Effect of antibiotic monensin on cell proliferation and IGF1R signaling pathway in human colorectal cancer cells

References

• Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA: A Cancer J Clinic. 2015;66:7–30.
   Web of Science ®Google Scholar
• Atkin WS, Edwards R, Kralj-Hans I, UK Flexible Sigmoidoscopy Trial Investigators, et al. Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial. Lancet. 2010;375(9726):1624–1633.
   PubMed Web of Science ®Google Scholar
• Brenner H, Kloor M, Pox CP. Colorectal cancer. Lancet. 2014;383(9927):1490–1502.
   PubMed Web of Science ®Google Scholar
• Miyamoto S, Nakanishi M, Rosenberg DW. Suppression of Colon carcinogenesis by targeting notch signaling. Carcinogenesis. 2013;34(10):2415–2423.
   PubMed Web of Science ®Google Scholar
• Suliman MA, Zhang Z, Na H, et al. Niclosamide inhibits Colon cancer progression through downregulation of the notch pathway and upregulation of the tumor suppressor miR-200 family. Int J Mol Med. 2016;38(3):776–784.
   PubMed Web of Science ®Google Scholar
• Gupta SC, Sung B, Prasad S, et al. Cancer drug discovery by repurposing: teaching new tricks to old dogs. Trends Pharmacol Sci. 2013;34(9):508–517.
   PubMed Web of Science ®Google Scholar
• Wang ZY, Quan Y, Zhang HY. Medical genetic inspirations for anticancer drug repurposing. Trends Pharmacol Sci. 2014;35(1):1–3.
   PubMed Web of Science ®Google Scholar
• Pressman BC. Ionophorous antibiotics as models for biological transport. Fed Proc. 1968;27(6):1283–1288.
   PubMedGoogle Scholar
• Ketola K, Vainio P, Fey V, et al. Monensin is a potent inducer of oxidative stress and inhibitor of androgen signaling leading to apoptosis in prostate cancer cells. Mol Cancer Ther. 2010;9(12):3175–3185.
   PubMed Web of Science ®Google Scholar
• Deng Y, Zhang J, Wang Z, et al. Antibiotic monensin synergizes with EGFR inhibitors and oxaliplatin to suppress the proliferation of human ovarian cancer cells. Sci Rep. 2015;5:17523.
   PubMed Web of Science ®Google Scholar
• Choi HS, Jeong EH, Lee TG, et al. Autophagy inhibition with monensin enhances cell cycle arrest and apoptosis induced by mTOR or epidermal growth factor receptor inhibitors in lung cancer cells. Tuberc Respir Dis. 2013;75(1):9–17.
   PubMedGoogle Scholar
• Tumova L, Pombinho AR, Vojtechova M, et al. Monensin inhibits canonical wnt signaling in human colorectal cancer cells and suppresses tumor growth in multiple intestinal neoplasia mice. Mol Cancer Ther. 2014;13(4):812–822.
   PubMed Web of Science ®Google Scholar
• Park WH, Kim ES, Jung CW, et al. Monensin-mediated growth inhibition of SNU-C1 Colon cancer cells via cell cycle arrest and apoptosis. Int J Oncol. 2003;22(2):377–382.
   PubMed Web of Science ®Google Scholar
• Park WH, Jung CW, Park JO, et al. Monensin inhibits the growth of renal cell carcinoma cells via cell cycle arrest or apoptosis. Int J Oncol. 2003;22(4):855–860.
   PubMed Web of Science ®Google Scholar
• Park WH, Kim ES, Kim BK, et al. Monensin-mediated growth inhibition in NCI-H929 myeloma cells via cell cycle arrest and apoptosis. Int J Oncol. 2003;23(1):197–204.
   PubMed Web of Science ®Google Scholar
• Park WH, Seol JG, Kim ES, et al. Monensin-mediated growth inhibition in human lymphoma cells through cell cycle arrest and apoptosis. Br J Haematol. 2002;119(2):400–407.
   PubMed Web of Science ®Google Scholar
• Park WH, Lee MS, Park K, et al. Monensin-mediated growth inhibition in acute myelogenous leukemia cells via cell cycle arrest and apoptosis. Int J Cancer. 2002;101(3):235–242.
