The effect of drug interactions on bleeding risk associated with warfarin therapy in hospitalized patients

References

• Bell RG, Sadowski JA, Matschiner JT. Mechanism of action of warfarin. Warfarin and metabolism of vitamin K 1. Biochemistry. 1972; 11: 1959–61
   PubMed Web of Science ®Google Scholar
• Shorr RI, Ray WA, Daugherty JR, Griffin MR. Concurrent use of nonsteroidal anti-inflammatory drugs and oral anticoagulants places elderly persons at high risk for hemorrhagic peptic ulcer disease. Arch Intern Med. 1993; 153: 1665–70
   PubMedGoogle Scholar
• Johnsen SP, Sorensen HT, Mellemkjoer L, Blot WJ, Nielsen GL, McLaughlin JK, et al. Hospitalisation for upper gastrointestinal bleeding associated with use of oral anticoagulants. Thromb Haemost. 2001; 86: 563–8
   PubMed Web of Science ®Google Scholar
• Lanas A, Garcia-Rodriguez LA, Arroyo MT, Gomollon F, Feu F, Gonzalez-Perez A, et al. Risk of upper gastrointestinal ulcer bleeding associated with selective cyclo-oxygenase-2 inhibitors, traditional non-aspirin non-steroidal anti-inflammatory drugs, aspirin and combinations. Gut. 2006; 55: 1731–8
   PubMed Web of Science ®Google Scholar
• Gasse C, Hollowell J, Meier CR, Haefeli WE. Drug interactions and risk of acute bleeding leading to hospitalisation or death in patients with chronic atrial fibrillation treated with warfarin. Thromb Haemost. 2005; 94: 537–43
   PubMed Web of Science ®Google Scholar
• Jönsson AK, Spigset O, Jacobsson I, Hägg S. Cerebral haemorrhage induced by warfarin—the influence of drug-drug interactions. Pharmacoepidemiol Drug Saf. 2007; 16: 309–15
   PubMedGoogle Scholar
• Lindh JD, Holm L, Dahl ML, Alfredsson L, Rane A. Incidence and predictors of severe bleeding during warfarin treatment. J Thromb Thrombolysis. 2008; 25: 151–9
   PubMed Web of Science ®Google Scholar
• Battistella M, Mamdami MM, Juurlink DN, Rabeneck L, Laupacis A. Risk of upper gastrointestinal hemorrhage in warfarin users treated with nonselective NSAIDs or COX-2 inhibitors. Arch Intern Med. 2005; 165: 189–92
   PubMed Web of Science ®Google Scholar
• Johnson S, Rogers K, Delate T, Witt D. Outcomes associated with combined antiplatelet and anticoagulant therapy. Chest. 2008; 133: 948–54
   PubMed Web of Science ®Google Scholar
• Laine K, Forsström J, Grönroos P, Irjala K, Kailajärvi M, Scheinin M. Frequency and clinical outcome of potentially harmful drug metabolic interactions in patients hospitalized on internal and pulmonary medicine wards: focus on warfarin and cisapride. Ther Drug Monit. 2000; 22: 503–9
   PubMedGoogle Scholar
• Piper JM, Ray WA, Daugherty JR, Griffin MR. Corticosteroid use and peptic ulcer disease: role of nonsteroidal anti-inflammatory drugs. Ann Intern Med. 1991; 114: 735–40
   PubMed Web of Science ®Google Scholar
• Hernandez-Diaz S, Rodriguez LA. Steroids and risk of upper gastrointestinal complications. Am J Epidemiol. 2001; 153: 1089–93
   PubMed Web of Science ®Google Scholar
• Nielsen GL, Sorensen HT, Mellemkjoer L, Blot WJ, McLaughlin JK, Tage-Jensen U, et al. Risk of hospitalization resulting from upper gastrointestinal bleeding among patients taking corticosteroids: a register-based cohort study. Am J Med. 2001; 111: 541–5
   PubMed Web of Science ®Google Scholar
• Carson JL, Strom BL, Schinnar R, Duff A, Sim E. The low risk of upper gastrointestinal bleeding in patients dispensed corticosteroids. Am J Med. 1991; 91: 223–8
