Neuropsychiatric Implications of Thyroid Hormone and Benzodiazepine Interactions

References

• Task Force. Benzodiazepine dependence, Toxicity and Abuse. Task Force Report of the American Psychiatric Association, Washington, DC 1990
   Google Scholar
• Greenblatt D J., Allen M D, Shader R I. Toxicity of high-dose flu-razepam in the elderly. Clin Pharmacol Ther 1977; 21: 355–61
   PubMed Web of Science ®Google Scholar
• Ray W A., Griffin M R., Schaffner W, Baugh D K., Melton L J., III. Psychotropic drug use and the risk of hip fracture. New Engl J Med 1987; 316: 363–9
   PubMed Web of Science ®Google Scholar
• Larson E B., Kukull W A., Buchner D, Reifler B V. Adverse drug reactions associated with global cognitive impairment in elderly persons. Annals Internal Med 1987; 107: 169–173
   PubMed Web of Science ®Google Scholar
• Whybrow P, Ferrell R. Thyroid state and human behavior: contributions from a clinical perspective. The Thyroid Axis, Drugs, and Behavior, A Prange, Jr. Raven Press, New York 1974; 5–27
   Google Scholar
• Simons R J., Simon J M., Demers L M., Santen R J. Thyroid dysfunction in elderly hospitalized patients. Effect of age and severity of illness. Arch Intern Med 1990; 150: 1249–1253
   Google Scholar
• Osterweil D, Syndulko K, Cohen S N., Pettler-Jennings P D., Hershman J M., Cummings J L., Tourtellotte W W., Solomon D H. Cognitive function in non-demented older adults with hypothyroidism. J Am Geriatr Soc 1992; 40: 325–335
   PubMed Web of Science ®Google Scholar
• Lewis G, Alessi C, Imperial J, Refetoff S. Low serum free thyroxine index in ambulating elderly is due to a resetting of the threshold of thyrotropin feedback suppression. J Clin Endo Metab 1991; 73: 843–849
   Google Scholar
• Runnels B, Garry P, Hunt W, Standefer J. Thyroid function in a healthy elderly population: implications for clinical evaluation. J Gerontol 1991; 46: B39–44
   Google Scholar
• Mori T, Inoue D, Kosugi S, Miyamoto M, Nishin K, Sagawa H, Akamizu T, Yokota T, Nakamura H, Namikawa M, Imura H. Effects of low dose L-triiodothyronine administration on mental, behavioural and thyroid states in elderly subjects. Endocrinol Japon 1988; 35: 585–592
   Google Scholar
• Wartofsky L, Ingbar S H. Diseases of the thyroid. Harrison's Principles of Internal Medicine. 12th ed, J D Wilson, E Braunwald, K J Isselbacher, R G Petersdorf, J B Martin, A S Fauci, R K Root. McGraw-Hill, Inc, New York 1991; 1692–1712
   Google Scholar
• DeNayer P. Thyroid hormone action at the cellular level. Hormone Rec 1987; 26: 48–57
   Google Scholar
• Fliegel L, Newton E, Burns K, Michalak M. Molecular cloning of cDNA encoding a 55 KDa multifunctional thyroid hormone binding protein of skeletal muscle sarcoplasmic reticulum. J Biol Chem 1991; 265: 15496–15502
   Google Scholar
• Ashizawa K, Kato H, McPhie P, Cheng S -Y. Regulation of thyroid hormone binding to its cytosolic binding protein by L-á-alanine. Biochem Biophys Res Comm 1990; 167: 587–592
   Google Scholar
• Larsen P R. The thyroid. Cecil Textbook of Medicine. 17th ed, J B Wyngaarden, L H Smith. W B Saunders Co., Philadelphia 1985; 1275–1299
   Google Scholar
• Dratman M B., Crutchfield F L., Gordon J T., Jennings A S. lodothyronine homeostasis in rat brain during hypo- and hyperthyroidism. Am J Physiol 1983; 245: E189–E193
   Google Scholar
• Hesch R -D, Brabant G, Kohrle J. Metabolism of the thyroid hormones with respect to cytoprotection. Klin Wochenschr 1986; 64(Suppl VII)149–154
   Google Scholar
• Dratman M B., Crutchfield F L., Futaesaku Y, Goldberger M E., Murray M. [125I]Triiodothyronine in the rat brain: evidence for neural localization and axonal transport derived from thaw-mount film autoradiography. J Comp Neurol 1987; 260: 392–408
   Google Scholar
• Goldman M, Dratman M B., Crutchfield F L., Maruniak J A., Jennings A S., Gibbons R D. Heart rate response to triiodothyronine: evidence for a central nervous system site of thyroid hormone action. J Clin Invest 1985; 76: 1622–1625
   Google Scholar
• Ruiz-Marcos A, Sanchez-Toscano F, Esobar del Rey F, Morreale de Escobar G. Reversible morphological alterations of cortical neurons in juvenile hypothyroidism in the rat. Brain Res 1980; 3: 91–102
   Google Scholar
• Gould E, Westlind-Danielsson A, Frankfurt M, McEwen B. Sex differences and thyroid hormone sensitivity of hippocampal cells. J Neuroscience 1990; 10: 996–1003
   PubMed Web of Science ®Google Scholar