   PubMed Web of Science ®Google Scholar
• Kim SH, Kim KY, Yu SN, et al. Monensin induces PC-3 prostate cancer cell apoptosis via ROS production and Ca2+ homeostasis disruption. Anticancer Res. 2016;36(11):5835–5843.
   PubMed Web of Science ®Google Scholar
• Yoon MJ, Kang YJ, Kim IY, et al. Monensin, a polyether ionophore antibiotic, overcomes TRAIL resistance in glioma cells via endoplasmic reticulum stress, DR5 upregulation and c-FLIP downregulation. Carcinogenesis. 2013;34(8):1918–1928.
   PubMed Web of Science ®Google Scholar
• Dayekh K, Johnson-Obaseki S, Corsten M, et al. Monensin inhibits epidermal growth factor receptor trafficking and activation: synergistic cytotoxicity in combination with EGFR inhibitors. Mol Cancer Ther. 2014;13(11):2559–2571.
   PubMed Web of Science ®Google Scholar
• Luo X, Chen J, Song WX, et al. Osteogenic BMPs promote tumor growth of human osteosarcomas that harbor differentiation defects. Lab Invest. 2008;88(12):1264–1277.
   PubMed Web of Science ®Google Scholar
• Su Y, Luo X, He BC, et al. Establishment and characterization of a new highly metastatic human osteosarcoma cell line. Clin Exp Metastasis. 2009;26(7):599–610.
   PubMed Web of Science ®Google Scholar
• Su Y, Wagner ER, Luo Q, et al. Insulin-like growth factor binding protein 5 suppresses tumor growth and metastasis of human osteosarcoma. Oncogene. 2011;30(37):3907–3917.
   PubMed Web of Science ®Google Scholar
• He BC, Gao JL, Zhang BQ, et al. He TC: tetrandrine inhibits wnt/beta-catenin signaling and suppresses tumor growth of human colorectal cancer. Mol Pharmacol. 2011;79(2):211–219.
   PubMed Web of Science ®Google Scholar
• Wang N, Zhang W, Cui J, et al. The piggyBac Transposon-Mediated expression of SV40 T antigen efficiently immortalizes mouse embryonic fibroblasts (MEFs). PLoS One. 2014;9(5):e97316.
   PubMed Web of Science ®Google Scholar
• He BC, Chen L, Zuo GW, et al. Synergistic antitumor effect of the activated PPARgamma and retinoid receptors on human osteosarcoma. Clin Cancer Res. 2010;16(8):2235–2245.
   PubMed Web of Science ®Google Scholar
• Li R, Zhang W, Cui J, et al. Targeting BMP9-promoted human osteosarcoma growth by inactivation of notch signaling. Curr Cancer Drug Targets. 2014;14(3):274–285.
   PubMed Web of Science ®Google Scholar
• Liao Z, Nan G, Yan Z, et al. The anthelmintic drug niclosamide inhibits the proliferative activity of human osteosarcoma cells by targeting multiple signal pathways. Curr Cancer Drug Targets. 2015;15(8):726–738.
   PubMed Web of Science ®Google Scholar
• Cheng H, Jiang W, Phillips FM, et al. Osteogenic activity of the fourteen types of human bone morphogeneticproteins (BMPs). J Bone Joint Surg Am. 2003;85-A:1544–1552.
   PubMed Web of Science ®Google Scholar
• Kang Q, Song WX, Luo Q, et al. A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells. Stem Cells Dev. 2009;18(4):545–559.
   PubMed Web of Science ®Google Scholar
• Kang Q, Sun MH, Cheng H, et al. Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery. Gene Ther. 2004;11(17):1312–1320.
   PubMed Web of Science ®Google Scholar
• Luo J, Deng ZL, Luo X, et al. A protocol for rapid generation of recombinant adenoviruses using the AdEasy system. Nat Protoc. 2007;2(5):1236–1247.
   PubMed Web of Science ®Google Scholar
• Kong Y, Zhang H, Chen X, et al. Destabilization of heterologous proteins mediated by the GSK3beta phosphorylation domain of the beta-Catenin protein. Cell Physiol Biochem. 2013;32(5):1187–1199.
