Polymorphisms in glucose homeostasis genes are associated with cardiovascular and renal parameters in patients with diabetic nephropathy

References

• Rao Kondapally Seshasai S, Kaptoge S, Thompson A, Emerging Risk Factors Collaboration, et al. Diabetes mellitus, fasting glucose, and risk of cause-specific death. N Engl J Med. 2011;364(9):829–841.
   PubMed Web of Science ®Google Scholar
• Alicic RZ, Rooney MT, Tuttle KR. Diabetic kidney disease: Challenges, progress, and possibilities. Clin J Am Soc Nephrol. 2017;12(12):2032–2045.
   PubMed Web of Science ®Google Scholar
• Palsson R, Patel UD. Cardiovascular complications of diabetic kidney disease. Adv Chronic Kidney Dis. 2014;21(3):273–280.
   PubMed Web of Science ®Google Scholar
• Brownlee M. The pathobiology of diabetic complications: a unifying mechanism. Diabetes. 2005;54(6):1615–1625.
   PubMed Web of Science ®Google Scholar
• Nathan DM, Cleary PA, Backlund JY, Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research Group, et al. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med. 2005;353(25):2643–2653.
   PubMed Web of Science ®Google Scholar
• Pistrosch F, Natali A, Hanefeld M. Is hyperglycemia a cardiovascular risk factor? Diabetes care. Diabetes Care. 2011;34 Suppl 2(Suppl 2):S128–S31.
   PubMedGoogle Scholar
• Patel A, MacMahon S, Chalmers J, ADVANCE Collaborative Group, et al. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med. 2008;358(24):2560–2572.
   PubMed Web of Science ®Google Scholar
• Duckworth W, Abraira C, Moritz T, VADT Investigators, et al. Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med. 2009;360(2):129–139.
   PubMed Web of Science ®Google Scholar
• Gerstein HC, Miller ME, Byington RP, Action to Control Cardiovascular Risk in Diabetes Study Group, et al. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med. 2008;358(24):2545–2559.
   PubMed Web of Science ®Google Scholar
• Wanner C, Lachin JM, Inzucchi SE, EMPA-REG OUTCOME Investigators, et al. Empagliflozin and clinical outcomes in patients with type 2 diabetes mellitus, established cardiovascular disease, and chronic kidney disease. Circulation. 2018;137(2):119–129.
   PubMed Web of Science ®Google Scholar
• Jardine AG, Fellstrom B, Logan JO, et al. Cardiovascular risk and renal transplantation: post hoc analyses of the assessment of lescol in renal transplantation (ALERT) study. Am J Kidney Dis. 2005;46(3):529–536.
   PubMed Web of Science ®Google Scholar
• Vallon V. Glucose transporters in the kidney in health and disease. Pflugers Arch - Eur J Physiol. 2020;472(9):1345–1370.
   PubMed Web of Science ®Google Scholar
• Lam JT, Martin MG, Turk E, et al. Missense mutations in SGLT1 cause glucose-galactose malabsorption by trafficking defects. Biochim Biophys Acta. 1999;1453(2):297–303.
   PubMed Web of Science ®Google Scholar
• Drexel H, Leiherer A, Saely CH, et al. Are SGLT2 polymorphisms linked to diabetes mellitus and cardiovascular disease? Prospective study and meta-analysis. Biosci Rep. 2019;39(8):BSR20190299.
   Web of Science ®Google Scholar
• Tziastoudi M, Stefanidis I, Zintzaras E. The genetic map of diabetic nephropathy: evidence from a systematic review and meta-analysis of genetic association studies. Clin Kidney J. 2020;13(5):768–781.
   PubMed Web of Science ®Google Scholar
• Katzmann JL, Mason AM, Marz W, et al. Genetic variation in sodium-glucose cotransporter 2 and heart failure. Clin Pharmacol Ther. 2021;110(1):149–158.
   PubMed Web of Science ®Google Scholar
• Qin LJ, Lv Y, Huang QY. Meta-analysis of association of common variants in the KCNJ11-ABCC8 region with type 2 diabetes. Genet Mol Res. 2013;12(3):2990–3002.