• Patel A J., Hayashi M, Hunt A. Role of thyroid hormone and nerve growth factor in the development of choline acetyltransferase and other cell-specific marker enzymes in the basal forebrain of the rat. J Neurochem 1988; 50: 803–811
   PubMed Web of Science ®Google Scholar
• Mason G A., Bondy S, Nemeroff C B., Walker C H., Prange A J., Jr. The effects of thyroid state on beta-adrenergic and serotonergic receptors in rat brain. Psychoneuroendocrinology 1987; 12: 261–270
   PubMedGoogle Scholar
• McEwen B S., Coirini H, Danielsson A, Frankfurt M, Gould E, Mendelson S, Schumacher M, Segarra M, Woolley C. Steroid and thyroid hormones modulate a changing brain. J Steroid Biochem Molec Biol 1991; 40: 1–14
   Google Scholar
• Atterwill C K., Bunn S J., Atkinson D J., Smith S L., Heal D J. Effects of thyroid status on presynaptic α2–adrenoceptor function and β-adrenoceptor binding in the rat brain. J Neural Transm 1984; 59: 43–55
   Google Scholar
• Savard P, Merand Y, Di Paolo T, Dupont A. Effects of thyroid state on serotonin, 5–hydroxyindoleacetic acid and substance P contents in discrete brain nuclei of adult rats. Neurosci 1983; 10: 1399–1404
   Google Scholar
• Crocker A D., Cameron D L. Evidence for post-synaptic changes mediating increased behavioural sensitivity to dopamine receptor agonists in hypothy-roid rats. Prog Neuro-Psychopharmacol & Biol Psychiat 1988; 12: 607–615
   Google Scholar
• Ito J M., Valcana T, Timiras P S. Effect of hypo-and hyperthyroidism on regional monoamine metabolism in the adult rat brain. Neuroendocrinology 1977; 24: 55–64
   Google Scholar
• Vaccari A. Decreased central serotonin function in hypothyroidism. Europ J Pharmacol 1982; 82: 93–95
   Google Scholar
• Sandrini M, Marrama D, Vergoni A, Bertolini V. Effects of thyroid status on the characteristics of alpha 1–, alpha2–, beta, imipramine and GABA receptors in the rat brain. Life Sci 1991; 48: 659–666
   Google Scholar
• Dubovsky S L. Generalized anxiety disorder: new concepts and psy-chopharmacologic therapies. J Clin Psychiatry 1990; 51(1 Suppl)3–40
   Google Scholar
• Paul S M. Anxiety and depression: a common neurobiological substrate?. J Clin Psychiatry 1988; 49(10, Suppl)13–16
   Google Scholar
• Coyle J T., Price D L., DeLong M R. Alzheimer's disease: a disorder of cortical cholinergic innervation. Science 1983; 219: 1184–90
   PubMed Web of Science ®Google Scholar
• Catala M D., Quay W B., Timiras P S. Effects of thyroid hormone on light/dark melatonin synthesis and release by young and maturing rat pineal glands in vitro. Int J Devl Neurosci 1988; 6: 285–288
   Google Scholar
• Reichlin S. The Pineal. Cecil Textbook of Medicine. 17th ed, J B Wyngaarden, L H Smith. WB Saunders Co., Philadelphia 1985; 1273–75
   Google Scholar
• Guerrero J M., Puig-Domingo M, Reiter R J. Thyroxine 5′-deiodinase activity in pineal gland and frontal cortex: Nighttime increase and the effect of either continuous light exposure or superior cervical ganglionectomy. Endocrinology 1988; 122: 236–241
   PubMedGoogle Scholar
• Tanaka K, Murakami M, Greer M A. Rhythmicity of triiodothyronine generation by type II thyroxine 5′-deiodinase in rat pineal is mediated by a β–adren-ergic mechanism. Endocrinology 1987; 121: 74–77
   PubMedGoogle Scholar
• Utiger R D. Thyrotropin: assay and secretory physiology in man. Werner's The Thyroid, A Fundamental and Clinical Text. 5th ed, L E Braverman, S H Ingbar. Harper and Row, New York 1986
   Google Scholar
• Drugan R, Holmes P. Central and peripheral benzodiazepine receptors: involvement in an organism's response to physical and psychological stress. Neuroscience & Biobehavioral Reviews 1991; 15: 277–298
   PubMedGoogle Scholar
• Doble A, Martin I A. Multiple benzodiazepine receptors: no reason for anxiety. Trends Pharmacol Sci 1992; 13: 76–81
   PubMed Web of Science ®Google Scholar
• Ruano D, Vizuete M, Cano J, Machado A, Vitorica J. Heterogeneity in the allosteric interaction between the γ-aminobutyric acid (GABA) binding site and three different benzodiazepine binding sites of the GABAa/benzodiazepine receptor complex in the rat nervous system. J Neurochem 1992; 58: 485–493
   PubMedGoogle Scholar
• Jones E A. Benzodiazepine receptor ligands and hepatic encephalopa-thy: further unfolding of the GABA story. Hepatology 1991; 14: 1286–1290
   Google Scholar
• Verma A, Snyder S H. Peripheral type benzodiazepine receptors. Annu Rev Pharmacol Toxicol 1989; 29: 307–22
   PubMed Web of Science ®Google Scholar
