Metabolic syndrome: Clinical concept and molecular basis

References

• The IDF consensus worldwide definition of the metabolic syndrome, Available from http://www.idf.org/webdata/docs/Metabolic_syndrome_definition.pdf.
   Google Scholar
• Tokunaga K., Matsuzawa Y., Ishikawa K., Tarui S. A novel technique for the determination of body fat by computed tomography. Int J Obes 1983; 7: 437–45
   PubMed Web of Science ®Google Scholar
• Fujioka S., Matsuzawa Y., Tokunaga K., Tarui S. Contribution of intraabdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity. Metabolism 1987; 36: 54–9
   PubMed Web of Science ®Google Scholar
• Kanai H., Matsuzawa Y., Kotani K., Keno Y., Kobatake T., Nagai Y., et al. Close correlation of intra‐abdominal fat accumulation to hypertension in obese women. Hypertension 1990; 16: 484–90
   PubMed Web of Science ®Google Scholar
• Matsuzawa Y., Fujioka S., Tokunaga K., Tarui S. Classification of obesity with respect to morbidity. Proc Soc Exp Biol Med 1992; 200: 197–201
   PubMedGoogle Scholar
• Reaven G. M. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 1988; 37: 1595–607
   PubMed Web of Science ®Google Scholar
• Kaplan N. M. The deadly quartet. Upper‐body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. Arch Intern Med 1989; 149: 1514–20
   PubMed Web of Science ®Google Scholar
• DeFronzo R. A., Ferrannini E. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 1991; 14: 173–94
   PubMed Web of Science ®Google Scholar
• Vague J. La differentiation sexuelle facteur determinant des formes de l'obesite. Presse Med 1947; 30: 339–40
   Google Scholar
• Kissebah A. H., Vydelingum N., Murray R., Evans D. J., Hartz A. J., Kalkhoff R. K., et al. Relation of body fat distribution to metabolic complications of obesity. J Clin Endocrinol Metab 1982; 54: 254–60
   PubMed Web of Science ®Google Scholar
• Larsson B., Svardsudd K., Welin L., Wilhelmsen L., Bjorntorp P., Tibblin G. Abdominal adipose tissue distribution, obesity, and risk of cardiovascular disease and death: 13 year follow up of participants in the study of men born in 1913. Br Med J Clin Res Ed 1984; 288: 1401–04
   PubMed Web of Science ®Google Scholar
• Nakamura T., Tokunaga K., Shimomura I., Nishida M., Yoshida S., Kotani K., et al. Contribution of visceral fat accumulation to the development of coronary artery disease in non‐obese men. Atherosclerosis 1994; 107: 239–46
   PubMed Web of Science ®Google Scholar
• Koutsari C., Jensen M. D. Thematic review series: patient‐oriented research. Free fatty acid metabolism in human obesity. J Lipid Res 2006; 47: 1643–50
   PubMed Web of Science ®Google Scholar
• Kuriyama H., Yamashita S., Shimomura I., Funahashi T., Ishigami M., Aragane K., et al. Enhanced expression of hepatic acyl‐coenzyme A synthetase and microsomal triglyceride transfer protein messenger RNAs in the obese and hypertriglyceridemic rat with visceral fat accumulation. Hepatology 1998; 27: 557–62
   Google Scholar
• White A. L., Graham D. L., LeGros J., Pease R. J., Scott J. Oleate‐mediated stimulation of apolipoprotein B secretion from rat hepatoma cells. A function of the ability of apolipoprotein B to direct lipoprotein assembly and escape presecretory degradation. J Biol Chem 1992; 267: 15657–64
   Google Scholar
• Kishida K., Kuriyama H., Funahashi T., Shimomura I., Kihara S., Ouchi N., et al. Aquaporin adipose, a putative glycerol channel in adipocytes. J Biol Chem 2000; 275: 20896–902
   PubMed Web of Science ®Google Scholar
• Maeda N., Funahashi T., Hibuse T., Nagasawa A., Kishida K., Kuriyama H., et al. Adaptation to fasting by glycerol transport through aquaporin 7 in adipose tissue. Proc Natl Acad Sci U S A 2004; 101: 17801–06
   PubMed Web of Science ®Google Scholar
• Shimomura I., Hammer R. E., Richardson J. A., Ikemoto S., Bashmakov Y., Goldstein J. L., et al. Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP‐1c in adipose tissue: model for congenital generalized lipodystrophy. Genes Dev 1998; 12: 3182–94
   PubMed Web of Science ®Google Scholar
