heart rhythm society. aha/accf/hrs recommendations for the standardization and interpretation of the electrocardiogram: part iii: intraventricular conduction disturbances: a scientific statement from the american heart association electrocardiography and arrhythmias committee, council on clinical cardiology; the american college of cardiology foundation, and the heart rhythm society. endorsed by the international society for computerized electrocardiology. J Am Coll Cardiol. 2009;53(11):976–981. doi:10.1016/j.jacc.2008.12.013.
  • Franz MR, Zabel M. Electrophysiological basis of QT dispersion measurements. Prog Cardiovasc Dis. 2000;42(5):311–324. doi:10.1053/pcad.2000.0420311. PMID: 10768310.
  • Day CP, McComp LM, Campbell RWF. QT dispersion: an indication of arrhythmia risk in patients with long QT intervals. Br Heart J. 1990;63(6):342–344. doi:10.1136/hrt.63.6.342.
  • Klein Hesselink EN, Klein Hesselink MS, deBock Gh, et al. Long-term cardiovascular mortality in patients with differentiated thyroid carcinoma: an observational study. J Clin Oncol. 2013;31(32):4046–4053. doi:10.1200/JCO.2013.49.1043.
  • Biondi B, Cooper DS. Thyroid hormone suppression therapy. Endocrinol Metab Clin North Am. 2019;48(1):227–237. doi:10.1016/j.ecl.2018.10.008.
  • Liu C, Lv H, Li Q, Fu S, Tan J, Wang C. Effect of thyrotropin suppressive therapy on heart rate variability and QT dispersion in patients with differentiated thyroid cancer. Medicine (Baltimore). July 10, 2020;99(28):e21190. doi:10.1097/MD.0000000000021190.
  • Toulis KA, Viola D, Gkoutos G, Keerthy D, Boelaert K, Nirantharakumar K. Risk of incident circulatory disease in patients treated for differentiated thyroid carcinoma with no history of cardiovascular disease. Clin Endocrinol (Oxf). 2019;91(2):323–330. doi:10.1111/cen.13990.
  • Klein Hesselink EN, Lefrandt JD, Schuurmans EP, Burgerhof JG, Groen B, Gansevoort RT. Increased risk of atrial fibrillation after treatment for differentiated thyroid carcinoma. J Clin Endocrinol Metab. 2015;100(12):4563–4569. doi:10.1210/jc.2015-2782.
  • Shao Y, Ojamaa K, Klein I, Ismail-Beigi F. Thyroid hormone stimulates Na, K-ATPase gene expression in the hemodynamically unloaded heterotopically transplanted rat heart. Thyroid. 2000;10(9):753–759. doi:10.1089/thy.2000.10.753.
  • Ulivieri A, Lavra L, Magi F, Morgante A, Calò L, Polisca P. Thyroid hormones regulate cardiac repolarization and QT-interval related gene expression in hiPSC cardiomyocytes. Sci Rep. 2022;12(1):568. doi:10.1038/s41598-021-04659-w.
  • Galetta F, Franzoni F, Fallahi P, Rossi M, Carpi A, Rubello D. Heart rate variability and QT dispersion in patients with subclinical hypothyroidism. Biomed Pharmacother. 2006;60(8):425–430. doi:10.1016/j.biopha.2006.07.009.
  • Bakiner O, Ertörer ME, Haydardedeoglu FE, Bozkırlı E, Tütüncü NB, ˘demirag NG. subclinical hypothyroidism is characterized by increased QT interval dispersion among women. Med Princ Pract. 2008;17(5):390–394. doi:10.1159/000141503.
  • Alonso H, Fernández-Ruocco J, Gallego M, et al. Thyroid stimulating hormone directly modulates cardiac electrical activity. J Mol Cell Cardiol. 2015;89:280–286. doi:10.1016/j.yjmcc.2015.10.019.
  • Owecki M, Michalak A, Nikisch E, Sowiński J. Prolonged ventricular repolarization measured by corrected QT interval (QTc) in subclinical hyperthyroidism. Horm Metab Res. 2006;38(1):44–47. doi:10.1055/s-2006-924977.
  • Galetta F, Franzoni F, Fallahi P, Tocchini L, Graci F, Gaddeo C. Changes in autonomic regulation and ventricular repolarization induced by subclinical hyperthyroidism. Biomed Pharmacother. 2010;64(8):546–549. doi:10.1016/j.biopha.2009.10.001.
  • Brusseau V, Tauveron I, Bagheri R, Ugbolue UC, Magnon V, Bouillon-Minois JB. Effect of hyperthyroidism treatments on heart rate variability: A systematic review and meta-analysis. Biomedicines. 2022;10(8):1982. doi:10.3390/biomedicines10081982.
  • Cai Z, Dai M, Zhang Y, Zhong H, Tan T, Bao M. Imbalance of cardiac autonomic nervous activity and increase of ventricular repolarization dynamicity induced by thyroid hormones in hyperthyroidism. Auton Neurosci. 2018;213:86–91. doi:10.1016/j.autneu.2018.06.006.
  • Kaminski G, Makowski K, Michałkiewicz D, et al. The influence of subclinical hyperthyroidism on blood pressure, heart rate variability, and prevalence of arrhythmias. Thyroid. 2012;22(5):454–460. doi:10.1089/thy.2010.0333.
  • Brusseau V, Tauveron I, Bagheri R, et al. Heart rate variability in hyperthyroidism: A systematic review and meta-analysis. Int J Environ Res Public Health. 2022;19(6):3606. doi:10.3390/ijerph19063606.
  • Eustatia-Rutten CF, Corssmit EP, Heemstra KA, et al. Autonomic nervous system function in chronic exogenous subclinical thyrotoxicosis and the effect of restoring euthyroidism. J Clin Endocrinol Metab. 2008;93(7):2835–2841. doi:10.1210/jc.2008-0080.

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