• Gavish M, Katz Y, Bar-Ami S, Weizman R. Biochemical, physical and pathological aspects of the peripheral benzodiazepine receptor. J Neurochem 1992; 58: 1589–1601
   Google Scholar
• McEnery M, Snowman A, Trifiletti R, Snyder S. Isolation of the mi-tochondrial benzodiazepine receptor: Association with the voltage-dependent anion channel and the adenine nucleotide carrier. Proc Natl Acad Sci, USA 1992; 89: 3170–3174
   PubMed Web of Science ®Google Scholar
• Papadopoulos V, Mukhin A G., Costa E, Krueger K E. The peripheral-type benzodiazepine receptor is functionally linked to leydig cell steroidogenesis. J Biol Chem 1990; 265: 3772–3779
   PubMed Web of Science ®Google Scholar
• Wang J KT, Morgan J I., Spector S. Benzodiazepines that bind at peripheral sites inhibit cell proliferation. Proc Natl Acad Sci, USA 1984; 81: 753–756
   PubMed Web of Science ®Google Scholar
• Roy A. Cerebrospinal fluid diazepam binding inhibitor in depressed patients and normal controls. Neuropharm 1991; 30: 1441–1444
   PubMedGoogle Scholar
• Papadopoulos V, Berkovich A, Krueger K, Costa E, Guidotti A. Diazepam binding inhibitor and its processing products stimulate mitochondrial steroid biosynthesis via an interaction with mitochondrial benzodiazepine receptors. Endocrinology 1991; 129: 1481–1488
   PubMedGoogle Scholar
• Izquierdo I, Medina J H. GABAA receptor modulation of memory: the role of endogenous benzodiazepines. Tr Pharmacol Sci 1991; 12: 260–265
   PubMed Web of Science ®Google Scholar
• Majewska M D. Neurosteroids: GABA-agonistic and GABA-antago-nistic modulators of the GABAA receptor. Neurosteroids and Brain Function, E Costa, S M Paul. Fidia Research Foundation Symposium Series, Thieme Medical Publishers, Inc, New York 1991; vol 8: 109–118
   Google Scholar
• Lan N C., Bolger M B., Purdy R, Gee K W. A steroid recognition site associated with central GABAA receptors. Neurosteroids and Brain Function, E Costa, S M Paul. Fidia Research Foundation Symposium Series, Thieme Medical Publishers, Inc., New York 1991; vol 8: 103–108
   Google Scholar
• Smith S S. The effects of estrogen and progesterone on GABA and glutamate responses at extrahypothalamic sites. Neurosteroids and Brain Function, E Costa, S M Paul. Fidia Research Foundation Symposium Series, Thieme Medical Publishers, Inc., New York 1991; vol 8: 87–94
   Google Scholar
• Purdy R H., Moore P H, Jr, Morrow A L., Paul S M. The 3α-hydroxy ring A-reduced metabolites of progesterone and deoxycorticosterone: natural li-gands of central GABAA receptors. Neurosteroids and Brain Function, E Costa, S M Paul. Fidia Research Foundation Symposium Series, Thieme Medical Publishers, Inc., New York 1991; vol 8: 95–102
   Google Scholar
• Rothstein J, Garland W, Puia G, Montagna P, Tinuper P, Cortelli P, Avoni P, Plazzi G, Sforza E, Lugaresi E, Guidotti A. Endogenous positive allosteric modulators for GABAA receptors (endozepines): a cause of stupor and coma?. Society for Neuroscience. 22nd Annual Meeting, Anaheim, CA., 1992, Abstract #8.9
   Google Scholar
• Kragie L, Forrester M L., Cody V. Structural characteristics of benzodiazepine compounds which inhibit triiodothyronine cellular uptake. The Endocrine Society. Annual Meeting, San Antonio, TX, 1992, Abstract # 428
   Google Scholar
• Movius E G., Phyillaier M M., Robbins J. Phloretin inhibits cellular uptake and nuclear receptor binding of triiodothyronine in human HepG2 hepatocarci-noma cells. Endocrinology 1989; 124: 1988–1997
   Google Scholar
• Topliss D J., Kolliniatis E, Barlow J W., Lim C -F, Stockigt J R. Uptake of 3,5,3′-triiodothyronine by cultured rat hepatoma cells is inhibitable by nonbile acid cholephils, diphenylhydantoin, and nonsteroidal antiinflammatory drugs. Endocrinology 1989; 124: 980–987
   Google Scholar
• Kragie L, Doyle D. Benzodiazepines inhibit temperature-dependent L- [125I]triiodothyronine accumulation into human liver, human neuroblast, and rat pituitary cell lines. Endocrinology 1992; 130: 1211–1216
   PubMedGoogle Scholar
• Blondeau J -P, Osty J, Francon J. Characterization of the thyroid hormone transport system of isolated hepatocytes. J Biol Chem 1988; 263: 2685–2692
   PubMed Web of Science ®Google Scholar
• Eckel J, Rao G S., Rao M L., Breuer H. Uptake of L-tri-iodothyronine by isolated rat liver cells. Biochem J 1979; 182: 473–491
   PubMed Web of Science ®Google Scholar
• Mol J A., Krenning E P., Docter R, Rozing J, Hennemann G. Inhibition of iodothyronine transport into rat liver cells by a monoclonal antibody. J Biol Chem 1986; 261: 7640–7643
