2,349
Views
1
CrossRef citations to date
0
Altmetric
Research Article

Unsupervised clustering identifies sub-phenotypes and reveals novel outcome predictors in patients with dialysis-requiring sepsis-associated acute kidney injury

ORCID Icon, , , , ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon show all
Article: 2197290 | Received 22 Jul 2022, Accepted 25 Mar 2023, Published online: 12 Apr 2023

References

  • Uchino S, Kellum JA, Bellomo R, et al. Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA. 2005;294(7):1–13.
  • Kellum JA, Chawla LS, Keener C, et al. The effects of alternative resuscitation strategies on acute kidney injury in patients with septic shock. Am J Respir Crit Care Med. 2016;193(3):281–287.
  • Kellum JA, Romagnani P, Ashuntantang G, et al. Acute kidney injury. Nat Rev Dis Primers. 2021;7(1):52.
  • Bagshaw SM, Uchino S, Bellomo R, et al. Septic acute kidney injury in critically ill patients: clinical characteristics and outcomes. Clin J Am Soc Nephrol. 2007;2(3):431–439.
  • Wu VC, Chueh SJ, Chang JT, et al. Acute kidney injury and septic Shock-Defined by updated sepsis-3 criteria in critically ill patients. J Clin Med. 2019;8(10):1731.
  • Fiorentino M, Tohme FA, Wang S, et al. Long-term survival in patients with septic acute kidney injury is strongly influenced by renal recovery. PLoS ONE. 2018;13(6):e0198269.
  • Chen YY, Wu VC, Huang WC, et al. Norepinephrine administration is associated with higher mortality in dialysis requiring acute kidney injury patients with septic shock. J Clin Med. 2018;7(9):274.
  • Barbar SD, Clere-Jehl R, Bourredjem A, et al. Timing of Renal-Replacement therapy in patients with acute kidney injury and sepsis. N Engl J Med. 2018;379(15):1431–1442.
  • Jarvisalo MJ, Hellman T, Uusalo P. Mortality and associated risk factors in patients with blood culture positive sepsis and acute kidney injury requiring continuous renal replacement therapy-A retrospective study. PLoS ONE. 2021;16(4):e0249561.
  • Lee KH, Ou SM, Tsai MT, et al. AN69 filter membranes with high ultrafiltration rates during continuous venovenous hemofiltration reduce mortality in patients with Sepsis-Induced multiorgan dysfunction syndrome. Membranes (Basel). 2021;11(11):837.
  • Leligdowicz A, Matthay MA. Heterogeneity in sepsis: new biological evidence with clinical applications. Crit Care. 2019;23(1):80.
  • Pickkers P, Darmon M, Hoste E, et al. Acute kidney injury in the critically ill: an updated review on pathophysiology and management. Intensive Care Med. 2021;47(8):835–850.
  • Alobaidi R, Basu RK, Goldstein SL, et al. Sepsis-associated acute kidney injury. Semin Nephrol. 2015;35(1):2–11.
  • Liu J, Xie H, Ye Z, et al. Rates, predictors, and mortality of sepsis-associated acute kidney injury: a systematic review and meta-analysis. BMC Nephrol. 2020;21(1):318.
  • Peerapornratana S, Manrique-Caballero CL, Gomez H, et al. Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment. Kidney Int. 2019;96(5):1083–1099.
  • Kuwabara S, Goggins E, Okusa MD. The pathophysiology of Sepsis-Associated AKI. Clin J Am Soc Nephrol. 2022;17(7):1050–1069.
  • Zarbock A. The journey begins: personalized acute kidney injury therapy. Crit Care Med. 2021;49(10):1822–1825.
  • Monti S, Tamayo P, Mesirov J, et al. Consensus clustering: a Resampling-Based method for class discovery and visualization of gene expression microarray data. Machine Learning. 2003;52(1/2):91–118.
  • Ahmad T, Lund LH, Rao P, et al. Machine learning methods improve prognostication, identify clinically distinct phenotypes, and detect heterogeneity in response to therapy in a large cohort of heart failure patients. J Am Heart Assoc. 2018;7(8):e008081.
  • Guo Q, Lu X, Gao Y, et al. Cluster analysis: a new approach for identification of underlying risk factors for coronary artery disease in essential hypertensive patients. Sci Rep. 2017;7:43965.
  • Ahlqvist E, Storm P, Karajamaki A, et al. Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables. Lancet Diabetes Endocrinol. 2018;6(5):361–369.
  • Seymour CW, Kennedy JN, Wang S, et al. Derivation, validation, and potential treatment implications of novel clinical phenotypes for sepsis. JAMA. 2019;321(20):2003–2017.
  • Zheng Z, Waikar SS, Schmidt IM, et al. Subtyping CKD patients by consensus clustering: the chronic renal insufficiency cohort (CRIC) study. JASN. 2021;32(3):639–653.
  • Bhatraju PK, Zelnick LR, Herting J, et al. Identification of acute kidney injury subphenotypes with differing molecular signatures and responses to vasopressin therapy. Am J Respir Crit Care Med. 2019;199(7):863–872.
  • Wiersema R, Jukarainen S, Vaara ST, et al. Two subphenotypes of septic acute kidney injury are associated with different 90-day mortality and renal recovery. Crit Care. 2020;24(1):150.
  • Chaudhary K, Vaid A, Duffy A, et al. Utilization of deep learning for subphenotype identification in Sepsis-Associated acute kidney injury. CJASN. 2020;15(11):1557–1565.
  • Park J, Shrestha R, Qiu C, et al. Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease. Science. 2018;360(6390):758–763.
