Variability of blood eosinophil count and prognosis of COPD exacerbations

References

• Global Initiative for Chronic Obstructive Lung Disease. Global strategy for diagnosis, management, and prevention of COPD [Internet] [updated 2018; cited 2020 Jan 5]. Available from: http://www.goldcopd.org
   Google Scholar
• Menga G, Fernandez Acquier M, Echazarreta AL, et al. Prevalence of alpha-1 antitrypsin deficiency in COPD patients in Argentina. The DAAT.AR Study. Arch Bronconeumol. 2020;56(9):571–577.
   PubMed Web of Science ®Google Scholar
• García-Sanz MT, Cánive-Gómez JC, Senín-Rial L, et al. One-year and long-term mortality in patients hospitalized for chronic obstructive pulmonary disease. J Thorac Dis. 2017;9(3):636–645.
   PubMed Web of Science ®Google Scholar
• Padilla-Galo A, Olveira Fuster C. Bronchiectasis in COPD and asthma. More than just a coincidence. Arch Bronconeumol. 2019;55(4):181–182.
   PubMed Web of Science ®Google Scholar
• Izquierdo JL, Morena D, González Y, et al. Clinical management of COPD in a real-world setting. A big data analysis. Arch Bronconeumol. 2020;57(2):94–100.
   PubMed Web of Science ®Google Scholar
• De la Rosa Carrillo D, López-Campos JL, Alcázar Navarrete B, et al. Consensus document on the diagnosis and treatment of chronic bronchial infection in chronic obstructive pulmonary disease. Arch Bronconeumol. 2020;56(10):651–664.
   PubMed Web of Science ®Google Scholar
• Roche N, Chapman KR, Vogelmeier CF, et al. Blood eosinophils and response to maintenance chronic obstructive pulmonary disease treatment. Data from the FLAME trial. Am J Respir Crit Care Med. 2017;195(9):1189–1197.
   PubMed Web of Science ®Google Scholar
• López-Campos JL, Carrasco-Hernández L, Román Rodríguez L, et al. The clinical implications of triple therapy in fixed-dose combination in COPD: from the trial to the patient. Arch Bronconeumol. 2020;56(4):242–248.
   PubMed Web of Science ®Google Scholar
• Montes de Oca M, López Varela MV, Acuña A, et al. Incorporating new evidence on inhaled medications in COPD. The Latin American Chest Association (ALAT) 2019. Arch Bronconeumol. 2020;56(2):106–113.
   PubMed Web of Science ®Google Scholar
• Díaz López JM, Giran González B, Alcázar-Navarrete B. Personalized medicine in chronic obstructive pulmonary disease: how close are we? Arch Bronconeumol. 2019;56(7):420–421.
   PubMed Web of Science ®Google Scholar
• Mathioudakis AG, Janssens W, Sivapalan P, et al. Acute exacerbations of chronic obstructive pulmonary disease: in search of diagnostic biomarkers and treatable traits. Thorax. 2020;75(6):520–527.
   PubMed Web of Science ®Google Scholar
• Mycroft K, Krenke R, Górska K. Eosinophils in COPD. Current concepts and clinical implications. J Allergy Clin Immunol Pract. 2020;8(8):2565–2574.
   PubMed Web of Science ®Google Scholar
• Singh D, Bafadhel M, Brightling CE, et al. Blood eosinophil counts in clinical trials for chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2020;202(5):660–671.
   PubMed Web of Science ®Google Scholar
• Landis S, Suruki R, Maskel J, et al. Demographic and clinical characteristics of COPD patients at different blood eosinophil levels in the UK Clinical Practice Research Datalink. COPD. 2018;15(2):177–184.
   PubMedGoogle Scholar
• Schumann DM, Tamm M, Kostikas K, et al. Stability of the blood eosinophilic phenotype in stable and exacerbated COPD. Chest. 2019;156(3):456–465.
   PubMed Web of Science ®Google Scholar
• Greulich T, Tüffers J, Mager S, et al. High eosinophil blood counts are associated with a shorter length of hospital stay in exacerbated COPD patients - a retrospective analysis. Respir Res. 2020;21(1):106.
   PubMed Web of Science ®Google Scholar
• Adir Y, Hakrush O, Shteinberg M, et al. Circulating eosinophil levels do not predict severe exacerbations in COPD: a retrospective study. ERJ Open Res. 2018;4(3):00022–2018.
   PubMedGoogle Scholar
• MacDonald MI, Osadnik CR, Bulfin L, et al. Low and high blood eosinophil counts as biomarkers in hospitalized acute exacerbations of COPD. Chest. 2019;156(1):92–100.
   PubMed Web of Science ®Google Scholar
• Nuñez A, Marras V, Harlander M, et al. Association between routine blood biomarkers and clinical phenotypes and exacerbations in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2020;15:681–690.
   PubMed Web of Science ®Google Scholar
• Kim VL, Coombs NA, Staples KJ, et al. Impact and associations of eosinophilic inflammation in COPD: analysis of the AERIS cohort. Eur Respir J. 2017;50(4):1700853.
   PubMed Web of Science ®Google Scholar
• Soler-Cataluña JJ, Novella L, Soler C, et al. Clinical characteristics and risk of exacerbations associated with different diagnostic criteria of asthma-COPD Overlap. Arch Bronconeumol. 2020;56(5):282–290.