• Maeda K., Okubo K., Shimomura I., Mizuno K., Matsuzawa Y., Matsubara K. Analysis of an expression profile of genes in the human adipose tissue. Gene 1997; 190: 227–35
   PubMed Web of Science ®Google Scholar
• Shimomura I., Funahashi T., Takahashi M., Maeda K., Kotani K., Nakamura T., et al. Enhanced expression of PAI‐1 in visceral fat: possible contributor to vascular disease in obesity. Nat Med 1996; 2: 800–03
   PubMed Web of Science ®Google Scholar
• Funahashi T., Nakamura T., Shimomura I., Maeda K., Kuriyama H., Takahashi M., et al. Role of adipocytokines on the pathogenesis of atherosclerosis in visceral obesity. Intern Med 1999; 38: 202–06
   PubMed Web of Science ®Google Scholar
• Hotamisligil G. S., Shargill N. S., Spiegelman B. M. Adipose expression of tumor necrosis factor‐alpha: direct role in obesity‐linked insulin resistance. Science 1993; 259: 87–91
   PubMed Web of Science ®Google Scholar
• Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., Friedman J. M. Positional cloning of the mouse obese gene and its human homologue. Nature 1994; 372: 425–32
   PubMed Web of Science ®Google Scholar
• Maeda K., Okubo K., Shimomura I., Funahashi T., Matsuzawa Y., Matsubara K. cDNA cloning and expression of a novel adipose specific collagen‐like factor, apMa (Adipose Most Abundant gene transcript 1). Biochem Biophys Res Commun 1996; 221: 286–9
   PubMed Web of Science ®Google Scholar
• Arita Y., Kihara S., Ouchi N., Takahashi M., Maeda K., Miyagawa J., et al. Paradoxical decrease of an adipose‐specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999; 257: 79–83
   PubMed Web of Science ®Google Scholar
• Ryo M., Nakamura T., Kihara S., Kumada M., Shibazaki S., Takahashi M., et al. Adiponectin as a biomarker of the metabolic syndrome. Circ J 2004; 68: 975–81
   PubMed Web of Science ®Google Scholar
• Okamoto Y., Arita Y., Nishida M., Muraguchi M., Ouchi N., Takahashi M., et al. An adipocyte‐derived plasma protein, adiponectin, adheres to injured vascular walls. Horm Metab Res 2000; 32: 47–50
   PubMed Web of Science ®Google Scholar
• Ouchi N., Kihara S., Arita Y., Maeda K., Kuriyama H., Okamoto Y., et al. Novel modulator for endothelial adhesion molecules: adipocyte‐derived plasma protein, adiponectin. Circulation 1999; 100: 2473–6
   PubMed Web of Science ®Google Scholar
• Ouchi N., Kihara S., Arita Y., Okamoto Y., Maeda K., Kuriyama H., et al. Adiponectin, adipocyte‐derived plasma protein, inhibits endothelial NF‐kB signaling through cAMP‐dependent pathway. Circulation 2000; 102: 1296–301
   PubMed Web of Science ®Google Scholar
• Arita Y., Kihara S., Ouchi N., Maeda K., Kuriyama H., Okamoto Y., et al. Adipocyte‐derived plasma protein, adiponectin, acts as a platelets growth factor‐BB‐binding protein and regulates growth factor‐induced common postreceptor signal in vascular smooth muscle cell. Circulation 2002; 105: 2893–8
   PubMed Web of Science ®Google Scholar
• Ouchi N., Kihara S., Arita Y., Nishida M., Matsuyama A., Okamoto Y., et al. Adipocyte‐derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte‐derived macrophages. Circulation 2001; 103: 1057–63
   PubMed Web of Science ®Google Scholar
• Yokota T., Oritani K., Takahashi I., Ishikawa J., Matsuyama A., Ouchi N., et al. Adiponectin, a novel member of soluble defense collagens, negatively regulates the growth of myelo‐monocytic progenitors and the functions of macrophages. Blood 2000; 96: 1723–32
   PubMed Web of Science ®Google Scholar
• Kumada M., Kihara S., Ouchi N., Kobayashi H., Okamoto Y., Ohashi K., et al. Adiponectin specifically increased tissue inhibitor of metalloproteinase‐1 through interleukin‐10 expression in human macrophages. Circulation 2004; 109: 2046–9
   PubMed Web of Science ®Google Scholar
• Okamoto Y., Kihara S., Ouchi N., Nishida M., Arita Y., Kumada M., et al. Adiponectin reduces atherosclerosis in apolipoprotein E‐deficient mice. Circulation 2002; 106: 2767–70
   PubMed Web of Science ®Google Scholar