   Google Scholar
• Osty J, Valensi P, Samsom M, Francon J, Blondeau J -P. Transport of thyroid hormones by human erythrocytes: kinetic characterization in adults and newborms. J Clin Endocrinol Metab 1990; 71: 1589–1595
   PubMedGoogle Scholar
• Zhou Y, Samson M, Osty J, Francon J, Blondeau J -P. Evidence for a close link between the thyroid hormone transport system and the aromatic amino acid transport system T in erythrocytes. J Biol Chem 1990; 265: 1700–4
   Google Scholar
• Goncalves E, Lakshmanan M, Cahnmann H J., Robbins J. High-affinity binding of thyroid hormones to neuroblastoma plasma membranes. Biochim Biopys Acta 1990; 1055: 151–156
   Google Scholar
• Goncalves E, Lakshmanan M, Pontecorvi A, Robbins J. Thyroid hormone transport in a human glioma cell line. Molec Cellular Endocrinol 1990; 69: 157–165
   Google Scholar
• Lakshmanan M, Goncalves E, Lessly G, Foti D, Robbins J. The transport of thyroxine into mouse neuroblastoma cells, NB41A3: the effect of L-system amino acids. Endocrinology 1990; 126: 3245–3250
   PubMed Web of Science ®Google Scholar
• Lakshmanan M, Goncalves E, Pontecorvi A, Robbins J. Differential effect of a new thyromimetic on triiodothyronine transport into myoblast and hep-atoma and neuroblastoma cells. Biochim Biophys Acta 1992; 1133: 213–217
   Google Scholar
• Zemel L R., Biezunski D R., Shapiro L E., Surks M I. 5,5′-diphenylhy-dantoin decreases the entry of 3,5,3′-triiodo-L-thyronine but not L-thyroxine in cultured GH-producing cells. Acta Endocrinologica 1988; 117: 392–398
   Google Scholar
• Pontecorvi A, Robbins J. Energy-dependent uptake of 3,5,3′-triiodo-L-thyronine in rat skeletal muscle. Endocrinology 1986; 119: 2755–2761
   Google Scholar
• Pontecorvi A, Lakshmanan M, Robbins J. Different intracellular and intranuclear transport of triiodothyronine enantiomers in rat skeletal myoblasts. Endocrinology 1988; 123: 2922–2929
   Google Scholar
• Docter R, Krenning E P., Bernard H F., Hennemann G. Active transport of iodothyronines into human cultured fibroblasts. J Clin Endocrinol Metab 1987; 65: 6214–6228
   Google Scholar
• Mitchell A, Manley S, Mortimer R. Membrane transport of thyroid hormone in the human choriocarcinoma cell line, JAR. Mol Cell Endocrinol 1992; 87: 139–145
   Google Scholar
• Leonard J. Regulation of T3 production in the brain. Acta Medica Austriaca 1992, Sonderheft 1: 5–8, Jg. 19/1992
   Google Scholar
• Robbins J, Lakshmanan M. The movement of thyroid hormones in the central nervous system. Acta Medica Austriaca 1992, Sonderheft 1: 21–25, Jg. 19/1992
   Google Scholar
• Kragie L. Requisite structural characteristics for benzodiazepine inhibition of triiodothyronine uptake into a human liver cell line. Life Sci 1992; 51: PL83–PL88
   Google Scholar
• Kragie L, Doyle D. Benzodiazepine inhibition of triiodothyronine uptake into human liver cell line has a unique structure activity relationship. Society for Neuroscience. Annual Meeting, New Orleans, LA, 1991, Abstract # 537.10
   Google Scholar
• Ottenweller J E., Tapp W N., Natelson B H. Effects of chronic alprazo-lam treatment on plasma concentrations of glucocorticoids, thyroid hormones, and testosterone in cardiomyopathic hamsters. Psychopharmacology 1989; 98: 369–371
   Google Scholar
• Joels L A., Drummond A H. The interaction of benzodiazepines with thyrotropin-releasing hormone receptors on clonal pituitary cells. Br J Pharmacol 1989; 96: 450–456
   Google Scholar
• Gershengorn M C., Thaw C N., Geras-Raaka E. Benzodiazepine modulate voltage-sensitive calcium channels in GH3 pituitary cells at sites distinct from thyrotropin-releasing hormone receptors. Endocrinology 1988; 123: 541–544
   Google Scholar
• du Pont J S., Israel J -M. Evidence of a direct action of triiodothyronine (T3) on the cell membrane of GH3 cells: an electrophysiological approach. Experientia 1987; 43: 596–598
   Google Scholar
• du Pont J S. Is reverse triiodothyronine a physiological nonactive competitor for the action of triiodothyronine upon the electrical properties of GH3 cells?. Neuroendocrinology 1991; 54: 146–150
   Google Scholar
• Rinehart R K., Barbaz B, Iyengar S, Ambrose F, Steel D J., Neale R F., Petrack B, Bittiger H, Wood P, Williams M. Benzodiazepine interactions with central thyroid-releasing hormone binding sites: characterization and physiological significance. J Pharm Exptl Therap 1986; 238: 178–185
   Google Scholar