  • Wu H, Kirita Y, Donnelly EL, et al. Advantages of Single-Nucleus over Single-Cell RNA sequencing of adult kidney: rare cell types and novel cell states revealed in fibrosis. JASN. 2019;30(1):23–32.
  • Lin YF, Ko WJ, Chu TS, et al. The 90-day mortality and the subsequent renal recovery in critically ill surgical patients requiring acute renal replacement therapy. Am J Surg. 2009;198(3):325–332.
  • Wu VC, Huang TM, Lai CF, et al. Acute-on-chronic kidney injury at hospital discharge is associated with long-term dialysis and mortality. Kidney Int. 2011;80(11):1222–1230.
  • Lai CF, Wu VC, Huang TM, et al. Kidney function decline after a non-dialysis-requiring acute kidney injury is associated with higher long-term mortality in critically ill survivors. Crit Care. 2012;16(4):R123.
  • Shiao CC, Huang YT, Lai TS, et al. Perioperative body weight change is associated with in-hospital mortality in cardiac surgical patients with postoperative acute kidney injury. PLoS ONE. 2017;12(11):e0187280.
  • Bellomo R, Kellum JA, Ronco C, et al. Acute kidney injury in sepsis. Intensive Care Med. 2017;43(6):816–828.
  • Levey AS, Eckardt KU, Dorman NM, et al. Nomenclature for kidney function and disease: executive summary and glossary from a kidney disease: improving global outcomes (KDIGO) consensus conference. Transpl Int. 2020;33(9):999–1009.
  • Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA. 2016;315(8):801–810.
  • Raith EP, Udy AA, Bailey M, et al. Prognostic accuracy of the SOFA score, SIRS criteria, and qSOFA score for in-Hospital mortality among adults with suspected infection admitted to the intensive care unit. JAMA. 2017;317(3):290–300.
  • Pan HC, Huang TM, Sun CY, et al. Predialysis serum lactate levels could predict dialysis withdrawal in type 1 cardiorenal syndrome patients. EClinicalMedicine. 2022;44:101232.
  • Levey AS, Bosch JP, Lewis JB, et al. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of diet in renal disease study group. Ann Intern Med. 1999;130(6):461–470.
  • Chen YS, Lin JW, Yu HY, et al. Cardiopulmonary resuscitation with assisted extracorporeal life-support versus conventional cardiopulmonary resuscitation in adults with in-hospital cardiac arrest: an observational study and propensity analysis. Lancet. 2008;372(9638):554–561.
  • Kellum JA. How can we define recovery after acute kidney injury? Considerations from epidemiology and clinical trial design. Nephron Clin Pract. 2014;127(1-4):81–88.
  • Austin PC, Lee DS, Fine JP. Introduction to the analysis of survival data in the presence of competing risks. Circulation. 2016;133(6):601–609.
  • Valenzuela JF, Monterola C, Tong VJC, et al. Health and disease phenotyping in old age using a cluster network analysis. Sci Rep. 2017;7(1):15608.
  • Shiao CC, Chang YH, Yang YF, et al. Association between regional economic status and renal recovery of dialysis-requiring acute kidney injury among critically ill patients. Sci Rep. 2020;10(1):14573.
  • Zarbock A, Kullmar M, Ostermann M, et al. Prevention of cardiac Surgery-Associated acute kidney injury by implementing the KDIGO guidelines in High-Risk patients identified by biomarkers: the PrevAKI-Multicenter randomized controlled trial. Anesth Analg. 2021;133(2):292–302.
  • Molinari L, Heskia F, Peerapornratana S, et al. Limiting acute kidney injury progression in sepsis: study protocol and trial simulation. Crit Care Med. 2021;49(10):1706–1716.
  • Fidalgo P, Bagshaw SM. Chronic kidney disease in the intensive care unit. In: Arici M, editor. Management of chronic kidney disease: a clinician’s guide. Berlin, Heidelberg: springer Berlin Heidelberg; 2014. p. 417–438.
  • Dahlerus C, Segal JH, He K, et al. Acute kidney injury requiring dialysis and incident dialysis patient outcomes in US outpatient dialysis facilities. CJASN. 2021;16(6):853–861.
  • Wonnacott A, Meran S, Amphlett B, et al. Epidemiology and outcomes in community-acquired versus hospital-acquired AKI. Clin J Am Soc Nephrol. 2014;9(6):1007–1014.
  • Famous KR, Delucchi K, Ware LB, et al. Acute respiratory distress syndrome subphenotypes respond differently to randomized fluid management strategy. Am J Respir Crit Care Med. 2017;195(3):331–338.
  • Hsu YC, Hsu CW. Septic acute kidney injury patients in emergency department: the risk factors and its correlation to serum lactate. Am J Emerg Med. 2019;37(2):204–208.
  • Passos RDH, Ramos JGR, Gobatto A, et al. Lactate clearance is associated with mortality in septic patients with acute kidney injury requiring continuous renal replacement therapy: a cohort study. Medicine (Baltimore). 2016;95(40):e5112.
  • Forni LG, Darmon M, Ostermann M, et al. Renal recovery after acute kidney injury. Intensive Care Med. 2017;43(6):855–866.
  • Kellum JA, Sileanu FE, Bihorac A, et al. Recovery after acute kidney injury. Am J Respir Crit Care Med. 2017;195(6):784–791.
  • Bhatraju PK, Cohen M, Nagao RJ, et al. Genetic variation implicates plasma angiopoietin-2 in the development of acute kidney injury Sub-phenotypes. BMC Nephrol. 2020;21(1):284.