• Matsuda M., Shimomura I., Sata M., Arita Y., Nishida M., Maeda N., et al. Role of adiponectin in preventing vascular stenosis—the missing link of adipo‐vascular axis. J Biol Chem 2002; 277: 37487–91
   PubMed Web of Science ®Google Scholar
• Shibata R., Sato K., Pimentel D. R., Takemura Y., Kihara S., Ohashi K., et al. Adiponectin protects against myocardial ischemia‐reperfusion injury through AMPK‐ and COX‐2‐dependent mechanisms. Nat Med 2005; 11: 1096–103
   PubMed Web of Science ®Google Scholar
• Ouchi N., Kihara S., Funahashi T., Nakamura T., Nishida M., Kumada M., et al. Reciprocal association of C‐reactive protein with adiponectin in blood stream and adipose tissue. Circulation 2003; 107: 671–4
   PubMed Web of Science ®Google Scholar
• Kumada M., Kihara S., Sumitsuji S., Kawamoto T., Matsumoto S., Ouchi N., et al. Association of hypo‐adiponectinemia with coronary artery disease in men. Arterioscl Thromb Vasc Biol 2003; 23: 85–9
   PubMed Web of Science ®Google Scholar
• Zoccali C., Mallamaci F., Tripepi G., Cutrupi S., Parlongo S., Malatino L., et al. Adiponectin, the most abundant adipocyte‐derived protein, is functionally related to metabolic risk factors and predicts cardiovascular outcomes in end stage renal disease. J Am Soc Nephrol 2002; 13: 134–41
   PubMed Web of Science ®Google Scholar
• Pischon T., Girman C. J., Hotamisligil G. S., Rifai N., Hu F. B., Rimm E. B. Plasma adiponectin levels and risk of myocardial infarction in men. JAMA 2004; 291: 1730–7
   PubMed Web of Science ®Google Scholar
• Efstathiou S. P., Tsioulos D. I., Tsiakou A. G., Gratsias Y. E., Pefanis A. V., Mountokalakis T. D. Plasma adiponectin levels and five‐year survival after first‐ever ischemic stroke. Stroke 2005; 36: 1915–19
   PubMed Web of Science ®Google Scholar
• Weyer C., Funahashi T., Tanaka S., Hotta K., Matsuzawa Y., Pratley R. E., et al. Hypoadiponectinemia in obesity and type 2 diabetes: Evidence for a role of insulin resistance and/or hyperinsulinemia. J Clin Endocrinol Metab 2001; 86: 1930–5
   PubMed Web of Science ®Google Scholar
• Hotta K., Funahashi T., Bodkin N. L., Ortmeyer H. K., Arita Y., Hansen B. C., et al. Circulating concentrations of the adipocyte protein, adiponectin, are decreased in parallel with reduced insulin sensitivity during the progression to type‐2 diabetes in rhesus monkeys. Diabetes 2001; 50: 1126–33
   PubMed Web of Science ®Google Scholar
• Maeda N., Shimomura I., Kishida K., Nishizawa H., Matsuda M., Nagaretani H., et al. Diet‐induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 2002; 8: 731–7
   PubMed Web of Science ®Google Scholar
• Lindsay R. S., Funahashi T., Hanson R. L., Matsuzawa Y., Tanaka S., Tataranni P. A., et al. Adiponectin protects against development of type 2 diabetes in the Pima Indian population. Lancet 2002; 360: 57–8
   PubMed Web of Science ®Google Scholar
• Kondo H., Shimomura I., Matsukawa Y., Kumada M., Takahashi M., Matsuda M., et al. Association of adiponectin/ACRP30/AdipoQ mutation with type 2 diabetes mellitus. A candidate gene for the insulin resistance syndrome. Diabetes 2002; 51: 2325–58
   PubMed Web of Science ®Google Scholar
• Ohashi K., Ouchi N., Kihara S., Funahashi T., Nakamura T., Sumitsuji S., et al. Adiponectin I164T mutation is associated with the metabolic syndrome and coronary artery disease. J Am Coll Cardiol 2004; 43: 1195–200
   PubMedGoogle Scholar
• Ouchi N., Kobayashi H., Kihara S., Kumada M., Sato K., Inoue T., et al. Adiponectin stimulates angiogenesis by promoting cross‐talk between AMP‐activated protein kinase and Akt signaling in endothelial cells. J Biol Chem 2004; 279: 1304–09
   PubMed Web of Science ®Google Scholar
• Chen H., Montagnani M., Funahashi T., Shimomura I., Quon M. J. Adiponectin stimulates production of nitric oxide in vascular endothelial cells. J Biol Chem 2003; 278: 45021–6
   PubMed Web of Science ®Google Scholar
• Ouchi N., Ohishi M., Kihara S., Funahashi T., Nakamura T., Nagaretani H., et al. Association of hypoadiponectinemia with impaired vasoreactivity. Hypertension 2003; 42: 231–4