• Simasko S, Horita A. Chlordiazepoxide displaces thyrotropin-releasing hormone (TRH) binding. Eur J Pharmacol 1984; 98: 419–23
   Google Scholar
• Glue P, Bailey J, Wilson S, Hudson A, Nutt D J. Thyrotropin-releasing hormone selectively reverses lorazepam-induced sedation but not slowing of saccadic eye movements. Life Sciences 1992; 50: PL25–PL30
   Google Scholar
• Go T, Ito M, Okuno T, Mikawa H. Effect of thyroid hormones on benzodiazepine receptors in neuron-enriched primary cultures. J Neurochem 1988; 51: 1497–1500
   Google Scholar
• Medina J H., De Robertis E. Benzodiazepine receptor and thyroid hormones: in vivo and in vitro modulation. J Neurochem 1985; 44: 1340–1344
   Google Scholar
• Gavish M, Weizman A, Okun F, Youdim M BH. Modulatory effects of thyroxine treatment on central and peripheral benzodiazepine receptors in the rat. J Neurochem 1986; 47: 1106–1110
   PubMed Web of Science ®Google Scholar
• Nagy A, Lajtha A. Thyroid hormones and derivatives inhibit fluni-trazepam binding. J Neurochem 1983; 40: 414–417
   Google Scholar
• Kragie L, Smiehorowski R. Peripheral benzodiazepine receptor binding in hypothyroid rat ventricles. Society for Neuroscience. Annual Meeting, Annaheim, CA, 1992, Abstract #486.15
   Google Scholar
• Nunez J, Couchie D, Aniello F, Bridoux A. Regulation by thyroid hormone of microtubule assembly and neuronal differentiation. Neurochem Res 1991; 16: 975–982
   PubMed Web of Science ®Google Scholar
• Morgan J I., Johnson M D., Wang J KT, Sonnefeld K H., Spector S. Peripheral-type benzodiazepines influence ornithine decarboxylase levels and neu-rite outgrowth in PC12 cells. Proc Natl Acad Sci USA 1985; 82: 5223–5226
   Google Scholar
• Moreno-Sanchez R, Bravo C, Gutierrez J, Newman A H., Chiang P K. Release of Ca2+ from heart and kidney mitochondria by peripheral-type benzodiazepine receptor ligands. Int J Biochem 1991; 23: 207–213
   Google Scholar
• McKenzie M L., Thomaskutty K G., Swift M L., Pointer R H. Interaction between insulin and thyroid hormones on the control of carbohydrate and lipid metabolism in rat adipose tissue. Biochem Medicine & Metabolic Biol 1987; 38: 31–87
   Google Scholar
• Cuparencu B, Madar J, Horak J, Sildan N, De Santis D, Budetta S N., Marmo E. Effects of benzodiazepine receptors antagonist PK 11195 on glucose uptake by the diaphragms of diabetic rats. Current Therap Res 1990; 48: 744–748
   Google Scholar
• Cuparencu B, Horak J, Marmo E, De Santis D E L, Lo Sasso C, Rossi F. The influence of the peripheral-type benzodiazepine receptor antagonist PK11195 on blood glucose and serum lipid levels in rats. Interactions with di-azepam. Current Therap Res 1991; 49: 409–414
   Google Scholar
• Laird H E, II, Gerrish K C., Duerson K C., Putnam C W., Russell D H. Peripheral benzodiazepine binding sites in Nb 2 node lymphoma cells: effects on prolactin-stimulated proliferation and ornithine decarboxylase activity. Eur J Pharmacol 1989; 171: 25–35
   Google Scholar
• Arora P, Hanna E E., Skolnick P. Suppression of cytotoxic T lymphocyte (CTL) activity by 7142, a benzodiazepine receptor 'inverse agonist'. Immunopharmacol 1991; 21: 91–98
   Google Scholar
• Haddad E E., Mashaly M M. Chicken growth hormone, triiodothyro-nine and thyrotropin releasing hormone modulation of the levels of chicken natural cell-mediated cytotoxicity. Develop Comp Immunol 1991; 15: 65–71
   Web of Science ®Google Scholar
• Proviniali M, Muzzioli M, Di Stefano G, Fabris N. Recovery of spleen cell natural killer activity by thyroid hormone treatment in old mice. Nat Immun Cell Growth Regul 1991; 10: 226–236
   Google Scholar
• Mahdavi V, Strehler E E., Periasamy M, Wieczorek D F., Izumo S, Nadal-Ginard B. Sarcomeric myosin heavy chain gene family; organization and pattern of expression. Med Sci Sports Exercise 1986; 18: 299–308
   Google Scholar
• Gustafson T A., Markham B E., Morkin E. Effects of thyroid hormone on α-actin and myosin heavy chain gene expression in cardiac and skeletal muscles of the rat: measurement of mRNA content using synthetic oligonucleotide probes. Circulation Res 1986; 59: 194–201
   PubMedGoogle Scholar
• Bandman E, Walker C R., Strohman R C. Diazepam inhibits myoblast fusion and expression of muscle specific protein synthesis. Science 1978; 200: 559–561
   Google Scholar
• Walker C R., Bandeman E, Strohman R C. Diazepam induces relaxation of chick embryo muscle fibers in vitro and inhibits myosin synthesis. Exp Cell Res 1979; 123: 285–291
   Google Scholar