   PubMed Web of Science ®Google Scholar
• Nichols CG, Singh GK, Grange DK. KATP channels and cardiovascular disease: suddenly a syndrome. Circ Res. 2013;112(7):1059–1072.
   PubMed Web of Science ®Google Scholar
• Sakamoto Y, Inoue H, Keshavarz P, et al. SNPs in the KCNJ11-ABCC8 gene locus are associated with type 2 diabetes and blood pressure levels in the japanese population. J Hum Genet. 2007;52(10):781–793.
   PubMed Web of Science ®Google Scholar
• Sokolova EA, Bondar IA, Shabelnikova OY, et al. Replication of KCNJ11 (p.E23K) and ABCC8 (p.S1369A) Association in russian diabetes mellitus 2 type cohort and Meta-Analysis. PLoS One. 2015;10(5):e0124662.
   PubMed Web of Science ®Google Scholar
• Arroyo D, Betriu A, Martinez-Alonso M, investigators from the NEFRONA study, et al. Observational multicenter study to evaluate the prevalence and prognosis of subclinical atheromatosis in a spanish chronic kidney disease cohort: baseline data from the NEFRONA study. BMC Nephrol. 2014;15:168.
   PubMed Web of Science ®Google Scholar
• Abajo M, Betriu A, Arroyo D, Investigators of the NEFRONA study, et al. Mineral metabolism factors predict accelerated progression of common carotid intima-media thickness in chronic kidney disease: the NEFRONA study. Nephrol Dial Transplant. 2017;32(11):1882–1891.
   PubMed Web of Science ®Google Scholar
• Touboul PJ, Hennerici MG, Meairs S, Advisory Board of the 3rd Watching the Risk Symposium 2004, 13th European Stroke Conference, et al. Mannheim intima-media thickness consensus. Cerebrovasc Dis. 2004;18(4):346–349.
   PubMed Web of Science ®Google Scholar
• Stein JH, Korcarz CE, Hurst RT, American Society of Echocardiography Carotid Intima-Media Thickness Task Force, et al. Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American society of echocardiography carotid Intima-Media thickness task force. Endorsed by the society for vascular medicine. J Am Soc Echocardiogr. 2008;21(2):93–111. quiz 189–90.
   PubMed Web of Science ®Google Scholar
• Kilpelainen TO, Lakka TA, Laaksonen DE, Finnish Diabetes Prevention Study Group, et al. Physical activity modifies the effect of SNPs in the SLC2A2 (GLUT2) and ABCC8 (SUR1) genes on the risk of developing type 2 diabetes. Physiol Genomics. 2007;31(2):264–272.
   PubMed Web of Science ®Google Scholar
• Phani NM, Guddattu V, Bellampalli R, et al. Population specific impact of genetic variants in KCNJ11 gene to type 2 diabetes: a case-control and meta-analysis study. PLoS One. 2014;9(9):e107021.
   PubMed Web of Science ®Google Scholar
• Rathmann W, Strassburger K, Bongaerts B, GDS Group, et al. A variant of the glucose transporter gene SLC2A2 modifies the glycaemic response to metformin therapy in recently diagnosed type 2 diabetes. Diab Tologia. 2019;62(2):286–291.
   Google Scholar
• Zimdahl H, Haupt A, Brendel M, et al. Influence of common polymorphisms in the SLC5A2 gene on metabolic traits in subjects at increased risk of diabetes and on response to empagliflozin treatment in patients with diabetes. Pharmacogenet Genomics. 2017;27(4):135–142.
   PubMed Web of Science ®Google Scholar
• Cui W, Du B, Cui Y, et al. Is rs759853 polymorphism in promoter of aldose reductase gene a risk factor for diabetic nephropathy? A meta-analysis. Eur J Med Res. 2015;20:14.
   PubMed Web of Science ®Google Scholar
• Karambataki M, Malousi A, Tzimagiorgis G, et al. Association of two synonymous splicing-associated CpG single nucleotide polymorphisms in calpain 10 and solute carrier family 2 member 2 with type 2 diabetes. Biomed Rep. 2017;6(2):146–158.