   PubMed Web of Science ®Google Scholar
• Ohashi K., Kihara S., Ouchi N., Kumada M., Fujita K., Hiuge A., et al. Adiponectin replenishment ameliorates obesity‐related hypertension. Hypertension 2006; 47: 1108–16
   PubMed Web of Science ®Google Scholar
• Shibata R., Ouchi N., Ito M., Kihara S., Shiojima I., Pimentel D. R., et al. Adiponectin‐mediated modulation of hypertrophic signals in the heart. Nat Med 2004; 10: 1384–9
   PubMed Web of Science ®Google Scholar
• Miyoshi Y., Funahashi T., Kihara S., Taguchi T., Tamaki Y., Matsuzawa Y., et al. Association of serum adiponectin levels with breast cancer risk. Clin Cancer Res 2003; 9: 5699–704
   PubMed Web of Science ®Google Scholar
• Mantzoros C., Petridou E., Dessypris N., Chavelas C., Dalamaga M., Alexe D. M., et al. Adiponectin and breast cancer risk. J Clin Endocrinol Metab 2004; 89: 1102–07
   PubMed Web of Science ®Google Scholar
• Petridou E., Mantzoros C., Dessypris N., Koukoulomatis P., Addy C., Voulgaris Z., et al. Plasma adiponectin concentrations in relation to endometrial cancer. A case‐control study in Greece. J Clin Endocrinol Metab 2003; 88: 993–7
   PubMed Web of Science ®Google Scholar
• Goktas S., Yilmaz M. I., Caglar K., Sonmez A., Kilic S., Bedir S. Prostate cancer and adiponectin. Urology 2005; 65: 1168–72
   PubMed Web of Science ®Google Scholar
• Wei E. K., Giovannucci E., Fuchs C. S., Willett W. C., Mantzoros C. S. Low plasma adiponectin levels and risk of colorectal cancer in men. a prospective study. J Natl Cancer Inst 2005; 97: 1688–94
   PubMed Web of Science ®Google Scholar
• Kamada Y., Matsumoto H., Tamura S., Fukushima J., Kiso S., Fukui K., et al. Hypoadiponectinemia accelerates hepatic tumor formation in a nonalcoholic steatohepatitis mouse model. J Hepatol 2007, Apr 9 [Epub ahead of print]
   Google Scholar
• Despres J. P., Golay A., Sjostrom L., Rimonabant in Obesity‐Lipids Study Group. Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia. N Engl J Med 2005; 353: 2121–34
   PubMed Web of Science ®Google Scholar
• Maeda N., Takahashi M., Funahashi T., Kihara S., Nishizawa H., Kishida K., et al. PPARγ ligands increase expression and plasma concentration of adiponectin, an adipose‐derived protein. Diabetes 2001; 50: 2094–9
   PubMed Web of Science ®Google Scholar
• Iwaki M., Matsuda M., Maeda N., Funahashi T., Matsuzawa Y., Makishima M., et al. Induction of adiponectin, a fat‐derived antidiabetic and antiatherogenic factor, by nuclear receptors. Diabetes 2003; 52: 1655–63
   PubMed Web of Science ®Google Scholar
• Furukawa S., Fujita T., Shimabukuro M., Iwaki M., Yamada Y., Nakajima Y., et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 2004; 114: 1752–61
   PubMed Web of Science ®Google Scholar
• Iwashima Y., Katsuya T., Ishikawa K., Kida I., Ohishi M., Horio T., et al. Association of hypoadiponectinemia with smoking habit in men. Hypertension 2005; 45: 1094–100
   PubMed Web of Science ®Google Scholar
• Kurata A., Nishizawa H., Kihara S., Maeda N., Sonoda M., Okada T., et al. Blockade of Angiotensin II type‐1 receptor reduces oxidative stress in adipose tissue and ameliorates adipocytokine dysregulation. Kidney Int 2006; 70: 1717–24
   PubMed Web of Science ®Google Scholar
• Funahashi T., Matsuzawa Y. Hypoadiponectinemia. A common basis for diseases associated with overnutrition. Curr Atheroscler Rev 2006; 8: 433–8
   Google Scholar
• Reducing Risks, Promoting Health Life. The World Health Report. World Health Organization, Geneva 2002
   Google Scholar
• Arai H., Yamamoto A., Matsuzawa Y., Saito Y., Yamada N., Oikawa S., et al. Prevalence of metabolic syndrome in the general Japanese population in 2000. J Atheroscler Thromb 2006; 13: 202–08
   PubMed Web of Science ®Google Scholar
• Nakamura T., Tsubono Y., Kameda‐Takemura K., Funahashi T., Yamashita S., Hisamichi S., et al. Magnitude of sustained multiple risk factors for ischemic heart disease in Japanese employees. A case‐control study. Circ J 2001; 65: 11–17
   Google Scholar