• Haefely W, Kyburz E, Gerecke M, Mohler H. Recent advances in the molecular pharmacology of benzodiazepine receptors and in the structure-activity relationships of their agonists and antagonists. Advances in Drug Research, B Testa. Academic Press, , NY 1985; vol.14: 165–323
   Google Scholar
• Christy N. The adrenal cortex in thyrotoxicosis. Werner & Ingbar's The Thyroid. 6th ed., L Braverman, R Utiger. JB Lippincott Co., Philadelphia, PA 1991; 806–820
   Google Scholar
• Gambert S. Environmental effects and physiologic variables. Werner & Ingbar's The Thyroid. 6th ed., L Braverman, R Utiger. JB Lippincott Co., Philadelphia, PA 1991; 347–357
   Google Scholar
• Curran T, Morgan J. Superinduction of c-fos by nerve growth factor. Science 1985; 229: 1265–1268
   PubMed Web of Science ®Google Scholar
• Zhang X -K, Wills K, Husmann M, Hermann T, Pfahl M. Novel pathway for thyroid hormone receptor action through interaction with jun and fos oncogene activities. Mol Cell Biol 1991; 11: 6016–6025
   PubMedGoogle Scholar
• Taylor R. Immediate-early genes may offer a new key to the circadian clock. J NIH Res 1990; 2: 49–53
   Google Scholar
• Szabolcs I, Schultheiss H, Astier H, Horster F. Age-related decreases in the thyrotropin (TSH) responsiveness to thyrotropin-releasing-hormone (TRH) stimulation and to the inhibitory effect of triiodothyronine (T3); in vitro study on superfused rat pituitaries. Exptl Gerontol 1991; 26: 347–355
   Google Scholar
• Rami A, Krieglstein J. Thyroxine attenuates hippocampal neuronal damage caused by ischemia in the rat. Life Sci 1992; 50: 645–650
   Google Scholar
• Viticchi C, Grinta R, Piantanelli L. Influence of age on the thyroid hormone-induced up-regulation of β–adrenoceptors in mouse brain cortex. Gerontology 1990; 36: 286–292
   Google Scholar
• Mooradian A D. The hepatic transcellular transport of 3,5,3′-tri-iodothyronine is reduced in aged rats. Biochim Biophys Acta 1990; 1054: 1–7
   Google Scholar
• Smith R, Divoll M, Gillespie W R., Greenblatt D J. Effect of subject age and gender on the pharmacokinetics of oral triazolam and temazepam. J Clin Psychopharmacol 1989; 3: 172–6
   Google Scholar
• Greenblatt D J., Shader R I., Harmatz J S. Implications of altered drug disposition in the elderly: studies of benzodiazepines. J Clin Pharmacol 1989; 29: 866–72
   PubMed Web of Science ®Google Scholar
• Reidenberg M M., Levy M, Warner H. Relationship between di-azepam dose, plasma level, age, and central nervous system. Clin Pharmacol Ther 1978; 23: 371–4, al e
   PubMed Web of Science ®Google Scholar
• Castleden C M., George C F., Marcer D, Hallet C. Increased sensitivity to nitrazepam in old age. Br Med J 1978; 1: 10–2
   Google Scholar
• Pomara N, Stanley B, Block R, et al. Increased sensitivity of the elderly to the central depressant effects of diazepam. J Clin Psychiatry 1985; 46: 185–7
   PubMed Web of Science ®Google Scholar
• Barnhill J G., Greenblatt D J., Miller L G., Gaver A, Harmatz J S., Shader R. Kinetic and dynamic components of increased benzodiazepine sensitivity in aging animals. J Pharmacol Exp Ther 1990; 253: 1153–61
   Google Scholar
• Greenblatt D, Harmatz J S., Shapiro L, Engelhardt N, Gouthro T A., Shader R I. Sensitivity to triazolam in the elderly. N Engl J Med 1991; 324: 1691–8
   PubMed Web of Science ®Google Scholar
• Whybrow P. Behavioral and psychiatric aspects of hypothyroidism. Werner & Ingbar's The Thyroid. Sixth ed., L Braverman, R Utiger. JB Lippincott Co., Philadelphia, PA 1991; 1078–1083
   Google Scholar
• Goodnick P J., Extein I L., Gold M S. TRH test identification of thyroid-responsive depression. Ann Clin Psychiatry 1989; 1: 175–178
   Google Scholar
• Arque J M., Segura R, Torrubia R. Correlation of thyroxine and thyroid-stimulating hormone with personality measurements: a study in psychosomatic patients and healthy subjects. Neuropsychobiology 1987; 18: 127–133
   Web of Science ®Google Scholar
• Kirkegaard C, Korner A, Faber J. Increased production of thyroxine and inappropriately elevated serum thyrotropin levels in endogenous depression. Biol Psychiatry 1990; 27: 472–6
   PubMed Web of Science ®Google Scholar
• Unden F, Ljunggren J -G, Kjellman B, Beck-Friis J, Wetterberg L. Twenty-four-hour serum levels of T4 and T3 in relation to decreased TSH serum levels and decreased TSH response to TRH in affective disorders. Acta psychiatr scand 1986; 73: 358–365
   Google Scholar