   PubMedGoogle Scholar
• Liu X, Qin J, Luo Q, et al. Cross-talk between EGF and BMP9 signalling pathways regulates the osteogenic differentiation of mesenchymal stem cells. J Cell Mol Med. 2013;17(9):1160–1172.
   PubMed Web of Science ®Google Scholar
• Wang Y, Hong S, Li M, et al. Noggin resistance contributes to the potent osteogenic capability of BMP9 in mesenchymal stem cells. J Orthop Res. 2013;31(11):1796–1803.
   PubMed Web of Science ®Google Scholar
• Gao Y, Huang E, Zhang H, et al. Crosstalk between wnt/beta-Catenin and estrogen receptor signaling synergistically promotes osteogenic differentiation of mesenchymal progenitor cells. PLoS One. 2013;8(12):e82436.
   PubMed Web of Science ®Google Scholar
• Tang N, Song WX, Luo J, et al. He TC: BMP9-induced osteogenic differentiation of mesenchymal progenitors requires functional canonical wnt/beta-catenin signaling. J Cell Mol Med. 2009;13(8B):2448–2464.
   PubMed Web of Science ®Google Scholar
• Ye J, Wang J, Zhu Y, et al. A thermoresponsive polydiolcitrate-gelatin scaffold and delivery system mediates effective bone formation from BMP9-transduced mesenchymal stem cells. Biomed Mater. 2016;11(2):025021.
   PubMed Web of Science ®Google Scholar
• Zhao C, Wu N, Deng F, et al. Adenovirus-mediated gene transfer in mesenchymal stem cells can be significantly enhanced by the cationic polymer polybrene. PLoS One. 2014;9(3):e92908.
   PubMed Web of Science ®Google Scholar
• Gao JL, Lv GY, He BC, et al. Ginseng saponin metabolite 20(S)-protopanaxadiol inhibits tumor growth by targeting multiple cancer signaling pathways. Oncol Rep. 2013;30(1):292–298.
   PubMed Web of Science ®Google Scholar
• Li M, Chen Y, Bi Y, et al. Establishment and characterization of the reversibly immortalized mouse fetal heart progenitors. Int J Med Sci. 2013;10(8):1035–1046.
   PubMed Web of Science ®Google Scholar
• Untergasser A, Cutcutache I, Koressaar T, et al. Primer3–new capabilities and interfaces. Nucleic Acids Res. 2012;40(15):e115.
   PubMed Web of Science ®Google Scholar
• Zhang Q, Wang J, Deng F, et al. TqPCR: a touchdown qPCR assay with significantly improved detection sensitivity and amplification efficiency of SYBR green qPCR. PLoS One. 2015;10(7):e0132666.
   PubMed Web of Science ®Google Scholar
• Miraglia E, Viarisio D, Riganti C, et al. Na+/H + exchanger activity is increased in doxorubicin-resistant human Colon cancer cells and its modulation modifes the sensitivity of the cells to doxorubicin. Int J Cancer. 2005;115(6):924–929.
   PubMed Web of Science ®Google Scholar
• Cleary I, Doherty G, Moran E, et al. The multidrug-resistant human lung tumour cell line, DLKP-A10, expresses novel drug accumulation and sequestration systems. Biochem Pharmacol. 1997;53(10):1493–1502.
   PubMed Web of Science ®Google Scholar
• Inno A, Di Salvatore M, Cenci T, et al. Is there a role for IGF1 R and c-MET pathways in resistance to cetuximab in metastatic colorectal cancer? Clin Colorectal Cancer. 2011;10(4):325–332.
   PubMed Web of Science ®Google Scholar
• Shali H, Ahmadi M, Kafil HS, et al. IGF1R and c-met as therapeutic targets for colorectal cancer. Biomed Pharmacother. 2016;82:528–536.
   PubMed Web of Science ®Google Scholar
• LeRoith D, Roberts CT. The insulin-like growth factor system and cancer. Cancer Lett. 2003;195(2):127–137.
   PubMed Web of Science ®Google Scholar