   PubMed Web of Science ®Google Scholar
• Dupuis J, Langenberg C, Prokopenko I, MAGIC investigators, et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet. 2010;42(2):105–116.
   PubMed Web of Science ®Google Scholar
• Gaulton KJ, Willer CJ, Li Y, et al. Comprehensive association study of type 2 diabetes and related quantitative traits with 222 candidate genes. Diabetes. 2008;57(11):3136–3144.
   PubMed Web of Science ®Google Scholar
• Laukkanen O, Lindstrom J, Eriksson J, Finnish Diabetes Prevention Study, et al. Polymorphisms in the SLC2A2 (GLUT2) gene are associated with the conversion from impaired glucose tolerance to type 2 diabetes: the finnish diabetes prevention study. Diabetes. 2005;54(7):2256–2260.
   PubMed Web of Science ®Google Scholar
• Willer CJ, Bonnycastle LL, Conneely KN, et al. Screening of 134 single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes replicates association with 12 SNPs in nine genes. Diabetes. 2007;56(1):256–264.
   PubMed Web of Science ®Google Scholar
• Chen G, Xu Y, Lin Y, et al. Association study of genetic variants of 17 diabetes-related genes/loci and cardiovascular risk and diabetic nephropathy in the chinese she population. J Diabetes. 2013;5(2):136–145.
   PubMed Web of Science ®Google Scholar
• Stefanidis I, Tziastoudi M, Tsironi EE, et al. The contribution of genetic variants of SLC2A1 gene in T2DM and T2DM-nephropathy: association study and meta-analysis. Ren Fail. 2018;40(1):561–576.
   PubMed Web of Science ®Google Scholar
• Gonzalez LM, Robles NR, Mota-Zamorano S, et al. Genetic variants in PGE2 receptors modulate the risk of nephrosclerosis and clinical outcomes in these patients. J Pers Med. 2021;11(8):772.
   Web of Science ®Google Scholar
• Mota-Zamorano S, Robles NR, Gonzalez LM, et al. Genetics variants in the epoxygenase pathway of arachidonic metabolism are associated with eicosanoids levels and the risk of diabetic nephropathy. J Clin Med. 2021;10(17):3980.
   PubMed Web of Science ®Google Scholar
• Gorostidi M, Sanchez-Martinez M, Ruilope LM, et al. Chronic kidney disease in Spain: Prevalence and impact of accumulation of cardiovascular risk factors. Nefrologia (Engl Ed). 2018;38(6):606–615.
   PubMed Web of Science ®Google Scholar
• Maqbool M, Cooper ME, Jandeleit-Dahm KAM. Cardiovascular disease and diabetic kidney disease. Semin Nephrol. 2018;38(3):217–232.
   PubMed Web of Science ®Google Scholar
• Kourtidou C, Stangou M, Marinaki S, et al. Novel cardiovascular risk factors in patients with diabetic kidney disease. Int J Mol Sci. 2021;22(20):11196.
   PubMed Web of Science ®Google Scholar
• Zhou XF, Zhou WE, Liu WJ, et al. A network pharmacology approach to explore the mechanism of HuangZhi YiShen capsule for treatment of diabetic kidney disease. J Transl Int Med. 2021;9(2):98–113.
   PubMed Web of Science ®Google Scholar
• Wang Z, Xiong H, Ren TYS. Repair of damaged pancreatic beta cells: New hope for a type 2 diabetes reversal? J Transl Int Med. 2021;9(3):150–151.
   PubMed Web of Science ®Google Scholar
• Ashcroft FM, Rorsman P. Electrophysiology of the pancreatic beta-cell. Prog Biophys Mol Biol. 1989;54(2):87–143.
   PubMed Web of Science ®Google Scholar
• Chavali S, Mahajan A, Tabassum R, et al. Association of variants in genes involved in pancreatic beta-cell development and function with type 2 diabetes in North indians. J Hum Genet. 2011;56(10):695–700.