• Kirkegaard C, Faber J. Free thyroxine and 3,3′,5′-triiodothyronine levels in cerebrospinal fluid in patients with endogenous depression. Acta Endocrinologica 1991; 124: 166–172
   PubMedGoogle Scholar
• Itoh N, Matsui N, Yaginuma H, Miyashita O, Sakai M. Serial DST, TRH test, and TRH-like immunoreactivity measurements in major affective disorders. Biol Psychiatry 1987; 22: 559–572
   Google Scholar
• Loosen P T., Prange A J., Jr. Serum thyrotropin response to thyrotropin releasing hormone in psychiatric patients; a review. Am J Psychiatry 1982; 139: 405–416
   PubMed Web of Science ®Google Scholar
• Extein I L., Gold M S. Thyroid hormone potentiation of tricyclics. Psychosomatics 1988; 29: 166–174
   Google Scholar
• Brochet D M., Martin P, Soubrie P, Simon P. Triiodothyronine potentiation of antidepressant-induced reversal of learned helplessness in rats. Psychiatry Res 1987; 21: 267–275
   Google Scholar
• Martin P, Massol J, Belon J P., Gaudel G, Soubrie P. Thyroid function and reversal by antidepressant drugs of depressive-like behavior (escape deficients) in rats. Neuropsychobiology 1987; 18: 21–26
   Google Scholar
• Whybrow P. Behavioral and psychiatric aspects of thyrotoxicosis. Werner & Ingbar's The Thyroid. Sixth ed., L Braverman, R Utiger. JB Lippincott Co., Philadelphia, PA 1991; 863–870
   Google Scholar
• Baumgartner A, Campos-Barros A, Meinhold H. Thyroid hormones and depressive illness: implications for clinical and basic research. Acta Medica Austriaca 1992, Sonderheft 1: 98–102, Jg. 19/1992
   Google Scholar
• Lacoste V, Wirtz-Justice A. Seasonal variation in normal subjects: an update of variables current in depression research. Seasonal Affective Disorders and Phototherapy, N E Rosenthal, M C Blehar. V. Guilford Press, New York 1989; 167–229
   Google Scholar
• Joffe R T., Levitt A J. Seasonal variation of peripheral thyroid hormone levels in major depression. J Affective Disorders 1991; 23: 49–51
   Google Scholar
• Wilson D A., Mulder R T., Joyce P R. Diurnal profiles of thyroid hormone are altered in depression. J Affective Disorders 1992; 24: 11–16
   Google Scholar
• Smith B D., Salzman C. Do benzodiazepines cause depression?. Hosp Commun Psychiatr 1991; 42: 1101–1102
   PubMedGoogle Scholar
• Ficarra B J., Nelson R A. Phobia as a symptom in hyperthyroidism. Am J Psychiatry 1977; 46: 432–33
   Google Scholar
• Lindemann C G., Zitrin C M., Klein D F. Thyroid dysfunction in phobic patients. Psychosomatics 1984; 24: 603–606
   Google Scholar
• Fishman S M., Sheehan D V., Carr D B. Thyroid indices in panic disorder. J Clin Psychiatry 1985; 46: 432–433
   Google Scholar
• Yeragani V, Rainey J, Pohl R, Ortiz A, Weinberger P, Gershon S. Thyroid hormone levels in panic disorder. Can J Psychiatry 1987; 32: 467–469
   Google Scholar
• Munjack D J., Palmer R. Thyroid hormones in panic disorder, panic disorder with agoraphobia, and generalized anxiety disorder. J Clin Psychiatry 1988; 49: 229–231
   Google Scholar
• Hollister L E. Pharmacotherapeutic considerations in anxiety disorders. J Clin Psychiatry 1986; 47(6 Suppl)33–36
   Google Scholar
• Noyes R, Jr, Garvey M, Cook B, Perry P. Benzodiazepine withdrawal: a review of the evidence. J Clin Psychiatry 1988; 49: 382–389
   PubMed Web of Science ®Google Scholar
• Guidotti A, Ferrero P, Fujimoto M, Santi R M., Costa E. Studies on the endogenous ligands (endocoids) for the benzodiazepine/beta carboline binding sites. Adv Biochem Psychopharmac 1986; 41: 137–148
   Google Scholar
• Rocca P, Ferrero P, Gualerzi A, Zanalda E, Malna G, Bergamasco B, Ravizza L. Peripheral-type benzodiazepine receptors in anxiety disorders. Acta Psychiatr Scand 1991; 84: 537–544
   PubMedGoogle Scholar
• Rickels K, Schweizer E, Case W, Greenblatt D. Long-term therapeutic use of benzodiazepines. I. Effects of abrupt discontinuation. Arch Gen Psychiatry 1990; 47: 899–907
   PubMed Web of Science ®Google Scholar
• Schweizer E, Rickels K, Case W, Greenblatt D. Long-term therapeutic use of benzodiazepines. II. Effects of gradual taper. Arch Gen Psychiatry 1990; 47: 908–915
   PubMed Web of Science ®Google Scholar
• Ashton H. Benzodiazepine withdrawal: an unfinished story. Br Med J 1984; 288: 1135–40
   PubMed Web of Science ®Google Scholar
• Lister R G., Linnoila M. Alcohol, the chloride ionophore and endogenous ligands for benzodiazepine receptors. Neuropharm 1991; 30: 1435–1440
   Google Scholar
• Mason G A., Stanley D A., Walker C H., Hashimoto H, Noonan L R., Prange A J., Jr. Chronic alcohol ingestion decreases pituitary-thyroid axis measures in Fischer-344 rats. Alcoholism 1988; 12: 731–734