   PubMed Web of Science ®Google Scholar
• Gonzalez-Barcala FJ, San-Jose ME, Nieto-Fontarigo JJ, et al. Blood eosinophils could be useful as a biomarker in chronic obstructive pulmonary disease exacerbations. Int J Clin Pract. 2019;73(12):e13423.
   Web of Science ®Google Scholar
• Chapman KR, Hurst JR, Frent SM, et al. Long-term triple therapy de-escalation to indacaterol/glycopyrronium in patients with chronic obstructive pulmonary disease (SUNSET): a randomized, double-blind, triple-dummy clinical trial. Am J Respir Crit Care Med. 2018;198(3):329–339.
   PubMed Web of Science ®Google Scholar
• Jabarkhil A, Moberg M, Janner J, et al. Elevated blood eosinophils in acute COPD exacerbations: better short- and long-term prognosis. Eur Clin Respir J. 2020;7(1):1757274.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Liang LR, Zhang S, et al. Blood eosinophilia and its stability in hospitalized COPD exacerbations are associated with lower risk of all-cause mortality. Int J Chron Obstruct Pulmon Dis. 2020;15:1123–1134.
   PubMed Web of Science ®Google Scholar
• Bafadhel M, Greening NJ, Harvey-Dunstan TC, et al. Blood eosinophils and outcomes in severe hospitalized exacerbations of COPD. Chest. 2016;150(2):320–328.
   PubMed Web of Science ®Google Scholar
• Zysman M, Deslee G, Caillaud D, et al. Relationship between blood eosinophils, clinical characteristics, and mortality in patients with COPD. COPD. 2017;12:1819–1824.
   Google Scholar
• Singh D, Kolsum U, Brightling CE, ECLIPSE Investigators, et al. Eosinophilic inflammation in COPD: prevalence and clinical characteristics. Eur Respir J. 2014;44(6):1697–1700.
   PubMed Web of Science ®Google Scholar
• Long GH, Southworth T, Kolsum U, et al. The stability of blood eosinophils in chronic obstructive pulmonary disease. Respir Res. 2020;21(1):15.
   PubMed Web of Science ®Google Scholar
• Casanova C, Celli BR, de-Torres JP, et al. Prevalence of persistent blood eosinophilia: relation to outcomes in patients with COPD. Eur Respir J. 2017;50(5):1701162.
   PubMed Web of Science ®Google Scholar
• Kadhim-Saleh A, Green M, Williamson T, et al. Validation of the diagnostic algorithms for 5 chronic conditions in the Canadian Primary Care Sentinel Surveillance Network (CPCSSN): a Kingston Practice-based Research Network (PBRN) report. J Am Board Fam Med. 2013;26(2):159–167.
   PubMed Web of Science ®Google Scholar
• Charlson ME, Pompei P, Ales KL, et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373–383.
   PubMedGoogle Scholar
• Pace E, Ferraro M, Minervini MI, et al. Beta defensin-2 is reduced in central but not in distal airways of smoker COPD patients. PLoS One. 2012;7(3):e33601.
   PubMed Web of Science ®Google Scholar
• Obesidad y sobrepeso. Organización Mundial de la salud [cited 2020 Jan 5]. Disponible en: https://www.who.int/es/news-room/fact-sheets/detail/obesity-and-overweight
   Google Scholar
• Dewan NA, Rafique S, Kanwar B, et al. Acute exacerbation of COPD: factors associated with poor treatment outcome. Chest. 2000;117(3):662–671.
   PubMed Web of Science ®Google Scholar
• Gonzalez-Barcala FJ, Calvo-Alvarez U, Salgado-Castro FJ, et al. Asthma exacerbations: factors related to longer hospital stay. Acta Clin Belg. 2017;72(6):379–384.
   PubMed Web of Science ®Google Scholar
• Ashton CM, Kuykendall DH, Johnson ML, et al. The association between the quality of inpatient care and early readmission. Ann Intern Med. 1995;122(6):415–421.
   PubMed Web of Science ®Google Scholar
• Turato G, Semenzato U, Bazzan E, et al. Blood eosinophilia neither reflects tissue eosinophils nor worsens clinical outcomes in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2018;197(9):1216–1219.
   PubMed Web of Science ®Google Scholar
• Singh D, Wedzicha JA, Siddiqui S, et al. Blood eosinophils as a biomarker of future COPD exacerbation risk: pooled data from 11 clinical trials. Respir Res. 2020;21(1):240.
   PubMed Web of Science ®Google Scholar
• Yun JH, Lamb A, Chase R, COPDGene and ECLIPSE Investigators, et al. Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2018;141(6):2037–2047.
   PubMed Web of Science ®Google Scholar
• Vedel-Krogh S, Nielsen SF, Lange P, et al. Blood eosinophils and exacerbations in chronic obstructive pulmonary disease. The Copenhagen General Population Study. Am J Respir Crit Care Med. 2016;193(9):965–974.
   PubMed Web of Science ®Google Scholar
• Miravitlles M, Monteagudo M, Solntseva I, et al. Blood eosinophil counts and their variability and risk of exacerbations in COPD: a population-based study. Arch Bronconeumol. 2020;57(1):13–20.
   PubMed Web of Science ®Google Scholar
• Ho J, He W, Chan MTV, et al. Eosinophilia and clinical outcome of chronic obstructive pulmonary disease: a meta-analysis. Sci Rep. 2017;7(1):13451.
   PubMed Web of Science ®Google Scholar