   PubMedGoogle Scholar
• Lanas A, Garcia-Rodríguez LA, Arroyo MT, Bujanda L, Gomollon F, Forne M, et al. Effect of antisecretory drugs and nitrates on the risk of ulcer bleeding associated with nonsteroidal anti-inflammatory drugs, antiplatelet agents, and anticoagulants. Am J Gastroenterol. 2007; 102: 507–15
   PubMed Web of Science ®Google Scholar
• Massó González EL, Garcia Rodríguez LA. Proton pump inhibitors reduce the long-term risk of recurrent upper gastrointestinal bleeding: an observational study. Aliment Pharmacol Ther. 2008; 28: 629–37
   PubMedGoogle Scholar
• Tirkkonen T, Laine K. Drug interactions with the potential to prevent prodrug activation as a common source of irrational prescribing in hospital inpatients. Clin Pharmacol Ther. 2004; 76: 639–47
   PubMed Web of Science ®Google Scholar
• Molenberghs G, Verbeke G. Models for discrete longitudinal data. Springer-Verlag, New York 2005
   Google Scholar
• Brown H, Prescott R. Applied mixed models in medicine. John Wiley & Sons, New York 1999
   Google Scholar
• Dunnett CW. A multiple comparison procedure for comparing several treatments with a control. J Am Stat Assoc. 1955; 50: 1096–121
   Web of Science ®Google Scholar
• Snaith A, Pugh L, Simpson CR, McLay JS. The potential for interaction between warfarin and coprescribed medication: a retrospective study in primary care. Am J Cardiovasc Drugs. 2008; 8: 207–12
   PubMed Web of Science ®Google Scholar
• Reus VI. Mental disorders. Harrison's principles of internal medicine15th ed, E Braunwald, AS Fauci, DL Kasper, DL Longo, JL Jameson. McGraw-Hill, New York 2001; 2542–57
   Google Scholar
• Lipsky PE. Rheumatoid arthritis. Harrison's principles of internal medicine15th ed, E Braunwald, AS Fauci, DL Kasper, SL Hauser, DL Longo, JL Jameson. McGraw-Hill, New York 2001; 1928–37
   Google Scholar
• de Abajo FJ, Rodriguez LA, Montero D. Association between selective serotonin reuptake inhibitors and upper gastrointestinal bleeding: population based case-control study. BMJ. 1999; 319: 1106–9
   PubMed Web of Science ®Google Scholar
• Hergovich N, Aigner M, Eichler HG, Entlicher J, Drucker C, Jilma B. Paroxetine decreases platelet serotonin storage and platelet function in human beings. Clin Pharmacol Ther. 2000; 68: 435–42
   PubMed Web of Science ®Google Scholar
• Meijer WE, Heerdink ER, Nolen WA, Herings RM, Leufkens HG, Egberts AC. Association of risk of abnormal bleeding with degree of serotonin reuptake inhibition by antidepressants. Arch Intern Med. 2004; 164: 2367–70
   PubMedGoogle Scholar
• Adamson JW, Longo DL. Anemia and polycythemia. Harrison's principles of internal medicine15th edn, E Braunwald, AS Fauci, DL Kasper, SL Hauser, DL Longo, JL Jameson. McGraw-Hill, New York 2001; 348–54
   Google Scholar
• Ertenli I, Kiraz S, Ozturk MA, Haznedaroglu I, Celik I, Calguneri M. Pathologic thrombopoiesis of rheumatoid arthritis. Rheumatol Int. 2003; 23: 49–60
   PubMed Web of Science ®Google Scholar
• Dentali F, Douketis JD, Lim W, Crowther M. Combined aspirin-oral anticoagulant therapy compared with oral anticoagulant therapy alone among patients at risk for cardiovascular disease: a meta-analysis of randomized trials. Arch Intern Med. 2007; 167: 117–24
   PubMed Web of Science ®Google Scholar