   PubMed Web of Science ®Google Scholar
• Koo BK, Cho YM, Park BL, et al. Polymorphisms of KCNJ11 (Kir6.2 gene) are associated with type 2 diabetes and hypertension in the korean population. Diabet Med. 2007;24(2):178–186.
   PubMed Web of Science ®Google Scholar
• Xiong C, Zheng F, Wan J, et al. The E23K polymorphism in Kir6.2 gene and coronary heart disease. Clin Chim Acta. 2006;367(1-2):93–97.
   PubMed Web of Science ®Google Scholar
• Liu NJ, Wu HH, Li YL, et al. An analysis of the association between a polymorphism of KCNJ11 and diabetic retinopathy in a chinese han population. Eur J Med Res. 2015;20:3.
   PubMed Web of Science ®Google Scholar
• Severino P, D'Amato A, Netti L, et al. Susceptibility to ischaemic heart disease: Focusing on genetic variants for ATP-sensitive potassium channel beyond traditional risk factors. Eur J Prev Cardiol. 2020;28(13):1495–1500.
   Web of Science ®Google Scholar
• Aka TD, Saha U, Shati SA, et al. Risk of type 2 diabetes mellitus and cardiovascular complications in KCNJ11, HHEX and SLC30A8 genetic polymorphisms carriers: a case-control study. Heliyon. 2021;7(11):e08376.
   PubMed Web of Science ®Google Scholar
• Marucci A, Rutigliano I, Fini G, et al. Role of actionable genes in pursuing a true approach of precision medicine in monogenic diabetes. Genes (Basel). 2022;13(1):117.
   PubMed Web of Science ®Google Scholar
• Laukkanen O, Pihlajamaki J, Lindstrom J, Finnish Diabetes Prevention Study Group, et al. Polymorphisms of the SUR1 (ABCC8) and Kir6.2 (KCNJ11) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. The finnish diabetes prevention study. J Clin Endocrinol Metab. 2004;89(12):6286–6290.
   PubMed Web of Science ®Google Scholar
• Song J, Yang Y, Mauvais-Jarvis F, et al. KCNJ11, ABCC8 and TCF7L2 polymorphisms and the response to sulfonylurea treatment in patients with type 2 diabetes: a bioinformatics assessment. BMC Med Genet. 2017;18(1):64.
   PubMedGoogle Scholar
• Gurzeler E, Ruotsalainen AK, Laine A, et al. SUR1-E1506K mutation impairs glucose tolerance and promotes vulnerable atherosclerotic plaque phenotype in hypercholesterolemic mice. PLoS One. 2021;16(11):e0258408.
   PubMed Web of Science ®Google Scholar
• Zhou K, Yee SW, Seiser EL, ACCORD Investigators, et al. Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin. Nat Genet. 2016;48(9):1055–1059.
   PubMed Web of Science ®Google Scholar
• Le MT, Lobmeyer MT, Campbell M, et al. Impact of genetic polymorphisms of SLC2A2, SLC2A5, and KHK on metabolic phenotypes in hypertensive individuals. PLoS One. 2013;8(1):e52062.
   PubMed Web of Science ®Google Scholar
• Thorens B. GLUT2, glucose sensing and glucose homeostasis. Diab Tologia. 2015;58(2):221–232.
   Google Scholar
• Ordelheide AM, Bohm A, Kempe-Teufel D, et al. Common variation in the sodium/glucose cotransporter 2 gene SLC5A2 does neither affect fasting nor glucose-suppressed plasma glucagon concentrations. PLoS One. 2017;12(5):e0177148.
   PubMed Web of Science ®Google Scholar
• Dekkers CCJ, Gansevoort RT. Sodium-glucose cotransporter 2 inhibitors: extending the indication to non-diabetic kidney disease? Nephrol Dial Transplant. 2020;35(Suppl 1):i33–i42.
   PubMed Web of Science ®Google Scholar
• Poznyak A, Grechko AV, Poggio P, et al. The diabetes Mellitus-Atherosclerosis connection: the role of lipid and glucose metabolism and chronic inflammation. Int J Mol Sci. 2020;21(5):1835.
   Web of Science ®Google Scholar