   Google Scholar
• Loosen P T., Prange A J., Jr, Wilson I C. TRH (protirelin) in depressed alcoholic men: behavioral changes and endocrine responses. Arch Gen Psychiatry 1979; 36: 540–547
   PubMed Web of Science ®Google Scholar
• Loosen P T., Wilson I C., Dew B W., et al. Thyotropin-releasing hormone (TRH) in abstinent alcoholic men. Am J Psychiatry 1983; 140: 1145–1149
   PubMed Web of Science ®Google Scholar
• Willenbring M L., Anton R F., Spring W D., Jr, Shafer R B., Dorus W. Thyrotropin and prolactin response to thyrotropin-releasing hormone in depressed and nondepressed alcoholic men. Biol Psychiatry 1990; 27: 31–38
   PubMed Web of Science ®Google Scholar
• Loosen P T., Dew B W., Prange A J., Jr. Long-term predictors of outcome in abstinent alcoholic men. Am JPsychiatry 1990; 147: 1662–1666
   Google Scholar
• Roy A, Bissette G, Nemeroff C B., DeJong J, Ravitz B, Adinoff B, Linnoila M. Cerebrospinal fluid thyrotropin-releasing hormone concentrations in alcoholics and normal controls. Biol Psychiatry 1990; 28: 767–772
   Google Scholar
• Adinoff B, Nemeroff C B., Bissette G, Martin P R., Linnoila M. Inverse relationship between CSF TRH concentrations and the TSH response to TRH in abstinent alcohol-dependent patients. Am J Psychiatry 1991; 148: 1586–1588
   Google Scholar
• Perrild H, Hansen J M., Arnuing K, Olsen P Z., Danielsen U. Intellectual impairment after hyperthyroidism. Acta Endocrinologica 1986; 112: 185–191
   Google Scholar
• Jefferys D, Funder J. Thyroid hormones and the acquisition and retention of behavioural responses. Endocrinology 1989; 123: 1103–1105
   Google Scholar
• Dysken M W., Falk A, Pew B, Kuskowski M, Krahn D D. Gender differences in TRH-stimulated TSH and prolactin in primary degenerative dementia and elderly controls. Biol Psychiatry 1990; 28: 144–150
   Google Scholar
• Ichibangase A, Mishikawa M, Iwasaka T, Kobayashi T, Inada M. Relation between thyroid and cardiac functions and the geriatric rating scale. Acta Neurol Scand 1990; 81: 491–498
   Google Scholar
• Percy M E., Dalton A J., Markovic V D., McLachlan D RC, Gera E, Hummel J T., Rusk A CM, Somerville M J., Andrews D F., Walfish P G. Autoimmune thyroiditis associated with mild “subclinical” hypothyroidism in adults with Down syndrome: a comparison of patients with and without manifestations of Alzheimer disease. Am J Med Genet 1990; 36: 148–154
   PubMed Web of Science ®Google Scholar
• Ewins D L., Rosser M N., Butler J, Roques P K., Mullan M J., McGregor A M. Association between autoimmune thyroid disease and Familial Alzhelmer's disease. Clin Endocrinology 1991; 35: 93–96
   Google Scholar
• Sutherland M, Wong L, Somerville M, Handley P, Yoong L, Bergeron C, McLachlan D. Reduction of thyroid hormone receptor c-ERB Aα mRNA levels in the hippocampus of Alzheimer as compared to Huntington brain. Neurobiol Aging 1992; 13: 301–312
   Google Scholar
• Ghoneim M M., Mewaldt S P. Benzodiazepines and human memory: a review. Anesthesiology 1990; 72: 926–938
   PubMed Web of Science ®Google Scholar
• Bixler W O., Kales A, Manfredi R L., Vgontzas A N., Tyson K L., Kales J D. Next-day memory impairment with triazolam use. The Lancet 1991; 337: 827–830
   PubMed Web of Science ®Google Scholar
• Owen F, Poulter M, Waddington J L., Mashal R D., Crow T J. [3H]Ro5–4864 and [3H]flunitrazepam binding in kinate-lesioned rat striatum and in temporal cortex of brains from patients with senile dementia of the Alzheimer type. Brain Res 1983; 278: 373–375
   PubMed Web of Science ®Google Scholar
• Bidder M, Ratzoni G, Weizman A, Blumensohn R, Norymberg M, Tyano S, Gavish M. Platelet benzodiazepine binding in Alzheimer's Disease. Biol Psychiatry 1990; 28: 641–643
   Google Scholar
• Steindl P, Puspok A, Druml W, Ferenci P. Beneficial effect of pharmacological modulation of the GABAA-benzodiazepine receptor on hepatic en-cephalopathy in the rat: comparison with uremic encephalopathy. Hepatology 1991; 14: 963–968
   Google Scholar
• Larsen P R., Silva J E., Kaplan M M. Relationships between circulating and intracellular thyroid hormones: physiological and clinical implications. Endocrine Reviews 1981; 2: 87–102
   PubMed Web of Science ®Google Scholar
• Silva J, Matthews P. Production rates and turnover of triiodothyro-nine in rat-developing cerebral cortex and cerebellum. J Clin Invest 1984; 74: 1035–1049
   PubMedGoogle Scholar